"Overview of the Harvard Catalyst Imaging Program"


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"Overview of the Harvard Catalyst Imaging Program"

  1. 1. Overview of the Harvard Catalyst Imaging program Randy Gollub,MD,PhD; Valerie Humblet,PhD http://catalyst.harvard.edu April 28, 2009
  2. 2. Institutions participating in Harvard CTSC <ul><li>  Academic Healthcare Centers </li></ul><ul><li>Beth Israel-Deaconess Medical Center </li></ul><ul><li>Brigham and Women’s Hospital </li></ul><ul><li>Massachusetts General Hospital </li></ul><ul><li>Children’s Hospital Boston </li></ul><ul><li>Specialty Hospitals and Institutes </li></ul><ul><li>Dana-Farber Cancer Institute </li></ul><ul><li>Forsyth Dental Institute </li></ul><ul><li>Joslin Diabetes Center </li></ul><ul><li>Massachusetts Eye and Ear Infirmary </li></ul><ul><li>McLean Hospital </li></ul><ul><li>Schepens Eye Research Institute </li></ul><ul><li>Massachusetts Institutes of Technology </li></ul><ul><li>Harvard University </li></ul><ul><li>Faculty of Arts and Sciences </li></ul><ul><li>Harvard Business School </li></ul><ul><li>Harvard School of Dental Medicine </li></ul><ul><li>Harvard Divinity School </li></ul><ul><li>Graduate School of Design </li></ul><ul><li>Graduate School of Education </li></ul><ul><li>Kennedy School of Government </li></ul><ul><li>Harvard Law School </li></ul><ul><li>Harvard Medical School </li></ul><ul><li>Harvard School of Public Health </li></ul><ul><li>Harvard School of Engineering </li></ul><ul><li>Community Healthcare Institutions </li></ul><ul><li>Cambridge Health Alliance </li></ul><ul><li>HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare </li></ul>Yearly budget: $38 million (23 NIH + 15 matching)
  3. 3. Harvard Catalyst <ul><li>Programs (Selected list) </li></ul><ul><ul><li>Development of Novel C/T Methodologies </li></ul></ul><ul><ul><li>Biomedical Informatics </li></ul></ul><ul><ul><li>Research Education, Career Development </li></ul></ul><ul><ul><li>Pilot studies </li></ul></ul><ul><ul><li>Community Engagement </li></ul></ul><ul><ul><li>Design and Biostatistics </li></ul></ul><ul><ul><li>Diversity and Health Disparities Research </li></ul></ul><ul><ul><li>Ethics </li></ul></ul><ul><ul><li>Linkages across the institutions </li></ul></ul><ul><ul><li>Regulatory Knowledge and Support </li></ul></ul>
  4. 4. Imaging Consortium Team Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Site Co-Director Robert Lenkinski, Site Co-Director Neil Rofsky, Site Co-Director Clare Tempany, Site Co-Director Ron Kikinis, Site Co-Director Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Site Co-Director Simon Warfield, Site Co-Director Annick D. Van den Abbeele, Site Co-Director Jeff Yap, Site Co-Director Gordon J. Harris, Site Co-Director Annick D. Van den Abbeele, Site Co-Director William Hanlon, Core Manager Valerie Humblet, Imaging Liaison Yong Gao, XNAT Engineer
  5. 5. Mission of the Imaging Consortium <ul><li>Expand imaging in clinical research </li></ul><ul><ul><li>Build infrastructure (software, image analysis and visualization tools, cross-site acquisition tools) </li></ul></ul><ul><ul><li>Provide expert consultation in the use of imaging as part of clinical translational research </li></ul></ul><ul><ul><li>Educate and advise about available imaging and image processing capabilities in the Harvard environment. </li></ul></ul><ul><ul><li>Provide education at the local and national level (participation in RSNA education program) </li></ul></ul>
  6. 6. Image Consortium Consultation Service
  7. 7. Technologies and Expertise <ul><li>Cancer imaging, MRI, PET, CT, fMRI, US, pediatric imaging, neuroimaging. </li></ul><ul><li>Focused on assisting with planning and design of research proposals and/or methods for image analysis. </li></ul><ul><li>Consultation is available for the preparation of a grant or IRB submission. </li></ul><ul><li>We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies. </li></ul>
  8. 8. Examples of Imaging Consultation <ul><li>Standardization of physiologic monitoring system for MRI. </li></ul><ul><ul><li>Deployed at 6 institutions (MGH, BWH.BIDMC, CHB, MIT, Harvard) </li></ul></ul><ul><ul><li>Creation of a biomedical engineer working group </li></ul></ul>
  9. 9. Examples of Imaging Consultation <ul><li>Development of lingual nerve imaging (MGH-BIDMC) </li></ul><ul><ul><li>MGH maxillofacial surgeon contacted us regarding pre-op imaging of lingual nerve </li></ul></ul><ul><ul><li>Bob Lenkinski (BIDMC) had expertise in MRI nerve imaging </li></ul></ul><ul><ul><li>Healthy volunteer was scanned at BIDMC </li></ul></ul><ul><ul><li>Head and neck radiologist (BIDMC) will help with reading of images </li></ul></ul>
  10. 10. Examples of Imaging Consultation <ul><li>Study of brain-development in premature infants (new collaboration: CHB-BWH-MGH) </li></ul>Slicer (BWH): quantitative tractography ( Gilmore, 2007 AJNR) CHB : new Fetal-Neonatal Neuroimaging and Developmental Science Center Optical Imaging of Cerebral Oxygenation in Infants ( MGH )
  11. 11. Medical Imaging Informatics <ul><li>Examples: </li></ul><ul><ul><li>Clinical: </li></ul></ul><ul><ul><ul><li>Ruling out appendicitis based on CT scans. Are there metrics that can be found by analyzing clinical data? </li></ul></ul></ul><ul><ul><ul><li>Quantitative output from Freesurfer for Alzheimer disease </li></ul></ul></ul><ul><ul><li>Research: </li></ul></ul><ul><ul><ul><li>Helping TIMC get easier access to PACS system for clinical trials </li></ul></ul></ul>
  12. 12. Medical Imaging Informatics <ul><li>IT Catalyst infrastructure: </li></ul><ul><ul><li>i2b2: scalable computational framework to help translation of genomic findings. </li></ul></ul><ul><ul><li>BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. </li></ul></ul><ul><ul><li>NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer. </li></ul></ul>
  13. 13. Medical Imaging Informatics Data Repository (CRC) File Repository Identity Management Ontology Management Correlation Analysis De - Identification Of data Natural Language Processing Annotating Genomic Data #1 Project Management Workflow Framework Annotating Genomic Data #2 PACS PACS i2b2 HIVE Dr X Desktop Pediatric rare disease Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr W Desktop Quantitative cancer biomarkers XNAT Enterprise
  14. 14. Educational Program <ul><li>Mission: Provide lectures, tutorials, and educational materials promoting the use of imaging to junior investigators and associated research staff </li></ul><ul><li>Tailored lectures: Host on-site and based on discipline (oncology, neuro, cardiology, pediatrics, etc) </li></ul><ul><li>Generic imaging modules: Basic principles of imaging, quantitative methods, clinical trial design with imaging endpoints, imaging risks and considerations for informed consent forms </li></ul><ul><li>Dissemination: through national networks (CTSA, RSNA, IRAT, SNM) </li></ul>
  15. 15. Pilot funds <ul><li>Eligibility: All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. </li></ul><ul><li>First round: 62 projects funded (out of 602) </li></ul><ul><li>Funds: Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. (80 grants expected) </li></ul><ul><li>Deadlines: Letter of intent: May 13, 2009 </li></ul><ul><li>Full application: June 12, 2009 </li></ul><ul><li>Contact: Harvard Catalyst Research Navigators 617 432-7800 </li></ul>
  16. 16. http://catalyst.harvard.edu [email_address] www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC