Immunology viii malt

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Immunology viii malt

  1. 1. Mucosal immune system (MALT)
  2. 2. MALT (Mucous Associated Lymphoid Tissue) <ul><li>GALT (Gut Associated Lymphod tissue) </li></ul><ul><li>BALT (Bronchi Associated Lymphoid Tissue) </li></ul><ul><li>Immune stissues of the urinary tract, genital tract, conjunctiva, middle ear… </li></ul><ul><li>Includes also brest gland! </li></ul>
  3. 3. Anatomy of MALT <ul><li>Diffuse tissue containing lymphocytes and other cells of the immune system in submucosa. </li></ul><ul><li>Specialized organs: </li></ul><ul><ul><li>Waldeyer´s ring </li></ul></ul><ul><ul><li>Payer´s patches </li></ul></ul><ul><ul><li>Appnedix </li></ul></ul>
  4. 4. Mucosal immune system (MALT) <ul><li>Antigenic stimulation in one part of MALT leads to immune response also in other compartments of MALT. </li></ul><ul><li>IgA is a predomina n t immunoglobulin secreted through the epitelial cells. </li></ul><ul><li>Oral administration of antigens frequently leads to induction of immune tolerance. </li></ul><ul><li>Intraepitelial lymphocytes - CD8+, restricted antigenic specifi ci ty. </li></ul>
  5. 5. Common Immune System of Mucous Membranes
  6. 6. Střevo novorozence krevní oběh Mléčná žláza sliznice a žlázy střevo matky bakterie a potrava lymfatické uzliny mízovod Společný imunitní systém sliznic
  7. 7. Homing of Lymphocytes <ul><li>The directed migration of subsets of circulating lymphocytes into particular tissue sites. </li></ul><ul><li>Regu lated by se l ective expression of adhesion molecules called homing receptors on lymphocytes. </li></ul><ul><li>Tissue speciphic endothelial ligands are called addressins. </li></ul>
  8. 8. High endotelial venules <ul><li>Specialized venules. The site where lymphpocytes leave the blood stream and migrate into lymph nodes, spleen, organs of MALT. </li></ul><ul><li>Adhesion molecules enable selective attachment of various types of lymphocytes. </li></ul>
  9. 9. Downloaded from: StudentConsult (on 15 July 2006 09:09 AM) © 2005 Elsevier Circulation of lymphocytes
  10. 10. Downloaded from: StudentConsult (on 20 July 2006 11:29 AM) © 2005 Elsevier
  11. 11. Intraepitelial T-lymphocytes <ul><li>TCR  or  </li></ul><ul><li>Extrathymic differentiation </li></ul><ul><li>First line of specific immune response </li></ul><ul><li>Predominantly CD8+ </li></ul><ul><li>Low antigenic specificity of TCR </li></ul>
  12. 12. M-cells <ul><li>Speciali z ed enterocytes responsible for transport of antigens from the gut towards the immunocompe tent cells inside the Payer´s patches. </li></ul><ul><li>Transport in mediated by transcytosis. </li></ul>
  13. 13. Lymphocyte circulation in GALT www.prn.org/.../hiv_1_gastrointestinal_galt_267

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