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  1. 1. Definition 􀂄 Immunodeficiency disorders are a group of disorders in which part of the immune system is missing or defective. 􀂄 Therefore, the body's ability to fight infections is impaired and the person is prone to frequent infections that are generally more severe, last longer and heal slowly. 􀂄 In addition there may be increased susceptibility to some cancers
  2. 4. Immunodeficiency Diseases <ul><li>An inborn or primary immunodeficiency </li></ul><ul><ul><li>Results from hereditary or congenital defects that prevent proper functioning of innate, humoral, and/or cell-mediated defenses </li></ul></ul>
  3. 5. <ul><li>An acquired or secondary immunodeficiency </li></ul><ul><ul><li>Results from exposure to various chemical and biological agents </li></ul></ul>
  4. 10. SCIDs <ul><li>Severe combined immunodeficiency </li></ul><ul><li>Body’s ability to make lymphocytes is impaired or nonexistent </li></ul><ul><li>High vulnerability to infection </li></ul><ul><li>Has been successfully treated using gene therapy </li></ul>
  5. 26. <ul><li>Because AIDS arises from the loss of helper T cells </li></ul><ul><ul><li>Both humoral and cell-mediated immune responses are impaired </li></ul></ul>
  6. 27. T Cell Decline <ul><li>Release of new viral particles kills the host T cell </li></ul><ul><li>The body is constantly making new T cells, but cannot outpace the rate of destruction </li></ul><ul><li>As infection proceeds, T cell numbers inevitably decline </li></ul>
  7. 30. Effect of T Cell Decline <ul><li>CD4 helper T cells play a vital role in immune function </li></ul><ul><li>They are required for both cell-mediated and antibody-mediated immunity </li></ul><ul><li>Infected individual becomes vulnerable to other infections, which eventually result in death </li></ul>