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Latest Advances in Cannabis Production Processes

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Research updates at ACS Boston 2018 about curing, extraction, transformation and monitoring of cannabis.

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Latest Advances in Cannabis Production Processes

  1. 1. www.outco.com Dr. Markus Roggen VP Extraction OutCo, San Diego 1 Latest Advances in Cannabis Production Processes
  2. 2. www.outco.com • Curing Research Update • Extraction Research Update • Reaction Progress Monitoring • Cannabinoid Transformations 2 Abstract
  3. 3. www.outco.com 3 What is Drying and Curing? Dry Room Conditions • 60-74˚F • 40-60% humidity • Water Activity monitoring • Aim for <0.65Aw by day 5-7 Curing Conditions • Different containers • bucket, glass, box, bag, … • Ambient conditions • 40-50% humidity, 70˚F • Length of time • At least 1 week, up to 3 month
  4. 4. www.outco.com • Moisture loss is driven by a difference in vapor pressure • Balance between inhibiting mold growth and terpene loss Water Activity during Dry and Cure 0.45 0.55 0.65 0.75 0.85 0.95 0 5 10 15 20 25 30 WaterActivity Day Water Activity Aw of 0.65 represents the value in which Botrytis cannot continue to grow Terpene Content (% dry weight) Rapid Dry Slow Dry Lemonade Haze 1.42 1.82 Sour Tangie 1.69 2.2
  5. 5. www.outco.com Does anything happen to THC, CBD, …? 5 Cannabinoids during Cure 15% 20% 25% 0 5 10 15 20 25 30 35 Cannabinoidbywt. Days of Cure Potency
  6. 6. www.outco.com Maybe to individual terpenes? 6 Terpenes during Cure 0 2 4 6 8 10 12 0 2 4 6 0 5 10 15 20 25 Terpenesbywt. Days of cure AutoCure Terpenes Limonene Bisabolol Linalool Humulene bCP Myrcene
  7. 7. www.outco.com Does anything happen to THC, CBD, …? 7 Cannabinoids during Cure 18 20 22 24 26 28 30 0 1 2 3 4 5 6 7 8 9 w% Weeks I II III IV V
  8. 8. www.outco.com 8 Terpenes during Cure 0 0.5 1 1.5 2 0 1 2 3 4 5 6 7 8 9 w% Weeks Total Terpens I II III IV V
  9. 9. www.outco.com 9 Terpenes during Cure 0 0.05 0.1 0.15 0.2 0.25 0 2 4 6 8 10 w% Weeks Myrcene I II III IV V 0 0.05 0.1 0.15 0.2 0 2 4 6 8 10 w% Weeks bCaryophylene I II III IV V 0 0.2 0.4 0.6 0.8 0 2 4 6 8 10 w% Weeks aPinene
  10. 10. www.outco.com • Production Yield • Production Costs • Extract Constitution/Quality • Legal Aspects 10 Extraction Optimization
  11. 11. www.outco.com a= 14.9 xT + 123 xp + 18.4 xTxp 11 Analyzing the DoE, THC Recovery (Super)
  12. 12. www.outco.com Does milling destroy THC? Optimizing your Extraction Process 0% 1% 2% %decarb by Size 0 0.2 0.4 0.6 0.8 1 1.2 1.4 %wt. Terpenes by Size
  13. 13. www.outco.com But it does give you higher yields! Optimizing your Extraction Process 20 22 24 26 28 30 32 34 Non-Ground Food Blender 2 mm 6 mm 10 mm %Recovery Cannabinoid Recovery by Size 75 80 85 90 95 Non-Ground Food Blender 2 mm 6 mm 10 mm %Recovery Terpene Recovery by Size
  14. 14. www.outco.com 30 35 40 45 50 55 Non-Ground Food Blender 2 mm 6 mm 10 mm %conc. Terpene Concentration F1 Higher is better, Food Blender wins 0 1 2 3 4 5 Non-Ground Food Blender 2 mm 6 mm 10 mm %conc. Terpene Concentration F2 Lower is better, 2mm wins How about precision? Optimizing your Extraction Process
  15. 15. www.outco.com 0 2 4 6 Non-Ground Food Blender 2 mm 6 mm 10 mm %conc. Cannabinoid Concentration F1 Lower is better, 10mm wins 55 60 65 70 75 Non-Ground Food Blender 2 mm 6 mm 10 mm %conc. Cannabinoid Concentration F2 Higher is better, 2mm wins How about precision? Optimizing your Extraction Process
  16. 16. www.outco.com Packing Density and THC Whereabouts Optimizing your Extraction Process StartFullHalfLoose Flow  1 2 3 4 5 6 7 8 9 % wt. THC
  17. 17. www.outco.com 17 Visual Guide to Extracts
  18. 18. www.outco.com 18 Decarboxylation
  19. 19. www.outco.com 19 Reaction Progress Analytics Example spectra of cannabis extract throughout the course of decarboxylation by the application of heat.
  20. 20. www.outco.com 20 Reaction Progress Analytics Cannabinoid concentration plots over the course of decarboxylation for 3 separate decarboxylation reactions.
  21. 21. www.outco.com THC CBN 21 CBN Formation
  22. 22. www.outco.com Apeks Supercritical Fritsch PerkinElmer Henkelman 22 Thanks
  23. 23. www.outco.com 23 The Crew Blake Grauerholz Taylor Trah Matt Zbiec Chris Cortina and team Thank You

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