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  1. 1. Your first mentored grant proposal: The National Institutes of Health F and K proposals, and Foundations Alison K. Hall, Ph.D. Case School of Medicine Office of Graduate Education
  2. 2. You are at a critical juncture in training productive self-reliant about to embark on independent careers becoming physician-scientists Often write a grant to seek financial support and recognition for research
  3. 3. Why do you want a mentored grant? 1. Makes the relationship with the PI explicit 2. Benefits associated with grant 3. Looks good on your resume 4. Great learning experience 5. The future inclues an R01…
  4. 4. The Number of Pre-Doctoral and Post-Doctoral Research Training Positions on NIH Training Grants and Fellowships (NRSA) Fiscal Year 2005 8,367 1,267 5,621 1,635 0 1,000 2,000 3,000 4,000 5,000 6,000 7,000 8,000 9,000 10,000 Fellowships Training Grants Pre-Doctoral Positions Post-Doctoral Positions (86.8%) (13.2%) (22.5%) (77.5%)
  5. 5. Where do you start? Communicate your PI, potential mentors your chairperson the Office of Research/ Univ Review, compliance Are you ready? pilot data time to focus deadlines Do you qualify? appointment status US citizens, permanent residents
  6. 6. The Number of Research Training Positions on NIH Training Grants and Fellowships (NRSA) Fiscal Years 1996 - 2005 0 2 4 6 8 10 12 14 16 18 Thousands 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 Fellowships Training Grants
  7. 7. Number of Fellowship (F31) Applications Reviewed and Awarded Fiscal Years 1990 – 2005 0 300 600 900 1200 1500 1990199119921993199419951996199719981999200020012002200320042005 Received Awarded
  8. 8. The F30 National Research Service Award (NRSA) for individual Predoctoral MD/PhD fellows set stipend scale and supplement
  9. 9. The F32 NRSA Jan. 9, 2006 Stipends for Kirschstein-NRSA awards 2006 Postdoctoral Years of Experience: 0 $36,996 1 $38,976 2 $41,796 3 $43,428 4 $45,048 5 $46,992 6 $48,852 7 or more $51,036 Institutional Allowance $5,500 Research supplies, health insurance, travel to mtgs Program announcements
  10. 10. Components of Participating Organizations National Institute on Aging (NIA/NIH), ( National Institute on Alcohol Abuse and Alcoholism (NIAAA/NIH), ( National Institute on Deafness and Other Communication Disorders (NIDCD/NIH), (http://www. National Institute on Drug Abuse (NIDA/NIH), ( National Institute of Environmental Health Sciences (NIEHS/NIH), ( National Institute of Mental Health (NIMH/NIH), ( National Institute of Neurological Disorders and Stroke (NINDS/NIH), ( Office of Dietary Supplements (ODS/NIH), ( April 5 August 5 December 5 Individual fellowships (F31) for minority students or students with disabilities have special receipt dates
  11. 11. The F31 NRSA There are some 25 Institutes at NIH that each have mission Look at CRISP database QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture. As director of the National Institute of General Medical Sciences from 1974 to 1993, Ruth Kirschstein MD was the first woman institute director at the National Institutes of Health (NIH). Throughout her career, she has worked as an administrator, fundraiser, and scientific researcher, investigating possible public health responses in the midst of crisis and conservatism.
  12. 12. Stipends 20,772 (suppplement) Tuition and fees (formula) Health insurance Institutional Allowance 30 fellows receive an institutional allowance of $2,750 per 12- month period to non-federal, or nonprofit sponsoring institutions to help defray such awardee expenses as research supplies, equipment, books, and travel to scientific meetings.
  13. 13. 2002 Number number total cost success reviewed awarded awarded 1000s rate* MD 202 91 4,602 45 PHD 1,336 516 20,813 38.6 all 1,538 607 25,415 39.5 The F32 NRSA is a reasonable goal:
  14. 14. Grant NumberPI NameProject Title 5F32GM074554-02ARMBRUSTER, BLAINECreation of designer biogenic amine receptors 5F30DC007274-02 BALU, RAMANIIntrinsic properties of olfactory bulb mitral cells 5F30NS050913-02 COWAN, THOMASAssistive Device Control With Brain Surface Signals 1F31NR008984-01A 2DIMARCO, MARGUERITEUtilization Dental Care by Homeless Children 5F30ES011931-04 ETLING, MICHELEInitiation of Experimental Colitis by Commensal Flora 5F31HD049326-02 JAGODNIK, KATHLEENUpper Extrem. Control Using Reinforcement Learning 5F31MH073296-02 LERCH, JESSICAMolecular Genetics of the Serotonin System 5F31NR009344-02 MURROCK, CAROLYNDance and Physical Activity in Afr. American Women 1F32AA015833-01 PRITCHARD, MICHELEEgr-1 and EtOH-induced hepatic leukocyte recruitment 5F31HD041926-04 ROHDE, TREENAPREDOC FELLOWSH FOR STUDENTS WITH DISABILITIES 5F31MH074241-02 SAMUELS, IVYERK2 Specific Function of the CNS 1F32CA115150-01A1 SWEENEY, COLINRetroviral Insertional Mutagenesis in LMO1 Stem Cells 5F32AG024031-02 WILKINSON, BRANDYMechanisms of Abeta-Stimulated ROS in Microglia
  15. 15. Prepare the Application: read the instructions!! start early, seek internal reviewers a. Candidate US citizen or permanent resident Doctoral degree (many ok) b. Sponsor and Training Environment c. Research Proposal Up to 3 yrs c. Training Potential-impt! d. Vertebrate Animals, Human Subjects etc. e. Three letters of reference f. 3 times per year, usu Apr 5, Aug 5, Dec 5 The A1 or A2. You may have to resubmit…
  16. 16. NRSA Review Criteria •Candidate: •previous academic and research performance •potential to become an important contributor •Sponsor and Training Environment: •quality of the training environment •qualifications of the sponsor as a mentor for the proposed research training experience. •Research Proposal: •merit of the scientific proposal •relationship to the candidate's career plans. •Training Potential: •value of the proposed fellowship experience as it relates to the candidate's needs in preparation for a career as an independent researcher.
  17. 17. The K08 Mentored Clinical Scientist Development Award For clinically trained persons to pursue research careers in basic or clinical sciences. Must apply within 3 years of clinical Training (residency +1 year of clinical fellowship) K08->K02-> R01 up to $85,000 salary up to $50,000 costs/ year up to five years, non-renewable
  18. 18. QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture.
  19. 19. QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture.
  20. 20. QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture.
  21. 21. The K08 Prepare the Application: read the instructions!! a. Candidate b. Research Plan c. Career Development Plan/ Training Plan d. Environment/ Institutional support e. Mentor* f. Vertebrate Animals, Human Subjects etc. g. The A1 or A2. You may have to resubmit… h. (The summary statement)
  22. 22. The K08 Candidate** **some Institutes require faculty app’t (eg Instructor) Basic Science Mentor/co Mentor: 1. Good working relationship 2. Often funded by NIH 3. Expert in this area 4. Experienced trainer
  23. 23. The K08 Career Development Plan (very important) • Focused and relevant • New techniques, new area, could be funded • Present at meetings, review grants, external courses • Update didactics • Create an oversight committee familiar with research, career goals, meet six mos for feedback
  24. 24. Research Plan •Provide preliminary data to support rationale, approach. Focus! •Include study of Research Ethics, animals etc.
  25. 25. The K08 See supplementary info at each institute Insure protected time -Do not assume that 75% means anything except 75% of your total working hours -These estimates are carefully reviewed essential that your chair state this not contingent on receipt of the grant -50% Neurosurgery
  26. 26. What happens to your application after it leaves the mailbox? Center for Scientific Review receives the application assigned to the Initial review group or “Study section” Review for SCIENTIFIC MERIT and TRAINING POTENTIAL. Summary statement, see NIH Commons Scores and percentiles. NRSAs are not streamlined Priority score 100-500, with 100 is best. Rewrite? Respond to critique Funded?Progress report each year
  27. 27. Inside the NIH Grant Review Process 39 min video NIH Center for Scientific Review Includes R01/K08/ R03 Download proposals View the video on the web Helpful Hints for an NLHBI K08 Application
  28. 28. Grantwriting Resources Grantpersonship: An Instruction Manual NIMH Grant Application Process FASEB Grantsmanship Training Program Grant Application Writer’s Handbook, Reif-Lehrer
  29. 29. What about foundations and organization fellowships? Public charitable organizations- MDA, AHA, ACS Derives support from members of the public Foundations-Private, Corporate derives support from a family, individual or corporation see The Foundation Center (Richard Sohn, Research Admin has subscr.) often have a disease focus may support non US citizens Often have one deadline per year
  30. 30. Where to find these other grants? Grantsnet “Initial MD postdoc, dermatology, skin” examples: 18. LRF Postdoctoral Fellowship Awards Program Sponsor: Medical Foundation Program Type: Anatomy, Biochemistry, Bioengineering, Bioinformatics, Biology, Biophysics, Cell Biology, Chemistry, Developmental Biology, Immunology, Microbiology, Molecular Biology, Physiology, Structural Biology Deadline(s): 11/15/2005 23. Research Grants Sponsor: American Skin Association, Inc. Program Type: Biology, Cancer, Cell Biology, Clinical Research, Developmental Biology, Disease-Specific Research Skin Cancer/Melanoma, Psoriasis, Epidemiology, Immunology, Molecular Biology, Structural Biology, Other (specify): Vitiligo, Childhood Skin Diseases/Disfigurement, Pigment Cell Biology and Auto-immune Inflammatory Skin Diseases Deadline(s): 10/03/2005