Oral malignant epithelial tumors

1. Squamous cell Carcinoma Basal Cell Carcinoma Spindle Cell Carcinoma
Intro.
Or. Prickle cells Basal Cells Prickle cells
Epitheloid Carcinoma
-The most common oral malignant neoplasm
Rodent Ulcer
-the most common carcinoma in men
-No tendency for Metastasis but it may kill by Direct
Invasion
Etiology Tobacco, alcohol Promoting factors Syphilis important in cancer of L & T anterior 2/3
Trauma & Dental infection Not significant etiological factor
Nutritional deficiency Iron deficiency in Plummer-Vinson Syndrome
Sunlight important factor in fair skinned outdoor male workers
Viruses VZV which linked to any malignant neoplasm
1. Ultraviolet Radiation; due to prolonged exposure to
sunlight
NB: -Rare in blacks because their skin is protected by
Skin Pigmentation
Unknown
Clinical
S&S Leukoplakia, erythroplakia, Swelling, erosion & ulceration
-Ulcer characterized by
1. Slightly raised borders 2. Easily bleeding floor 3. foul odor
4. Fixation to the underlying tissue 5. Painless unless infected 6. doesn’t respond to treatment
-Small elevated papule; ulcerates & heals &
breakdown again
-Crusted ulcer with rolled borders (spreading laterally)
-Untreated lesion enlarge, may erode into cartilage
& bone
-Exophytic Polypoid
-Swelling, pain & non-healed ulcer
Site T (mostly), B.M, L, G, F, P & M.S -Middle third of the face; doesn’t arise from Oral
Mucosa & never seen inside oral cavity unless it arrive
by Direct Invasion & Infiltration from the skin
Oral lesion Lower L, T, AR & G
Upper respiratory & alimentary tract
Age 58y but may occurs in young 4th decade (young adult/children) 57y
Sex Male (10 times) & diminished Male Male
Histopathology
Well Moderate Poor
Similarity Similar to normal (fun. & morph.) Tumor cells loss certain features
Less resemblance to normal
Tumor cells
Show little resemblance
keratinization Keratin pearls & individual cell
keratinization
Little Keratin formation No keratin formation
Arrangement Sheets & nests (most character) Sheets No nests
Scattered in C.T
Dysplastic
Features
Minimal; -Hyperchromatism
-Polymorphism
-Mitotic figure
Prominent; -Hyperchromatism
-Polymorphism
-Mitotic figure (greater number)
Complete features (11)
a. C.T
1. Collagen fibers interlacing & rarely in
bundles
2. Fibroblasts (active & numerous)
3. New bone small Foci
X ray NO NO NO
D.D
T
P Good