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Jan van der Greef
“Transformation to a
Health-ecosysteem”
Connectivity
A systems view looks at the world in terms of
dynamic patterns of (non-linear) relationships
and organization
.
Van der Gr...
Lao Tzu (604 BC - 531 BC)
If you do not change direction,
you may end up where you are heading.
Future of Health Care ???
Future driven by Health EconomicsFuture driven by Disease Economics
Time for a different
(Systems) View?
The Challenge in current Health Care: Medicine-related
> “One-size fits all” to Personalized Medicine
An Early Lesson
What a Genome Cannot Tell Us
What Cannot Be Learnt from a Genome
One Animal
One Genome
Two States
There is more to life
than DNA
Understanding
from
a S...
Biomarkers
Pathways
System
Knowledge
Informatics
Transcripts
Proteins
Metabolites
Proteins
Metabolites
Systems Biology, to...
Entire Correlation Network : Organized complexity
~3400 nodes
~17000 edges
abs R > 0.8
Patterns of self-organization are t...
Treatment a Treatment b Treatment c
Empirical Medicine
Biomarker-guided
therapy
Treatment a
Treatment b
Treatment c
Biomar...
Nature Vol 520, p 609–611, 2015
What is Health ??
WHO 1948 :
“A state of complete physical, mental, and social well-
being and not merely the absence of d...
…………..Towards a new definition of health
Lancet 2009; vol.373, march 7: p.781
….ability to adapt and self-manage in
the face of social, physical and emotional challenges
…… towards a new definition of...
Homeostasis
AllostasisAdapted state
of the system
Disease
“Disease management”
Focus on single symptom
“Health promotion”
...
“Systems Thinking, natural products
and the future of Health Care”
• Smallest bird and animal with a backbone
• Has the la...
In these “Blue Zones” they found that people reach age 100
at rates 10 times greater than in the United States.
Health Pro...
 “The dominant model of disease today is biomedical, and it
leaves no room within its framework for the social, psycholog...
Correlation Network : Organized complexity
How to find Phenotypic differences
In the Health – Disease space ?
SYSTEM BIOLOGY : New insights, new options ?
Bioinformatics
“OMICS
”
Oltvai et al Science 298 (2002) 763
Life’s Complexity
Pyramid
Phenomenological
Systems perspective...
“ East is East and West is West and
never the Twain shall meet? ”
Science 19 December 2014:
Vol. 346 p. 1569
Symptom relat...
Subtype B
Subtype A
Targeted care – disease phenotype focus
theranostics related to efficacy and adverse effects
Stratifie...
Subtype B
Subtype A
disease phenotyping
Stratified/Individualized Care
Symptom/Signs
Molecular pathology
One-size-fits-all...
New diagnostic tools available for System Diagnosis?
How to measure
coherence in
organization?
Life Complexity Pyramid
How...
Bioluminescence is directly related to
Dynamic Systems Organisation (Chronobiology)
Every organism (every cell) emits ligh...
“The human body
literally glimmers”
The light intensity emitted by
the body is 1000 times lower
than the sensitivity of ou...
UPE-technology measures light emission dynamics
L:palm R:dorsum
R:palm L:dorsum
Reactive Oxygen Species (ROS), free radica...
Healthy (N=50)
pre-diabetes (N=50)
patient (N=50)
-0,05 0,00 0,05 0,10 0,15 0,20 0,25 0,30
0
5
10
15
20
25
30
35
Noofobs
T...
Paramecia are widespread in freshwater, brackish and marine environments
Observed mutual influence on population growth
is...
Human – Human intentional healing influences Algae bioluminescence
Biofield
Communication
Roel en Eduard van Wijk et al.
The music of Life :
System coherence :
biophoton dynamics of left and right hands
The Rhythm of Life is a collaboration between designers / artists Mike Thompson, Susana Cámara Leret and
Dave Young and th...
Psychology Words (psychotherapy)
Body language
Nutrition
Medicine
Life Style advice
Health care provider
World view
Spirit...
Patient-Physician relationships
Otto Scharmer, U-Theory
Mensgerichte
Zorg
……. towards a Human-oriented
Health Care Ecosystem
Production
oriented Care
Outcome
oriented Care
Human
...
From reductionism
to systems biology
From disease
to personalized system wellness
Perspectives
“I”-llness <> “We”-llness
Transformatie to a Health-Ecosysteem, J v/d Greef
Transformatie to a Health-Ecosysteem, J v/d Greef
Transformatie to a Health-Ecosysteem, J v/d Greef
Transformatie to a Health-Ecosysteem, J v/d Greef
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Transformatie to a Health-Ecosysteem, J v/d Greef

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Congres The Art of Self-Healing, 7th of October 2016, Antropia Driebergen

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Transformatie to a Health-Ecosysteem, J v/d Greef

  1. 1. Jan van der Greef “Transformation to a Health-ecosysteem”
  2. 2. Connectivity
  3. 3. A systems view looks at the world in terms of dynamic patterns of (non-linear) relationships and organization . Van der Greef, Jan, 2011. All systems go. Article in Nature, Perspective, Volume 480, p. 87.
  4. 4. Lao Tzu (604 BC - 531 BC) If you do not change direction, you may end up where you are heading. Future of Health Care ???
  5. 5. Future driven by Health EconomicsFuture driven by Disease Economics Time for a different (Systems) View?
  6. 6. The Challenge in current Health Care: Medicine-related > “One-size fits all” to Personalized Medicine
  7. 7. An Early Lesson What a Genome Cannot Tell Us
  8. 8. What Cannot Be Learnt from a Genome One Animal One Genome Two States There is more to life than DNA Understanding from a Systems Perspective?
  9. 9. Biomarkers Pathways System Knowledge Informatics Transcripts Proteins Metabolites Proteins Metabolites Systems Biology, towards personalized fingerprints Systems Analysis Tissue Cell Organism Measurement Interpretation Systems cannot be understood by studying fundamental constituents, the properties of the parts are not intrinsic but can be understood within the context of the whole
  10. 10. Entire Correlation Network : Organized complexity ~3400 nodes ~17000 edges abs R > 0.8 Patterns of self-organization are the key
  11. 11. Treatment a Treatment b Treatment c Empirical Medicine Biomarker-guided therapy Treatment a Treatment b Treatment c Biomarker-Guided Medicine Personalized Health strategies based on drugs developed via a reductionistic focus and the “golden-standard” clinical trial design are limited !! Van der Greef Jan; Hankemeier Thomas; McBurney Robert N, Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials? Pharmacogenomics 2006;7(7):1087-94. Towards biomarkers & Biomarker fingerprints
  12. 12. Nature Vol 520, p 609–611, 2015
  13. 13. What is Health ?? WHO 1948 : “A state of complete physical, mental, and social well- being and not merely the absence of disease, or infirmity.”
  14. 14. …………..Towards a new definition of health Lancet 2009; vol.373, march 7: p.781
  15. 15. ….ability to adapt and self-manage in the face of social, physical and emotional challenges …… towards a new definition of health
  16. 16. Homeostasis AllostasisAdapted state of the system Disease “Disease management” Focus on single symptom “Health promotion” Focus on salutogenesis Resilience to different stimuli physical, psychological, social, spiritual Challenge
  17. 17. “Systems Thinking, natural products and the future of Health Care” • Smallest bird and animal with a backbone • Has the largest brain of all birds (4.2% bw) • Only bird that can fly backwards • Heart rate up to 1260 beats/min • Wing beat up to 200/sec • Can lower metabolic rate to 1/15th and body temperature by 20-50 degrees during torgor • Can switch from nectar to insect diet Resilience ??
  18. 18. In these “Blue Zones” they found that people reach age 100 at rates 10 times greater than in the United States. Health Promotion By Reverse Engineering Longevity Dan Buettner
  19. 19.  “The dominant model of disease today is biomedical, and it leaves no room within its framework for the social, psychological and behavioral dimensions of illness.”  “How much longer must medicine’s science be bound by a 17th century world view?” >>> biopsychosocial model George L Engel (1913-1999) The need for a new medical model: a challenge for biomedicine, Science, 1977,196:129-132 New insights Slide adapted after Ton Nicolai
  20. 20. Correlation Network : Organized complexity How to find Phenotypic differences In the Health – Disease space ?
  21. 21. SYSTEM BIOLOGY : New insights, new options ?
  22. 22. Bioinformatics “OMICS ” Oltvai et al Science 298 (2002) 763 Life’s Complexity Pyramid Phenomenological Systems perspective Chinese Medicine
  23. 23. “ East is East and West is West and never the Twain shall meet? ” Science 19 December 2014: Vol. 346 p. 1569 Symptom relations as bridge between Chinese and Western medicine, a step towards Personalized Health/Medicine DIAGNOSIS is KEY !!
  24. 24. Subtype B Subtype A Targeted care – disease phenotype focus theranostics related to efficacy and adverse effects Stratified/Individualized Care Symptom/Signs Molecular pathology @ @ Disease - symptom management 1 disease -1 target – 1 (block buster) drug Patient Wellness focus Integrated systems approach Life style Psychology/Consciousness Environment, Nutrition Medicine One-size-fits-all Personalized Health Care Ecosystem Symptom/Signs Molecular pathology fingerprint Diagnosis is key !!
  25. 25. Subtype B Subtype A disease phenotyping Stratified/Individualized Care Symptom/Signs Molecular pathology One-size-fits-all Heng Wei Sub-typing : early Diabetes type 2 Herman van Wietmarschen Sub-typing : Rheumatoid Arthritis J. Clinical Reumatology, 2009, 15 ,330-337 Mol. BioSyst., 2012, 8, 1482–1491 Diagnosis is key !!
  26. 26. New diagnostic tools available for System Diagnosis? How to measure coherence in organization? Life Complexity Pyramid How to measure interrelation with the outside world?
  27. 27. Bioluminescence is directly related to Dynamic Systems Organisation (Chronobiology) Every organism (every cell) emits light ( bioluminescence) , which is unique in wavelength, duration, timing and rhythms (information & communication) 1923 Alexander Gavrilovich Gurwitsch Алекса́ндр Гаври́лович Гу́рвич Roel en Eduard Van Wijk
  28. 28. “The human body literally glimmers” The light intensity emitted by the body is 1000 times lower than the sensitivity of our naked eyes. Human biophoton emission is invisible to the naked eye but can be detected by Ultra-weak Photon Emission (UPE)-TECHNOLOGY
  29. 29. UPE-technology measures light emission dynamics L:palm R:dorsum R:palm L:dorsum Reactive Oxygen Species (ROS), free radical reactions and excited chemiluminescence species >> sources of photon emission
  30. 30. Healthy (N=50) pre-diabetes (N=50) patient (N=50) -0,05 0,00 0,05 0,10 0,15 0,20 0,25 0,30 0 5 10 15 20 25 30 35 Noofobs The squeezing parameter r show differences between groups of healthy, pre- patient and patient subjects (M. Orszag, Quantum optics 2000) Quantum photon signal analysis in health and disease 4 parameters to describe the properties of the signal, i.e., the magnitudes and phases of the two complex parameters: α = |α| exp (iΦ) ξ = r exp (iθ) Roel en Eduard van Wijk et al. – Sino-Dutch center for Preventive and Personalized Medicine
  31. 31. Paramecia are widespread in freshwater, brackish and marine environments Observed mutual influence on population growth is stopped with Visible Light filter Fels D (2009) Cellular Communication through Light. PLoS ONE 4(4): e5086. doi:10.1371 Communication by Light Paramecia in closed container Paramecia in closed container Filter
  32. 32. Human – Human intentional healing influences Algae bioluminescence Biofield Communication Roel en Eduard van Wijk et al.
  33. 33. The music of Life : System coherence : biophoton dynamics of left and right hands
  34. 34. The Rhythm of Life is a collaboration between designers / artists Mike Thompson, Susana Cámara Leret and Dave Young and the SD PPM / Netherlands Metabolomics Centre. The artists investigate the potential of sensory data experiences, through an ambiguous data collection process
  35. 35. Psychology Words (psychotherapy) Body language Nutrition Medicine Life Style advice Health care provider World view Spirituality Patient Physiology Family Culture Socialnetwork Self-identity Diagnosis & Treatment in a Personalized Health Care Ecosystem Relationship between patient and Health Care provider is key (compassion)
  36. 36. Patient-Physician relationships Otto Scharmer, U-Theory
  37. 37. Mensgerichte Zorg ……. towards a Human-oriented Health Care Ecosystem Production oriented Care Outcome oriented Care Human (Compassion) oriented Care 4P Health  Personalized  Preventive  Participatory  Predictive 2012 20202007 Participation society Integrated Medicine Information society
  38. 38. From reductionism to systems biology From disease to personalized system wellness Perspectives “I”-llness <> “We”-llness

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