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MJBizCon2017: Production Optimization

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Presented at MJBiz Conference 2017 in Las Vegas. An overview of every aspect of the cannabis production pipeline and how to optimize it.

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MJBizCon2017: Production Optimization

  1. 1. © 2017 Anne Holland Ventures Inc. All rights reserved. Production Optimization Dr. Markus Roggen OutCo Vice President, Extraction
  2. 2. © 2017 Anne Holland Ventures Inc. All rights reserved. Where to grow? Outdoor: •Low facility costs •Low operational costs •Only one harvest per year •Considered to be of lower quality Cultivating: Where to grow
  3. 3. © 2017 Anne Holland Ventures Inc. All rights reserved. Where to grow? Indoor: •Considered to be of highest quality •Full environmental control •High facility costs •High operational costs Cultivating: Where to grow
  4. 4. © 2017 Anne Holland Ventures Inc. All rights reserved. Where to grow? Greenhouse: •Potential for very high quality •Use sunlight •Multiple harvest per year •High facility costs •Very little experience in this industry Cultivating: Where to grow
  5. 5. © 2017 Anne Holland Ventures Inc. All rights reserved. Environmental control: • 45-50% humidity • Day: 70-80˚F • Night: 68˚F, total light exclusion Cultivating: How to - Indoor
  6. 6. © 2017 Anne Holland Ventures Inc. All rights reserved. Organic pest management: • Prevention, prevention, prevention • Bio security • Limited access • Shoe covers, overalls, hairnet • Sterilization • Clear incoming plants Cultivating: How to - Indoor
  7. 7. © 2017 Anne Holland Ventures Inc. All rights reserved. Automation •Irrigation •Fertilizer •Climate Cultivating: How to - Indoor
  8. 8. © 2017 Anne Holland Ventures Inc. All rights reserved. • Monitoring plants • Strain fits space & labor • Time requirements • Media parameters • Track staff • Defoliation time (4 min/sq.ft.) • Propagation • Scouting Cultivating: How to - Indoor
  9. 9. © 2017 Anne Holland Ventures Inc. All rights reserved. Adjust schedule for ripeness • Subjective • Trichome development Harvesting
  10. 10. © 2017 Anne Holland Ventures Inc. All rights reserved. Plants prepped for harvest • Flush: water, no nutrients: • Remove nitrogen • Drought: • Possibly starch to sugar conversion • Pre-dry • Mitigate pest Harvesting • Long dark period: • 3 days dark • Mobilize sugar • Stress plant: • To trigger protective mode • Produce secondary metabolites
  11. 11. © 2017 Anne Holland Ventures Inc. All rights reserved. • Sanitized room • Bleach, UV light, SaniDate • Filter circulating air • UV, HEPA • Clean room practice • Overalls, booties, gloves • Room layout • Consistent airflow, temperature Drying: Facility
  12. 12. © 2017 Anne Holland Ventures Inc. All rights reserved. • Cut plants to reduce wet mass load • Hang plants for optimal air circulation Drying: Plant handling
  13. 13. © 2017 Anne Holland Ventures Inc. All rights reserved. • Ultra precise climate controlled room •Low temperature to preserve terpenes •Low humidity against mold •High humidity against crispy buds Drying: Ambient conditions
  14. 14. © 2017 Anne Holland Ventures Inc. All rights reserved. • 60-74˚F • 40-60% humidity • Water Activity monitoring • Aim for <0.65Aw by day 5-7 • Don’t over-dry • Prevent terpene loss • Low temperature Drying: By the numbers
  15. 15. © 2017 Anne Holland Ventures Inc. All rights reserved. • Different containers • bucket, glass, box, bag, … • Ambient conditions • 40-50% humidity, 70˚F • Length of time • At least 2 weeks, up to 3 month Curing
  16. 16. © 2017 Anne Holland Ventures Inc. All rights reserved. •What is a cure? •Think: Aging in wines •Molecular changes Curing 0.45 0.55 0.65 0.75 0.85 0.95 0 5 10 15 20 25 30 WaterActivity Day of cure Water Activity
  17. 17. © 2017 Anne Holland Ventures Inc. All rights reserved. •What is a cure? •Think: Aging in wines •Molecular changes Curing 0 2 4 6 8 10 12 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 0 5 10 15 20 25 Day of cure Terpenes Limonene Bisabolol Linalool bCP Myrcene Humulene Expon. (Limonene) Poly. (Bisabolol) Expon. (Linalool) Expon. (bCP) Poly. (Myrcene) Expon. (Humulene)
  18. 18. © 2017 Anne Holland Ventures Inc. All rights reserved. • Clean room practice • Overalls, booties, gloves • Sterile scissors • Isopropanol: yes • 70% for sterilization • >90% for cleaning • Denatured Ethanol: no! • Includes methanol! Trimming: The setup
  19. 19. © 2017 Anne Holland Ventures Inc. All rights reserved. • Kind of trimming: • Machine trimmers • Hand trimming • Robots? • Goal: • Maximize aesthetics • Minimize breakage Trimming: The process
  20. 20. © 2017 Anne Holland Ventures Inc. All rights reserved. • Track productivity • Strain specific • ≥1.5 lbs/day·person • Grading • Separation of flower size/quality Trimming: The numbers
  21. 21. © 2017 Anne Holland Ventures Inc. All rights reserved. • Use mill to grind material for extraction • Optimize preroll draw by particle size Milling 210 220 230 240 250 260 0 1 2 3 4 5 6 7 YpR(g) PS (mm) Optimizing Particle Size
  22. 22. © 2017 Anne Holland Ventures Inc. All rights reserved. • Track everything! • Strain • Lot number • Date of harvest • Clean your machine! • Service your machine! Extracting
  23. 23. © 2017 Anne Holland Ventures Inc. All rights reserved. • Production yield • Production costs • Extract constitution/quality • Legal aspects Extracting: What is the best system?
  24. 24. © 2017 Anne Holland Ventures Inc. All rights reserved. Extracting: Optimize – For what: • Yield per Run YpR • Yield per Week YpW • Cannabinoid Conc. CC • Terpene Content TC • Recovery Rec – With what: • Temperature T • Pressure P • Time t • Flow Rate FR • Particle Size PS
  25. 25. © 2017 Anne Holland Ventures Inc. All rights reserved. Extracting: Optimize – For what: • Yield per Run YpR • Yield per Week YpW • Cannabinoid Conc. CC • Terpene Content TC • Recovery Rec – With what: • Temperature T • Pressure P • Time t • Flow Rate FR • Particle Size PS
  26. 26. © 2017 Anne Holland Ventures Inc. All rights reserved. Extracting: Optimization – For what: • Recovery Rec – With what: • Time t Experiment t (h) Rec (g) 1 4 53.0 2 8 103 3 18 263 4 34 367 Raw n/a 500 0 100 200 300 400 0 5 10 15 20 25 30 35 40 YieldTHC(g) Time (t) Optimizing Run Time Mass Transfer Diffusion
  27. 27. © 2017 Anne Holland Ventures Inc. All rights reserved. • Test multiple factors simultaneously • Few test for whole space response surface • Higher order effects of factors • Fast and efficient Extracting: Design of experiment
  28. 28. © 2017 Anne Holland Ventures Inc. All rights reserved. Extracting: DoE, THC Recovery • a= 14.9 xT + 123 xp + 18.4 xTxp
  29. 29. © 2017 Anne Holland Ventures Inc. All rights reserved. Extracting: DoE, %Terpene • a= - 14.9 xT - 11.7 xp + 16.8 xTxp
  30. 30. © 2017 Anne Holland Ventures Inc. All rights reserved. Extracting: Visual guide
  31. 31. © 2017 Anne Holland Ventures Inc. All rights reserved. • Cannabinoids • Do not dissolve in water • Do dissolve in oil • Solids • THCA • CBD • Gel-like • THC • Liquid • Terpenes Formulating: Basics
  32. 32. © 2017 Anne Holland Ventures Inc. All rights reserved. • Audience • Intended use • Inhale • Ingest • Topical • Intended effect • Psychoactive or not psychoactive Formulating: What to consider
  33. 33. © 2017 Anne Holland Ventures Inc. All rights reserved. • Comply to current rules • Appeal to customer • Consider unit price • Stability, shelf life • THC in tincture degrades by 30% in one month in sunlight Packaging
  34. 34. © 2017 Anne Holland Ventures Inc. All rights reserved. The Crew Blake Grauerholz Taylor Trah Matt Zbiec Chris Cortina and team
  35. 35. © 2017 Anne Holland Ventures Inc. All rights reserved. • Roggen, M.; Clear vs. Pure: How Fallacies and Ignorance of Extraction Misrepresent the Cannabis Flower. Cannabis Industry Journal August 3rd, Online Editorial • Cortina, C.; Roggen, M.; Comply! Terpene and Testing Aug./Sept. 2017, 36-41 • Grauerholz, B.; Roggen, M.; Journey Down the Production Pipeline. Terpene and Testing June/July 2017, 35-39 • Roggen, M.; Best Before Dates. Terpene and Testing Online Editorial • Roggen, M.; How to optimize your extraction operation. A case study in supercritical CO2 extraction. Terpene and Testing May/June 2017, 35- 40 Further Reading
  36. 36. © 2017 Anne Holland Ventures Inc. All rights reserved. THANK YOU! Dr. Markus Roggen 858-281-8696 mroggen@outco.com OutCo

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