3. Who am I?
• Born in Germany
• Germans only drink beer
• Highschool with focus on chemistry and math
• One guy used cannabis, but he was from a different school
• M/Sci Chemistry from Imperial College, London (2008)
• Voted “university hardest to find drugs at”
4. Who am I?
• PhD Organic Chemistry at ETH Zürich with Prof. Carreira (2012)
• PostDoc Physical Organic Chemistry at Scripps with Prof. Blackmond (2013)
• Colorado just legalized, wrong state
• Trip to Berlin to visit brother (2014)
• Finally learn what cannabis smells like
7. Where am I now?
Complex Biotech Discovery Ventures
CBDV is a young research venture that seeks to add fundamental scientific
insight to the field of cannabis production.
We seek to support the cannabis industry by establishing a centralized
hub in Vancouver, BC for collaborative research focused on:
• Process Design
• Process Optimization
• Process Analytics
• Formulation Research
8. Where am I now?
CBDV collaborates with academic, industry and private groups around the
globe. Some highlights of those collaborations are:
• University of British Columbia, Vancouver
• Loyalist College, Belleville
• Vialpando, LLC by Dr. Monica Vialpando
• Veridient Science by Dr. Linda Klumpers
• Fritsch Milling
9. What have I done?
I don’t know what cannabis is, so I try to understand it from first principle
• In-process analytics for reaction control
• Kinetic studies to understand mechanisms
• Computational studies to understand mechanisms
• Chemometrics and data analytics for process control and optimization
• Process development, like crystallization
Fundamental Cannabis Chemistry
11. How do You Decarboxylate?
There is a lack of universal agreement regarding reaction conditions.
• Oven heating
• Hot plate
• Oil bath
12. Don’t Decarboxylate to Long
Problems of excess heating:
• Availability of instruments
• Higher costs of production
• Side reaction and degradation
• Lower yields
0 1000 2000 3000 4000 5000 6000
Elapsed Time (Minutes)
13. Reaction Monitoring of Decarboxylation
• Subjective determination of reaction completeness
• Reactionary approach
• Inconsistent batches
• Lack of quality & process control
• Small sample volume
14. In-Process Analytics
Infrared spectroscopy is a useful tool for reaction monitoring.
Sample 023 By Administrator Date Thursday, July 12 2018
Sample 041 By Administrator Date Thursday, July 12 2018
1750 8001600 1400 1200 1000
_ Start THCA
23. Computational Studies
1: Work by Alex Siegel, presented at Emerald Conference 2020
• Δ9-THC isomerizes to Δ8-THC under heat or acid
• Δ10-THC and Δ6a,10a-THC have also been found1
• What other THC isomers are possible?
30. Post-Processing: Crystallization
• The process of solidifying atoms or molecules into
highly organized structures
• Commonly used in the hemp industry to purify CBD
• Current standard procedures use pentane or
35. Thank You
Thanks go to our collaborators:
• Blake Grauerholz, OutCo
• Taylor Trah, OutCo
• Dr. Allison Justice, Hemp Mine
• Ariel Bohman, PerkinElmer
• Dr. Toby Astill, PerkinElmer
• Barry Schubmehl, Fritsch Milling
• Antonio Marelli, Imperial College
• Weiying He, UBC
CEO: Dr. Markus Roggen
Dr. Roggen has been actively involved in the cannabis industry for over 5 years in
executive positions overseeing production, R&D and process optimization for multiple
producers. Dr. Roggen is also a trusted advisor and mentor for multiple startups, startup
accelerators and organizations.
Co-Founder: Prof. Glenn Sammis
Prof. Sammis is an Associate Professor in the Chemistry Department at the University of
British Columbia. He has built an internationally recognized research group working on
the development of novel synthetic methods for the preparation of natural products and
Our team covers a wide range of expertise, including analytical chemistry, process
chemistry, engineering physics, data science and statistics.