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Healthy Ageing through
Technoculture
Marios Kyriazis
ELPIs Foundation for Indefinite Lifespans
www.elpisfil.org
How to conquer ageing
• Biotechnology?
• Drugs and supplements?
• Nanotechnology?
• Stem cells?
• Artificial Intelligence?
The fallacy of the longevity elixir
PROBLEMS:
• Stem cells: harvesting, delivery, compatibility, bone marrow
transplants
•...
BIOLOGY OF AGEING
CELLS
DNA
LYSOSOMES
ABNORMAL
PROTEINS
FREE
RADICALS
MITOCHONDRIA
CROSS
LINKS
A wider view of ageing
ELIMINATION OF AGEING
BIOLOGY
EPIGENE
TICS
LIFESTYLE
REPAIR
BIOMEDICINE
REPRODUCTION
GENDER
EVOLUTION
CULTURE
ETHICS
CONFL...
I concentrate on Technology and Culture
Technology Culture
Both concepts are based on
INFORMATION
A meaningful set of data or patterns which influence the formation or
transformatio...
Information
+ Complexity Functionality Fitness Survival
Organisation
How to increase information
content
1. Enriched environment, hormetic challenges
2. Social hyper-connectivity (real and vi...
Hormesis
An adaptive response of cells and
organisms to a moderate,
intermittent, challenge.
Hormesis describes phenomena
...
Examples of hormesis
Nutritional
Physical
Sexual
Social
Environmental Enrichment
Experimental animals are
exposed to an enriched
environment- a habitat
augmentation. This has
sev...
Challenge
Here, a challenge is defined as a situation that potentially carries
biological value for an organism, so that t...
The balance between age-related degeneration and health depends on:
A. How well our repair processes are maintained throug...
Use of internet and longevity
Global Brain
Internet connections
An Irregular, Useful
Guest
Second, usefulness
• Humanity is not going to improve if its members
don't make an effort to ac...
The end?
ELPIs Foundation for Indefinite
Lifespans
www.elpisfil.org
drmarios@live.it
Meeting to discuss these concepts: 3r...
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Healthy ageing through technoculture

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How to use information in order to reduce age-related disease.
The discussion includes hormesis and environmental enrichment.

Published in: Health & Medicine
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Healthy ageing through technoculture

  1. 1. Healthy Ageing through Technoculture Marios Kyriazis ELPIs Foundation for Indefinite Lifespans www.elpisfil.org
  2. 2. How to conquer ageing • Biotechnology? • Drugs and supplements? • Nanotechnology? • Stem cells? • Artificial Intelligence?
  3. 3. The fallacy of the longevity elixir PROBLEMS: • Stem cells: harvesting, delivery, compatibility, bone marrow transplants • Tissue engineering: harvesting, surgical transplants • Genetic therapies: technical issues, delivery, integration in the body • Nano-medicine: unknown results, side effects • Pharmacological therapies: compliance, interactions, polypharmacy
  4. 4. BIOLOGY OF AGEING CELLS DNA LYSOSOMES ABNORMAL PROTEINS FREE RADICALS MITOCHONDRIA CROSS LINKS
  5. 5. A wider view of ageing
  6. 6. ELIMINATION OF AGEING BIOLOGY EPIGENE TICS LIFESTYLE REPAIR BIOMEDICINE REPRODUCTION GENDER EVOLUTION CULTURE ETHICS CONFLICT RESOLUTION RISKS TECHNOLOGY HYPER CONNECTION GLOBAL BRAIN COMPLEXITY SCIENCE CYBERNETICS SOCIETY ENVIRON MENT SMART CITIES POLITICS
  7. 7. I concentrate on Technology and Culture Technology Culture
  8. 8. Both concepts are based on INFORMATION A meaningful set of data or patterns which influence the formation or transformation of other data or patterns, in order to reduce uncertainty and help achieve a goal
  9. 9. Information + Complexity Functionality Fitness Survival Organisation
  10. 10. How to increase information content 1. Enriched environment, hormetic challenges 2. Social hyper-connectivity (real and virtual/online) 3. Behavioural models: goal-seeking behavior, search for excellence, a bias for action 4. The pursuit of innovation, diversification, creativity, novelty, and the avoidance of routine.
  11. 11. Hormesis An adaptive response of cells and organisms to a moderate, intermittent, challenge. Hormesis describes phenomena where there is low dose stimulation, high dose inhibition. Nutritional, physical, mental and chemical challenges may result in mild damage which upregulates repair mechanisms. In an attempt to repair this damage, age-related damage is also repaired.
  12. 12. Examples of hormesis Nutritional Physical Sexual Social
  13. 13. Environmental Enrichment Experimental animals are exposed to an enriched environment- a habitat augmentation. This has several positive effects on health, specifically on brain and immune function.
  14. 14. Challenge Here, a challenge is defined as a situation that potentially carries biological value for an organism, so that the organism is inclined to act. A challenge provokes action because it represents a situation in which not acting will lead to an overall lower fitness than acting.
  15. 15. The balance between age-related degeneration and health depends on: A. How well our repair processes are maintained through artificial (item-based) pharmacological, genetic, cellular, biotechnological and other physical interventions. B. Through utilising challenging exposure to information with consequent improvement of function.
  16. 16. Use of internet and longevity
  17. 17. Global Brain
  18. 18. Internet connections
  19. 19. An Irregular, Useful Guest Second, usefulness • Humanity is not going to improve if its members don't make an effort to achieve something higher. Third, quest • Always seek novelty, never be satisfied, never sit quiet and 'relax' for long periods. Be inquisitive, always ask 'why' and don't take anything at face value. • Try to get to the top but don't stop there. There is always something higher. • Come up with new ideas, and then try to achieve them. First, irregularity We thrive on change, challenges and unexpected events. A ‘power-law’ lifestyle: frequent low level activities, some medium level ones, and rare intense activities. Ever-changing, imaginative and unpredictable activities improve immunity, reduce inflammation, improve nerve-growth factors, and many others.
  20. 20. The end? ELPIs Foundation for Indefinite Lifespans www.elpisfil.org drmarios@live.it Meeting to discuss these concepts: 3rd Symposium ‘Pathways to Indefinite Lifespans’ 0n Saturday 23 May 2015, In Larnaca, Cyprus

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