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  1. 1. APRIL 2007D eAlumni e p a r t m e n t of n D o D o n t i c s Newsletter THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO Greetings from San Antonio! S pring has been very noticeable this year in San Antonio: we had record amounts of rain in March, and this year’s crop of pollen is also making both faculty and students appear quite satisfied with the quality of the resulting treatments, the efficiency of the method and the student’s ease in learning this records. Since spring has sprung, it must be time technique. In addition, we have formalized a case again to give you an update on your Department of complexity worksheet that helps students to identify Endodontics. cases within their scope and cases that should be Our endodontic mission is as focused as ever: referred to the endo specialty clinic staffed by our delivering superior clinical training and cutting- residents. edge research. One of our major goals is to create One newly emerging field in endodontics is an outstanding residency program. There are four regenerative endodontics. Regenerative endodontics key factors in attaining this goal: talented faculty, has been defined as biologically based procedures motivated residents, state-of-the-art equipment, and designed to replace damaged structures, including generous support. You are certainly one of our keys dentin and root structures, as well as cells of the to success. Without your continued support, San pulp-dentin complex. This is an exciting topic since Antonio would not be where it is today. If I don’t see it offers an alternative approach that one day might you Philadelphia to give you my thanks, please take be able to restore the pulp-dentin complex thereby this note as my gratitude for your continued support. potentially saving our patient’s natural teeth from The Chairman’s Address The Greek philosopher Heraclitus is credited extraction and implant replacement. Accordingly, the with saying that the only constant is change. That field appears to be emerging as a new and potentially has certainly been true for our Graduate Program. very important area for endodontics and the JOE has Since our fall newsletter, Dr. Scott Schwartz made recently published review articles (Murray et al., JOE the difficult decision to step down from the position 33:377, 2007; Nakashima and Akamine JOE 31:711, of Program Director and to accept a position in the 2005), case reports (Chueh and Huang JOE 32:1205, VA system across the street. Scott is an outstanding 2006; Banchs and Trope JOE 30:196, 2004) and basic endodontist and a skillful educator and while we research papers (Huang et al., JOE 32:1066, 2006; will miss his able hands directing the residency Saito et al., JOE 30:205, 2004; etc) on this topic. In program, I am very happy that he will continue on addition, the AAE has formed a standing committee as a faculty member in our Department and will staff on Regenerative Endodontics. Our Department is our residents during their rotations to the VA. Scott starting research in this area and we are pleased to accomplished much during his tenure as Program inform you that Todd Geisler, a first year resident, has Director and I have great respect for both he and his already submitted a grant to the AAEF on regenerative family. We currently are in the process of conducting endodontics. a nationwide search for a new Program Director All of this just means that tomorrow is coming ever and I am very gratified by the quality of the faculty faster. There is a continuing need for us to develop applicants. In addition, both Rachel Cox and Lily and adopt new technologies and new science into our Gutierrez have recently accepted promotions in other practices. As a member of the San Antonio family departments. Although it is always difficult to replace of endodontists, we hope that you share our pride in talented people, we are happy for their advancements contributing to that effort. and remain committed to the continued evolution of I hope to see you at our Alumni Reception on our outstanding residency program. Thursday night at the AAE meeting (6-8pm in Room Our undergraduate program has introduced a new Independence I of the Philadelphia Marriott). This hybrid instrumentation method into the undergrad is a great time to see old classmates, meet new alumni, clinic this year using ProFile and K3 rotary NiTi files. and to learn what’s new in your endodontic family. We have spent several years developing this method See you then, via the undergrad endo elective course and to date Ken
  2. 2. Notes from The P r o g r a m D i r e c t o rHello Alumni,Greetings from San Antonio! I hope you and your families all had a We have already scheduled next fall’s CE day for Saturday,great holiday season. We enjoyed a relatively mild winter here in south September 22, 2007 at the Marriott Northwest where Dr. SyngcukTexas with the exception of an amazing ice storm that actually closed Kim will be our featured speaker. Dr. Kim is the Louis I. Grossmanthe university for two full days in January. Please read on for more Professor and Chairman of the Department of Endodontics at theexciting activities associated with your residency program. University of Pennsylvania School of Dental Medicine. As most of you know, Dr. Kim is well known and respected for his research in dental pulp physiology and microcirculation. He also establishedFaculty and Staff Changes: the Microscope Training Center at Penn and developed a series ofS ince our last newsletter, much has happened here in the Department endodontic instruments for endodontic microsurgery, specifically the and I have some important updates to share with you. In December KiS ultrasonic tips as well as a complete set microsurgical instruments.Rachel Cox accepted a position in the Office of Academic Informatics Please mark your calendar now and make plans to join us for the Health Science Center and we certainly wish Rachel all the best Kim’s presentation in September. This is a wonderful opportunity toin her new position. During the search for her replacement, Lynn see old friends and obtain some outstanding continuing education atHigginbotham and Holly Tealer enthusiastically stepped up to the no charge.challenge and managed all of graduate program responsibilities fornearly two months. Thanks to Lynn and Holly for their outstandingefforts in support of the residency during that time. For the past six Welcome New Residents:weeks, Mrs. Donna Byrd has filled in admirably as our AcademicCoordinator for the Graduate Program, but unfortunately due topersonal circumstances, she is unable to continue in that position. At T his year we had more than 70 applicants for our 3 resident positions and I’m pleased to report that all 3 of our top choices accepted the invitation to join our program. The competition for resident slotsthis point, our search for a new Academic Coordinator is under way is very intense and we are indeed fortunate to have these exceptionaland we will keep you apprised of our progress. individuals entering our program.Another change in the department is the departure of our clinic office Welcome to:manager, Lily Gutierrez. We also wish Lily the best in her new position • Dr. Anibal Diogenes (Federal University of Pernambucoin Rehab Medicine in the Medical School. At this time, I’m pleased Dental School, Recife, Pernambuco, Brazil; University ofto report that we have welcomed Mrs. Erika Rodriguez as our new Nebraska at Kearney, MS in Molecular Biology; UTHSCSA,Dental Assistant Specialist/Office Manager in the Graduate Endodontic PhD in Pharmacology)Clinic. Erika comes to us with previous experience as an administrative • Dr. Jay Simonton (University of Colorado School of Dentistry;specialist, patient coordinator, dental manager, dental specialist and University of Colorado GPR program)dental assistant. She has eagerly accepted the many challenges of hernew position and the residents and staff really appreciate the outstanding • Dr. Ernesto Trevino (UTHSCSA Dental School; Audie Murphyjob she is doing in the Grad Clinic. VA AEGD program)One additional change will be occurring in the Department in July They will be joined this summer by two new Air Force residents to2007. At that time I will be transitioning from the position of program form an outstanding first year class:director here at UTHSCSA to the staff endodontist position at the • Lt Colonel Steven Klyn (University of Iowa College ofAudie Murphy VA Dental Clinic. This has been an extremely difficult Dentistry; Keesler AFB AEGD-2 program)decision for me to make because of the professional and personal • Captain Sterling Whipple (University of Colorado School ofsatisfaction I have received while working with the residents and staff Dentistry; Travis AFB AEGD program)in the Endodontic Department at the Health Science Center. I willcertainly miss the daily interaction with all of the wonderful, talentedresidents, faculty and staff members in the Department. I am pleased Progress Toward ABE Certification – Congrats!!!!! Ito report that I will retain an adjunct position at the University and look n the last newsletter we recognized the first group of residents toforward to continuing to work with the Endodontic Department and successfully challenge the written board examination prior tothe senior endodontic residents as they participate in the endodontic graduation. That group included Drs. Asma Khan, Bryce McCreary,rotation at the VA dental clinic. Lee Fulsaas, Shane Hanson, Kent Sabey and Michael Suhler. At this time it is my pleasure to report that Drs. Tracy Clark, Shawn Gilbert and Damaries Candelario-Soto recently passed the case history portionReport on Annual Alumni Continuing Education Day: of the board certification process. Congratulations and best of luck toO ur 8th Annual Alumni Continuing Education Day held at the end of September 2006 was quite a success. We had an excellentturnout which included many of our alumni, current residents and staff. Tracy, Shawn and Damaries as they prepare for and challenge the oral exam!In addition, we were joined by an exceptional group of interviewees We are especially pleased to see our senior residents and graduatesfor five hours of outstanding CE presented by Dr. Linda Levin from become involved in the board process and would love to help any ofthe University of North Carolina. Her talk entitled “Endodontic our alumni prepare for the board case portfolio and oral examinationMicrobiology: Debugging the Root Canal” was terrific and resulted in portions of the board certification quest. We would be happy tovery positive feedback from those in attendance. Continued on pg. 4
  3. 3. DEPARTMENT OF ENDODONTICS 2006 – 2007 Departmental Publications Ken Hargreaves, Chairman Lynn Higginbotham1) Berg KA, Zardeneta G, Hargreaves KM, 11) Patwardhan AM, Diogenes A, Berg KA, Postdoctoral Division Clarke WP, Milam SB. Fehrenbacher JC, Clarke WP, Akopian AN, Scott A. Schwartz, Director Integrins regulate opioid receptor signaling in trigeminal Hargreaves KM. John Andrews Ed Bernier John Calland ganglion neurons. PAR-2 agonists activate trigeminal nociceptors Carlos E. del Rio William G. Schindler Neuroscience. 2007 Feb 9;144(3):889-97. and induce functional competence in the delta Rick Schwartz William A. Walker Glenn R. Walters2) Henry MA, Hargreaves KM. opioid receptor. Peripheral mechanisms of odontogenic pain. Pain. 2006 Nov;125(102):114-24. Graduate Clinic Staff Dent Clin North Am. 2007 Jan; 51(1):19-44, v. 12) Bowles WR, Sabino M, Harding-Rose C, Erika Rodriguez Kim Villanueva3) Gibbs JL, Diogenes A, Hargreaves KM. Hargreaves KM. Neuropeptide Y modulates effects of bradykinin and Chronic nerve growth factor administration increases Pre-doctoral Division prostaglandin E2 on trigeminal nociceptors via the peripheral exocytotic activity of capsaicin-sensitive James Gilles, Director activation of the Y1 and Y2 receptors. cutaneous neurons. Holly R. Tealer Br J Pharmacol. 2007 Jan;150(1);72-9. Neurosci Lett. 2006 Aug 7;403(3):305-8. John D. Andrews Karl Keiser4) Goodis HE, Poon A, Hargreaves KM. 13) Gibbs JL, Flores CM, Hargreaves KM. Edwin J. Martin, Jr. Glenn R. Walters Tissue pH and temperature regulate pulpal nociceptors. Attenuation of capsaicin-evoked mechanical allodynia J Dent Res. 2006 Nov;85(11):1046-9. by peripheral neuropeptide Y Y1 receptors. Research Division Pain. 2006 Sep;124(1-2):167-74. Ken Hargreaves, Interim Director5) Jeske NA, Patwardhan AM, Gamper N, Price TJ, Akopian AN, Hargreaves KM. 14) Keiser K. Lola Barron Cannabinoid WIN 55, 212-2 regulates TRPV1 Magnification options in endodontics: A comparison of Michael Henry Asma Khan Erin Locke phosphorylation in sensory neurons. the operating microscope and the endoscope. J Biol Chem. 2006 Oct 27;281(43):32879-90. Tex Dent J. 2007 Feb;124(2):208-16. Neuropharmacology Lab6) Price TJ, Hargreaves KM, Cervero F. 15) Schwartz SA, Summitt JB. Armen Akopian Anibal Diogenes Jill Fehrenbacher Protein expression and mRNA cellular distribution of Guest editorial: Update on magnification and Gabriela Helesic Amol Patwardhan Griffin Perry the NKCC1 cotransporter in the dorsal root and illumination in dentistry. Niki Ruparel Xiaoling Sun Joe Vela trigeminal ganglia of the rat. Tex Dent J. 2007 Feb;124(2):170-1. Brain Res. 2006 Sep 27;1112(1):146-58. 16) Schwartz SA, Koch MA, Deas DE, Powell CA. Alumni Newsletter is published by the7) Henry MA, Freking AR, Johnson LR, Levinson SR. Combined endodontic-periodontic treatment of a palatal Department of Endodontics Increased sodium channel immunofluorescence at groove: a case report. Interim Managing Editor – Lynn Higginbotham *.* myelinated and demyelinated sites following an J Endod. 2006 Jun;32 (6):573-8. inflammatory and partial axotomy lesion of the rat infraorbital nerve. 17) Montellano AM, Schwartz SA, Beeson TJ. Contamination of tooth-colored mineral trioxide Attention Alumni Pain. 2006 Sep;124(1-2):222-33. aggregate used as a root-end filling material: 8) Diogenes A, Patwardhan AM, Jeske NA, Ruparel NB, a bacterial leakage study. J Endod. 2006 May;32(5):452-5. Goffin V, Akopian AN, Hargreaves KM. We extend a cordial invitation Prolactin modulates TRPV1 in female rat trigeminal 18) Vanderweele RA, Schwartz SA, Beeson TJ. sensory neurons. Effect of blood contamination on retention for you and your guest to attend J Neurosci. 2006 Aug 2;26(31):8126-36.9) Patwardhan AM, Jeske NA, Price TJ, Gamper N, characteristics of MTA when mixed with different liquids. Your J Endod. 2006 May;32(5):421-4. Akopian AN, Hargreaves KM. The cannabinoid WIN 55, 212-2 inhibits transient 19) Stuart CH, Schwartz SA, Beeson TJ. Alumni Association receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Reinforcement of immature roots with a new resin filling material. Reception Proc Natl Acad Sci U S A. 2006 Jul J Endod. 2006 Apr;32(4):350-3. 25;103(30):11393-8. Philadelphia, Pennsylvania 20) Schwartz RS.10) Price TJ, Flores CM, Cervero F, Hargreaves KM. Adhesive dentistry and endodontics. Part 2: bonding Thursday, April 26, 2007 The RNA binding and transport proteins staufen and in the root canal system-the promise and the problems: 6:00 - 8:00 pm fragile X mental retardation protein are expressed by a review. rat primary afferent neurons and localize to peripheral J Endod. 2006 Dec;32(12):1125-34. Philadelphia Marriott and central axons. Neuroscience. 2006 Sep 15;141(4):2107-16. Room - Independence I
  4. 4. ...NOTES FROm THE P R O g R A m D I R E C T O RContinued from pg. 2coordinate recall appointments to help you complete your board case Last but certainly not least, I would like to remind you to attend thewrite-ups; please let us know if we can assist you in the process. Edgar D. Coolidge Luncheon on Saturday, April 28th where our own Dr. Ken Hargreaves will receive the Louis I. Grossman Award. ThisI would also like to recognize and congratulate Dr. Bill Schindler as award “recognizes an author for cumulative publication of significanthe completes his sixth year as a Director of the American Board of research studies that have made an extraordinary contribution toEndodontics. Bill has done an outstanding job, not only as a member endodontics.” Congratulations Ken! I can think of no one moreof the Board, but also as secretary and president of the Board during deserving of this prestigious award.his tenure. We certainly owe him a great debt of gratitude for all he hasdone for our residents, the Board and our specialty. Thanks to Volunteer Faculty! Thanks also to our volunteers who generously give up their free time to share their endodontic knowledge and clinical expertise on a regularAAE Annual Session – Philadelphia basis in the Graduate Endodontic Clinic. Drs. Ed Bernier, John Calland,Reception! Presentations! Awards! Carlos del Rio, Rick Schwartz and Bill Walker add immeasurably to theF or those of you who will be attending the AAE Annual Session in Philadelphia, please plan to join us at our Annual Alumni Receptionon Thursday evening, April 26th. The reception will be held from 6:00 residents’ clinical experience as evidenced by the overwhelmingly positive resident course/faculty evaluations. Once again, thanks to everyone for your terrific support!to 8:00 p.m. in Independence I at the Philadelphia Marriott. We lookforward to seeing all of you there for an enjoyable evening. I hope to see you all at our reception at the Philadelphia Marriott on Thursday night.While you’re at the meeting, make a note to drop by and support Best regards,our talented and hard-working residents and postdoctoral fellows in Scott Schwartzpresenting their research findings in the following oral, poster and tableclinic presentations.Thursday, April 2611:45 a.m. Dr. Kenny Wiltbank – “The Effect of Selected Accelerants on the Physical Properties of AWARD WINNERS IN Mineral Trioxide Aggregate and Portland ENDODONTICS! Cement”3:45 p.m. Dr. Lisa Alvarado – “TRPA1 and TRPM8 Expressions in Normal and Cold-Sensitive Human Tooth Pulp”4:30 p.m. Dr. James Kitchens – “Trans-Dentinal Delivery of Calcitonin by Both Diffusion and Iontophoresis”Friday, April 278:00-11:00 a.m. Drs. Taylor Cotton and David Holden - Table Clinic describing applications of cone beam volumetric tomography in endodontics8:45 a.m. Dr. Brett Owatz – “Central Sensitization and the Development of Bilateral Mechanical Allodynia in Patients with Irreversible Pulpitis and Acute Periradicular Periodontitis”9:00 a.m. Dr. Anibal Diogenes – “Painful Infections: Drs. Lisa Alvarado, Kenny Wiltbank, Asma Khan Bacteria Regulate Nociceptors via TLR4 and CD14 Receptors” The American Association of Endodontists Foundation partnered10:15 a.m. Dr. Asma Khan – “Tumor Necrosis Factor-α with Dentsply International to recognize student excellence in Directly Modulates the Function of TRPV1 in research at the 2006 Annual Session of the American Association Rat Trigeminal Neurons” of Endodontists meeting in Honolulu, Hawaii.Saturday, April 28 Dr. Khan earned 5th place for her oral research presentation8:00-11:00 a.m. Dr. Caio Ferraz – “Potential Mechanisms for entitled: “The Effect of Calcium Hydroxide on Interleukin -1β.” Drs. Alvarado and Wiltbank earned 2nd place for their table clinic Exacerbated Pain Due to Infection: NGF presentation entitled: “Impact of Bisphosphonate-Associated Upregulates TLR4 and CD14 in Trigeminal Osteonecrosis on Endodontics.” Neurons” (Poster presentation)
  5. 5. Graduate endodontic case report Treated by Dr. Todd Geisler, 1st-Year Resident Use of Cone-Beam Volumetric Tomography in the Evaluation of a Maxillary RadiolucencyRadiographic examination is essential to diagnosis and treatment planning in endodontics. The interpretation ofan image can be confounded by the anatomy of both the teeth and surrounding structures. The ability to assessan area of interest in three dimensions may benefit both novice and experienced clinicians alike. High-resolutionlimited conebeam CT (CBCT) or Cone-beam volumetric tomography (CBVT) has been specially designed fordental applications.1 As opposed to sliced-image data of conventional CT imaging, CBVT captures a cylindricalvolume of data in one acquisition and thus offers distinct advantages over conventional CT including: increasedaccuracy, higher resolution, scan time reduction and radiation dose reduction.2 The ability to essentially eliminatesuperimposition of the surrounding structures makes CBVT superior to conventional periapical radiography.3 Theclinician is able to scroll through the entire volume and simultaneously view axial, frontal and sagittal (0.125-2.0mm-thick) two-dimensional sections (See Fig. 1). The axial and proximal (sagittal in the anterior; frontal in theposterior) views are of particular value, as they are generally not seen with conventional periapical radiography.In addition, processing software can create a three-dimensional image for further evaluation. CBVT may prove to Figure 1. Screen view of iDixel One Data a valuable diagnostic and treatment-planning tool in the modern endodontic practice. Note: axial, frontal and sagittal sections are viewed simultaneously. Case Report: A 29 year-old dentist was self-referred for consultation and treatment of tooth #8 with the chief complaint, “I had a filling done in November 2006 and there was a pulp exposure. They started the root canal and then the dentist noticed the internal resorption.” The patient sent a radiograph via email on 01/04/07 (See Fig. 2). Upon presentation to the UTHSCSA post-graduate endodontic clinic on 02/01/07, the patient reported no pain since the original pulpectomy had been completed in November 2006. Tooth #8 had been restored with Ketac-Silver™. The patient reported no history of trauma, orthodontic treatment or intracoronal bleaching. The patient’s medical history was non-contributory. Clinical findings: Pulp testing revealed that #8 was non-responsive to cold, non-tender to percussion and palpation. Probing depths were 2-3 mm and there was no evidence of sinus Figure 3. Intraoral photograph. Note: No evidence ofFigure 2. Historical radio- palatal swelling. tract or intraoral swelling (See Fig. 3). All adjacent teeth tested normal to pulp vitality tests.graph taken November 2006.The patient had been scheduled for a Cone-Beam Volumetric Tomographysurvey prior to presenting on 02/01/07. Figure 4 shows off-angleradiographs taken immediately prior to the scheduled CBVT.Radiographic findings: Interpretation of the radiographs revealed thepresence of a lingual radiolucency. The canal is clearly visible through theradiographic defect and the radiolucency appears to shift almost entirelyoff the root structure. The appearance is suggestive of either an externalresorptive defect or, more likely, pathosis within the palatal bone.Figures 5 & 6 show selected 2-D slices and a 3-D reconstruction of thecompleted CBVT survey. Figure 4. Conventional periapical radiographs. Multiple horizontal angles help to identify the position of the radiographic defect. CBVT findings: A large incisive foramen and canal were observed in intimate contact with lingual aspect of #8 root. The bony lesion measured approximately 5 mm in diameter and 6 mm in height. Differential diagnosis included but was not limited to: 1. Enlarged incisive foramen 2. Nasopalatine duct cyst. The patient was referred to OMS for evaluation and possible enucleation. Patient was evaluated on 03/26/07. OMS recommended that the radiolucency be monitored with the acquisition of a follow-up CBVT in 1 year.Figure 5. (from L to R) Sagittal view - Radiolucency is in intimate contact with the lingualportion of the root and is associated with the incisive canal/foramen. Axial view - Radiolucency Diagnosis #8: Previous partial treatment with normalis asymmetric. This may account for the lack of the classic “heart-shaped” lesion of a periapex. No internal or external resorption. Root canalnasopalatine duct cyst as seen with conventional periapical radiography. Frontal view - This is treatment and build-up were completed on 02/16/07a section taken just lingual to tooth #8. Essentially, one can eliminate the superimposition of thesurrounding structures to view the radiolucency without the confounding images of the teeth. (See Fig. 7).Note: The CBVT sections demonstrate a lack of either internal or external resorption. 1. Grondahl H-G, Huumonen S. Radiographic manifestations of periapical inflammatory lesions. How new radiological techniques may improve endodontic diagnosis and treatment planning. Endod Topics 2004;8:55-67. 2. Yajima A, Otonari-Yamamoto M, Sano T,etal. Conebeam CT (CB Throne®) applied to dentomaxillofacial region. Bull Tokyo Dent Coll 2006;47:133-41. 3. Lofthag-Hansen S, Huumonen S, Grondahl K, Grondahl HG. Limited cone-beam CT and intraoral radiography forFigure 6. 3-D reconstruction of the patient’s CBVT survey using Accurex processing software the diagnosis of periapical pathology. Oral Surg Oral Med(CyberMed International, Seoul, Korea). The volume can also be formatted into a movie (.avi), Oral Pathol Oral Radiol Endod 2007;103:114-9. Figure 7. Post-op radiograph.thereby allowing the clinician to rotate the image.
  6. 6. 2006 ANNUAL ALUmNI CE DAY San Antonio, TexasFrom left to right: Drs. Ken Hargreaves, Bill Schindler, Drs. James Kitchens, Scott Schwartz, Taylor CottonLinda Levin (guest speaker), Scott Schwartz.Drs. Mike Henry, Anibal Diogenes, Caio Ferraz Drs. Bryce McCreary and Asma KhanFrom left to right: Drs. Jim Gilles, Jack Martin, Air Force Residents (from left to right):Bill Walker, Bill Schindler, John Andrews Drs. Kim Wilkinson, Jarom Ray, Brian Min, Thad Chamberlain, Dennis Holt, Dusty Watts
  7. 7. RESEARCH DIVISION UPDATET he Department’s research program is continuing to grow. Asma Khan, Brett Owatz and Bryce McCrearyhave completed the initial studies on a new electronic force spring. The post-doc fellows are also doing fantastic. Asma Khan, BDS, PhD completed her endo residency last Decembertransducer that measures patient levels of mechanical pain and started as an Assistant Professor for research in the(imagine a digital tooth slooth). Their clinical research Department in January this year. She has been involved inresulted in three papers that will be published in the May, developing the “digital tooth slooth” described above andJune and July issues of the JOE. Congratulations for their her basic research has focused on the role of cytokines ingreat work! If it is possible for you to attend, I am sure regulating pain. Nathan Jeske, PhD completed his post-that you will enjoy hearing Lisa Alvarado, Anibal Diogenes, doc and started as an Assistant Professor in the Dept of OralAsma Khan, James Kitchens, Brett Owatz, and Kenny and Maxillofacial Surgery last fall. Jill Fehrenbacher, PhDWiltbank presenting their research at the AAE. In addition, is continuing her post-doc in studying the role of estrogenDr. Caio Ferraz, a Professor from the School of Dentistry of in regulating pain neurons and how this mechanism mightPiracicaba, University of Campinas, Piracicaba, Brazil, is explain sex differences in pain patients.completing his sabbatical year of research in our Department Erin Locke, RN and Xiaoling Sun, DDS, PhD continueand will be presenting his findings at the AAE. their masterful work on our clinical trials on endodontic pain Michael Henry is continuing his research on sodium patients. These clinical projects are where the rubber hitschannels and TRP channels in patients with irreversible the road: we plan on taking the best ideas from the lab andpulpitis. Michael is a superb dentist and neuroanatomist testing their utility as analgesics in our endo pain patients,who has mentored Lisa Alvarado, in her project on TRP and in dental pain neurons taken from patient volunteers. Itchannel expression in the dental pulp from teeth with is important to realize that none of our research comes fromirreversible pulpitis (see figure at right). As I mentioned our state budget. All of it is supported by federal (NIH)last year, Michael’s research is truly ground breaking and grants. Our residents will be presenting their work at therepresents a unique blend of art and science. Of course, AAE meeting and at our department’s research day, held onhaving a state-of-the-art confocal microscope, available the day of graduation, June the price of only a couple of Lamborghinis, provides - Kenhim with a tool that is unique among endo programs inthe country. Combined with Michael’s exceptional skillsas a neuroanatomist, we anticipate increased contributionsto our knowledge of pain mechanisms and new potentialapproaches to pain control. Our PhD students are doing great. Anibal Diogenessuccessfully defended his PhD last December and hispaper reporting the discovery of a novel “pain producing”neuropeptide that might contribute to gender differences inpain disorders has received strong accolades. Anibal willbe starting his endodontic residency here in July. Joe Velais in year 5 of his DDS, PhD program and is happy to bein his junior clinical year. His research is focusing on howadrenergic drugs (aka “vasoconstrictors”) alter pain neurons.Niki Ruparel is studying how marijuana-like compounds TRPA1, N52 and PGP9.5alter the pain response; a topic that not surprisingly always A confocal micrograph of TRPA1 (red), N52 (green) anddraws a large crowd. Niki is an advanced standing PhD PGP9.5 (blue) staining within nerve fibers from a painfulstudent who will be starting her dental school training human tooth pulp sample. The N52 and PGP9.5 staining identify nerve fibers. The TRPA1 staining is colocalizedin July for a combined DDS, PhD program. We are also within some of the nerve fibers and is also highly expressedhappy to have Phoebe Duckworth and Margaux Salas, two in inflammatory cells.first year PhD students, join us in their lab rotations this
  8. 8. Keep in touch with our department by e-mailArmen Akopian – Michael Henry - Griffin Perry – perryg@uthscsa.eduLisa T. Alvarado – Lynn Higginbotham – William Schindler – schindler@uthscsa.eduJohn D. Andrews – David Holden – Scott A. Schwartz – schwartzs@uthscsa.eduLola Barron – Karl Keiser – Xiaoling Sun – sunx@uthscsa.eduTaylor Cotton – Asma Khan – Holly R. Tealer – tealer@uthscsa.eduJill Fehrenbacher - James Kitchens – William A. Walker, III – walkerw@uthscsa.eduTodd Geisler – Erin Locke – Glenn R. Walters – walters@uthscsa.eduJames A. Gilles – Edwin J. Martin, Jr. – Kenneth Wiltbank – Wiltbank@uthscsa.eduKen Hargreaves – Brett Owatz – owatz@uthscsa.eduGabriela Helesic – Amol Patwardhan – Attention Alumni! If you have news about yourself that you would like mentioned in our newsletter, drop me a message at Your newsletter can only be successful with your support. Thanks! We receive Newsletters returned due to changes of address. Please inform us of your move so we can continue to keep in touch and send you the Newsletter. E-mail us at if you have relocated.The University of TexasHealth Science Center at San AntonioDepartment of Endodontics7703 Floyd Curl Drive • Mail Code 7892San Antonio, TX 78229-3900(210) 567-3381 Visit our Web Site at
  9. 9. Carlos E. del Rio Endowment in EndodonticsThanks to your generous pledges and contributions, The Carlos E. del Rio Endowment in Endodontics continues to grow. Total pledgesto date now exceed $312,000.With heartfelt thanks we recognize the selfless generosity of all contributors (alumni, faculty and friends). It is truly a statement incelebrating Dr. del Rio’s life-long dedication to excellence in endodontic education and to your commitment to fuel the continued growthof San Antonio Endodontics.★Denotes completion of 1st 5-year pledge as of 2/1/07.Stainless Level Silver Level ★ William Roth Platinum LevelNeil G. Begley ★ Robert Haller ★ E. Steve Senia Tracy ClarkDouglas Bethoney William J. Stewart ★ Jeremy J. SmithParvin Dinyarian Scott Sullins ★ Peter SpradlingJames Gilles Michael SuhlerKarl Keiser ★ Adali E. VelezMichael A. Koch Gold LevelAlberto Lopez-Torres ★ Lee Fox NiTi LevelGarry Myers ★ Shawn Gilbert ★ Ken HargreavesJohn Nelson ★ Robin Hinrichs ★ Heidi KanningScott Schwartz Joslyn Jenkins ★ Roy KaldestadWilliam Schindler ★ Daniel Keir ★ Richard SchwartzDouglas Thomas Kenneth Pearson ★ William A. WalkerRoderick Yasuda ★ Ivan Rodriguez J. Kevin Selden Your support is a key factor in our success in developing and maintaining the top-notch program we currently have in San Antonio. Please consider giving something back to the program that helped provide you with the wonderful practice and lifestyle you currently enjoy. Complete and return the form below with your donation, new pledge or a renewal of your 5-year pledge. Thanks in advance for your continued support! Enclosed is a tax-deductible gift of $ _________________________ made payable to UTHSCSA (please indicate “Dr. del Rio Endowment” on the memo line of the check.)I would like to make a gift by credit card Platinum Levelr VISA r Master Card r American Express r Discover A five-year pledge for $25,000 or more. A quarterly gift of $1,250 for 5 years. $________Cardholder Name:_______________________________________Card Account #:_________________________________________ NiTi LevelExpiration Date:________________________________________ A five-year pledge for $10,000 - $24,999. A quarterly gift of $500 for 5 years. $________Cardholder Signature:____________________________________ Gold LevelName:________________________________________________ A five-year pledge for $5,000 - $9,999.Home Address:_________________________________________ A quarterly gift of $250 for 5 years. $________City/State/Zip:__________________________________________ Silver LevelOffice Phone:___________________________________________ A five-year pledge for $2,500 - $4,999. A quarterly gift of $125 for 5 years. $________To ensure proper credit of your tax-deductible contribution, pleasecomplete this form and return it to: Stainless Steel LevelUTHSCSA External Affairs, 7703 Floyd Curl Drive, A one-time gift up to $5,000 $________MSC 7835, San Antonio, TX 78229-3900. Questions about the endowment? Questions about how to contribute? Please call (210) 567-3394 Please call (210) 567-2056