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Department of Biostatistics Newsletter


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Department of Biostatistics Newsletter

  1. 1. I N S I D E T H I S I S S U E : Letter from the Head 1 Student Infor- mation 2-4 In the News 5 Faculty News 9-11 Publications 12-18 U N I V E R S I T Y O F I O W A Department of Biostatistics Newsletter N O V E M B E R 2 0 0 9 S P EC I AL POINTS OF INTEREST: BSI 2009 6 CPH 10th Anniversary 8 StatFest/Field of Dreams 11 DEPARTMENT ADDRESS: College of Public Health Department of Biostatistics C22 General Hospital 200 Hawkins Drive Iowa City IA 52242-1009 Phone: (319) 384-5016 Fax: (319) 384-5018 Students and mentors from Summer 2009 (page 6). Letter from the Head Dear Friends: This year is the 10th anniversary of the College of Public Health and the College has already begun its year of celebration. Our Department of Bio- statistics has continued to flourish and we have travelled a long way since the offering of the first course in “Biostatistics” at the University of Iowa in 1947: sixty-two years ago. The sound scien- tific foundation provided by the Department of Preventive Medicine and Environmental Health has led to a fully operational and mature College of Public Health. This year we welcome our new faculty member, Professor Chris Coffey, who is also Deputy Di- rector of the Clinical Trials Statistical and Data Management Center, and we welcome our nine new graduate students. Our incoming graduate students are diverse, coming from Illinois, Texas, North Dakota, China, Minnesota, Arizona, Wis- consin, and two from Iowa. We look forward to their success here in the future, as we wish our thirteen graduates in 2009 success in their future endeavors. The economic recession has resulted in financial challenges and hardships throughout the Univer- sity and the state of Iowa. Even as we face these diffi- culties, we are pleased that construction of the new College of Public Health Building continues to progress rapidly. Lower than anticipated construc- tion costs mean that the entire space for the five Departments will be fully finished when we move in. We look forward with great antici- pation (and, admittedly, some trepidation about change) to moving into the new College of Public Health Building: the biggest excitement is that faculty and students will be across the hall from each other, rather than a 10-minute walk away. As the economy recovers, we look forward to continued growth and development of our col- lege in its mission to provide quality education in public health and related areas and high quality research and service. Very best wishes, and thanks from everyone here, to our friends and alumni for their contin- ued support and interest,
  2. 2. P A G E 2 Student Poster Presentations Chang YH, Chaloner K, Winokur P.: “An adaptive dose exploration design for the estimation of a Human Colonizing Dose 50 (HCD50) and Human Colonizing Dose 90 (HCD90).” Research Week, University of Iowa, Iowa City, IA, April 2009. Dastrup E, Lees MN, Dawson JD, Lee JD, Rizzo M: “Differences in simulated car following behavior of younger and older drivers.” Proceedings of the Fifth Interna- tional Driving Symposium on Human Factors in Driver Assessment, Training, and Vehicle Design, Big Sky, MT, June 2009. Jamal MK, Mason EE, Renquist KE, Xie D, Zimmerman MB, Samuel I. “Comparison of Open Roux-en-Y Gastric Bypass (RYGB) and Open Vertical Banded Gastroplasty (VBG) Outcomes”. 23rd Annual Meeting of American Society for Metabolic & Bariatric Surgery, San Francisco, CA, June 2009. Turner C, Xie D, Zimmerman B, Calarge CA. “Does Iron Status in Childhood Pre- dict Response to Psychostimulant Treatment in Children with ADHD?” 56th Annual Meeting of the American Academy of Child &Adolescent Psychiatry, Honolulu, HI, November 2009. Xu Y: “Mapping of Genetic Factors underlying Type I Diabetes in BB Rats using a Correlated Frailty Model”. Research Week, University of Iowa, Iowa City, IA, April 2009. Zhang J: “Bayesian Analysis and Classification of Two Quantitative Diagnostic Tests with False Negatives and No Gold Standard.” Research Week, University of Iowa, Iowa City, IA, April 2009. Zhang J: “Bayesian Analysis and Classification of Two Quantitative Diagnostic Tests with False Negatives and No Gold Standard.” Joint Statistical Meetings, Washington DC, August 2009. Student Oral Presentations Acion L and Cavanaugh J: “Likelihood- and quasi-likelihood-based model selection criteria for generalized linear models”. Seminario Interuniversitario de Investigacion en Ciencias Matematicas, Universidad de Puerto Rico en Rio Piedras, San Juan, Puerto Rico, March 2009. Chang YH, Chaloner K, Winokur P. “An adaptive dose exploration design for the estimation of a Human Colonizing Dose 50 (HCD50) and Human Colonizing Dose 90 (HCD90).” Bayesian Biostatistics Conference, Houston TX, January 2009. Shen S: "Analysis of exon splicing with Affymetrix Exon 1.0 Array". ISU Fall Con- ference on Statistics in Biology, Ames, IA, 2008. Yang M (Contributed Presentation): “Robust Bayesian Sample Size Determination for a Binomial Proportion with Application to the Design of Phase II Cancer Clinical Trials”. Joint Statistical Meetings, Washington DC, August 2009. D E P A R T M E N T O F B I O S T A T I S T I C S N E W S L E T T E R
  3. 3. P A G E 3 BSO Activities The Biostatistics Student Organiza- tion was busy this past year. Several activities were planned and carried out, including a Fall Picnic, an Ice Skat- ing event at the Coral Ridge Mall, and a Spring Picnic. The following presentations were given: Patrick J. Breheny: “Statistical Graphics and Visualization using R and GGobi” Li Liu: “Calling C/C++ Functions In side R and Version Control on Win- dows Platform” Also, Professor Jeffrey D. Dawson presented a talk introducing his re- search area and Asso- ciate Professor Kai Wang gave an intro- duction to statistical genetics presentation. Student Awards Lei Hua received the 2008 ENAR Student Paper Award for her thesis work. Patrick J. Breheny was the 2009 Milford E. Barnes Award recipient. Patrick J. Breheny and Ming Yang became new members of Delta Omega Honor Society. Lei Hua received the WISE (Women in Science and Engineering) Travel Grant, a $300 grant to present scholarly work. She presented “Spline-based Sieve Semiparametric Generalized Estimating Equation for Panel Count Data” in San Antonio for the ENAR Meeting in March 2009. Lei Hua Patrick Breheny Ming Yang
  4. 4. D E P A R T M E N T O F B I O S T A T I S T I C S N E W S L E T T E R Rachel Fonstad, MS: Analyst for Reeher, LLC, St. Paul, MN Yuan Wu, MS: PhD student in Applied Mathematics, University of Iowa Yufang Zhang, MS: PhD Student in PPHG, University of Iowa Levent Bayman:, MS RA III, Internal Medicine, VAMC Amy Johnson, MS: PhD student in Biostatistics, University of Iowa Stephanie Kliethermes, MS PhD student in Biostatistics, University of Iowa Shawn Lesh, MS: Biostatistician at St. Jude in Memphis, TN Rebecca Mastbergen, MS: Unknown Shihao (Kevin) Shen:, MS PhD student in Biostatistics at University of Iowa Yang Xu, MS: PhD student in Interdisciplinary Program in Genetics, University of Iowa Ming Yang, MS: PhD student in Biostatistics, University of Iowa Jun (Viven) Yin, MS: PhD student in Biostatistics, University of Iowa Patrick Breheny, PhD: Assistant Professor, Departments of Biostatistics and Statistics, Univer- sity of Kentucky Where Are our New Graduates? 2008-2009 Graduates MS Program: Fall Graduates: Rachel K. Fonstad Yuan Wu Yufang Zhang Spring Graduates: Levent Bayman Amy M. Johnson Stephanie A. Kliethermes Shawn M. Lesh Rebecca K. Mastbergen Shihao (Kevin) Shen Yang Xu MingYang Jun (Vivien)Yin PhD Program: Patrick J. Breheny Congratulations to our graduates! PhD Theses Patrick J. Breheny: “Regularized Methods for High- Dimensional and Bi-level Variable Selection. Advisor: Jian Huang. Defended April 24, 2009. P A G E 4
  5. 5. P A G E 5 In the News Eric Schaefer, MS ’05, is employed by PSU-Hershey, working in cancer research funded through the Penn State Hershey Cancer Institute. And he has become engaged to Jennifer Froelich. Dawei Liu announced the birth of his son, Yiliang, on October 11, 2008. Jane Chalmers, wife of Knute Carter, MS ‘07, passed away at home with her family at her side on December 6, 2008, after a courageous fight with cancer. Wei Zhang, PhD ‘05, welcomed the birth of his son, Ryan, on January 19, 2009. Yang Xu, MS ’09, is the proud father of Christopher Hanwei Xu, born on July 12, 2009. Lei Hua, MS ’07, gave birth to a baby girl, Rachel, on August 18, 2009. Emine Ozgur Bayman, PhD ’09, and Levent Bayman, MS, ‘09, welcomed baby girl, Sedef Bilge, on September 19, 2009. Iowa Summer Institute in Biostatistics (The Iowa SIB) The Department is the proud recipient of a grant from the NIH NHLBI and NCRR to join the SIBS family of Sum- mer Institutes in Biostatistics. Fifteen to twenty selected undergraduates will come to Iowa to learn about Biosta- tistics through hands-on case studies and be encouraged to enter graduate school in Biostatistics. Our Iowa SIB (or ISIB) will build on our partnership with the Alliance and will focus on recruiting minority students through the Alliance: specifically undergraduates majoring in math or biology (or both) who are studying at colleges or univer- sities without an extensive statistics or biostatistics curriculum. The Iowa SIB will be directed by Gideon Zamba, with assistance from Jeffrey Dawson, Jacob Oleson, Brian Smith, and Phil Kutzko, Professor of Mathematics and PI of the NSF Alliance. The principal investigator is Kathryn Chaloner, who will also assist. More details, along with links to all eight SIBS can be found at sibsweb.htm . The Department of Biostatistics is starting a new tradition with an annual lecture denoted the “Woolson Lecture”. Each year, a distinguished biostatistician will be invited to give a lecture on a topic of high current interest in biostatistics. The inaugural lec- ture will be given on April 19th , 2010 by (very appropriately) the founding chair and long time Division Director, Robert F. Wool- son, PhD. Inaugural Woolson Lecture The University of Iowa has announced that all alumni will have access to RefWorks as long as the institution has a subscription. This applies to both alums who created accounts when here and alums who want to create new ac- counts. The Library has delayed formally announcing this since they are unsure of the best way to share group codes since alumni cannot use the proxy server to connect or access the current group code. When they figure it out they will make an announcement. Meanwhile they are manually giving out the group code RWUI10 to use RefWorks. Click on RefWorks in the Popular Services section on the Hardin Library website: http:// . Alumni Access to RefWorks
  6. 6. P A G E 6 D E P A R T M E N T O F B I O S T A T I S T I C S N E W S L E T T E R 2009 ISIB students:  Leondra Lawson, Jamie Encarnacion, Keyla Pagan‐Rivera,  Tenecia Harris, Christopher Johnson The second Biostatistics Summer Initiative (BSI) program was held this past summer. BSI was created with the goal to increase the number of underrepresented minority students in our graduate program. The program trains selected undergraduate students, with math, biology, and/or sci- ence backgrounds, who are likely to be- come future biostatisticians. The program is run in conjunction with The National Alli- ance for Doctoral Studies in the Mathematical Sciences. The BSI offers seven weeks of summer training, including a five-week introduction to biostatistics course followed by a two- week research internship. Selected stu- dents for the BSI receive a scholarship ei- ther through the Alliance program or through the Department of Biostatistics. Students are supervised by a Biostatistics faculty member and assisted by a graduate research assistant who also provides help with their internship research projects. The projects give students exposure to research and opportunities to see medical science in action through biostatistics. After the supervised research, students present their accomplished research to faculty and other students at an Alliance meeting. The BSI is coordinated by Drs. Gideon Zamba, Jacob Oleson, Brian Smith, and Kathryn Chaloner. The 2009 cohort had six successful and talented students: Phyon Christopher, Jamie Encarnacion, Tenecia Harris, Christopher Johnson, Leondra Lawson, and Keyla Pagan-Rivera. In 2010, this program is an NHLBI- sponsored training program, the Iowa Summer Institute in Biostatistics (ISIB). If you know of any underrepresented minor- ity undergraduate students who may be interested in our summer program, please refer them to our website at http:// current_students/bsi/ or contact Gideon Zamba at or Terry Kirk at Biostatistics Summer Initiative 2009
  7. 7. P A G E 7 Message from Dean Susan Curry As the College of Public Health acknowledges its 10th anniversary during the 2009-10 academic year, it is not difficult to recognize the leading role our Depart- ment of Biostatistics has played in the college’s growth and development. Since our inception in 1999, our college has benefitted from the outstanding leadership of biostatisticians, such as Robert “Skip” Woolson and Leon Burmeister, each of whom has served in Associate Dean capacities. An established research powerhouse, the department has a well-deserved reputation for critical contribu- tions across a range of disciplines that intersect with public health, from the work of Bill Clarke in dia- betes to Jeffrey Dawson’s studies to assess elderly drivers. The de- partment’s strong commitment to student mentoring and teaching is evidenced by biostatistics faculty who have received the College of Public Health’s Outstanding Teaching Award: Joe Cavanaugh in 2006 and Ying Zhang in 2008. Through projects such as the Iowa Health Fact Book, led by Jacob Oleson and Jane Pendergast, the de- partment has been a leader in providing essential health information to health practitioners, policymak- ers, and researchers across the state. And recently, the Department of Biostatistics has again provided critical leadership for our college in the area of diversity initiatives. The Biostatistics Summer Initiative, led by Kathryn Chaloner, Jacob Oleson, Brian Smith, and Gideon Zamba, is a seven-week program that provides biostatistical training and ap- plied research opportunities for underrepresented mi- nority students. In 2009, Kathryn Chaloner received our Board of Advisors Award for Achievement in Community Engagement in recognition of her efforts to develop a collegiate culture that is welcoming of people from all backgrounds. As we look to the future of public health, one of the many reasons to be optimistic is the strong tradition of research excellence, interdisciplinary collaboration, and commitment to inclusiveness that is so evident in our Department of Biostatistics. Christopher S. Coffey, Ph.D., Professor of Biostatistics and Deputy Director of the Clinical Trials Statistical and Data Management Center, joined the Depart- ment of Biostatistics on July 31, 2009. Dr. Coffey received his Ph.D. in biosta- tistics from the University of North Carolina at Chapel Hill in 1999. He re- ceived both the 2000 Barry H. Margolin Award for excellence in doctoral re- search and 2005 Grizzle Distinguished Alumni Award from the Department of Biostatistics at UNC. He spent the last eight years on the faculty in the Depart- ment of Biostatistics at the University of Alabama at Birmingham (UAB). During his time at UAB, Dr. Coffey served as the Chair of the Faculty for the School of Public Health (SOPH), served as the Graduate Program Director in Biostatis- tics, and taught courses in survival analy- sis, theory of linear models, and ad- vanced clinical trials. He won the 2004 UAB President’s Excellence in Teaching Award for the SOPH. Dr. Coffey has over 60 publications in both journals of statistical importance (e.g., Biometrics) and prestigious applied journals (e.g., JAMA). Dr. Coffey has served as the lead statistician on a variety of applied projects, with a particular in- terest in the coordination of large ran- domized clinical trials. He is the current chair of the education committee for the Society of Clinical Trials. Dr. Coffey’s primary research interests include design issues such as power and sample size calculations, sample size re-estimation methods, and adaptive designs. He has helped develop methods for implement- ing internal pilot studies that allow the use of pilot data in the final analysis and published on this topic (e.g., Biometrics, Statistics in Medicine, Communications in Statistics). Chris’ wife Beth is currently a stay-at- home mom. She previously worked as a data coordina- tor for the Women’s Health Initia- tive site at UNC and at the UAB Compre- hensive Cancer Center. They have two children. Thomson is 11 and enjoys history and video games. Barrett is 5 and simply enjoys being active. Chris is an avid runner and sports enthu- siast (he has already gotten hooked on Iowa football). On a lighter note, he is also a fan of professional wrestling and has worked on a storyline for the WWE as a backup for a second profession. Anyone who is interested can ask him about his storyline for “The Professor”. However, if you ask about it, be prepared to hear the storyline in vivid detail. Meet Chris Coffey
  8. 8. P A G E 8 D E P A R T M E N T O F B I O S T A T I S T I C S N E W S L E T T E R The College of Public Health will be celebrating its 10th anniversary during the 2009 -2010 academic year. And thanks to support from private donors, in partnership with the University, the State of Iowa, and federal funding, we are anticipating the completion of our very own building. We will also publicly launch a campaign to raise private funds for the facility called the Building Today for a Healthy Tomorrow campaign. This $15 million fundraising goal includes $6 million for building con- struction and $9 million for faculty, student, and program support after the building opens. Ground was broken last year for the new facility which is scheduled to be com- pleted in late 2010. The new building, composed of glass and limestone and located on the site of the former International Center, will have 130,000 square feet of space and will integrate “green” design features, showcasing sustainability and envi- ronmental awareness. “The new building will help ensure an exceptional education for the leaders who will be faced with solving tomorrow’s critical public health issues,” says Dean Susan Curry, who began in her leadership role in August 2008. The College of Public Health has completed one full decade of providing students with a world-class public health education, and pursuing research and service activities that touch thousands of citizens both close to home and around the globe. College of Public Health’s 10th Anniversary
  9. 9. P A G E 9 Faculty News In recognition of her work promoting diversity, Kath‐ ryn Chaloner, Ph.D., Professor and Head, received  the College of Public Health’s award for faculty  achievement in community engagement on June 18.   This award is conferred annually by the Board of Advi‐ sors and recognizes a faculty member for application  of theory, research, and practice to address public  health challenges at the community level.    “Dr. Chaloner has undertaken impressive initiatives to  ensure continued growth in the number and diversity  of graduate students enrolled in the college, “ said  Stephen Ummel, chair of the College of Public Health  Board of Advisors.  “This award acknowledges her  committed and enthusiastic leadership to ensure that  the college’s diversity programs are an integral part  of a broader culture — a culture that is welcoming  people from all backgrounds.”    Dr. Chaloner worked to found the Biostatistics Sum‐ mer Initiative, a seven‐week program that provides  biostatistical training and applied research opportuni‐ ties for underrepresented minority students.  This  program is offered in conjunction with the National  Alliance for Doctoral Studies in the Mathematical Sci‐ ences.      In the summer of 2008 the first group of four Biosta‐ tistics Summer Initia‐ tive students com‐ pleted their training.   One of those students  is now a doctoral stu‐ dent enrolled in the  Biostatistics program.   Carmen Smith is the  first African American  Ph.D. candidate in the  history of the depart‐ ment.  Six students  were enrolled in the  2009 summer program.   Dr. Gideon Zamba di‐ rects the summer program and Drs. Brian Smith and  Jacob Oleson serve as mentors.  Dr. Kate Cowles, As‐ sociate Professor of Statistics and Actuarial Science,  also mentored a student in the summer 2009 session.    In September, the Department of Biostatistics, to‐ gether with the Alliance, hosted the StatFest/Field of  Dreams Conference.  Underrepresented students at‐ tended this conference to learn about careers and  graduate studies in statistics and other mathematical  sciences.    Dr. Chaloner is a mentor for the National Alliance for  Doctoral Studies in the Mathematical Sciences, which  is a consortium whose goals include encouraging un‐ derrepresented minority undergraduates to pursue  graduate degrees in the mathematical sciences.  It  provides them with  the preparation and support to  pursue these degrees.  Phillip Kutzko, UI Professor of  Mathematics, leads the Alliance.      Dr. Chaloner’s research interests include using Bayes‐ ian decision theory and Bayesian statistics for the de‐ sign of experiments and clinical trials.  She collabo‐ rates on research in HIV/AIDS studies and in clinical  trials of islet transplants in people with Type I diabe‐ tes.  She is an elected fellow for the American Asso‐ ciation for the Advancement of Science and the  American Statistical Associa‐ tion.    See page 6 for a description  of our new Iowa Summer  Institute in Biostatistics.    Dr. Chaloner (back left) with 2009 BSI students 
  10. 10. P A G E 1 0 D E P A R T M E N T O F B I O S T A T I S T I C S N E W S L E T T E R Dawei Liu, Assistant Professor of Biostatistics, and Ryan Carnahan, Clinical Assistant Professor of Epidemiology, were awarded the 2008- 2009 College of Public Health-Carver College of Medicine New Inves- tigator Research Award. The awards assist newly appointed faculty in the College of Public Health or the Roy J. and Lucille A. Carver Col- lege of Medicine to advance their research activities. Each recipient receives up to $10,000 of funding for independent research projects. The recipients’ awards were chosen on the basis of scientific merit, relevance to the College of Public Health mission, strategic plan and goals, and the probability of attracting subsequent extramural research funding. Dr. Liu’s winning research proposal was entitled “A Joint Modeling of Correlated Recurrent and Ter- minal Events with Multivariate Frailty in the Analysis of Driving Safety Data in Patients with Parkinson’s Disease.” Faculty News (cont.) Gideon Zamba, Assistant Professor of Biosta- tistics, judged a research competition at the Annual Biomedical Research Conference for Minority Students (ABRCMS) in Orlando, FL, last November. ABRCMS is the largest professional conference for biomedical students. This was the 8th year for this conference, which lasts four days and included more than 1,200 students participating in poster and oral presentations in biomedical and behavioral sciences. Dr. Zamba was one of three judges; those students receiving the highest scores in each scientific discipline and in each educa- tional level were given monetary awards of $250 for their outstanding research. The conference is designed to encourage underrepre- sented minority students to pursue advanced training in the biomedical and behavioral sciences and pro- vide faculty mentors with resources for facilitating the success of these students. This past year’s confer- ence included over 500 faculty and program directors and over 440 exhibitors. Dawson and Team Recognized for Driving Research Jeffrey Dawson, Professor of Biostatistics, and colleagues in the Uni- versity of Iowa Division of Neuroergonomics ( ~neuroerg/) received widespread recognition this year for their studies of drivers with neurological diseases. In the February 10th issue of Neurology, Dawson and coauthors reported the increase in safety er- rors made by 40 drivers with Alzheimer’s disease versus 114 elderly controls. They also showed which types of cognitive tests were pre- dictive of these safety errors, giving much-needed guidance to physi- cians and families who help decide when a patient with Alzheimer’s disease should no longer drive. “We found that tests which measured multiple domains of cognition were correlated with driving safety, whereas simple memory tests were not,” reports Dr. Dawson. “For example, being able to recognize and copy geo- metric shapes was predictive of safety, whereas the ability to memorize a list of 15 words was not as important. Unfortunately, there is so much variability in driving that we cannot propose specific cut-off values of cognitive tests that should be used as firm criteria for de- ciding when individuals should no longer drive. In the future, we hope to use in-vehicle
  11. 11. P A G E 1 1 Field of Dreams/StatFest Conference held on UI Campus The Third Annual Iowa Mathematical Field of Dreams Conference, sponsored in part by the Na- tional Science Foundation and held this year in conjunction with the American Statistical Asso- ciation’s StatFest Conference, allowed students to meet with representatives from graduate pro- grams across the country, talk with current graduate students, and explore career opportunities, including careers in public health. Around 90 underrepresented minority students from around the U.S. and 40 of their faculty men- tors met on the University of Iowa Campus September 25-27. The two events highlight academic graduate and career opportunities in the mathematical sciences. The Field of Dreams Conference is held by the National Alliance for Doctoral Studies in the Mathematical Sciences, an alliance among a group of mentors in the math/sciences depart- ments of the Iowa Regents Universities (Iowa State, University of Iowa, and University of Northern Iowa) together with several other gradu- ate departments in the math/sciences nationally and faculty members at colleges and universities that serve a large number of underrepresented minority undergraduate students in the U.S. The UI Department of Biostatistics co-sponsored the Iowa conference. The students learned about opportunities for fi- nancial aid and funding, what to look for in a graduate program, how to recognize a supportive environment, opportunities that come with a graduate degree, in addition to learning about the different math/science disciplines. Current students and faculty also shared their experiences and challenges of attending graduate programs and what is involved with moving from a minority school to a majority school. monitoring devices that would allow the cars themselves to be diagnostic tools, to supplement the infor- mation that can be obtained in a clinical setting.” Interviews with Dr. Dawson were featured in newspa- pers, television, radio, and internet reports, such as USA Today, the New York Times, the Miami Herald, CNN Health Reports, CBS News, and Scientific American Online. Current colleagues in the Division of Neuroergonomics include Drs. Matthew Rizzo (principal investigator), Steven Anderson, and Ergun Uc of the Department of Neurology, as well as PhD students Elizabeth Dastrup (MS, 2008) and Amy Johnson (MS, 2009). Some of the Puerto Ricans get together for a photo. The 2009 Iowa Health Fact Book is a broad-ranging report covering the health and health-related behaviors of Io- wans. Jacob Oleson and Jane Pendergast led development of the publication on behalf of the UI Center for Pub- lic Health Statistics working in collaboration with the Iowa Department of Public Health. New to the book this year is a section on “The Social Determinants of Health,” which focuses on behavioral conditions and coincides with the upcoming release of Healthy People 2020. Many of the data sets are presented by county so readers can follow Io- wans’ health and behaviors over time. To access the Fact Book online, visit factbook.
  12. 12. P A G E 1 2 Faculty Publications 2008 Strauss RG, Mock DM, Johnson KH, Cress GA, Burmeister LF, Zimmerman MB, Bell EF, Rijhsinghani A. A randomized clinical trial comparing immediate versus delayed clamping of the umbilical cord in preterm infants; short-term clinical and laboratory endpoints. Transfusion, 48(4):658 -665, 2008. Mock DM, Mock NI, Lankford GL, Burmeister LF, Strauss RG, Widness JA. Red cell volume can be accurately determined in sheep using a non-radioactive Biotin label. Pediatric Research, June 2008 [Epub ahead of print]. Sprince NL, Zwerling C, Whitten PS, Lynch CF, Burmeister LF, Gillette PP, Thu K, Alavanja MC. Farm activities associated with eye injuries in the Agricultural Health Study. J Agromedicine, 13 (1):17-22, 2008. Cavanaugh JE, Davies SL and Neath AA. Discrepancy-based model selection criteria using cross validation. In Statistical Models and Methods for Biomedical and Technical Systems, edited by F. Vonta, M. Nikulin, N. Limnios and C. Huber, pp. 473-485. Birkhauser, Boston, Massachusetts, 2008. Polgreen PM, Bohnett LC, Cavanaugh JE, Gingerich SB, Desjardin LE, Harris ML, Quinlisk MP and Pentella MA. The duration of mumps shedding following the onset of symptoms. Clinical Infectious Diseases 46:1447-1449, 2008. Shang J and Cavanaugh JE. Bootstrap variants of the Akaike information criterion for mixed model selection. Computational Statistics and Data Analysis 52:2004-2021, 2008. Kaskie B, Imhof S, Cavanaugh JE and Culp K. Civic engagement as a retirement role for aging Americans. The Gerontologist 48(3):368-377, 2008. Polgreen PM, Chen Y, Beekmann S, Srinivasan A, Neill MA, Gay T and Cavanaugh JE. Elements of influenza vaccination programs that predict higher vaccination rates: Results of an Emerging Infec- tions Network survey. Clinical Infectious Diseases 46:14-19, 2008. Bengtsson T and Cavanaugh JE. State-space discrimination and clustering of atmospheric time series data based on Kullback information measures. Environmetrics 19:103-121, 2008. Kaskie BK, Gregory D and Cavanaugh JE. The use of public mental health services by older Cali- fornians and complementary service system effects. Journal of Behavioral Health Sciences & Re- search 35:142-157, 2008. Kuntz JL, Holley S, Helms C, Cavanaugh JE, Vandeberg J, Herwaldt LA and Polgreen PM. Use of a pandemic preparedness drill to increase rates of influenza vaccination among healthcare workers. In- fection Control and Hospital Epidemiology 29:111-115, 2008. Burr T, Fry H, McVey B, Sander E, Cavanaugh J and Neath A. Performance of variable selection methods in regression using variations of the Bayesian information criterion. Communications in Sta- tistics – Simulation and Computation 37:507-520, 2008. Shang J and Cavanaugh JE. An assumption for the development of bootstrap variants of the Akaike information criterion in mixed models. Statistics & Probability Letters 78:1422-1429, 2008. Polgreen PM, Septimus EJ, Parry MF, Beekman SE, Cavanaugh JE, Srinivasan A, Talbot TR. Rela- tionship of influenza vaccination declination statements and influenza vaccination rates for healthcare workers in 22 US hospitals. Infection Control and Hospital Epidemiology 29(7):675-677, 2008. Shang J, Cavanaugh JE, and Wright FT. A Bayesian multiple comparison procedure for order- restricted mixed models. International Statistical Review 76:268-284, 2008. Pingel LC, Kohlgraf KG, Hansen CJ, Estman CG, Dietrich DE, Burnell KK, Srikantha RN, Xiao X, Bélanger M, Progulske-Fox A, Cavanaugh JE, Guthmiller JM, Johnson GK, Joly SA, Kurago ZB, Dawson DV, and Brogden KA. Human β-defensin 3 binds to hemagglutinin B (rHagB), a non- fimbrial adhesion from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine re- sponse. Immunology & Cell Biology 86:643-649, 2008. Warren JJ, Levy SM, Broffitt B, Cavanaugh JE, Kanellis MJ, and Weber-Gasparoni K. Considera- D E P A R T M E N T O F B I O S T A T I S T I C S N E W S L E T T E R
  13. 13. P A G E 1 3 tions on optimal fluoride intake using dental fluorosis and dental caries outcomes – A longitudinal study. To appear in Journal of Public Health Dentistry, 2008. Nov 21, 2008 [epub ahead of print]. Zhang W, Chaloner K, Cowles MK, Zhang Y, Stapleton JT. A Bayesian analysis of doubly censored data using a hierarchical Cox model. Stat Med 27:529-542, 2008. Chaloner K. Commentary on “Bayesians in clinical trials: asleep at the switch” by LA Moye. Statistics in Medicine 27:483-287, 2008. Zhang W, Zhang Y, Chaloner K, Stapleton JT. Imputation Methods for Doubly Censored HIV Data. In press, Journal of statisti- cal Computation and Simulation, 2008. Pasternak JJ, McGregor DG, Schroeder DR, Lanier WL, Shi Q, Hindman BJ, Clarke WR, Torner JC, Weeks JB, Todd MM; IHAST Investigators. Hyperglycemia in patients undergoing cerebral aneurysm surgery: its association with long-term gross neu- rologic and neuropsychological function. Mayo Clin Proc Apr; 83(4):406-17, 2008. McGregor DG, Lanier WL, Pasternak JJ, Rusy DA, Hogan K, Samra S, Hindman B, Todd MM, Schroeder DR, Bayman EO, Clarke W, Torner J, Weeks J on behalf of the Intraoperative Hypothermia for Aneurysm Surgery Trail Investigators. Effect of nitrous oxide on neurologic and neuropsychological function after intracranial aneurysm surgery. Anesthesiology 108:568-79, 2008. Coffey CS and Kairalla JA. Adaptive Designs: Progress and Challenges, Drugs in R&D 9(4):229-242, 2008. Gadbury GL, Supapakorn T, Coffey CS, Keith SW, and Allison DB. Application of Potential Outcomes to an Intentional Weight Loss Latent Variable Problem, Statistics and It’s Interface 1:87-97, 2008. Newsome BB, McClellan WM, Allison JJ, Eggers PW, Chen SC, Collins AJ, Kiefe CI, Coffey CS, and Warnock DG. Racial Dif- ferences in the Competing Risks of Mortality and End-Stage Renal Disease After Acute Myocardial Infarction, American Journal of Kidney Diseases 52:251-261, 2008. Hebert PR, Coffey CS, Byrne DW, Scott TA, Fagard RH, Rottman JN, Murray KT, and Oates JA. Treatment of Elderly Hyper- tensive Patients with Epithelial Sodium Channel Inhibitors Combined with a Thiazied Diurectic Reduces Coronary Mortality and Sudden Cardiac Death, Journal of the American Society of Hypertension 2:355-365, 2008. Kairalla JA, Coffey CS, and Muller KE. GLUMIP 2.0: SAS/IML Software for Planning Internal Pilots, Journal of Statistical Soft- ware 28(7):1-32, 2008. Yi N, Ding S, Keith SW, Coffey CS, and Allison DB. Bayesian Analysis of the Effect of Intentional Weight Loss on Mortality Rate, International Journal of Body Composition Research, in press, 2008. Elobeid M, Padilla M, McVie T, Thomas O, Brock D, Musser B, Lu K, Coffey C, Desmond R, St-Onge M, Gadde K, Heymsfield S, and Allison D. Missing Data in Randomized Clinical Trials for Weight Loss: Scope of the Problem, State of the Field, and Per- formance of Statistical Methods, PLoS One, in press, 2008. Brown DL and Coffey CS. A Shift to Shift Analysis? Neurology, in press, 2008. Coffey CS. Power Analysis, In Encyclopedia of Research Design, NJ Salkind (ed.), in press, 2008. Carter BL, Bergus GR, Dawson JD, Farris KB, Doucette WR, Chrischilles EA, and Hartz AJ. A randomized trial to evaluate phy- sician/pharmacist collaboration to improve blood pressure control. Journal of Clinical Hypertension, 10:260-271, 2008. Ernst ME, Weber CA, Dawson JD, O’Connor MA, Lin W, Carter BL, and Bergus GR. How well does a shortened time interval characterize results of a full ambulatory blood pressure monitoring session? Journal of Clinical Hypertension, 10:431-435, 2008. Dawson JD, Cavanaugh JE, Zamba KD, and Rizzo M. Modeling the variability of lateral vehicular control. 10th International Conference on Applications of Advanced Technologies in Transportation, Athens, Greece, May 28th-30st, 2008. Proceedings CD, 523, 2008. Carter BL, Farris KB, Abramowitz P, Weetman DB, Kaboli PJ, Dawson JD, James PA, Christensen AJ, and Brooks JM. The Iowa continuity of care study: background and methods. American Journal of Health-System Pharmacy, 17:1631-1642, 2008. Milchak JL, Carter BL, Ardery G, Dawson JD, Harmston M, and Franciscus CL. Physician adherence to blood pressure guide- lines and its effect on seniors. Pharmacotherapy, 28:843-851, 2008. Fravel MA, Ernst ME, Weber CA, Dawson JD, Carter BL, and Bergus GR. Influence of patient characteristics on success of am- bulatory blood pressure monitoring. Pharmacotherapy, 28(11):1341-1347, 2008 Rizzo M, Nawrot M, Sparks J, and Dawson J. First and second-order-motion perception after focal human brain lesions. Vision Research, 48(26):2682-2688, 2008. Huang J, Horowitz JL, and Ma SG. Asymptotic properties of bridge estimators in sparse high-dimensional regression models. Annals of Statistics 36:587-613, 2008. Huang J, Ma SG, Xie HL, and Zhang C-H. A group bridge approach for variable selection. Accepted for Publication by Bio- metrika, 2008.
  14. 14. P A G E 1 4 Faculty Publications 2008 (cont.) Xie HL, and Huang J. SCAD-penalized regression in high-dimensional partially linear models. Accepted for pub- lication by the Annals of Statistics, 2008. Huang J, Ma SG, and Zhang C-H. Adaptive lasso for sparse high-dimensional regression models. Statistica Sinica 18:1603-1618, 2008. Zhang C-H and Huang, J. Model-selection consistency of the LASSO in high- dimensional linear regression. Annals of Statistics 36:1567-1594, 2008. Ma SG and Huang J. Combining clinical and genomic covariates via Cov-TGDR. Cancer Informatics 3:381-388, 2008. Yan J and Huang J. Partly functional temporal process regression and semiparametric profile estimating func- tions. Accepted for publication by Biometrics 2008. Ma S and Huang J. Penalized feature selection and classification in bioinformatics. Briefings in Bioinformatics 9:392-403, 2008. Racila E, Brian K, Link BK, Weng WK, Wtizig TE, Ansell S, Maurer MJ, Huang J, Dahle C, Halwani A, Levy R, and Weiner GJ. A polymorphism in the complement component C1qA correlates with prolonged response follow- ing Ritux imab therapy of follicular lymphoma. Clinical Cancer Research 14:6697-6703, 2008. Zhang C-H and Huang J. The sparsity and bias of the lasso selection in high-dimensional linear regression. An- nals of Statistics 36:1657-1594, 2008. Huang J, Horowitz JL, and Ma SG. Asymptotic properties of bridge estimators in sparse high-dimensional regres- sion models. Annals of Statistics 36:587-613, 2008. Storer BE, Gooley TA, Jones MP. Adjusted estimates for time-to-event endpoints. Lifetime Data Analysis 14:484-495, 2008. Damiano PC, Momany ET, Carter KD, Jones MP, and Askelson NM. Time to First Dental Visit after Initially Enrolling in Medicaid and S-SCHIP. Medical Care 46(12):1234-1239, 2008. Yang, J, Peek-Asa C, Jones MP, Nordstrom DL, Taylor C, Young TL, and Zwerling C. Smoke Alarms by Type and Battery Life in Rural Households A Randomized Controlled Trial. American Journal of Preventive Medicine 35(1):20-24, 2008. Resnik L, Liu D, Mor V, and Hart DL. Benchmarking physical therapy clinic performance: Statistical methods to enhance internal validity when using observational data. Physical Therapy Journal, 88(9): 1078-87, 2008. Resnik L, Liu D, Mor V, and Hart DL. Predictors of physical therapy clinic performance in the treat- ment of patients with low back pain syndromes. Physical Therapy Journal, 88(9): 989-1004; discussion 1004-11, 2008. Liu D, Ghosh D, and Lin X. Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via logistic mixed models. BMC Bioinformatics, 9: 292, 2008. Hillner BE, Siegel BA, Shields,AF, Liu D, Gareen IG, Hunt E, and Coleman RE. Relationship of cancer type and the impact of PET and PET/CT on intended patient management: Findings of the National Oncologic PET Registry. Journal of Nuclear Medicine. In press, 2008. Hillner BE, Siegel BA, Shields AF, Liu D, Gareen IG, Hanna L, Stine SH, and Coleman RE. The impact of Positron Emission Tomography/Computed Tomography (PET/CT) and PET on expected management during cancer treatment: Findings of the National Oncologic PET Registry. Cancer. In press, 2008. Driscoll V, Oleson JJ, Jiang D, and Gfeller KG. The effects of training on recognition of musical in- struments presented through cochlear implant simulations. Journal of the American Academy of Audi- ology, in press, 2008. Oleson JJ, Breheny PJ, Pendergast JF, Ryan S, Litchfield RE, Myers-Geadelmann J. Impact of travel distance on WISEWOMAN intervention attendance for a rural population. Preventive Medicine, 47:565-569, 2008. Gatewood JG, Litchfield R, Ryan SJ, Geadelmann JD, Pendergast JF, Ullom KK. Perceived barriers to community-based health promotion program participation. American Journal Health Behavior, 32 D E P A R T M E N T O F B I O S T A T I S T I C S N E W S L E T T E R
  15. 15. P A G E 1 5 (3):260-272, 2008. Xie X-J, Pendergast J, and Clarke W. Increasing the power: A practical approach to goodness-of-fit test for logistic regression models with continuous predictors. Computational Statistics and Data Analysis, 52(5):2703-2713, 2008. Zhao Y, Brooks JM, Flanigan MJ, Chrischilles EA, Pendergast JF, Hunsicker LG. Early nephrology care and physician access factors in elderly patients with end-stage renal disease. Kidney International, 74(12):1596-1602, 2008. Oleson JJ, Breheny PJ, Pendergast JF, Ryan S, Litchfield RE, Myers-Geadelmann J. Impact of travel distance on WISE- WOMAN intervention attendance for a rural population. Preventive Medicine, 47(5):565-569, 2008. Morriss FH Jr, Abramowitz PW, Nelson SP, Milavetz G, Michael SL, Gordon SN, Pendergast JF, Cook EF. Effectiveness of a barcode medication administration system in reducing preventable adverse drug events in a neonatal intensive care unit: A pro- spective cohort study. Journal of Pediatrics, Sep 27, 2008 {Epub ahead of print]. Goodheart M, Jacobson G, Smith BJ, Zhou L. Chemoradiation for Invasive Cervical Cancer in Elderly Patients: Outcomes and Morbidity. International Journal of Gynecological Cancer, 18(1):95-103, 2008. Weydert CJ, Zhang Y, Sun W, Waugh TA, Teoh ML, Andringa KK, Aykin-Burns N, Spitz DR, Smith BJ, Oberley LW. In- creased Oxidative Stress Created by Adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis)2-chloroethyl)-1-nitrosourea) Inhib- its Breast Cancer Cell Growth. Free Radical Biological Medicine, 44(5):856-867, 2008. Coleman MC, Asbury CR, Daniels D, Du J, Aykin-Burns N, Smith BJ, Li L, Spitz DR, Cullen JJ. 2-Deoxy-D-Glucose Causes Cytotoxicity, Oxidative Stress, and Radiosensitization in Pancreatic Cancer. Free Radical Biology and Medicine, 44(3):322- 331, 2008. Khanna G, O’Dorisio MS, Menda Y, Glasier C, Deyoung B, Smith BJ, Graham M, Juweid M. Somatostatin Receptor Scinti- graphy in Surveillance of Pediatric Brain malignancies. Pediatric Blood Cancer, 50(3):561-566, 2008. van de Wetering CI, Coleman MC, Spitz DR, Smith BJ, Knudson M. Manganese Superoxide Dismutase Gene Dosage Affects Chromosomal Instability and Tumor Onset in a Mouse Model of T Cell Lymphoma. Free Radical Biology and Medicine, 44 (8):1677-1686, 2008. Mazumdar S, Rushton G, Smith BJ, Zimmerman D, Donham KJ. Geocoding Accuracy and the Recovery of Relationships be- tween Environmental Exposures and Health. International Journal of Health Geographics, 7:13, 2008. Adam, LA, Smith BJ, Calva-Cerqueira D, Howe JR, Lal G. Role for Limited Neck Exploration in Young Adults with Appar- ently Sporadic Primary Hyperparathyroidism. World Journal of Surgery, 32(7):1518-1524, 2008. Cullen JJ, Coleman MC, Asbury CR; Daniels D, Du J, Aykin-Burns N, Smith BJ, Li L, Spitz DR. 2-Deoxy-D-Glucose Causes Cytotoxicity, Oxidative Stress, and Radiosensitization in Pancreatic Cancer. Free Radical Biology & Medicine, 44(3):322-331, 2008. Smith BJ, Yan J, Cowles MK. Geostatistical Modeling for Data Fusion and Spatial Heteroskedasticity with R Package ramps. Journal of Statistical Software, 25(10),1-21, 2008. Smith BJ, Oleson JJ. Geostatistical Hierarchical Model for Temporally Integrated Data Measured with Error. Journal of Agri- cultural, Biological, and Environmental Statistics, 13(2),140-158, 2008. Lal G, Padmanabha L, Nicholson R, Smith BJ, Zhang L, Howe JR, Robinson RA, O’Dorisio S. ECM1 Expression in Thyroid Tumors - A Comparison of Real-Time RT-PCR and Immunohistochemistry. Journal of Surgical Research, 149(1):62-68, 2008. Luthe G, Boy RG, Jacobus J, Smith BJ, Rahaman A, Robertson LW, and Ludewig G. Xenobiotic Geometry and Media pH Determine Cytotoxicity through Solubility. Chemical Research in Toxicology, 21(5):1017-1027, 2008. Dennis LK, VanBeek MJ, Beane Freeman LE, Smith BJ, Dawson DV, Coughlin JA. Sunburns and Risk of Cutaneous Mela- noma: Does Age Matter? A Comprehensive Meta-analysis. Annals of Epidemiology, 18(8):614-627, 2008. Maddox C, Wang BX, Kirby PA, Wang K, Ludewig. Mutagenicity of 3-methylcholanthrene, PCB3, and 4-OH-PCB3 in the lung of transgenic BigBlue® rats. Environmental Toxicology and Pharmacology, 27(2):299-305, 2008. Wang K. Genetic association tests in the presence of epistasis or gene-environment interaction, Genetic Epidemiology,32:606- 614, 2008. Wang K. An analytic study of the power of popular quantitative-trait-locus mapping methods, Behavior Genetics, 38:554-559, 2008. Ho B-C, Epping E, Wang K, Andreasen NC, Librant A, Wassink TH. Basic helix-loop-helix transcription factor NEUEOG1 and schizophrenia: effects onillness susceptibility, MRI brain morphometry and cognitive abilities. Schizophrenia Research, 106:192-199, 2008. Staffey KS, Raghuveer D, Leonard A, Brooks, BA , Andrew M. Pretorius, BS; Laynez W, Ackermann, BS, Zamba KD, Dick- son, E, Kerber RE. Liquid ventilation with perfluorocarbons facilitates resumption of spontaneous circulation in a swine cardiac arrest model. Elsevier Resuscitation, 78:77-84, 2008.
  16. 16. P A G E 1 6 Faculty Publications 2008 (cont.) Zamba KD, Tsiamyrtizis P, Hawkins D. Sequential Bayesian control model for influenza-like-illness and early detection of intentional outbreaks. Health Edition of Quality Engineering, 20(4):495-507, 2008. Ahmed A, Zamba KD, DeGeest K, Lynch CF. The impact of surgery on survival of elderly women with endometrial cancer in the SEER Program from 1992-2002, Gynecologic Oncology, 111(1):35-40, 2008. Zamba KD. Statistical development of quality in medicine. The American Statistician, 62(4):359-360, 2008. Meyerholz DK, Piester TL, Sokolich JC, Light TD, Zamba KD. Morphologic parameters for assess- ment of burn severity in an acute burn injury rat model, International Journal of Experimental Pathol- ogy, in press, 2008.. Zhang W., Chaloner K., Cowles, M.K., Zhang Y., and Stapleton J.T. A Bayesian pooled analysis of doubly censored data using a hierarchical Cox model. Statistics in Medicine, 27:529-542, 2008. Shell JA, Carolan M, Zhang Y, and Dow KM. The longitudinal effects of cancer treatment on sexuality in individuals with lung cancer. Oncology Nursing Forum 35:73-79, 2008. Strauss RG, Mock DM, Johnson KJ, Cress GA, Burmeister LF, Zimmerman MB, Bell EF, Rijhsinghani A. A randomized clinical trial comparing immediate versus delayed clamping of the um- bilical cord in preterm infants: short-term clinical and laboratory endpoints. Transfusion, 48(4):658- 665, 2008. Choio YK, Kraft N, Zimmerman B, Jackson M, Rao SS. Fructose intolerance in IBS and utility of fructose-restricted diet. Journal of Clinical Gastroenterology, 2008 [Epub ahead of print]. Hayreh SS, Zimmerman MB. Optic disc edema in non-arteritic anterior ischemic optic neuropathy. Graefe’s Archive for Clinical and Experimental Ophthalmology, 245(8):1107-1121, 2007. Lutgendorf SK, Lamkin DM, Degeest K, Anderson B, Dao M, McGinn S, Zimmerman B, Maiseri H, Sood AK, Lubaroff DM. Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients. Brain, Behavior and Immunity, 22(6):890-900, 2008. Coreyll W, Fiedorowicz J, Zimmerman M, Young E. HPA-axis hyperactivity and mortality in psy- chotic depressive disorder: Preliminary findings. Psychoneuroendocrinology, 33(5):654-658, 2008. Hayreh SS, Zimmerman MB. Non-arteritic anterior ischemic optic neuropathy: Role of systemic cor- ticosteroid therapy. Graefe’s Archive for Clinical and Experimental Ophthalmology, 246(7):1029- 1046, 2008. Wallace RB, Gryzlak BM, Zimmerman MB, Nisly NL. Application of FDA Adverse Event Report data to the Surveillance of Dietary Botanical Supplements (May). Annals of Pharmacoptherapy, 42 (5):653-660, 2008. Tanaka MJ, Gryzlak BM, Zimmerman MB, Nisly NL, Wallace RB. Patterns of natural herb use by Asian and Pacific Islanders. Ethnicity and Health, 13(2):93-108, 2008. Bradley CS, Zimmerman MB, Wang Q, Nygaard IE, for the Women’s Health Initiative. Vaginal De- scent and Pelvic Floor Symptoms in Postmenopausal Women: A Longitudinal Study. Obstetrical Gy- necology, 111(5):1148-1153, 2008. Hayreh SS, Zimmerman MB. Nonarteritic anterior ischemic optic neuropathy: Clinical characteristics in diabetic patients versus nondiabetic patients. Ophthalmology, 115(10):1818-1825, 2008. Nisley NL, Gryzlak BM, Zimmerman MB, Wallace RB. Dietary supplement polypharmacy: An un- recognized public health problem? Evidence-Based Complementary and Alternative Medicine, Dec 5, 2007 [Epub ahead of print]. Hayreh SS, Zimmerman MB. Nonarteritic anterior ischemic optic neuropathy: Refractive error and its relationship to cup/disc ratio. Ophthalmology, 115(12):2275-2281, 2008. D E P A R T M E N T O F B I O S T A T I S T I C S N E W S L E T T E R
  17. 17. P A G E 1 7 Student Publications 2008-2009 Liguori NF, Klajn D, Acion L, et al. Epidemiological characteristics of pregnancy, delivery, and birth outcome in women with multiple sclerosis in Argentina (EMEMAR study). Multiple Sclerosis. 15(5):555-562, 2009. Calarge CA, Ellingrod VL, Acion L, et al. Variants of the dopamine D-2 receptor gene and risperidone-induced hyper- prolactinemia in children and adolescents. Pharmacogenetics and Genomics. 19(5):373-382, 2009. Calarge CA, Acion L, Kuperman S, et al. Weight gain and metabolic abnormalities during extended Risperidone treat- ment in children and adolescents. Journal of Child and Adolescent Psychopharmacology. 19(2):101-109, 2009. Vanotti S, Benedict RHB, Acion L, et al. Validation of the multiple sclerosis neuropsychological screening questionnaire in Argentina. Multiple Sclerosis. 15(2):244-250, 2009. Smith TC, Boese B, Capuano A, Gray GC. Occupational exposure to Streptococcus suis among U.S. swine workers. Emerging Infectious Diseases,14:1925-7, 2008. Kayali G, Setterquist SF, Capuano AW, Myers KP, Gill JS, Gray GC. Testing Human Sera for Antibodies against Avian Influenza Viruses: Horse RBC Hemagglutination Inhibition vs. Microneutralization Assays Journal of Clinical Virol- ogy,43:73-78, 2008. Landry ML, Lebeck MG, Capuano AW, McCarthy T, Gray GC. Adenovirus Type 3 Outbreak --- Connecticut, 2006. Journal of Medical Virology, 81:1380-1384, 2009. Damiano PC, Momany ET, Carter KD, Jones MP, Askelson NM. Time to first dental visit after initially enrolling in Medicaid and S-SCHIP. Medical Care, 46(12):1234-1239, 2008. Momany ET, Carter KD, Damiano PC. Outcomes of care for Iowa Medicaid managed care enrollees: State fiscal year 2007. P (A public report to the Iowa Department of Human Services and published on the PPC website). Public Policy Center, University of Iowa, 2008. Chalmers JM, Spencer AJ, Carter KD, King PL & Wright C 2009. Caring for oral health in Australian residential care. Dental Statistics and Research Series No. 48. Cat. No. DEN 193. Canberra: AIHW, 2009. Yang J, Peek-Asa C, Allareddy V, Phillips G, Zhang Y, Cheng G. Hospitalization for sports related injuries among chil- dren aged 5 to 18, in the United States, 2000-2003. Pediatrics. 119(4):e813-820, 2007. Yang J, Peek-Asa C, Corlette J, Cheng G, Foster DT, Albright J. Prevalence of and risk factors associated with symptoms of depression in competitive collegiate student athletes Clinical Journal of Sport Medicine. 17(6):481-487, 2007. Yang J, Peek-Asa C, Cheng G, Heiden E, Falb S, Ramirez M. Incidence and characteristics of school bus crashes and injuries. Accident Analysis and Prevention. 41:336–341, 2009. Uc EY, Rizzo M, Johnson AM, Dastrup E, Anderson S, Dawson JD. Road safety in drivers with Parkinson’s Disease. Neurology. Accepted for publication, 2009. Dawson JD, Anderson SW, Uc EY, Dastrup E, Rizzo M. Predictors of driving safety in early Alzheimer’s disease. Neu- rology. 72(6):521-7, 2009. Wolinsky FD, Bentler SE, Liu L, Obrizan M, Cook EA, Wright KB, Geweke JF, Chrischilles EA, Pavlik CE, Ohsfeldt RL, Jones MP, Richardson KK, Rosenthal GE, Wallace RB. Recent Hospitalization and the Risk of Hip Fracture Among Older Americans. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 64A(2):249-255, 2009. Xing Y*, Stoilov P, Kapur K, Han A, Jiang H, Shen S, Black DL, Wong WH.* MADS: A new and improved method for analysis of differential alternative splicing by exon-tiling microarrays. RNA. 14(8):1470-1479, 2008. (* joint corresponding authors) Lin L, Shen S, Tye A, Cai JJ, Jiang P, Davidson BL, Xing Y. Diverse splicing patterns of exonized Alu elements in human tissues. PLoS Genetics. 4(10):e1000225, 2008. Boudreau R, McBride J, Martins I, Shen S, Xing, Carter B, Davidson, BL. Non-allele-specific silencing of mutant and wildtype huntingtin demonstrates therapeutic efficacy in Huntington's disease mice. Molecular Therapy. 17(6):1053-63, 2009. Shuangge M, Jian H, Shen S. Identification of cancer-associated gene clusters and genes via clustering penalization. Statis- tics and Its Interface. 2(1):1-11, 2009. Lin L, Jiang P, Shen S, Seiko S, Davidson BL, Xing Y. Large-scale analysis of exonized mammalian-wide interspersed repeats (MIRs) in primate genomes. Human Molecular Genetics. 18:2204-2214, 2009. Warzecha CC, Shen S, Xing Y, Carstens RP. The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events. RNA Biology, in press, 2009.
  18. 18. Phone: 319-384-5016 Fax: 319-384-5018 University of Iowa Shen S., Warzecha CC., Carstens RP., Xing Y. MADS+: discovery of differential splicing events from Affymetrix exon junction array data. Bioinformatics, in press, 2009. Lin CL., Evans V., Shen S., Xing Y., Richter JD. The nuclear experience of CPEB: implications for RNA processing and translational control. RNA, in press, 2009. Calarge CA, Zimmerman MB, Xie D, Kuperman S, Schlechte JA. A cross-sectional evaluation of the effect of Risperi- done and selective Serotonin reuptake inhibitors on bone mineral density in boys. Journal of Clinical Psychiatry, in press, 2009. Polgreen PM, Bohnett LC, Yang M, Pentella MA, Cavanaugh JE. A spatial analysis of the spread of mumps in Iowa: the importance of college students and their spring-break-associated trave. Epidemiology and Infection. In Press, 2009. Polgreen PM, Yang M, Bohnett LC, Cavanaugh JE. A time series analysis of clostridium difficile and its seasonal asso- ciation with influenza. Infection Control and Hospital Epidemiology. Accepted for publication, 2009. Stapleton JT, Chaloner K, Zhang J, Klinzman D, Souza IE, Landay A, Fahey J, Pollard R, Mitsuyasu R. GBV-C vire- mia is associated with reduced CD4 expansion in HIV-infected people receiving HAART and interleukin-2 therapy. AIDS 23(5):605-610, 2009. Student Publications 2008-2009 (cont.) Alumni Newletter College of Public Health Department of Biostatistics C22 General Hospital 200 Hawkins Drive Iowa City IA 52242-1009 The Department of Biostatistics Mission Statement The overall mission of the Department has three components. The first component is to provide an excellent education in biostatistical theory and methods for students in the Depart- ment of Biostatistics, the College of Public Health, the Health Sciences, and The Univer- sity of Iowa. The second component is to con- duct outstanding biostatistical research and to collaborate with investigators in conducting outstanding scientific research. The third com- ponent is to use our skills to serve the Depart- ment of Biostatistics, the College of Public Health, The University of Iowa, the State of Iowa, and the wider public health and scientific community. http://www.public-health.uiowa.eduIf you have news items to share with our alumni, please email Ann Weber at