RTDResearch & Technology DevelopmentNanocomposites: present andfuture challenges forsustainable and safe industrialsolutio...
Summary»   Albelissa Approach to RTD»   Nanocomposites for sustainable    solutions    »   Nanotech trends & market    »  ...
Components of Innovation
ALBELISSA APPROACH TORTD
Stage-Gate Innovation Process
ALB RTD Innovation Process ALBELISSA RTD                 ALBELISSA                 Engineering
Categories of Innovation               An Innovation that cannot be used by customers inDisruptive     mainstream markets ...
RTD Services »   Let latent needs emerge (needs analysis) »   Provide technological bundling (tech HUB) »   Tech selection...
RTD integration and support»   Act as RTD outsource partner:    extension/integration of Customers’ R&D facilities    and ...
A FAST GROWING MARKET:NANOMEDICINE
NanomedicineNanomedicine is the application ofnanotechnology to achieve breakthroughsin healthcare.• It exploits the impro...
Nanomedical market
Nanomedical mkt figuresThe global nanomedicine market reached:  $63.8 billion in 2010   and $72.8 billion in 2011.The mark...
Point of Care Treatment(POCT) market               • Blood Glucose               •   Blood gas/Electrolytes               ...
Nanotech for Osteogenesisand osteointegrationSome figures displaying market potential: The clinical burden with fractures...
NANOCOMPOSITES FORFAST GROWING MARKETS:SOLUTIONS FOR BIO MED
Laser / inkjet             -patterning                                      (A) Laser-Guided Direct                      ...
Nanostructured fibres                    SEM (secondary                    electrons):                    adherent cells  ...
NanoparticlesMagnetofection technology(Magnetic target delivery) tocarry by magnetovectors invivo and in vitro tovehiculat...
NPs for magnetofectionTransfection via magnetic carriers (viromag) in rattstomach tissues
Magnetic nanovectorsMagnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects, Chris...
Theragnostics through nano-biomarkers/carriersNew diagnostic based on nanotechnologyto quantify disease-related biomarkers...
Theragnostics and imaging• Therapy- targeted delivery, nanovectors• Nano-assisted regenerative medicine  treatments of ost...
Dendrimers for theragnosticsDenrimers asnanocaleplatforms…other agentsare based onliposomes,emulsions, orothermacromolecul...
Bio SensorsScreen-printed Electrochemical Sensors and  Biosensors for Monitoring Metal PollutantsSPCEs modified with carbo...
CNT integration in ICs forbio-sensing applications               • Deposition platform on                 waferscale based...
Electrostatically actuatedNEMS Switch (CNT, SiNW)Three-state NEMS   switches. (a) Device   array design. (b-d)   Top-view ...
Nanosensor DeviceCharacterisation                    NW based                    devices show:                    • high s...
Electrochemical-basedNanobiosensors                           •   Blood Glucose                           •    Blood      ...
Nanotech for Osteogenesisand osteointegration nanotopography and biomaterials for  skeletal stem cells based bone repair...
Nano patterning  Square arrangements of nanopits maintain the  stem cells state for multiple passages (SEM)   In vitro dif...
Synthetic eye prosthesis:Nanomodified surfacesSynthetic eye prosthesis  (cornea implant):Layer-by-layer technique  (nanosc...
Abrasion resistance               Riblet-structure based               on embossed UV-curable               nanocomposite ...
HRSEM of ZnO coatedfabric   Fibers after sonication are homogeneously coated with   nanoparticles. The distribution of the...
Industrial scale unit Industrial prototype sketch
Mechanism of nano-coating»   The after-effects of the cavitation are several    hundred times greater in heterogeneous sys...
Nanoparticles:structure at micro-nano scale
Sono Antibacterial efficiency             Journal of Microbiology,        Biotechnology and Food Sciences        Singh et ...
NANOCOMPOSITE ANDNANOSTRUCURED SURFACESFOR INDUSTRIALAPPLICATIONS
RTD Domains & solutionsMaterial and material surface functionalisation;nanotechnologies:   »   Hard Coatings   »   Polymer...
Typical solutions  »   Enhancing wear and scratch resistance  »   Balistic properties  »   Provide chemical inertness  »  ...
Nanostructured Coatings                Show structural changes in the range of 10 nm                         Nanolayer-Str...
Tensile and mechanical properties                   -advantage-6: Multilayer Depositon                         Multilayer...
Micro-scale functional coatings                                         Top                     Top coating,        coatin...
Functional & decorative coatings •Machining, forming cutting •Components friction control •Superhard surfaces •Biocompatib...
Athomic layer depositionINRIM
Anti-dots
Surface energy & adhesion control inindustrial processes                       •Hydro- oleo-repellence                    ...
Modularity for industrial needs: batchand continuous processing solutions Univ. Studdgardt, Mugge Electronics             ...
FROM:FUNCTIONALITYTO:NANO-SUSTAINABILITYAND NANO-SAFETY
Integral Eco-design perspectiveSistemic approachTarget to:   »   Functional performance   »   Cost effectiveness   »   Env...
Environ. sustainabilty LCA                                                Final product: functionalised                   ...
LCA according to ISO 14040   Global Warming    Potential (GWP)    ISO 14041                              LIFE CYCLE FRAMEW...
CML 2 with toxicity assessment
Nanotoxicity assessment• Preparation protocols  • 1) for well defined test systems  • 2) For hazard assessment, i.e. in te...
Nanotoxicity - Genotoxicity• NMs / NPs features affecting  • Size, agglomeration, aggregation  •   shape and geometry (par...
EU prjs & initiativesNANOGenotox Prj on safety evaluation ofmanufactured NMs by characterisation of potentialgenotoxic haz...
Nanodevice Prj.Novel concept, methoods and technologies for theproductioon of Portable Easy-to-use devices formeasurementa...
Research: effects of MWCNTon Immune sys and lungs
Dispersed CNTs absorption inliving tissiues
Retention kinetics
Determinants of CNT toxicity What are the causes of the assessed CNTs toxicity:                  • Presence of metallic co...
EU Initiatives on nano-safety
Conclusions• Nanomaterials and NP based composites paved the  way to new components and system enhanced  functionalities i...
...any question?           massimo.perucca@albelissa.com                   www.albelissa.com                   Quality at ...
Albelissa nanoforum2012 perucca_2
Albelissa nanoforum2012 perucca_2
Albelissa nanoforum2012 perucca_2
Albelissa nanoforum2012 perucca_2
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Albelissa nanoforum2012 perucca_2

  1. 1. RTDResearch & Technology DevelopmentNanocomposites: present andfuture challenges forsustainable and safe industrialsolutions. Nanoforum 2012 Rome, 26 th September 2012
  2. 2. Summary» Albelissa Approach to RTD» Nanocomposites for sustainable solutions » Nanotech trends & market » Functionalities & solutions » Envi & human impact» Conclusions and question time
  3. 3. Components of Innovation
  4. 4. ALBELISSA APPROACH TORTD
  5. 5. Stage-Gate Innovation Process
  6. 6. ALB RTD Innovation Process ALBELISSA RTD ALBELISSA Engineering
  7. 7. Categories of Innovation An Innovation that cannot be used by customers inDisruptive mainstream markets – introduces new dimensions of performancesApplication Takes existing technologies into new markets to serve new purposes Improves established offering in markets,… performances,Product cost, usability, etc.Process Optimise industrial processes for existing offerings in established markets more efficient or effectiveExperiential Modifications that improve the customers’ overall experience with established offeringMarketing Improvements to customer-touching processes, such as communications or transactionsBusiness Changes the way you make money and the correspondingModel value proposition to customers Structural Capitalizes on changes that restructure an industry
  8. 8. RTD Services » Let latent needs emerge (needs analysis) » Provide technological bundling (tech HUB) » Tech selection & tech transfer » Wing to wing R&D solutions » Technology procurement » Technological scouting » Talent scouting » R&D outsource » Patent review & IPR industrial exploitation
  9. 9. RTD integration and support» Act as RTD outsource partner: extension/integration of Customers’ R&D facilities and infrastructure» Flexible staffing of RTD groups or selected and targeted applied research specialists to be allocated on identified development tasks/programmes» RTD Fund rasing: • Participation to EU projects • Proposals preparation • Submission • Consortium set up
  10. 10. A FAST GROWING MARKET:NANOMEDICINE
  11. 11. NanomedicineNanomedicine is the application ofnanotechnology to achieve breakthroughsin healthcare.• It exploits the improved and often novel physical, chemical and biological properties of materials at the nanometer scale.• Nanomedicine has the potential to enable early detection and prevention, and to essentially improve diagnosis, treatment and follow-up of diseases.
  12. 12. Nanomedical market
  13. 13. Nanomedical mkt figuresThe global nanomedicine market reached: $63.8 billion in 2010 and $72.8 billion in 2011.The market is expected to grow to $130.9 billion by 2016at a compound annual growth rate (CAGR) of 12.5% between years 2011 and 2016.Press Release published in January 2012 by Global Information Inc. (GII) toannounce the new market research report "Nanotechnology in MedicalApplications: The Global Market" by BCC Research.
  14. 14. Point of Care Treatment(POCT) market • Blood Glucose • Blood gas/Electrolytes • Hematology • Pregnancy/Fertility • Tumor markers • Cardiology • Coagulation • Infectious diseases • Drugs of Abuse • Clinical • Chemistry/Urinalysis
  15. 15. Nanotech for Osteogenesisand osteointegrationSome figures displaying market potential: The clinical burden with fractures alone costs 17€ billion to EU, $20billion to US annually. 8 million bone fractures in US nd 5-10% delayed healing/re-union Osteoporosis 75million people in EU, US, JP; increase of hip fracture of 310% (men) and 240% (women) by 2050
  16. 16. NANOCOMPOSITES FORFAST GROWING MARKETS:SOLUTIONS FOR BIO MED
  17. 17. Laser / inkjet -patterning (A) Laser-Guided Direct Write (LGDW) laser focused into a suspension of particles particles trapped by the light are pulled through the fluid and deposited on a target surface; (B) MAPLE DW a laser pulse focusing on the absorbing layer evaporates the matrix containing biological material on the lower side of the substrate due to localized heating and thus pushes the material towards the substrate; (C) Inkjet technology ejects material piezoelectric, thermally actuated or printed cell patterns with electrostatically actuated after 2 different cell types receiving a signal
  18. 18. Nanostructured fibres SEM (secondary electrons): adherent cells murine fibroblasts gold on carbon based nanostructured fibres [CRYSTAL project onCryo-banking of stem cells for human therapeutic application] 120 m
  19. 19. NanoparticlesMagnetofection technology(Magnetic target delivery) tocarry by magnetovectors invivo and in vitro tovehiculate compounds ableto modulate ENaC expressionby RNA interference to cureCystic fibrosis novel magnetic nanoparticles formulations based on Magnetofection, industrial products: SilenceMag, ViroMag and ViroMag R/L, by OZ Biosciences
  20. 20. NPs for magnetofectionTransfection via magnetic carriers (viromag) in rattstomach tissues
  21. 21. Magnetic nanovectorsMagnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects, Christian Planka, Olivier Zelphatib, Olga Mykhaylyka,Advanced Drug Delivery Reviews Volume 63, Issues 14–15, November 2011,Pages 1300–1331, Hybrid nanostructures for diagnostics and therapeutics
  22. 22. Theragnostics through nano-biomarkers/carriersNew diagnostic based on nanotechnologyto quantify disease-related biomarkersearlier and more personalised riskassessment before symptoms show upNanotechnology improve in vitrodiagnostic tests by providing moresensitive detection technologies bybinding nano-labels to disease-specificmolecules (surface functionalisation)SiNWsand CNTs are capable of detectingmolecules at ultra low concentrations
  23. 23. Theragnostics and imaging• Therapy- targeted delivery, nanovectors• Nano-assisted regenerative medicine treatments of osteoarthritis could include disease modifying therapies• In vitro, in vivo imaging: nanoparticle coating, to improve its efficiency of targeting and biocompatibility.
  24. 24. Dendrimers for theragnosticsDenrimers asnanocaleplatforms…other agentsare based onliposomes,emulsions, orothermacromolecularconstructs.
  25. 25. Bio SensorsScreen-printed Electrochemical Sensors and Biosensors for Monitoring Metal PollutantsSPCEs modified with carbon nanoparticles -> amperometric based sensor capable of determining Hg2+ levels as low as 1 ng/mL [1]Arduini F., Majorani C., Amine A., Moscone D., Palleschi G., Hg2+ detection by measuring thiol groups with a highly sensitive screen-printed electrode modified with a nanostructured carbon black film. Electrochim. Acta, 2011, 56, 4209–4215.
  26. 26. CNT integration in ICs forbio-sensing applications • Deposition platform on waferscale based on dielectrophoresis (DEP) • CNT-metal contact engineering • Fabrication of CNT-FET structures for characterization and tuning • Integration in process lines
  27. 27. Electrostatically actuatedNEMS Switch (CNT, SiNW)Three-state NEMS switches. (a) Device array design. (b-d) Top-view of a few devices.The labeling of terminals T2 and T3 is shown in panel b. Panel c illustrates the labeling of terminal T1, which represents the two device contacts held at an identical potential.
  28. 28. Nanosensor DeviceCharacterisation NW based devices show: • high sensitivity •Calibration •Stability •repetition
  29. 29. Electrochemical-basedNanobiosensors • Blood Glucose • Blood gas/Electrolytes • Hematology • Pregnancy/Fertility • Tumor markers • Oncology• Cardiology• Coagulation• Infectious diseases• Drugs of Abuse• Clinical/Enzymatic• Chemistry/Urinalysis
  30. 30. Nanotech for Osteogenesisand osteointegration nanotopography and biomaterials for skeletal stem cells based bone repair Osteoblasts enhanced adhesion to nanoscale (1-100nm) alumina, titania, hydroxy hapatite, Titanium Alloy (Ti6AL4V) w.r.t micro-scaled patterning of ceramic materials Electron beam litography for nanotopographic surface patterns
  31. 31. Nano patterning Square arrangements of nanopits maintain the stem cells state for multiple passages (SEM) In vitro differentiation of skeletal stem cells
  32. 32. Synthetic eye prosthesis:Nanomodified surfacesSynthetic eye prosthesis (cornea implant):Layer-by-layer technique (nanoscaled ionic polymers)For modification of haptic and edge
  33. 33. Abrasion resistance Riblet-structure based on embossed UV-curable nanocomposite containing nanosilica (resistant to abrasion) imitating shark skin surface (Fraunhofer IFAM Bremen)
  34. 34. HRSEM of ZnO coatedfabric Fibers after sonication are homogeneously coated with nanoparticles. The distribution of the particles is quite narrow primary particles are in a very low nanometric range (~ 30 nm)
  35. 35. Industrial scale unit Industrial prototype sketch
  36. 36. Mechanism of nano-coating» The after-effects of the cavitation are several hundred times greater in heterogeneous systems than in homogeneous systems.» In the SONO process, the ultrasonic waves promote the fast migration of the newly-formed NPs to the fabrics surface» Mechanical interaction may cause a local melting of the fibers at the contact sites, which may be the reason why the particles strongly adhere to the fabrics.
  37. 37. Nanoparticles:structure at micro-nano scale
  38. 38. Sono Antibacterial efficiency Journal of Microbiology, Biotechnology and Food Sciences Singh et al. 2012 : 2 (1) 106-120
  39. 39. NANOCOMPOSITE ANDNANOSTRUCURED SURFACESFOR INDUSTRIALAPPLICATIONS
  40. 40. RTD Domains & solutionsMaterial and material surface functionalisation;nanotechnologies: » Hard Coatings » Polymers functionalisation » Flat surfaces- continuous process » 3D shaped surfaces- batch process » Vacuum treatment » Atmospheric pressure treatment » Plasma / sol-gel / thermal treatment
  41. 41. Typical solutions » Enhancing wear and scratch resistance » Balistic properties » Provide chemical inertness » Adhesion control (hydro-/oil- phylic repellence) » Surface self cleaning/anti-fingerprint » Appearance (color) » Electrical and thermal properties (insulating/conducting layers) » Biocompatibility » Encapsulation of substrate
  42. 42. Nanostructured Coatings Show structural changes in the range of 10 nm Nanolayer-Struktur50 nm 100 nm Nanogradient Nanolayer Nanocomposite Interface structure on the grain boundary
  43. 43. Tensile and mechanical properties -advantage-6: Multilayer Depositon Multilayer Im proves Coating Toughness Source: A. Matthews, University of Hull, UK Scale: 500 nm
  44. 44. Micro-scale functional coatings Top Top coating, coating different stoichiometry, thickness =Coating 0,5 Tstructure Multilayer step A Total coating Multilayer thickness = T step B Gradient layer Multilayer, n.5 Adhesion layer alternate A+B layers, fixed stoichiometry, thickness = Metal substrate 0,5 T
  45. 45. Functional & decorative coatings •Machining, forming cutting •Components friction control •Superhard surfaces •Biocompatibility
  46. 46. Athomic layer depositionINRIM
  47. 47. Anti-dots
  48. 48. Surface energy & adhesion control inindustrial processes •Hydro- oleo-repellence •Hydrophylic •Non fouling •antibacterial •Anti fingerprint •Wear resistance •Chemical inertness
  49. 49. Modularity for industrial needs: batchand continuous processing solutions Univ. Studdgardt, Mugge Electronics Axyis – plasma jet SIDEL- vacuum deposition in cavities
  50. 50. FROM:FUNCTIONALITYTO:NANO-SUSTAINABILITYAND NANO-SAFETY
  51. 51. Integral Eco-design perspectiveSistemic approachTarget to: » Functional performance » Cost effectiveness » Environmental sustainability » Human SafetyThrough: » RTD on materials, products and processes » Life Cycle Costing » Life cycle assessment ISO 14040, nano-toxicology
  52. 52. Environ. sustainabilty LCA Final product: functionalised surfaceInputs (energy, raw Processmaterials) (Traditional or innovative) Outputs (air emissions, water emissions, solids,…) LCA CODE (Computation) Total Total rawGER GWP Acid POPC EU emissions materials
  53. 53. LCA according to ISO 14040 Global Warming Potential (GWP) ISO 14041 LIFE CYCLE FRAMEWORK Acidification Goal I Potential (AP) N definition T E R P Life Cycle R Eutrophication Inventory E T Potential (EP) A T I Impact O Assessment N Photochemical Ozone Creation Potential (POCP) ISO 14042 ISO 14043
  54. 54. CML 2 with toxicity assessment
  55. 55. Nanotoxicity assessment• Preparation protocols • 1) for well defined test systems • 2) For hazard assessment, i.e. in test media idealised vs. realistic conditinos• Establisch, validate and harmonize stanards operation protocols
  56. 56. Nanotoxicity - Genotoxicity• NMs / NPs features affecting • Size, agglomeration, aggregation • shape and geometry (particles, fibres, tubes, horns, membranes,...) • Surface properties (porosity) charge • Surface modifications, coatings, functional groups • Chiemical composition • Cristallinity • Solubility, dispersibility • Bio persistence • Hardness • Impurities, catalysits
  57. 57. EU prjs & initiativesNANOGenotox Prj on safety evaluation ofmanufactured NMs by characterisation of potentialgenotoxic hazardCharacterisation of NMs (CNTs, TiO2, SiO2):- Characterisation- Genotoxixcity- ToxicokineticsTesting of JRC repository using also NAPHIRA NMs DB & OECD hamonised templates, Synergies with ISO TC229. In vivo and in vitro testing.
  58. 58. Nanodevice Prj.Novel concept, methoods and technologies for theproductioon of Portable Easy-to-use devices formeasurementand Analysis of Airborne EngineeredNanoparticles in Workspace Air
  59. 59. Research: effects of MWCNTon Immune sys and lungs
  60. 60. Dispersed CNTs absorption inliving tissiues
  61. 61. Retention kinetics
  62. 62. Determinants of CNT toxicity What are the causes of the assessed CNTs toxicity: • Presence of metallic contaminants? • Surface defecs playing a role? • Crystallinity? • ...?
  63. 63. EU Initiatives on nano-safety
  64. 64. Conclusions• Nanomaterials and NP based composites paved the way to new components and system enhanced functionalities in conventional and cutting edge industrial sectors due bulk and surface properties• Development of innovative solutions based on nanomaterials display a huge potential especially in fast growing marktets such as biomedical for medical assays, diagnosis, therapy• Manufacture, commercialisation and use of NM- based devices and products addresses important issues of sustainability and safety: specific environmental and toxicity assessment has to be carreid out on a case to case basis through LCA and nanotoxicity assessment to support applicability.
  65. 65. ...any question? massimo.perucca@albelissa.com www.albelissa.com Quality at Work for You

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