Immunology iii immunoglobulins

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Immunology iii immunoglobulins

  1. 1.   Imunoglobulins – structure and function Production of immunoglobulins Genetic determination of immunoglobulin production Clonal selection theory
  2. 2. Antigen and epitope
  3. 7. Mole cule of IgG
  4. 8. Hypervaribale region of immunoglobulin molecule binds epitope of the antigen
  5. 9. Variable region of immunoglobulin molecule
  6. 12. Isotype switching
  7. 13. Clonal selection theory
  8. 14. Downloaded from: StudentConsult (on 18 July 2006 11:29 AM) © 2005 Elsevier Activation and differentiation of B -lymphocytes
  9. 15. Downloaded from: StudentConsult (on 18 July 2006 11:29 AM) © 2005 Elsevier
  10. 16. Isotype <ul><li>The class or subclass of an immunoglobulin. </li></ul><ul><li>Antigenic determinats are on constant part of immunoglobulin molecule. </li></ul>
  11. 17. Idiotype <ul><li>An antigenic determinant on the variable region of a specific antibody. </li></ul>
  12. 18. Interaction Idiotype-antiidiotype Shoenfeld Y: Na ture Medicine   10 , 17 - 18 (2004)
  13. 19. www.immunology.klimov.tom.ru/1-1.php .
  14. 20. IgG
  15. 22. Primary and secondary immune response gsbs.utmb.edu/microbook/ch001c.htm
  16. 23. Downloaded from: StudentConsult (on 18 July 2006 11:29 AM) © 2005 Elsevier
  17. 24. IgM on B-cell membrane
  18. 25. Expression of surface immunoglobulins on B-cells
  19. 27. Downloaded from: StudentConsult (on 20 July 2006 11:29 AM) © 2005 Elsevier Formation of Secretory IgA
  20. 28. <ul><li>Affinity: The strength of the binding be t ween a single site of an antibody (one variable region) and an epitope . </li></ul><ul><li>Avidity : The overall strength of interaction between and antibody and antigen. The avidity depends on affinity and the valency of interactions. </li></ul>
  21. 29. Antibody affinity http://pathmicro.med.sc.edu/mayer/rx-2.jpg
  22. 30. Antibody affinity
  23. 31. Biologic al functions of immunoglobulin molecules <ul><li>Activation of complement system (IgG, IgM) </li></ul><ul><li>Opsonization (particularly IgG) </li></ul><ul><li>Neu t ralizati o n of antigens (IgG, IgA, IgM) </li></ul><ul><li>Adherence interference (IgA, IgG) </li></ul><ul><li>Anibody dependent cellular cytotoxicity (ADCC) </li></ul><ul><li>Agglutation, precipitation (IgG, IgM) </li></ul><ul><li>Mast cells degranulation (IgE) </li></ul><ul><li>Transport through placenta (IgG) </li></ul><ul><li>Imunoregul a tion ( mainly IgG) </li></ul>
  24. 32. Antibody dependent cellular cytotoxicity (ADCC) http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/humoral/5classes/u3fg33a.html

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