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COSMETIC EFFECTIVENESS OF TOPICALLY APPLIED HYDROLYSED KERATIN PEPTIDES AND LIPIDS DERIVED FROM WOOL C. BARBA, S. MÉNDEZ, ...
INTRODUCTION WOOL Complex macromolecular structure composed primarily of keratin proteins  COMPOSITION External lipids  In...
METHODS “ IN VIVO” STUDIES Volunteers acclimatizing 15min, 20ºC, 60%HR Topical application zone: Volar forearm Volunteers ...
RESULTS AND DISCUSSION SKIN CAPACITANCE Important increase on skin capacitance in the sites to which keratin samples were ...
RESULTS AND DISCUSSION SKIN ELASTICITY Increase in skin elasticity for the zones to which the keratin peptides were applie...
RESULTS AND DISCUSSION SORPTION-DESORPTION TEST Higher values of initial absorption of water and a greater capacity for re...
CONCLUSIONS <ul><li>The beneficial effect of application of the wool keratin peptide samples on healthy skin has been demo...
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Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids from wool Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids from wool

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Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids from wool Cosmetic effectiveness of topically applied hydrolysed keratin peptides and lipids from wool

  1. 1. COSMETIC EFFECTIVENESS OF TOPICALLY APPLIED HYDROLYSED KERATIN PEPTIDES AND LIPIDS DERIVED FROM WOOL C. BARBA, S. MÉNDEZ, A. RODDICK-LANZILOTTA, R. KELLY, J.L. PARRA and L. CODERCH Skin Research and Technology 2008; 14: 243-248
  2. 2. INTRODUCTION WOOL Complex macromolecular structure composed primarily of keratin proteins COMPOSITION External lipids Internal wool lipids (IWL) No keratin proteins Keratin proteins (85-95%) Give wool desirable properties such as strength, insolubility and moisture regain. Rich in cholesterol, free fatty acids, cholesterol sulphate and ceramides. Form liposomes with stable bilayer structure. Lipids Proteins
  3. 3. METHODS “ IN VIVO” STUDIES Volunteers acclimatizing 15min, 20ºC, 60%HR Topical application zone: Volar forearm Volunteers 6 Samples <ul><li>Keratin sample 1 </li></ul>Parameters <ul><li>Elasticity </li></ul><ul><li>Capacitance </li></ul>Initial Application  Measurement Sorption-Desorption Test <ul><li>Keratin sample 2 </li></ul><ul><li>IWL Liposomes </li></ul><ul><li>NaCl, Placebo 1 </li></ul><ul><li>Water, Placebo 2 </li></ul>(Peptide aqueous solution) (Peptide IWL liposome solution) 1  24h 2  24h 3  24h 4  24h 5  72h
  4. 4. RESULTS AND DISCUSSION SKIN CAPACITANCE Important increase on skin capacitance in the sites to which keratin samples were applied during all the treatment period.       P<0.05, calculated between samples and placebo
  5. 5. RESULTS AND DISCUSSION SKIN ELASTICITY Increase in skin elasticity for the zones to which the keratin peptides were applied and for the zones treated with IWL liposomes.      P<0.05, calculated between samples and placebo
  6. 6. RESULTS AND DISCUSSION SORPTION-DESORPTION TEST Higher values of initial absorption of water and a greater capacity for retention observed for the areas treated with the keratin samples.
  7. 7. CONCLUSIONS <ul><li>The beneficial effect of application of the wool keratin peptide samples on healthy skin has been demonstrated with improved hydration and elasticity. </li></ul><ul><li>The moisture sorption-desorption profile obtained showed higher values of initial absorption of water for the skin zones treated with the two keratin formulations. </li></ul><ul><li>Higher skin elasticity values were obtained following treatment with the IWL liposomes. </li></ul>Hydrolysed peptides derived from wool may be applied alone or combined with wool internal lipids structured as liposomes improving in both cases the hydration, elasticity and moisture sorption-desorption profile. CONCLUSIONS

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