ALB RTD Innovation Process ALBELISSA RTD ALBELISSA Engineering
Categories of Innovation An Innovation that cannot be used by customers inDisruptive mainstream markets – introduces new dimensions of performancesApplication Takes existing technologies into new markets to serve new purposes Improves established offering in markets,… performances,Product cost, usability, etc.Process Optimise industrial processes for existing offerings in established markets more efficient or effectiveExperiential Modifications that improve the customers’ overall experience with established offeringMarketing Improvements to customer-touching processes, such as communications or transactionsBusiness Changes the way you make money and the correspondingModel value proposition to customers Structural Capitalizes on changes that restructure an industry
RTD integration and support» Act as RTD outsource partner: extension/integration of Customers’ R&D facilities and infrastructure» Flexible staffing of RTD groups or selected and targeted applied research specialists to be allocated on identified development tasks/programmes» RTD Fund rasing: • Participation to EU projects • Proposals preparation • Submission • Consortium set up
NanomedicineNanomedicine is the application ofnanotechnology to achieve breakthroughsin healthcare.• It exploits the improved and often novel physical, chemical and biological properties of materials at the nanometer scale.• Nanomedicine has the potential to enable early detection and prevention, and to essentially improve diagnosis, treatment and follow-up of diseases.
Nanomedical mkt figuresThe global nanomedicine market reached: $63.8 billion in 2010 and $72.8 billion in 2011.The market is expected to grow to $130.9 billion by 2016at a compound annual growth rate (CAGR) of 12.5% between years 2011 and 2016.Press Release published in January 2012 by Global Information Inc. (GII) toannounce the new market research report "Nanotechnology in MedicalApplications: The Global Market" by BCC Research.
Point of Care Treatment(POCT) market • Blood Glucose • Blood gas/Electrolytes • Hematology • Pregnancy/Fertility • Tumor markers • Cardiology • Coagulation • Infectious diseases • Drugs of Abuse • Clinical • Chemistry/Urinalysis
Nanotech for Osteogenesisand osteointegrationSome figures displaying market potential: The clinical burden with fractures alone costs 17€ billion to EU, $20billion to US annually. 8 million bone fractures in US nd 5-10% delayed healing/re-union Osteoporosis 75million people in EU, US, JP; increase of hip fracture of 310% (men) and 240% (women) by 2050
NANOCOMPOSITES FORFAST GROWING MARKETS:SOLUTIONS FOR BIO MED
Laser / inkjet -patterning (A) Laser-Guided Direct Write (LGDW) laser focused into a suspension of particles particles trapped by the light are pulled through the fluid and deposited on a target surface; (B) MAPLE DW a laser pulse focusing on the absorbing layer evaporates the matrix containing biological material on the lower side of the substrate due to localized heating and thus pushes the material towards the substrate; (C) Inkjet technology ejects material piezoelectric, thermally actuated or printed cell patterns with electrostatically actuated after 2 different cell types receiving a signal
Nanostructured fibres SEM (secondary electrons): adherent cells murine fibroblasts gold on carbon based nanostructured fibres [CRYSTAL project onCryo-banking of stem cells for human therapeutic application] 120 m
NanoparticlesMagnetofection technology(Magnetic target delivery) tocarry by magnetovectors invivo and in vitro tovehiculate compounds ableto modulate ENaC expressionby RNA interference to cureCystic fibrosis novel magnetic nanoparticles formulations based on Magnetofection, industrial products: SilenceMag, ViroMag and ViroMag R/L, by OZ Biosciences
NPs for magnetofectionTransfection via magnetic carriers (viromag) in rattstomach tissues
Magnetic nanovectorsMagnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects, Christian Planka, Olivier Zelphatib, Olga Mykhaylyka,Advanced Drug Delivery Reviews Volume 63, Issues 14–15, November 2011,Pages 1300–1331, Hybrid nanostructures for diagnostics and therapeutics
Theragnostics through nano-biomarkers/carriersNew diagnostic based on nanotechnologyto quantify disease-related biomarkersearlier and more personalised riskassessment before symptoms show upNanotechnology improve in vitrodiagnostic tests by providing moresensitive detection technologies bybinding nano-labels to disease-specificmolecules (surface functionalisation)SiNWsand CNTs are capable of detectingmolecules at ultra low concentrations
Theragnostics and imaging• Therapy- targeted delivery, nanovectors• Nano-assisted regenerative medicine treatments of osteoarthritis could include disease modifying therapies• In vitro, in vivo imaging: nanoparticle coating, to improve its efficiency of targeting and biocompatibility.
Dendrimers for theragnosticsDenrimers asnanocaleplatforms…other agentsare based onliposomes,emulsions, orothermacromolecularconstructs.
Bio SensorsScreen-printed Electrochemical Sensors and Biosensors for Monitoring Metal PollutantsSPCEs modified with carbon nanoparticles -> amperometric based sensor capable of determining Hg2+ levels as low as 1 ng/mL Arduini F., Majorani C., Amine A., Moscone D., Palleschi G., Hg2+ detection by measuring thiol groups with a highly sensitive screen-printed electrode modified with a nanostructured carbon black film. Electrochim. Acta, 2011, 56, 4209–4215.
CNT integration in ICs forbio-sensing applications • Deposition platform on waferscale based on dielectrophoresis (DEP) • CNT-metal contact engineering • Fabrication of CNT-FET structures for characterization and tuning • Integration in process lines
Electrostatically actuatedNEMS Switch (CNT, SiNW)Three-state NEMS switches. (a) Device array design. (b-d) Top-view of a few devices.The labeling of terminals T2 and T3 is shown in panel b. Panel c illustrates the labeling of terminal T1, which represents the two device contacts held at an identical potential.
Nanosensor DeviceCharacterisation NW based devices show: • high sensitivity •Calibration •Stability •repetition
Nanotech for Osteogenesisand osteointegration nanotopography and biomaterials for skeletal stem cells based bone repair Osteoblasts enhanced adhesion to nanoscale (1-100nm) alumina, titania, hydroxy hapatite, Titanium Alloy (Ti6AL4V) w.r.t micro-scaled patterning of ceramic materials Electron beam litography for nanotopographic surface patterns
Nano patterning Square arrangements of nanopits maintain the stem cells state for multiple passages (SEM) In vitro differentiation of skeletal stem cells
Synthetic eye prosthesis:Nanomodified surfacesSynthetic eye prosthesis (cornea implant):Layer-by-layer technique (nanoscaled ionic polymers)For modification of haptic and edge
Abrasion resistance Riblet-structure based on embossed UV-curable nanocomposite containing nanosilica (resistant to abrasion) imitating shark skin surface (Fraunhofer IFAM Bremen)
HRSEM of ZnO coatedfabric Fibers after sonication are homogeneously coated with nanoparticles. The distribution of the particles is quite narrow primary particles are in a very low nanometric range (~ 30 nm)
Industrial scale unit Industrial prototype sketch
Mechanism of nano-coating» The after-effects of the cavitation are several hundred times greater in heterogeneous systems than in homogeneous systems.» In the SONO process, the ultrasonic waves promote the fast migration of the newly-formed NPs to the fabrics surface» Mechanical interaction may cause a local melting of the fibers at the contact sites, which may be the reason why the particles strongly adhere to the fabrics.
RTD Domains & solutionsMaterial and material surface functionalisation;nanotechnologies: » Hard Coatings » Polymers functionalisation » Flat surfaces- continuous process » 3D shaped surfaces- batch process » Vacuum treatment » Atmospheric pressure treatment » Plasma / sol-gel / thermal treatment
Typical solutions » Enhancing wear and scratch resistance » Balistic properties » Provide chemical inertness » Adhesion control (hydro-/oil- phylic repellence) » Surface self cleaning/anti-fingerprint » Appearance (color) » Electrical and thermal properties (insulating/conducting layers) » Biocompatibility » Encapsulation of substrate
Nanostructured Coatings Show structural changes in the range of 10 nm Nanolayer-Struktur50 nm 100 nm Nanogradient Nanolayer Nanocomposite Interface structure on the grain boundary
Tensile and mechanical properties -advantage-6: Multilayer Depositon Multilayer Im proves Coating Toughness Source: A. Matthews, University of Hull, UK Scale: 500 nm
Micro-scale functional coatings Top Top coating, coating different stoichiometry, thickness =Coating 0,5 Tstructure Multilayer step A Total coating Multilayer thickness = T step B Gradient layer Multilayer, n.5 Adhesion layer alternate A+B layers, fixed stoichiometry, thickness = Metal substrate 0,5 T
Integral Eco-design perspectiveSistemic approachTarget to: » Functional performance » Cost effectiveness » Environmental sustainability » Human SafetyThrough: » RTD on materials, products and processes » Life Cycle Costing » Life cycle assessment ISO 14040, nano-toxicology
Environ. sustainabilty LCA Final product: functionalised surfaceInputs (energy, raw Processmaterials) (Traditional or innovative) Outputs (air emissions, water emissions, solids,…) LCA CODE (Computation) Total Total rawGER GWP Acid POPC EU emissions materials
LCA according to ISO 14040 Global Warming Potential (GWP) ISO 14041 LIFE CYCLE FRAMEWORK Acidification Goal I Potential (AP) N definition T E R P Life Cycle R Eutrophication Inventory E T Potential (EP) A T I Impact O Assessment N Photochemical Ozone Creation Potential (POCP) ISO 14042 ISO 14043
Nanotoxicity assessment• Preparation protocols • 1) for well defined test systems • 2) For hazard assessment, i.e. in test media idealised vs. realistic conditinos• Establisch, validate and harmonize stanards operation protocols
EU prjs & initiativesNANOGenotox Prj on safety evaluation ofmanufactured NMs by characterisation of potentialgenotoxic hazardCharacterisation of NMs (CNTs, TiO2, SiO2):- Characterisation- Genotoxixcity- ToxicokineticsTesting of JRC repository using also NAPHIRA NMs DB & OECD hamonised templates, Synergies with ISO TC229. In vivo and in vitro testing.
Nanodevice Prj.Novel concept, methoods and technologies for theproductioon of Portable Easy-to-use devices formeasurementand Analysis of Airborne EngineeredNanoparticles in Workspace Air
Research: effects of MWCNTon Immune sys and lungs
Conclusions• Nanomaterials and NP based composites paved the way to new components and system enhanced functionalities in conventional and cutting edge industrial sectors due bulk and surface properties• Development of innovative solutions based on nanomaterials display a huge potential especially in fast growing marktets such as biomedical for medical assays, diagnosis, therapy• Manufacture, commercialisation and use of NM- based devices and products addresses important issues of sustainability and safety: specific environmental and toxicity assessment has to be carreid out on a case to case basis through LCA and nanotoxicity assessment to support applicability.
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