Immunology x vaccination

1,115 views

Published on

Published in: Business, Technology
0 Comments
3 Likes
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
1,115
On SlideShare
0
From Embeds
0
Number of Embeds
16
Actions
Shares
0
Downloads
38
Comments
0
Likes
3
Embeds 0
No embeds

No notes for slide
  • In 1798, Jenner introduced 1 st vaccination ( vacca : cow) following his experimentation with isolates of cow pox virus from ‘Blossom’.
  • Immunology x vaccination

    1. 1. Active and passive immunization
    2. 2. Passive immuni z ation <ul><li>Substitution of missing spec if ic antibodies protecting against infectious disease or treating the infectious disease . </li></ul><ul><li>Used mainly in infecti o us diseases or diseases caused by toxins . </li></ul><ul><li>Prompt but short-term effect. </li></ul><ul><li>No immunological memory is induced. </li></ul>
    3. 3. Active immunization <ul><li>Induction of immune memory by harmless antigen . </li></ul><ul><li>In the case of infection by a pathogen prompt secondary immune response protects the immunized person from the disease. </li></ul><ul><li>Has protective, but no therapeutic effect. </li></ul>
    4. 4. Active and passive immunisation
    5. 5. Antisera used in human medicine <ul><li>Against bacterial infections: Tetanus (human), Diphteria (equine), Botulism (equine) </li></ul><ul><li>Against viral infetions: Hepatitis B (human), Rabies (equine), Varicella-zoster (human), CMV (human), tick-born encephalitis (human), hepatitis A, measles and other viral infections (pooled human immunoglobulin) </li></ul><ul><li>Against snake or black widow spider toxins </li></ul><ul><li>Anti Rh </li></ul>
    6. 6. Edward Jenner Discovery of small pox vaccine
    7. 7. Primary and secondary immune response gsbs.utmb.edu/microbook/ch001c.htm
    8. 8. Downloaded from: StudentConsult (on 18 July 2006 11:29 AM) © 2005 Elsevier Formation of memory cells after antigenic challenge
    9. 9. Downloaded from: StudentConsult (on 18 July 2006 11:29 AM) © 2005 Elsevier Primary and secondary immune response
    10. 10. „ Classical“ vaccines <ul><li>Atenuated microbes : BCG (against TBC), mumps, measles rubella, varicella , cholera, yellow fever, poliomyelitis, </li></ul><ul><li>Inactivated microorganisms : rabies, hepatitis A, tick-born encephalitis, poliomyelitis, cholera, plague . Formerly pertussis. </li></ul><ul><li>Toxoids : tetanus , diphteria </li></ul>
    11. 11. „ Modern“ vaccines <ul><li>Subunit : influenza , pertussis </li></ul><ul><li>Polysaccharide : Heamophilus influenzae B (conjugated), Meningococcus (group A a C, conjugate d on non-conjugated), Pneumococcus (conjugate and non-conjugated) </li></ul><ul><li>Recombinant : hepatitis B </li></ul>
    12. 12. „ Future (?)“ vaccines <ul><li>Synthetic polypeptides </li></ul><ul><li>Antiidiotype antibodies </li></ul><ul><li>DNA vaccines </li></ul><ul><li>Vector vaccines </li></ul><ul><li>Antigens inserted into food (bananas, potatoes) </li></ul>
    13. 13. Anti-idiotypic antibodies

    ×