C u r r i c u l u m V i t a e
DAVID LOMINADZE, Ph.D.
Department of Physiology and Biophysics
School of Medicine, HSC, A-11...
David Lominadze, Ph.D. 2009
2
2/92 – 8/99 Assistant to the Head, Microcirculation Research Center, I.Beritashvili Institut...
David Lominadze, Ph.D. 2009
3
ORGANIZED SCIENTIFIC SYMPOSIUMS
2009 “Role of Fibrinogen in Microcirculation” (D. Lominadze,...
David Lominadze, Ph.D. 2009
4
Post-doctoral Fellows Given Research Training
Leila Gobejishvili, Ph.D. 2001 - 2002
Nina Tsa...
David Lominadze, Ph.D. 2009
5
Poster presentations: National / International Meetings
1. Mamisashvili VA, Baratashvili IK,...
David Lominadze, Ph.D. 2009
6
19. Schuschke DA, Lominadze D, Saari JT, Miller FN. Von Willebrand factor (vWF) but not supe...
David Lominadze, Ph.D. 2009
7
42. Roberts AM, Ovechkin AV, Lominadze D, Tyagi SC. Chronic pulmonary volume overload
increa...
David Lominadze, Ph.D. 2009
8
3. Lominadze DG. About a possible role of microrheological properties of blood during regula...
David Lominadze, Ph.D. 2009
9
Awarded but declined
Supplement to HL080394 P.I. D. Lominadze (5 % effort) 12/07 - 02/11
NIH...
David Lominadze, Ph.D. 2009
10
3. Lominadze DG, Shinkarenko VS, Mamisashvili VA. Study of the trajectory of erythrocyte
mo...
David Lominadze, Ph.D. 2009
11
23. Lominadze D, Tsakadze N, Sen U, Falcone JC, D’Souza SE. Fibrinogen- and its fragment D-...
David Lominadze, Ph.D. 2009
12
42. Lee J-F, Gordon S, Wang L, Lominadze D, Lee M-J. Balance of S1P1 and S1P2 signaling
reg...
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David Lominadze, Ph.D.

  1. 1. C u r r i c u l u m V i t a e DAVID LOMINADZE, Ph.D. Department of Physiology and Biophysics School of Medicine, HSC, A-1115 University of Louisville 500 South Preston Street Louisville, KY 40202 Tel.: (502) 852 - 4902 Fax: (502) 852 - 6239 E-mail: dglomi01@louisville.edu EDUCATION 9/73 - 6/79 Attended and graduated from Tbilisi State University, Tbilisi, Georgia. Specialty: Physics Subspecialty: Biophysics During this period: 9/73 - 4/76 Work in the area of image distinction and programming. Laboratory Assistant in the Department of Pattern Recognition, Institute of Control Systems, Georgian Academy of Sciences. 4/76 - 9/76 Work in the area of hydrodynamics. Laboratory Assistant in the Laboratory of Hydrodynamics, Institute of Machine Mechanics, Georgian Academy of Sciences 10/78 - 6/79 Graduate Research Diploma (corresponds to Master’s Degree) received in June, 1979 Thesis Title: "Energy transfer during electronic excitation of acridine orange in DNA-Cu2+ solution complex". Department of Analysis by Nuclear and Optical Methods, Institute of Physics, Georgian Academy of Sciences. Adviser: Prof. V. Bregadze, Ph.D. 10/85 - 6/90 Research for degree of Candidate of Sciences (Biology, Human and Animal Physiology). Diploma (corresponds to Ph.D.) received in June, 1990. Thesis Title: "Blood Flow Structure, Determining Resistance in Microvessels." Laboratory of Physiology and Pathology of Cerebral Circulation, I.Beritashvili Institute of Physiology, Tbilisi, Rep. of Georgia. Adviser: Prof. G. Mchedlishvili, MD., Ph.D. ACADEMIC APPOINTMENTS: 10/79 – 12/80 Junior Research Scientist in the Department of Physics of Atmosphere, Institute of Geophysics, Georgian Academy of Sciences 11/80 - 2/87 Postgraduate research in the area of microcirculation and blood rheology. Engineer , then Senior Engineer in the Laboratory of Physiology and Pathology of Cerebral Circulation, I.Beritashvili Institute of Physiology, Georgian Academy of Sciences 2/87 - 9/90 Junior Research Scientist and then Research Scientist, Microcirculation Research Center, I.Beritashvili Institute of Physiology. 4/90 - 5/93 Head of Microrheology Sector, Microcirculation Research Center, I.Beritashvili Institute of Physiology. 9/90 - 8/96 Senior Research Scientist, Microcirculation Research Center, I.Beritashvili Institute of Physiology.
  2. 2. David Lominadze, Ph.D. 2009 2 2/92 – 8/99 Assistant to the Head, Microcirculation Research Center, I.Beritashvili Institute of Physiology, Georgian Academy of Sciences, Tbilisi, Rep. of Georgia. Head: Prof. G. Mchedlishvili, MD., Ph.D. 9/92 – 8/99 Adjunct Assistant Professor, Center for Applied Microcirculatory Research, University of Louisville, USA. 8/95 – 7/00 Adjunct Assistant Professor, Department of Physiology and Biophysics, University of Louisville, USA. 8/96 – 8/99 Leading Research Scientist, Microcirculation Research Center, I.Beritashvili Institute of Physiology, Tbilisi, Rep. of Georgia. 1/99 - 9/99 Leading Research Scientist, Tbilisi State University, Tbilisi, Rep. of Georgia. 8/99 - 7/00 Assistant Research Scientist, Center for Applied Microcirculatory Research, University of Louisville, USA. Director: Prof. Frederick N. Miller, Ph.D. 7/00 - 11/02 Assistant Research Scientist, Department of Physiology and Biophysics, University of Louisville, USA. Chairman: Prof. Irving G. Joshua, Ph.D. 11/02-06/08 Assistant Professor (Term), Department of Physiology and Biophysics, University of Louisville, Louisville, KY, USA. Chairman: Prof. Irving G. Joshua, Ph.D. 07/08- present Assistant Professor (Tenure track), Department of Physiology and Biophysics, University of Louisville, Louisville, KY, USA. Chairman: Prof. Irving G. Joshua, Ph.D. PROFESSIONAL MEMBERSHIP and ACTIVITIES (since) American Physiological Society (2004) American Heart Association (2002) International Society for Clinical Hemorheology (1998) European Society for Microcirculation (1993) American Society of Microcirculation (1992) Georgian Society of Microcirculation and Clinical Hemorheology (treasurer, till 1993) (1987) Georgian Society of Physiology (1987) Georgian Society of Pathophysiology (1982) HONORS and AWARDS 1991 Travel Award from Organization of World Congress for Microcirculation (Louisville, USA) 1998 Travel Award from Organization of 20th European Conference on Microcirculation (Paris, France) 2009 American Heart Association, Research Administration Volunteer Recognition Award (9.08.09) COMMITTEE ASSIGNMENT and ADMINISTRATIVE SERVICES 1998 Co-Chaired (together with Dr. Tim Neild, Department of Physiology, Flinders University, Adelaide, Australia) a session and evaluated the poster presentations for the Conference Award. 20th European Conference on Microcirculation, Paris, France. 2003 - 2009 Judging the poster presentations. “Research ! Louisville”, University of Louisville, Louisville, KY.
  3. 3. David Lominadze, Ph.D. 2009 3 ORGANIZED SCIENTIFIC SYMPOSIUMS 2009 “Role of Fibrinogen in Microcirculation” (D. Lominadze, Chair) at the 11th International Congress on Amino Acids, Peptides, and Proteins. August 3-7, 2009. Vienna, Austria. Abstracts are published in Amino Acids. 2009: 37(Supplement 1): S73. ADVISORY COUNCILS, JOURNAL EDITORIAL BOARDS, PEER REVIEWER Grant Reviewer 2006 - 2007 AHA, Southern and Ohio Valley Research Consortium, Committee 2B. 2008 - 2009 AHA, Region 1, Vascular Biology and Blood Pressure Regulation Peer Review Committee Editorial Duties 2009 – present Section Editor, Amino Acids, The forum for amino acid, peptide and protein research. Editor-in-Chief: G. Lubec. Reviewer (manuscripts for journals) 1999 – present Journal of Laboratory and Clinical Medicine, Microcirculation (Ed: Neil D. Granger); American Journal Physiology, Heart and Circulatory Physiology (Ed. Julian H. Lombard). American Journal Physiology, Cell Physiology (Ed. John Geibel). FEBS Journal (Ed. John B. Lowe). European Journal of Pharmacology (Ed. W.H. Gispen) TEACHING 1996/1997 “Introduction to rheological properties of blood”. Course developer and Lecturer. Department of Physiology, School of Medicine, University of Louisville, Louisville, USA. One lecture, 16 students. 1999 "Introduction to General Biology” PHZB-101. Course director, Course developer, and Lecturer. American University of Hawaii (University of Hawaii, Seven Waterfront Plaza, Suite 400, 500 Ala Moana Blvd., Honolulu, HI 96813), Tbilisi Campus. 40 lectures, 36 students. 2001 - 2008 “Physiology methods/blood rheology” – PHZB-625. Lecturer. Department of Physiology, School of Medicine, University of Louisville, Louisville, USA. 2 lectures, 12-21 students. 2007 - present “Peripheral Circulation” – PHZB-605. Lecturer. Department of Physiology, School of Medicine, University of Louisville, Louisville, KY, USA. 6 lectures, 18-24 students. Graduate Students Given Research Training Alexander Ovechkin, MD. 2002 - 2003 Kara Sedoris (Collins) 2002 - 2004 Valerie Moss 2002 Sharon Gordon 2003 - 2005 Shridhar Thirumalai 2003 - 2004 Walter Rodriguez, MD. 2003 Anuj Patel 2004 Matt Turina 2004 Mesia Steed 2004 - 2008 Lichun Wang 2007 Motaz Qadan, MD. 2008 - present Shrikant Givvimani, MD 2008 - present
  4. 4. David Lominadze, Ph.D. 2009 4 Post-doctoral Fellows Given Research Training Leila Gobejishvili, Ph.D. 2001 - 2002 Nina Tsakadze, MD., Ph.D. 2002 - 2003 Neetu Tyagi, Ph.D. 2004 - 2008 Karni Moshal, Ph.D. 2004 - 2008 Alexander Ovechkin, MD., Ph.D. 2005 - 2006 Utpal Sen, Ph.D. 2005 - 2008 Adrienne Bratcher, Ph.D. 2007 Munish Kumar, Ph.D. 2007 - 2008 Soumi Kundu, Ph.D. 2008 - present Paras Mishra, Ph.D. 2008 - present Natia Qipshidze, M.D. 2008 - present Jingjing Liu, Ph.D. (Pharmacology) 2009 Post-doctoral Fellows Trained Na Li, MD., Ph.D. 2007 Phani K. Patibandla, Ph.D. 2007 - 2009 Summer Students Given Research Training Daniel Jackson Summer 2006 (Graduated from University of Louisville, 2007) Calvin Williams Summer 2007 (Morehouse College, Atlanta, GA, 2007) Advisor to a Medical Summer Student Ashley Blaske Summer 2009 (I year medical student, U of L) Project: “Mechanisms of increased thrombotic abnormalities during preeclampsia” D. Lominadze, T. Robinson, and J. King - Co-investigators (5% effort) 05/09-09/09 ABSTRACTS and PRESENTATION Oral presentations: National / International Meetings Lominadze DG. Analysis of rheological properties of blood in microvessels during ischemia. International Symposium: "Pathogenesis and Monitoring of Hypoxic-Ischemic Brain Injuries", Rudolstadt, GDR. 1989. Lominadze D, N. Tsakadze, J.C. Falcone, S.E. D’Souza. Fibrinogen-mediated changes in microvascular reactivity. At: Novel Concepts in the Local Regulation of Vascular Tone. Experimental Biology 2004, Washington, DC, USA Lominadze D and Tyagi SC. Microvascular leakage during acute hyperhomocysteinemia. AHA Scientific Sessions 2004. New Orleans, LO, November 8, 2004, # 669. Patibandla PK, Sen U, Tyagi N, Dean WL, Tyagi SC, Roberts AM, Lominadze D. Effects of fibrinogen interaction with endothelial cells. 13th International Congress of Biorheology and 6th International Conference on Clinical Hemorheology. Penn State University, State College, PA. July 9-13, 2008. Lominadze D. Fibrinogen-induced endothelial cell layer permeability, role of MMP. 11th International Congress on Amino Acids, Peptides, and Proteins. August 3-7, 2009. Vienna, Austria
  5. 5. David Lominadze, Ph.D. 2009 5 Poster presentations: National / International Meetings 1. Mamisashvili VA, Baratashvili IK, Lominadze DG, Mchedlishvili GI. About blood flow structure in microvessels depending on flow velocity. In: “Damage and Regulatory Processes of the Body” Abstracts of 3rd All-Union Congress of Pathophysiologists. Moscow, USSR. 1982; 142. 2. Mamisashvili VA, Baratashvili IK, Lominadze DG. Behaviour and interactions of erythrocytes in microvessels as a factor determining blood flow resistance during ischemia. In: "Actual Questions of Altered Haemodynamics and Regulation of Microcirculation in Clinic and Experiment," Abstracts of 3rd All- Union Conference on Microcirculation. Moscow, USSR. 1984; 224-225. 3. Lominadze DG. Orientation and interactions of red blood cells in microvessels as a factor determining blood flow rate during cerebral ischemia. In: "Physiology, Pathoyphysiology and Pharmacology of Cerebral Circulation". Abstracts of the First All-Union Conference. Erevan, USSR. 1984; 95-96. 4. Mamisashvili VA, Lominadze DG, Mchedlishvili GI. The red blood cell behaviour in microvessels during ischemia. In: 4th European Conference on Clinical Haemorheology, Siena, Italy. 1985; 187. 5. Mamisashvili VA, Lominadze DG. Behaviour and interactions of red blood cells as a factor determining resistance in microvessels. In: The 50th Jubilee Congress of the Hungarian Physiological Society and the IUPS, Sponsored Satellite Symposia, Budapest, 1985; No. 195: 154. 6. Mamisashvili VA, Lominadze DG. Blood flow fluidity changes in microvessels during ischemia. 4th Workshop of collaborative investigations of the Institute of Physiology, Georgian Academy of Sciences and the Medical Research Center, Poland Academy of Sciences “Cerebral Ischemia and Edema” 24-26 April, 1986; 9-10. 7. Lominadze DG. Red blood cells behaviour in larger microvessels. In: Fifth World Congress for Microcirculation, Louisville, KY, USA. 1991; 66. 8. Lominadze DG, Mchedlishvili GI. Radial displacements and velocity fluctuations of red blood cells in microvessels. In: FASEB J. 1994; 8(5): M103. 9. Lominadze DG, Schuschke DA, Miller FN. Chronic L-arginine prevents cholesterol attenuated vasodilation to acetylcholine and serotonin in the microcirculation of rats. In: FASEB J. 1994; 8(4): A2322. 10. Lominadze DG, Saari JT, Miller FN, Justus DE, Schuschke DA. The aggregation and adhesion of platelets from dietary copper-deficient rats. In: FASEB J. 1995; 9(4): A4254. 11. Roberts AM, Arcellana RC, Robinson TW, West C, Lominadze DG. Platelet activating factor- induced platelet adhesion and constriction of pulmonary arterioles in the intact rat lung. In: FASEB J. 1995; 9(4): A4146. 12. Lominadze DG, Saari JT, Miller FN, Justus DE, Schuschke DA. Adhesion of Platelets from copper-adequate and copper-deficient rats to cultured endothelial cells. 9th International Congress of Biorheology and 2nd International Conference on Clinical Hemorheology (Big Sky, Montana, USA. 1995). In: Biorheology. 1995; 32(2-3): 228-229(F23). 13. Miller FN, Schuschke DA, Lominadze DG. Copper: a dietary nutrient essential for normal microvascular function. The Second Asian Congress for Microcirculation. August 18-20, 1995; Beijing, China. 14. Lominadze DG, Saari JT, Miller FN, Schuschke DA. Effect of shear forces on platelet thrombus formation during copper deficiency in rats. in: FASEB J. 1996; 10(3): A253. 15. Gurevich VS, Lominadze DG, Adeagbo ASO, Burov SV, Popov YG, Leko MV, Miller FN, Schuschke DA. Usage of RGD peptide for targeted nitric oxide delivery. 6th Erfurt Conference on platelets. Platelet Activation in Vascular disease: Detection, Clinical Significance and Treatment. Erfurt, Germany. 1996. 16. Lominadze DG, Saari JT, Miller FN, Schuschke DA. In vivo platelet thrombus formation in microvessels of copper deficient rats. Sixth World Congress for Microcirculation, Munich, Germany, 1996. In: Int. J. Microcirc. Clin. Exp. 1996; 16(S1): 182. 17. Lominadze DG, Joshua IG, Schuschke DA. Thrombus formation in microvessels of spontaneously hypertensive rats. Sixth World Congress for Microcirculation, Munich, Germany, 1996. In: Int. J Microcirc. Clin. Exp. 1996; 16(S1): 233. 18. Gurevich VS, Burov SV, Popov YuG, Leco MV, Lominadze D, Miller FN, Schuschke DA. 5- Fluorouracil derivative containing synthetic peptide ARG-GLU-ASP (RGD) sequence. A novel compound for local drug delivery. 68 European Journal of Clinical Investigation. 1997; 27 (Supplement 1): A14.
  6. 6. David Lominadze, Ph.D. 2009 6 19. Schuschke DA, Lominadze D, Saari JT, Miller FN. Von Willebrand factor (vWF) but not superoxide dismutase (SOD) restores attenuated platelet thrombosis in copper-deficient rats. In: FASEB J. 1998; 12(4): A241. 20. Lominadze D, Joshua IG, Schuschke DA. Comparison of blood flow shear rate values in microvessels of young and mature spontaneously hypertensive rats. In: Journal of Vascular Research. 1998; 35(S2):34. (20th European Conference on Microcirculation, Paris, France, 1998). 21. Lominadze D, Joshua IG, Schuschke DA. Red blood cell aggregation in spontaneously hypertensive rats. In: Journal of Vascular Research. 1998; 35(S2):34. (20th European Conference on Microcirculation, Paris, France, 1998). 22. Salia N, Momtselidze N, Kurtskhalia E, Lominadze D, Shakarishvili R, Solomonia R, Mchedlishvili G. Influence of lipid peroxidation on red blood cell aggregation. In: Biorheology. 1999; 36(1,2): 169. 23. Lominadze D, Momtselidze N, Mchedlishvili G, Joshua IG, Schuschke DA. Red blood cell aggregability during development of hypertension: comparison of experimental and clinical study. In: Biorheology. 1999; 36(1,2): 108. 24. Lominadze D, Kuchukhidze G, Momtselidze N, Aloeva M, Shakarishvili R, Mchedlishvili G, Joshua IG, Schuschke DA. Alteration of erythrocyte aggregability during hypertension. In: FASEB J. 2000; 14(4): A672. 25. Lominadze D, Schuschke DA, Joshua IG. In vivo platelet thrombus formation in microvessels of renovascular hypertensive rats. In: FASEB J. 2001; 15(4): A466. 26. Lominadze D, Dean WL. Specific binding involvement in fibrinogen-induced erythrocyte aggregation. In: FASEB J. 2002; 16(4): A82. 27. Schuschke D, Percival S, Lominadze D, Saari J, Lentsch A. Copper deficiency increases lung and heart ICAM-1 expression during endotoxemia. In: FASEB J. 2002; 16(4): A990. 28. Lominadze D, Saari JT, Schuschke DA. Neutrophil migration under agarose is altered by copper deficiency. In: FASEB J. 2003; 17(4): A1128. 29. Ovechkin A, Roberts AM, Collins KJ, Robinson TW, Lominadze D. Inhibition of inducible nitric oxide synthase attenuates increased platelet adhesion in pulmonary arterioles during lung ischemic - reperfusion in rabbits. In: FASEB J. 2003; 17(4): A416. 30. Lominadze D, Tsakadze N, Falcone JC, D’Souza SE. Fibrinogen-mediated changes in microvascular reactivity. In: FASEB J. 2004; 18(4): A1202. 31. Ovechkin A, Roberts AM, Collins KJ, Robinson TW, Lominadze D. Early postischemic vasoconstriction correlates with platelet but not leukocyte adhesion in pulmonary arterioles in rabbits. In: FASEB J. 2004; 18(4): A617. 32. Roberts AM, Ovechkin A, Lominadze D, Collins KJ, Robinson TW, Tyagi SC. Increased matrix metalloproteinase activity is associated with platelet-arteriolar interactions during pulmonary ischemia- reperfusion in rabbits. FASEB J. 2004; 18(4): A618. 33. Lominadze D, Falcone JC, D’Souza SE. Fibrinogen binding to vascular endothelial cells. Abstracts of the 5th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology. San Francisco, 2004. Arteriosclerosis, Thrombosis and Vascular Biology. 24(5): E71(P122), 2004. 34. Lominadze D and Tyagi SC. Microvascular leakage during acute hyperhomocystenemia. AHA Scientific Sessions 2004. Circulation. 2004; 110(17): III-141. 35. Roberts AM, Moshal KS, Smart LE, Ovechkin AV, Sedoris KJ, Lominadze D, Robinson TW, Tyagi SC. Increased MMP activity and platelet adhesion in subpleural arterioles during pulmonary ischemia- reperfusion are attenuated by iNOS inhibition in rabbits. FASEB J. 2005; 19(5): A1328. 36. Lominadze D, Roberts AM, Tyagi SC. Hyperhomocysteinemia increases brain microvascular leakage in mice. FASEB J. 2005; 19(4): A177. 37. Lominadze D, Roberts AM, Tyagi SC, Dean WL. Fibrinogen and its role in microcirculation during cardiovascular and cerebrovascular disorders. AHA Research Symposium. 2005 Dallas, TX, Nov. 12. 38. Lominadze D, Roberts AM, Tyagi N, Moshal KS, Tyagi SC. Acute hyperhomocysteinemia-induced leakage in mouse pial vessels. Stroke. 2006; 37(2): 685 (P191). 39. Lominadze D, Tyagi N, Moshal KS, Tyagi SC, Dean WL, Roberts AM. Fibrinogen-induced vasoconstriction. FASEB J. 2006; 20(4): A284. 40. Lominadze D, Gozal D, Roberts AM. Platelet thrombogenesis during Intermittent hypoxia in mice. FASEB J. 2006; 20(4): A791. 41. Tyagi N, Ovechkin AV, Mosahl KS, Lominadze D, Steed M, Tyagi SC. Mitochondrial mechanism of microvascular endothelial cell apoptosis induced by homocysteine. FASEB J. 2006; 20(5): A1461.
  7. 7. David Lominadze, Ph.D. 2009 7 42. Roberts AM, Ovechkin AV, Lominadze D, Tyagi SC. Chronic pulmonary volume overload increases lung MMP-9 activity and is associated with pulmonary remodeling in mice. FASEB J. 2006; 20(5): A1262. 43. Lominadze D, Tyagi N, Tyagi SC, Dean WL, Roberts AM. Fibrinogen-induces endothelial cell permeability by increasing F-actin formation. Experimental Biology 2007, Washington DC. April, 2007. FASEB J. 2007; 21: 590.4 44. Tyagi N, Tyagi SC, Lominadze D. Homocysteine-induced endothelial cell permeability, role of - aminobuturic acid A (GABAA) receptor. FASEB J. 2007; 21: 590.7. 45. Roberts AM, Rodriguez W, Akabua EA, Tyagi N, Tyagi SC, Gosal E, Lominadze D. Fibrinogen/fibrin deposition and corresponding microvascular leakage caused by pulmonary ischemia- reperfusion in the rabbit lung. FASEB J. 2007; 21: 979.8 46. Tyagi N, Moshal KS, Sen U, Lominadze D, Tyagi SC. Activation of GABAA receptor ameliorates homocysteine-induced MMP-9 by ERK pathway. FASEB J. 2007; 21: 594.9 47. Tyagi N, Steed M, Gillespie W, Rosenberger DS, Lominadze D, Sen U, Moshal KS, Henderson BC, Tyagi SC.Differential expression of the GABAA receptor subunits in the kidney and cardiovascular system. FASEB J. 2007; 21: 594.8. 48. Tyagi N, Dean WL, Roberts AM, Tyagi SC, Lominadze D. Elevation in fibrinogen content affects the tight junction proteins and increases endothelial cell permeability. FASEB J. 2008; 22: 926.11. 49. Sen U, Tyagi N, Moshal KS, Dean WL, Roberts AM, Tyagi SC, Lominadze D. Increased fibrinogen content induces release of endothelin-1 from endothelial cells. FASEB J. 2008; 22: 732.12. 50. Tyagi N, Kumar M, Pushpakumar SB, Lominadze D, Moshal KS, Sen U, Vacek TP, Tyagi SC. Homocysteine attenuates blood brain barrier function by inducing oxidative stress and the junctional proteins. FASEB J. 2008; 22: 734.7. 51. Kumar M, Tyagi N, Sathnur Pk, Moshal KS, Sen U, Lominadze D, Tyagi SC. Mechanism of homocysteine-induced dementia/spasm. FASEB J. 2008; 22: 734.9. 52. Roberts AM, Perez-Abadia G, Conhaim RL, Lominadze D. Inhibition of inducible nitric oxide synthase attenuates platelet activation and fibrinogen/fibrin deposition in pulmonary microvessels caused by lung ischemia-reperfusion in rabbits. FASEB J. 2008; 22: 1150.14. 53. Patibandla PK, Sen U, Tyagi N, Dean WL, Tyagi SC, Roberts AM, Lominadze D. Effects of fibrinogen interaction with endothelial cells. Biorheology. 2008; 45(1,2): 111. 54. Lominadze D, Patibandla PK, Tyagi N, Sen U, Dean WL, Tyagi SC, Roberts AM. Effects of elevated levels of fibrinogen in microcirculation. 25th Conference of the European Society on Microcirculation. August, 2008, Budapest, Hungary. Journal of Vascular Research. 2008; 45(Suppl. 2): 94. 55. Patibandla PK, Tyagi N, Tyagi SC, Dean WL, Roberts AM, Lominadze D. An elevated fibrinogen increases matrix metalloproteinases activity in cardiac microvascular endothelial cells. FASEB J. 2009; 23: 592.10. 56. Tyagi N, Givvimani S, Kumar M, Kundu S, Gillespie WM, Mishra P, Sathnur Pk, Lominadze D, Sen U, Tyagi SC. Activation of GABAA receptor protects mitochondria and reduces cerebral ischemia. FASEB J. 2009; 23: 614.8. 57. Roberts AM, Akabua EA, Lominadze D, Gozal E. Inducible nitric oxide synthase inhibition attenuates lung injury and decreases NADPH oxidase expression and activation during ischemia- reperfusion in the ventilated rabbit lung. FASEB J. 2009; 23: 620.2. 58. Lominadze D. Fibrinogen-induced endothelial cell layer permeability, role of MMP. Amino Acids. 2009: 37(Supplement 1): S74. Poster presentations: Local / Regional Meetings 1. Mamisashvili VA, Lominadze DG. Blood flow fluidity changes in microvessels during ischemia. In: “Cerebral Ischemia and Edema” Proceedings of the 4th working meeting of the participants of the collaborative studies of Iv.Beritashvili Institute of Physiology, Georgian Academy of Sciences and of the Center of Experimental and Clinical Medicine of Poland Academy of Sciences. Tbilisi, USSR. 1986, 9-10. 2. Mamisashvili VA, Lominadze DG. Effect of the blood flow structuring on blood rheological properties in living microvessels. In: Modern Problems of Neurobiology. Abstracts of All-Union Conference, dedicated to the 50th anniversary of the Iv.Beritashvili Institute of Physiology, Georgian Academy of Sciences”. Tbilisi. 1986; 224-225.
  8. 8. David Lominadze, Ph.D. 2009 8 3. Lominadze DG. About a possible role of microrheological properties of blood during regulation of microcirculation. In: "Mechanisms of Injury and Regulation and their Correction", Kishinev, USSR. 1987; 24. 4. Kuchukhidze G, Momtselidze N, Aloeva M, Shakarishvili R, Mchedlishvili G, Joshua IG, Schuschke DA, Lominadze D. Erythrocyte aggregability changes during hypertension. In: Proceedings of Jackson Cardiovascular-Renal Meeting 2000. Abstract # 103. (Jackson, Mississippi. Novemeber 8-11, 2000). 5. Tyagi N, Ovechkin AV, Steed MB, Lominadze D, Shah AP, Tyagi SC. Mechanism of microvascular endothelial cell apoptosis in hyperhomocysteinemia. Research Louisville 2005. (Second place, Post- Doctoral) 6. Lominadze D, Roberts AM, Tyagi SC, Dean WL. Mechanism of fibrinogen-induced vasoconstriction. Research Louisville 2005. (Third place, Faculty) 7. Blaske A, Robinson, King J, Lominadze D. Mechanisms of protective effect of estriol during induced inflammation in human endothelial cells. Research Louisville, 2009. Major Lectures and Visiting Professorships 2007 Department of Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, and the Center for Diabetes and Endocrine Research, University of Toledo, College of Medicine. 2007 Sol Sherry Thrombosis Research Center, Temple University, School of Medicine. 2008 Department of Pharmacology, Toxicology, and Physiology, Marshall University 2008 Department of Pharmacology, University of Mississippi 2008 Department of Physiology and Biophysics, Georgetown University Medical Center 2008 Department of Physiology and Biophysics, Virginia Commonwealth University 2009 Department of Physiology LSU Health Sciences Center LSU Health Sciences Center. March 31. “Effects of increased content of fibrinogen on microcirculation”. RESEARCH FUNDING Complete University of Louisville, Medical School Foundation “Correlation of changes of blood rheological properties with development of hypertension”. D. Lominadze, Co-Investigator (P.I.: Joshua, IG). $9,998/direct year 01/97- 07/98 University of Louisville, Intramural Research Incentive Grants, Research Initiation Grant “Microcirculatory mechanisms underlying the development of systemic and pulmonary hypertension in response to intermittent hypoxia”. P.I.: D. Lominadze. $4,000/direct year 01/04 - 12/05 Grant-in-Aid. (P.I.: Roberts, AM) 07/01/05 - 12/31/06 D. Lominadze - Co-investigator 5% effort and 10% collaboration Am. Lung Association, Kentucky Affiliate $39,996/direct year Platelet-Endothelial Responses During Lung Reperfusion 0235317N (P.I. D. Lominadze, 70% effort) 07/01/02 - 06/30/06 AHA, National, SDG $65,000/ direct year (no cost extension 7/06-2/07) Mechanisms of platelet thrombogenesis and erythrocyte aggregability changes in hypertensive rats R01 HL-71010-05 (P.I. S.C. Tyagi) 06/02 – 05/06 D. Lominadze - Co-investigator (10% effort) NIH/NHLBI $250,000/year (no cost extension till 05/07) Mechanism of vascular remodeling in hyperhomocysteinemia R 01 DK55030 (P.I. D.A. Schuschke) 04/01/05 - 11/30/09 D. Lominadze - Co-investigator (10% effort) Effort on this grant has ended. NIH/NIDDK $140,128/direct year Leukocyte adhesion in copper deficient microcirculation
  9. 9. David Lominadze, Ph.D. 2009 9 Awarded but declined Supplement to HL080394 P.I. D. Lominadze (5 % effort) 12/07 - 02/11 NIH/NHLBI $168,201/direct year “Fibrinogen-Induced Vasoconstriction during Hypertension” ACTIVE R01 HL080394 P.I. D. Lominadze (40 % effort) 03/07 - 02/12 NIH/ NHLBI $250,000/direct year “Fibrinogen-Induced Vasoconstriction during Hypertension” R01 NL-71010 (P.I. S.C. Tyagi) 04/07 – 03/11 D. Lominadze - Co-investigator (5% effort) NIH/NHLBI $250,000/direct year “Mechanism of vascular remodeling in hyperhomocysteinemia” R01 HL-88012 (P.I. S.C. Tyagi) 06/07 – 05/12 D. Lominadze - Co-investigator (5% effort) NIH/NHLBI $250,000/direct year “Endothelial-myocyte uncoupling in cardiac arrhythmia” R01 NS-51568 (P.I. S.C. Tyagi) 10/07 – 09/12 D. Lominadze - Co-investigator (10% effort) NIH/NHLBI $218,000/direct year “Mechanism of cerebral vascular remodeling” R01 HL 071071 (P.I. M-J. Lee, Wayne State University) 04/09 – 3/13 D. Lominadze - Co-investigator (Subcontract, 20% effort) NIH/NHLBI $250,000/direct year “Sphingolipid signaling in endothelial function” PENDING T35 HL 071486 (P.I. C.A. Hornung) 08/09 – 07/14 D. Lominadze - Co-investigator (5% effort) “Mechanisms of increased thrombotic abnormalities during preeclampsia” NIH/NHLBI $606,646/direct year requested “For Bench to Bed-side; Introduction to Clinical and Translational Research” PUBLICATIONS Peer-reviewed publications 1. Mamisashvili VA, Baratashvili IK, Lominadze DG. Velocity profile in microvessels depending upon the velocity and concentration of erythrocytes. USSR J. Physiol. (Fiziol Zh SSSR Im I.M. Sechenova) 1982; 68(12): 1673-1679. 2. Mamisashvili VA, Baratashvili IK, Lominadze DG. Formation of velocity profile in microvessels. Proc. Georgian Acad. of Sci. Biol. Series. 1984; 10(3): 197-203.
  10. 10. David Lominadze, Ph.D. 2009 10 3. Lominadze DG, Shinkarenko VS, Mamisashvili VA. Study of the trajectory of erythrocyte movement in microvessels using a method of automatic image analysis. Biull. Eksp. Biol. Med. 1990; 109(4): 343-344. 4. Lominadze DG, Mchedlishvili GI, Mamisashvili VA. Changes of blood flow structure in precapillary type microvessels during significant slowing-down of flow. Patol. Fiziol. and Eksp. Terap. 1991; 1: 36-38. 5. Mchedlishvili GI, Beritashvili NI, Lominadze DG. Quantitative estimation of erythrocyte aggregability in human blood samples. Patol. Fiziol. Eksp. Terap. 1992; 3: 50-52. 6. Mchedlishvili G, Beritashvili N, Lominadze D, Tsinamdzvrishvili B. Technique for direct and quantitative evaluation of erythrocyte aggregability in blood samples. Biorheology. 1993; 30(2): 153-161. 7. Schuschke DA, Miller FN, Lominadze DG, Feldhoff RC. L-arginine restores cholesterol-attenuated microvascular responses in the rat cremaster. International Journal of Microcirculation: Clinical and Experimental. 1994; 14(4): 204-211. 8. Lominadze DG, Miller FN, Schuschke DA. Chronic L-arginine prevents cholesterol-attenuation of vasodilation to acetylcholine and serotonin. Endothelium. 1995; 3: 151-157. 9. Lominadze DG, Saari JT, Miller FN, Catalfamo JL, Justus DE, Schuschke DA. Platelet aggregation and adhesion during dietary copper deficiency in rats. Thrombosis and Haemostasis. 1996; 75(4): 630-634. 10. Gurevich VS, Lominadze DG, Adeagbo ASO, Burov SV, Popov YG, Leko MV, Miller FN, Schuschke DA. Anti-thrombotic and vasorelaxant properties of a novel synthetic RGD peptide containing nitric oxide. Pharmacology. 1997; 55(1): 1-9. 11. Lominadze D, Saari JT, Miller FN, Catalfamo JL, Schuschke DA. Von Willebrand factor restores impaired platelet thrombogenesis in copper-deficient rats. The Journal of Nutrition. 1997; 127(7):1320- 1327. 12. Lominadze D, Joshua IG, Schuschke DA. In vivo platelet thrombus formation in microvessels of spontaneously hypertensive rats. American Journal of Hypertension. 1997; 10(10): 1140-1146. 13. Lominadze D, Joshua IG, Schuschke DA. Increased erythrocyte aggregation in spontaneously hypertensive rats. American Journal of Hypertension. 1998; 11(7): 784-789. 14. Lominadze D, Joshua IG, Catalfamo JL, Schuschke DA. Platelet thrombus formation in microvessels of young spontaneously hypertensive rats. Clinical and Experimental Hypertension. 1998; 20(8): 917-937. 15. Lominadze D, Saari JT, Miller FN, Catalfamo JL, Percival SS, Schuschke DA. In vitro platelet adhesion to endothelial cells at low shear rates during copper deficiency in rats. The Journal of Trace Elements in Experimental Medicine. 1999; 12(1): 25-36. 16. Lominadze D, Mchedlishvili G. Red blood cell behavior at low flow rate in microvessels. Microvascular Research. 1999; 58(2): 187-189. 17. Lominadze D, Joshua IG, Schuschke DA. Blood flow shear rates in arterioles of spontaneously hypertensive rats at early and established stages of hypertension. Clinical and Experimental Hypertension. 2001; 23(4): 317-328. 18. Lominadze D, Dean WL. Involvement of fibrinogen specific binding in erythrocyte aggregation. FEBS Letters. 2002; 517(1-3): 41-44. (Equal contribution by the authors) 19. Lominadze D, Schuschke DA, Joshua IG, Dean WL. Increased ability of erythrocytes to aggregate in spontaneously hypertensive rats. Clinical and Experimental Hypertension. 2002; 24(5): 397-406. 20. Schuschke DA, Percival SS, Lominadze D, Saari JT, Lentsch AB. Tissue-specific ICAM-1 expression and neutrophil transmigration in the copper-deficient rat. Inflammation. 2002; 26(6): 297-303. 21. Roberts AM. Ovechkin AV, Mowbray JG, Robinson TW, Lominadze D. Effects of pulmonary ischemia-reperfusion on platelet adhesion in subpleural arterioles in rabbits. Microvascular Research. 2004; 67(1): 29-37. (First Published in September 3; doi:10.1016/j.mvr.2003.09.003). 22. Lominadze D, Saari JT, Percival SS, Schuschke DA. Proinflammatory effects of copper deficiency on neutrophils and lung endothelial cells. Immunology and Cell Biology. 2004; 82: 231-238.
  11. 11. David Lominadze, Ph.D. 2009 11 23. Lominadze D, Tsakadze N, Sen U, Falcone JC, D’Souza SE. Fibrinogen- and its fragment D- induced vascular constriction. American Journal of Physiology, Heart and Circulatory Physiology. 2005; 288(3): H1257--H1264. (First published in November 11, 2004; doi:10.1152/ajpheart.00856.2004). 24. Ovechkin AV, Lominadze D, Sedoris KC, Gozal E, Robinson TW, Roberts AM. Inhibition of inducible nitric oxide synthase attenuates platelet adhesion in subpleural arterioles caused by lung ischemia-reperfusion in rabbits. Journal of Applied Physiology. 2005; 99(6): 2423-2432. (First published in 2004, doi:10.1152/japplphysiol.01302.2004). 25. Tyagi SC, Lominadze D, Roberts AM. Homocysteine in microvascular endothelial cell barrier permeability. Cell Biochemistry and Biophysics. 2005; 43(1): 37-44. 26. Tyagi N, Moshal KS, Lominadze D, Ovechkin AV. Tyagi SC. Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip Goldblatt hypertension mouse model. Canadian Journal of Physiology and Pharmacology. 2005; 83(7): 583-594. 27. Gordon S, Lominadze D, Saari JT, Lentsch AB, Schuschke DA. Impaired deformability of copper- deficient neutrophils. Experimental Biology and Medicine. 2005; 230(8): 543-548. 28. Lominadze D, Roberts AM, Tyagi N, Tyagi SC. Homocysteine causes cerebrovascular leakage in mice. American Journal of Physiology, Heart and Circulatory Physiology. 2006; 290: H1206-H1213. (First published in October 28, 2005; doi: 10.1152/ajpheart.00376.2005) 29. Shastry S, Tyagi N, Moshal KS, Lominadze D, Hayden MR, Tyagi SC. GABA receptors ameliorate Hcy-mediated integrin-shedding and constrictive collagen remodeling in microvascular endothelial cells. Cell Biochemistry and Biophysics. 2006; 45 (2): 157-166. 30. Tyagi N, Ovechkin AV, Lominadze D, Moshal KS, Tyagi SC. Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia. Journal of Cellular Biochemistry. 2006; 98(5): 1150-1162. 31. Ovechkin AV, Tyagi N, Sen U, Lominadze D, Steed MM, Moshal KS, Tyagi SC. 3- Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinimic mice. Am J Physiol Lung Cell Mol Physiol 2006; 291(5): L905-L911. 32. Rosenberger D, Moshal KS, Kartha GK, Tyagi N, Sen U, Lominadze D, Maldonado C, Roberts AM, Tyagi SC. Arrhythmia and Neuronal/Endothelial Myocyte Uncoupling in Hyperhomocysteinemia. Archives of Physiology and Biochemistry. 2006; 112(4): 219-227. 33. Tyagi N, Moshal KS, Lominadze D, Sen U, Ovechkin AV, Tyagi SC. Ciglitazone ameliorates Hcy- mediated mitochondrial translocation and MMP-9 activation in endothelial cells by inducing PPAR activity. Cell Mol Biol. 2006; 52(5): 21-27. 34. Ovechkin AV, Lominadze D, Sedoris KC, Robinson TW, Tyagi SC, Roberts AM. Lung ischemia- reperfusion injury: implications of oxidative stress and platelet-arteriolar wall interactions. Archives of Physiology and Biochemistry. 2007; 113(1): 1-12. 35. Moshal KS, Camel CK, Kartha GK, Steed MM, Tyagi N, Sen U, Kang YJ, Lominadze D, Maldonado C, Tyagi SC. Cardiac dys-synchronization and arrhythmia in hyperhomocysteinemia. Current Neurovascular Research. 2007; 4(4): 289-294. 36. Tyagi N, Moshal KS, Tyagi SC, Lominadze D. GABAA receptor mitigates homocysteine-induced endothelial cell permeability. Endothelium. 2007; 14(6): 315-323. 37. Tyagi N, Lominadze D, Gillespie W, Moshal KS, Rosenberger DS, Steed M, Sen U, Tyagi SC. Differential expression of the γ-aminobutyric acid receptor A (GABAA) and its subunits in various tissue. Clinical Chemistry and Laboratory Medicine. 2007; 45(12): 1777-1784. 38. Kumar M, Tyagi N, Moshal KS, Sen U, Pushpakumar SB, Vacek T, Lominadze D, Tyagi SC. GABAA receptor agonist mitigates homocysteine-induced cerebrovascular remodeling in knockout mice. Brain Research. 2008; 1221: 147-153. 39. Tyagi N, Roberts AM, Dean WL, Tyagi SC, Lominadze D. Fibrinogen induces endothelial cell permeability. Molecular and Cellular Biochemistry. 2008; 307(1-2):13-22. 40. Falcone JC, Lominadze D, Johnson WT, Schuschke DA. Endothelial cell-derived nitric oxide mobilization is attenuated in copper-deficient rats. Applied Physiology, Nutrition, and Metabolism. 2008; 33 (6): 1073-1078. 41. Kundu S, Kumar M, Sen U, Mishra PK, Tyagi N, Metreveli N, Lominadze D, Rodriguez W, Tyagi SC. Nitrotyrosinylation, Remodeling and Endothelial-Myocyte Uncoupling in iNOS, cystathionine beta synthase (CBS) knockouts, and CBS/iNOS Double Knockouts, J Cellular Biochem. 2008; 106(1): 119-126.
  12. 12. David Lominadze, Ph.D. 2009 12 42. Lee J-F, Gordon S, Wang L, Lominadze D, Lee M-J. Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature. American Journal of Physiology, Heart and Circulatory Physiology. (doi: 10.1152/ajpheart.00097.2008) 2009: 296(1): H33-H42. (DL and M-JL are equally contributed senior authors) 43. Sen U, Tyagi N, Patibandla PK, Dean WL, Tyagi SC, Roberts AM, Lominadze D. Fibrinogen- induced production of endothelin-1 from endothelial cells. American Journal of Physiology - Cell Physiology. 2009; 296(4): C840-C847. 44. Tyagi N, Vacek TP, Sen U, Moshal KS, Tyagi SC, Lominadze D. Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway. Journal of Cellular Physiology. 2009; 220(1): 257-266. 45. Patibandla PK, Tyagi N, Dean WL, Tyagi SC, Roberts AM, Lominadze D. Fibrinogen induces alteration of endothelial cell tight junction proteins. Journal of Cellular Physiology. 2009; 221(1): 195-203. 46. Qadan M, Gardner SA, Vitale D, Lominadze D, Joshua IG, Polk HC. Hypothermia and surgery: Immunologic mechanisms for current practice. Annals of Surgery. 2009; 250(1): 134-140. 47. Lominadze D, Dean WL, Tyagi SC, Roberts AM. Mechanisms of fibrinogen-induced microvascular dysfunction during cardiovascular disease. Acta Physiologica. 2009; (In press). In preparation: . Tyagi N, Qipshidze N, Kundu S, Gillespie WM, Givvimani S, Lominadze D, Tyagi SC. Hydrogen sulfide mitigates matrix metalloproteinase-9 activity and neurovascular permeability in hyperhomocysteinemic mice. . Lominadze G, Tyagi N, Roberts AM, Tyagi SC, Cai J, Pierce WH, Dean WL, Lominadze D. Fibrinogen-induced changes in endothelial cell proteome. Molecular and Cellular Proteomics. . Lominadze D, Gozal D, Roberts AM. Platelet thrombus formation in microvessels of mice with intermittent hypoxia. Non Peer-reviewed publications (book chapters and invited publications) 1. Lominadze DG. Investigation of some microrheological parameters of blood flow by means of television-computer system. In: "Television Microscopy during Investigation of Heart-Vessel System", Leningrad, USSR. 1990; pp. 22-23. 2. Lominadze DG. Investigation of blood flow structure in microvessels by automatic image analysis methods. In: Shoshenko, KA (Ed.): "Methods of Investigation of Mass Transport in Microcirculatory System". Novosibirsk (USSR). 1991; pp. 97-100. 3. Lominadze DG. Summary of chapter: Red blood cell aggregation and deformability, and comments No.: 1.2.2.18, 3.1.3.7, 3.2.2.1, 3.2.2.7, 3.2.3.11, 3.2.3.18, 3.2.4.6, 3.2.4.10, 3.3.1.3, 3.3.3.6. In: (Eds.: G. Mchedlishvili, M.F. Tomita, R.T. Tuma (Eds.): "Microcirculation of the Brain". Nova Science Pub., Inc. New York. 1992. 4. Miller FN, Lominadze DG, Schuschke DA. Copper: a dietary nutrient essential for normal microvascular function. In: H. Niimi, R-j. Xiu, T. Saweda, and C. Zheng (Eds.): Microcirculation Approach to Asian Traditional Medicine: Strategy of the Scientific Evaluation. Elsevier Science, Amsterdam. 1996; pp. 51-53. 5. Schuschke DA, Saari JT, Miller FN, Lominadze DG. Microvascular control mechanisms in copper deficiency. The Journal of Trace Elements in Experimental Medicine. 1996; 9: 63-72. 6. Lominadze D. Internet Virtual Symposium, the Seventh Tbilisi Symposium. In: G. Mchedlishvili, M. Tomita, and G.W. Schmid-Schönbein (Eds.): Hemorheology in Microcirculation: Pathological Changes. The Keio Journal of Medicine. 2000; 4(supplement 3): pages: 18,19, 29, 39-41. Updated on: October 5, 2009

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