Oral herpes paper presentation

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  • Greetings to you all, i am Falcao Roland,i am broadcasting about how Dr olori saved my life, i was infected with Genital Herpes for A year, my medical Dr told me that there i no total cure and i began to take pill to sustain my self. One day i went to see my medical doctor and i saw a lady who was extremely happy and i asked to know the reason of her happiness and she told me that she was infected with simplex HERPES disease and a herbal doctor called Dr olori cured her with herbal medicine, i did not believe so i asked my medical doctor to know if she was truly confirmed Herpes positive before, and my medical doctor told me yes that a miracle just happened so i asked her to give me the details of the dr so i could ask him if he could also cure mine and she gave me Dr olori Email: droloriherbalcenter@gmail.com I contacted him that very evening and i explained my problem to him and he prepared a medicine and send to me, when i received the medicine he told me how to take it for a period of days and i took it exactly as he said and went for a medical test i was surprise to see my test result as herpes negative. I am so happy, my family and friends that rejected me are back, thank you God. I guarantee you that Dr Olori has solution to all kind of problem if you are facing any stress you can contact him via email droloriherbalcenter@gmail.com or droloriherbalcenter@yahoo.com, call +2349053311935 You can also reach him on website http://drolorimiraclemedicine.webs.com/
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  • This is real take it serious, who will believe that a herb can cure herpes, i navel believe that this will work i have spend a lot when getting drugs from the hospital to keep me healthy, what i was waiting for is death because i was broke, one day i hard about this great man who is well know of HIV and cancer cure, i decided to email him, unknowingly to me that this will be the end of the herpes in my body, he prepare the herb for me, and give me instruction on how to take it, at the end of the one month, he told me to go to the hospital for a check up, and i went, surprisingly after the test the doctor confirm me negative, i thought it was a joke, i went to other hospital was also negative, then i took my friend who was also herpes positive to the Dr Agumagu, after the treatment she was also confirm negative . He also have the herb to cure cancer. please i want every one with this virus to be free, that is why am dropping his email address, agumaguspelltemple@outlook.com or agumaguspelltemple@gmail.com do email him he is a great man. the government is also interested in this DR, thank you for saving my life, and I promise I will always testify for your good work call his number +233200116937.
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Oral herpes paper presentation

  1. 1. • ‘HERPES’ – most common viral infection in oral cavity .• The term ‘herpes simplex’ –herpes labialis(cold sores) & herpes progenital(genital herpes), fever blisters
  2. 2. • Herpes viridae family includesI. HSV-1II. HSV-2III. Varicella zosterIV. Epstein –Barr virusV. CytomegalovirusVI. HHV-6VII. HHV 7VIII. HHV 8IX.Herpes virus simian
  3. 3. • HSV-1 (oral herpes) - permanent infection , very infectious• Oral herpes simplex virus infection(HSV 1) – herpes simplex virus(HSV)
  4. 4. Structure:• VIRION - > double stranded - DNA genome,icosahedral protein cage - capsid ,lipid bilayer –envelope ,envelope joined to capsid – tegument .•HSV1 & HSV2 – 74 genes within genome .• DNA core – control replication & infectivity of thevirus .
  5. 5. • Ballooning degeneration, contain intranuclear inclusions known as Lipschitiz bodies.• Cytoplasm of the infected cell forms giant cells .
  6. 6.  Types of HSV –> HSV 1 - >physical contact in oral cavity .• HSV 2 ->’new epidemic disease’ -contracted through sexual contact . HSV 1 &2 occurs as:1. Primary infection2. Recurrent infection – milder than primary infection
  7. 7. Susceptible host Virus primary infection Recurrent manifestationClinical Subclinicaldisease 1% disease 99% Excitants Carries (70% -80% of population) Antibodies & virus presist
  8. 8. • Primary infection• Incubation period –> 1-26 days.• Prodromal Symptoms –( fever ,headache ,loss of appetite , tiredness , irritation .)• Appearance- group of small red bumps that blister, begin to dry , form yellow crust - preceded by itching &burning -10 to14 days• Red swollen , bleeding gums or sore throat and enlarged lymph node• Gingivastomatitis - in infant from mother• HSV -latent infection in trigeminal ganglion
  9. 9. • Severe in immunodeficient & neonates .• Complication – meningoencephalitis and keratoconjuctivis
  10. 10. • Impetigo• Aphthous ulcers• Hand foot & mouth disease
  11. 11.  Clinical Lab test:• Smear test• Tissue culture• Biopsy
  12. 12.  Antiviral• Acyclovir -> orally- 400mg -800mg .• injection-10mg/kg body weight .• Famciclovir -> 250mg & 500mg .• Valacyclovir -> 500mg & 1gm Antibiotic- (secondary infection like bacteria )• Always keep the infected area dry
  13. 13. VIRAL THYMIDINE KINASECELLULAR KINASE
  14. 14. ACYCLOVIR• Used to treat herpes group of virus• Pharmacokinetics – poor biocompatibility 20%• widely distributed• Excreted- mainly in urine ,renal impairment dose reduction• Effective in normal as well as deficient immune status• Adverse effect – tiredness ,rashes ,hypotension• Toxicity ->1. Decrease in Glomerular filtration rate &produces reversible neurological manifestation to higher doses
  15. 15. FAMCYCLOVIR• Ester prodrug of guanine nucleoside –penciclovir• Good oral biocompatibility ,prolonged intracellular t ½ active triphosphate metabolite• Treat ->Herpes zoster(shingles)->500mg every 8 hours HSV2 ->250mg 5 days Herpes labialis (immunodeficient patients)- >1500mg oral dose• Toxicity is more in famciclovir especially in bone marrow
  16. 16. VALACYCLOVIR• VALACYCLOVIR –herpes simplex• Prodrug ->esterases ->aminoacid valine->via hepatic first pass metabolism,greater biocompatibility(55%) than acyclovir(10-20%)• Dosage –Valtrex ->500mg & 1mg /day• Adverse effect –Vertigo ,edema ,arthralgia
  17. 17. • Avoid touching the affected area .• Vaccines – under research• HSV 2 – condoms can be used

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