SlideShare a Scribd company logo

EDITORIAL GRAPHENE and DERIVATES CHEMICO-PHYSICAL AND TOXICOLOGICAL PROPERTIES IN m RNA vaccine MANIFACTURING STRATEGY - STATE OF EVIDENCE

editorial

1 of 19
Download to read offline
EDITORIAL
GRAPHENEand DERIVATES : PHYSICO- CHEMICAL and TOXICOLOGY properties in
the m- Rna VACCINE MANIFACTURING STRATEGY
Needed specific proof of absence for the regulatory aspects
AUTHORS
1)Luisetto M IMA academy Marijnskaya , professorship toxicology , pharmacology
natural science branch italy
2) Tarro G ,President of the T & L de Beaumont Bonelli Foundation for Cancer
Research, Naples Italy
3) Edbey K, Professor, Departmentof Chemistry, Libya PhysicalChemistry,
University of Benghazi, Libya
Keywords : Graphene, covid -19 , m RNA, vaccine, side effects ,
toxicology,chemistry manifacturing tecnhnology and materials, contaminations,
impurity
Corresponding author :luisetto M maurolu65@gmail.com +393402479620 italy PC
29121
Abstract
Observing thefact that every year various registerd and authorized drugs are
recalled by the public regulatory agency ( in example last Ranitidin cases due by the
possibility of impurity presence of a cancerogenic sustantia ) it is interesting to
observethe innovative production strategy of somem RNA vaccine .
Also for the bio- technological drugs product the regulatory agency ask quality
stantard for impurity for the obiously safety implications.
The biotechnological drugs , as the classic chemical drugs , due by the complex
manifacturing process useraw material and industrialprocedurethat require
Great quality monitoring according the GMP normativerules.
So it is no to strange to discuss of impurities in this new kind of products
And also for the covid-19 vaccine.
Introduction
This work startby recent and really interesting new evicence ( DISINFECTIONad
Natura Docet Darkfield microscopeanalysis n 1/ 2022 ) and other research works
published also by university professors and other professionals . ( CAMPRA P
univerisy of ALMEIRA , YOUNG R O , YOUNG Mi LEE et al , GIOVANNINI F et al) .
Before of all it was done a review of interesting article related the chemico- physical
and toxicological property of graphene derivates ( also woks published before the
Covid-19 Pandemia) as well as distribution profile related the way of
subministration.
Itwas also analyzed ADR charactheristics that somerecent Covid-19 vaccinehave
reported in the pharmacovigilance center ( national and international ) .
Great attention was done towards the verify of the manifacturing technology used
in field od
m RNA vaccine since formthe research in oncology.
Fromliterature Grapheneand Grafene Oxide GO and other derivates are subjectof
many use in bio- technological research : in diagnostic field but also in production
and expecially in last decades.
Itis possibleto report Carrier or adiuvant or extractive property ( there are study
that show increase in immune responceafter their use) , and objectof research for
INTRA NASAL covid-19 vaccine.
Properties to improve RNA extraction- purification in manifacturing field.
( absrobtion property, increase RNA stability )
In someliterature are described use of pegylated nanolipids whit graphene oxide
In m RNA Vaccineresearch development. ( some producers can providethis raw
material and the technical and security sheet are easy available on internet ) .
On literature as well as by bio-technological producers there are variuos products
made of MAGNETIC MICROBEAS used for extraction of RNA derivates.
This are all use Knowed at today and easily verifible in biomedical database since
not suspicious times .
Interesting also to note as there is also a PREPRINT written by the CEO of a great
pharmaceutical industry that produces innovative covid-19 vaccineand other
researcher of the same indutry reportamong the reagent for production of a covid-
vaccine per non human primates magnetic micro beads . ( see reference on article
under publication as reported ).
(And on literature are reported article works about grapheneGO - magnetic
microbeads.).
Materials andmethods
With an observationalpoin of view some relevant literature is analyzed in order to
producea global conclusion related the topics of this work .
Results
Fromliterature :
Results
Are reported reference ( 1-46)
Discussion
So related to all of this , matching the evidence of sometest on vials of vaccine as
well as reseacth on dark filed miscrosocpy and related the fact that the toxicological
profile of this particles seem to correlate with the ADRreported ( rare thrombosys
, pericarditis and other ).
Also the chemico-phyicalproperties of this particles are so peculiar and make
possibleto give explanation of somephenomena.
According the authors it is clear that it is needed to deeply investigate this evidence
verifying the manifacturing technological process in order to clear if are presence
or not possible pollutants residues of production even if this are not declared and
reported on official techincal sheet and registered by public health authorities.
(In the raw materials , reagents of final product).
The pharmaceutical producers useoften to buy raw materials form other producers
The same author submitto the researcher to analyzea more wider and significative
number of vials of the various vaccinefor covid-19 , trought various and certified
independet laboratory and using the blind technique.
To confirm this proposalthere are the evidence collected in some university as in
some research study reported ( TURIN UNIVERSITY- CHEMISTRYfaculty ,
CAMPRA P. - UNIVERSITYOF ALMERIA professor CHEMICAL SCIENCE).
Regarding the contaminants it is of interest to report thay in 26 August2021 BBC
news Coronavirus pandemic Japan suspends 1.6 million Moderna doses over
contamination fears A staff of Japan"s supermarketgroup Aeon receives a doseof
the Moderna vaccine“Japan has suspended the use of about 1.63 million doses of
the Moderna vaccine due to contamination.
A metallic substantia the react with magnete finded in some lots .
Of interest finally to remember two recent italian judgesententia : PISA EFIRENZE
2022 it was recognized in one cause- effect relationship between a covid-19
vaccination and a Thromobocitopenia reaction in an 16 years old ,and in the other
case the judge written that this vaccine are experimental , Dna invasive, potentially
of irreversibleeffect and not prevedile at today .
Even if this drugs areofficially registered by regulatory agency during the last years
In example somecountries restricted uses of some covid-19 vaccinein determinate
subpopulation even initially not done .
The same some technical sheet was recomded to be updated by EMA PRAC
introducing some Rare ADR not presentin the first approved VACCINE oneor also
changed the name of the vaccinein order To update registrativedocuments
reporting new controindications.
Conclusion
As global concusion it is possibleto ask to the innovative vaccine producers to
provideofficial written proof of chemico-analytical absence of graphene and
derivates in the final vaccine product.( the same by the international regulatory
agency ).
The same to providefull clarification of the bio-technological manifacturing process
Even if there are patent of industrialsecret
REFERENCES
1)Campra, P. (2021, June28). Grapheneoxide detection in aqueous suspension:
Observationalstudy in optical and electron
microscopy.https://www.docdroid.net/rNgtxyh/microscopia-de-vial-corminaty-dr-
campra-firma-e-1-fusionado-pdf
2) Young, R. O. (2021, February 5). Scanning & Transmission Electron Microscopy
Reveals GrapheneOxide in CoV-19 Vaccines. Dr. Robert
Young. https://www.drrobertyoung.com/post/transmission-electron-microscopy-
reveals-graphene-oxide-in-cov-19-vaccines
3) Foreign Materials in Blood Samples of Recipients of COVID19 Vaccines
Young Mi Lee MD1, Sunyoung Park MD, PhD, IBCLC2, and Ki-Yeob Jeon MD, PhD,
ScD3
1 Hanna GynecologistClinic Doryeong-ro 7, KumgSung Building, 2nd Fl., Jeju, Jejudo,
63098, Republic of Korea (SouthKorea), Tel: +82-64-711-7717, E-mail:
youngmil95@gmail.com(ORCID ID: 0000-0002-1210-4726)
4) disinfection 1/ 2022 organo diA.T.T.A. (AssociazioneTossicologie Tecnici
Ambientali) Analisi al microsopio in campo scuro sulsanguedi 1006 soggetti
sintomatici dopo vaccinazionecon due tipi di vaccino a M rna
5)J. Phys. Mater. 3 (2020) 034009https://doi.org/10.1088/2515-7639/ab9317
Journalof Physics: Materials
Graphene, other carbon nano-materials and the immune system:
toward nanoimmunity-by-design
Ad

Recommended

IMA 2022 Marijnskaya certificate GRAPHENE and DERIVATES chemico -physical ...
IMA  2022 Marijnskaya certificate GRAPHENE and  DERIVATES  chemico -physical ...IMA  2022 Marijnskaya certificate GRAPHENE and  DERIVATES  chemico -physical ...
IMA 2022 Marijnskaya certificate GRAPHENE and DERIVATES chemico -physical ...M. Luisetto Pharm.D.Spec. Pharmacology
 
Pdf Book -GRAPHENE and DERIVATES PHYSICO- CHEMICAL AND TOXICOLOGY properti...
Pdf Book -GRAPHENE and  DERIVATES  PHYSICO- CHEMICAL  AND TOXICOLOGY properti...Pdf Book -GRAPHENE and  DERIVATES  PHYSICO- CHEMICAL  AND TOXICOLOGY properti...
Pdf Book -GRAPHENE and DERIVATES PHYSICO- CHEMICAL AND TOXICOLOGY properti...M. Luisetto Pharm.D.Spec. Pharmacology
 
WHITE PAPER - m RNA vaccine production Quality control- regulatory and toxic...
WHITE PAPER - m RNA vaccine production Quality control-  regulatory and toxic...WHITE PAPER - m RNA vaccine production Quality control-  regulatory and toxic...
WHITE PAPER - m RNA vaccine production Quality control- regulatory and toxic...M. Luisetto Pharm.D.Spec. Pharmacology
 
SWJPS-Graphene and Derivates Physico-Chemical and Toxicology Properties in th...
SWJPS-Graphene and Derivates Physico-Chemical and Toxicology Properties in th...SWJPS-Graphene and Derivates Physico-Chemical and Toxicology Properties in th...
SWJPS-Graphene and Derivates Physico-Chemical and Toxicology Properties in th...M. Luisetto Pharm.D.Spec. Pharmacology
 
Nanotechnology in Consumer Products: An Update on Regulatory Responses and Li...
Nanotechnology in Consumer Products: An Update on Regulatory Responses and Li...Nanotechnology in Consumer Products: An Update on Regulatory Responses and Li...
Nanotechnology in Consumer Products: An Update on Regulatory Responses and Li...kurfirst
 
TOXICITY AND SAFETY RELATED TO NANOPHARMACEUTICAL
TOXICITY AND SAFETY RELATED TO NANOPHARMACEUTICALTOXICITY AND SAFETY RELATED TO NANOPHARMACEUTICAL
TOXICITY AND SAFETY RELATED TO NANOPHARMACEUTICALMohd Asad Farooqui
 

More Related Content

Similar to EDITORIAL GRAPHENE and DERIVATES CHEMICO-PHYSICAL AND TOXICOLOGICAL PROPERTIES IN m RNA vaccine MANIFACTURING STRATEGY - STATE OF EVIDENCE

Chemical Characterization of Plastic Used in Medical Products
Chemical Characterization of Plastic Used in Medical ProductsChemical Characterization of Plastic Used in Medical Products
Chemical Characterization of Plastic Used in Medical ProductsSGS
 
Ich guidelines
Ich guidelinesIch guidelines
Ich guidelinesAnshul2593
 
Computational toxicology book slides
Computational toxicology book slidesComputational toxicology book slides
Computational toxicology book slidesSean Ekins
 
Kits for modulation of anti-rejection therapies and early detection of neurod...
Kits for modulation of anti-rejection therapies and early detection of neurod...Kits for modulation of anti-rejection therapies and early detection of neurod...
Kits for modulation of anti-rejection therapies and early detection of neurod...Toscana Open Research
 
David Glass BIO World Congress Synthetic Biology Regulation july 2015
David Glass BIO World Congress Synthetic Biology Regulation july 2015David Glass BIO World Congress Synthetic Biology Regulation july 2015
David Glass BIO World Congress Synthetic Biology Regulation july 2015David Glass
 
Safety in Bioprocessing Facilities FINAL
Safety in Bioprocessing Facilities FINALSafety in Bioprocessing Facilities FINAL
Safety in Bioprocessing Facilities FINALOmid Shiraz
 
NANOTECHNOLOGY IN TUBERCULOSIS
NANOTECHNOLOGY IN TUBERCULOSISNANOTECHNOLOGY IN TUBERCULOSIS
NANOTECHNOLOGY IN TUBERCULOSISAniket Vaidya
 
Cmdr 209 galenic hospita-l laboratory during covid-19 emergency a practical ...
Cmdr 209 galenic hospita-l laboratory during covid-19 emergency  a practical ...Cmdr 209 galenic hospita-l laboratory during covid-19 emergency  a practical ...
Cmdr 209 galenic hospita-l laboratory during covid-19 emergency a practical ...M. Luisetto Pharm.D.Spec. Pharmacology
 
Choosing Chemicals for Precautionary Regulation: A Filter Series Approach (2005)
Choosing Chemicals for Precautionary Regulation: A Filter Series Approach (2005)Choosing Chemicals for Precautionary Regulation: A Filter Series Approach (2005)
Choosing Chemicals for Precautionary Regulation: A Filter Series Approach (2005)morosini1952
 
tecovirimat as a Potential Bioavailable inhibitor against MPXVgp158 establish...
tecovirimat as a Potential Bioavailable inhibitor against MPXVgp158 establish...tecovirimat as a Potential Bioavailable inhibitor against MPXVgp158 establish...
tecovirimat as a Potential Bioavailable inhibitor against MPXVgp158 establish...Dr Varruchi Sharma
 
Nature nanotech 2007 165 regulatory
Nature nanotech 2007 165 regulatoryNature nanotech 2007 165 regulatory
Nature nanotech 2007 165 regulatoryMike Helmus
 
nature nanotech 2007 165 regulatory
nature nanotech 2007 165 regulatorynature nanotech 2007 165 regulatory
nature nanotech 2007 165 regulatoryMike Helmus
 
Metal Nanoparticles and their Safety Processing in Functional Foods
Metal Nanoparticles and their Safety Processing in Functional FoodsMetal Nanoparticles and their Safety Processing in Functional Foods
Metal Nanoparticles and their Safety Processing in Functional FoodsAl Baha University
 

Similar to EDITORIAL GRAPHENE and DERIVATES CHEMICO-PHYSICAL AND TOXICOLOGICAL PROPERTIES IN m RNA vaccine MANIFACTURING STRATEGY - STATE OF EVIDENCE (20)

Chemical Characterization of Plastic Used in Medical Products
Chemical Characterization of Plastic Used in Medical ProductsChemical Characterization of Plastic Used in Medical Products
Chemical Characterization of Plastic Used in Medical Products
 
Ich guidelines
Ich guidelinesIch guidelines
Ich guidelines
 
Computational toxicology book slides
Computational toxicology book slidesComputational toxicology book slides
Computational toxicology book slides
 
Kits for modulation of anti-rejection therapies and early detection of neurod...
Kits for modulation of anti-rejection therapies and early detection of neurod...Kits for modulation of anti-rejection therapies and early detection of neurod...
Kits for modulation of anti-rejection therapies and early detection of neurod...
 
David Glass BIO World Congress Synthetic Biology Regulation july 2015
David Glass BIO World Congress Synthetic Biology Regulation july 2015David Glass BIO World Congress Synthetic Biology Regulation july 2015
David Glass BIO World Congress Synthetic Biology Regulation july 2015
 
Safety in Bioprocessing Facilities FINAL
Safety in Bioprocessing Facilities FINALSafety in Bioprocessing Facilities FINAL
Safety in Bioprocessing Facilities FINAL
 
NANOTECHNOLOGY IN TUBERCULOSIS
NANOTECHNOLOGY IN TUBERCULOSISNANOTECHNOLOGY IN TUBERCULOSIS
NANOTECHNOLOGY IN TUBERCULOSIS
 
Tiêu chuẩn phòng sạch trong sản xuất vaccine
Tiêu chuẩn phòng sạch trong sản xuất vaccine Tiêu chuẩn phòng sạch trong sản xuất vaccine
Tiêu chuẩn phòng sạch trong sản xuất vaccine
 
COVID-19 Project ppt (1).pptx
COVID-19 Project ppt (1).pptxCOVID-19 Project ppt (1).pptx
COVID-19 Project ppt (1).pptx
 
839
839839
839
 
Cmdr 209 (1)
Cmdr 209 (1)Cmdr 209 (1)
Cmdr 209 (1)
 
Cmdr 209 galenic hospita-l laboratory during covid-19 emergency a practical ...
Cmdr 209 galenic hospita-l laboratory during covid-19 emergency  a practical ...Cmdr 209 galenic hospita-l laboratory during covid-19 emergency  a practical ...
Cmdr 209 galenic hospita-l laboratory during covid-19 emergency a practical ...
 
ICH guideline.pdf
ICH guideline.pdfICH guideline.pdf
ICH guideline.pdf
 
Choosing Chemicals for Precautionary Regulation: A Filter Series Approach (2005)
Choosing Chemicals for Precautionary Regulation: A Filter Series Approach (2005)Choosing Chemicals for Precautionary Regulation: A Filter Series Approach (2005)
Choosing Chemicals for Precautionary Regulation: A Filter Series Approach (2005)
 
tecovirimat as a Potential Bioavailable inhibitor against MPXVgp158 establish...
tecovirimat as a Potential Bioavailable inhibitor against MPXVgp158 establish...tecovirimat as a Potential Bioavailable inhibitor against MPXVgp158 establish...
tecovirimat as a Potential Bioavailable inhibitor against MPXVgp158 establish...
 
ICH Guidelines
ICH Guidelines ICH Guidelines
ICH Guidelines
 
Nature nanotech 2007 165 regulatory
Nature nanotech 2007 165 regulatoryNature nanotech 2007 165 regulatory
Nature nanotech 2007 165 regulatory
 
nature nanotech 2007 165 regulatory
nature nanotech 2007 165 regulatorynature nanotech 2007 165 regulatory
nature nanotech 2007 165 regulatory
 
Metal Nanoparticles and their Safety Processing in Functional Foods
Metal Nanoparticles and their Safety Processing in Functional FoodsMetal Nanoparticles and their Safety Processing in Functional Foods
Metal Nanoparticles and their Safety Processing in Functional Foods
 
Baccarelli Receptor Dioxins
Baccarelli Receptor DioxinsBaccarelli Receptor Dioxins
Baccarelli Receptor Dioxins
 

More from M. Luisetto Pharm.D.Spec. Pharmacology

Acceptance letter 25052 (1)-2 SUDDEN CARDIAC DEATHS BEFORE - AFTER COVID -19 ...
Acceptance letter 25052 (1)-2 SUDDEN CARDIAC DEATHS BEFORE - AFTER COVID -19 ...Acceptance letter 25052 (1)-2 SUDDEN CARDIAC DEATHS BEFORE - AFTER COVID -19 ...
Acceptance letter 25052 (1)-2 SUDDEN CARDIAC DEATHS BEFORE - AFTER COVID -19 ...M. Luisetto Pharm.D.Spec. Pharmacology
 
ICRJ-2-1071 Monoliths in the mRNA Vaccine Purification Process the Silica Res...
ICRJ-2-1071 Monoliths in the mRNA Vaccine Purification Process the Silica Res...ICRJ-2-1071 Monoliths in the mRNA Vaccine Purification Process the Silica Res...
ICRJ-2-1071 Monoliths in the mRNA Vaccine Purification Process the Silica Res...M. Luisetto Pharm.D.Spec. Pharmacology
 
Current Research in Vaccines ACCEPTATION LETTER m R.N.A. PURIFICATIONS PROCES...
Current Research in Vaccines ACCEPTATION LETTER m R.N.A. PURIFICATIONS PROCES...Current Research in Vaccines ACCEPTATION LETTER m R.N.A. PURIFICATIONS PROCES...
Current Research in Vaccines ACCEPTATION LETTER m R.N.A. PURIFICATIONS PROCES...M. Luisetto Pharm.D.Spec. Pharmacology
 
Graphene Derivates Carbon Products and Separation Properties : the M R.N.A. P...
Graphene Derivates Carbon Products and Separation Properties : the M R.N.A. P...Graphene Derivates Carbon Products and Separation Properties : the M R.N.A. P...
Graphene Derivates Carbon Products and Separation Properties : the M R.N.A. P...M. Luisetto Pharm.D.Spec. Pharmacology
 
m R.N.A. Purifications Process: Affinity Chromato-Graphy, Magnetic Beads and ...
m R.N.A. Purifications Process: Affinity Chromato-Graphy, Magnetic Beads and ...m R.N.A. Purifications Process: Affinity Chromato-Graphy, Magnetic Beads and ...
m R.N.A. Purifications Process: Affinity Chromato-Graphy, Magnetic Beads and ...M. Luisetto Pharm.D.Spec. Pharmacology
 
JOURNAL OF FORENSIC PATHOLOGY ARTICLE IN PRESS LUISETTO ET AL 2022.docx
JOURNAL OF FORENSIC PATHOLOGY ARTICLE IN PRESS LUISETTO ET AL 2022.docxJOURNAL OF FORENSIC PATHOLOGY ARTICLE IN PRESS LUISETTO ET AL 2022.docx
JOURNAL OF FORENSIC PATHOLOGY ARTICLE IN PRESS LUISETTO ET AL 2022.docxM. Luisetto Pharm.D.Spec. Pharmacology
 
Raman (Rs) Spettroscopy for Biopharmaceutical Quality Control and Pat Raw Mat...
Raman (Rs) Spettroscopy for Biopharmaceutical Quality Control and Pat Raw Mat...Raman (Rs) Spettroscopy for Biopharmaceutical Quality Control and Pat Raw Mat...
Raman (Rs) Spettroscopy for Biopharmaceutical Quality Control and Pat Raw Mat...M. Luisetto Pharm.D.Spec. Pharmacology
 
MENTAL ENERGY cover image by ALESSANDRA FALEGGI-Authors luisetto M et al 202...
MENTAL ENERGY cover image by ALESSANDRA FALEGGI-Authors luisetto M et  al 202...MENTAL ENERGY cover image by ALESSANDRA FALEGGI-Authors luisetto M et  al 202...
MENTAL ENERGY cover image by ALESSANDRA FALEGGI-Authors luisetto M et al 202...M. Luisetto Pharm.D.Spec. Pharmacology
 
Sars-cov2 Spike protein and derivates toxicology :fertility and teratogen eva...
Sars-cov2 Spike protein and derivates toxicology :fertility and teratogen eva...Sars-cov2 Spike protein and derivates toxicology :fertility and teratogen eva...
Sars-cov2 Spike protein and derivates toxicology :fertility and teratogen eva...M. Luisetto Pharm.D.Spec. Pharmacology
 
Luisetto M ND agosto 2022 estratto in lingua italiana pubb. 05-08-2022 GRA...
Luisetto M  ND agosto 2022 estratto in lingua italiana pubb. 05-08-2022   GRA...Luisetto M  ND agosto 2022 estratto in lingua italiana pubb. 05-08-2022   GRA...
Luisetto M ND agosto 2022 estratto in lingua italiana pubb. 05-08-2022 GRA...M. Luisetto Pharm.D.Spec. Pharmacology
 
Cbi 7 cypress certificate luisetto m prof.ssorship pharmacology toxicology
Cbi 7 cypress certificate luisetto m prof.ssorship pharmacology   toxicologyCbi 7 cypress certificate luisetto m prof.ssorship pharmacology   toxicology
Cbi 7 cypress certificate luisetto m prof.ssorship pharmacology toxicologyM. Luisetto Pharm.D.Spec. Pharmacology
 
Sentenza laureati in farmacia vecchio ordinamento sulmona classi di conco...
Sentenza laureati in farmacia vecchio ordinamento    sulmona  classi di conco...Sentenza laureati in farmacia vecchio ordinamento    sulmona  classi di conco...
Sentenza laureati in farmacia vecchio ordinamento sulmona classi di conco...M. Luisetto Pharm.D.Spec. Pharmacology
 
Officially accepted abstract pdf iran international biotech conf. 2021 lu...
Officially accepted abstract pdf  iran international  biotech  conf.  2021 lu...Officially accepted abstract pdf  iran international  biotech  conf.  2021 lu...
Officially accepted abstract pdf iran international biotech conf. 2021 lu...M. Luisetto Pharm.D.Spec. Pharmacology
 
Mauro luisetto invitation letter for international graduation cypress unive...
Mauro luisetto  invitation letter for international graduation  cypress unive...Mauro luisetto  invitation letter for international graduation  cypress unive...
Mauro luisetto invitation letter for international graduation cypress unive...M. Luisetto Pharm.D.Spec. Pharmacology
 
preprint Pdf book epidemiology and diffusion of some relevant virus latitude...
 preprint Pdf book epidemiology and diffusion of some relevant virus latitude... preprint Pdf book epidemiology and diffusion of some relevant virus latitude...
preprint Pdf book epidemiology and diffusion of some relevant virus latitude...M. Luisetto Pharm.D.Spec. Pharmacology
 
Attestato iscrizione uniparma la certificazione manageriale luisetto m
Attestato iscrizione uniparma la certificazione manageriale luisetto mAttestato iscrizione uniparma la certificazione manageriale luisetto m
Attestato iscrizione uniparma la certificazione manageriale luisetto mM. Luisetto Pharm.D.Spec. Pharmacology
 

More from M. Luisetto Pharm.D.Spec. Pharmacology (20)

Acceptance letter 25052 (1)-2 SUDDEN CARDIAC DEATHS BEFORE - AFTER COVID -19 ...
Acceptance letter 25052 (1)-2 SUDDEN CARDIAC DEATHS BEFORE - AFTER COVID -19 ...Acceptance letter 25052 (1)-2 SUDDEN CARDIAC DEATHS BEFORE - AFTER COVID -19 ...
Acceptance letter 25052 (1)-2 SUDDEN CARDIAC DEATHS BEFORE - AFTER COVID -19 ...
 
Teoria del libro PLUS IMAGO- PHILOSOPHIA ET SCIENTIA
Teoria del libro PLUS IMAGO- PHILOSOPHIA ET SCIENTIA  Teoria del libro PLUS IMAGO- PHILOSOPHIA ET SCIENTIA
Teoria del libro PLUS IMAGO- PHILOSOPHIA ET SCIENTIA
 
Teoria del libro PLUS IMAGO- PHILOSOPHIA ET SCIENTIA.pdf
Teoria del libro PLUS IMAGO- PHILOSOPHIA ET SCIENTIA.pdfTeoria del libro PLUS IMAGO- PHILOSOPHIA ET SCIENTIA.pdf
Teoria del libro PLUS IMAGO- PHILOSOPHIA ET SCIENTIA.pdf
 
ICRJ-2-1071 Monoliths in the mRNA Vaccine Purification Process the Silica Res...
ICRJ-2-1071 Monoliths in the mRNA Vaccine Purification Process the Silica Res...ICRJ-2-1071 Monoliths in the mRNA Vaccine Purification Process the Silica Res...
ICRJ-2-1071 Monoliths in the mRNA Vaccine Purification Process the Silica Res...
 
Current Research in Vaccines ACCEPTATION LETTER m R.N.A. PURIFICATIONS PROCES...
Current Research in Vaccines ACCEPTATION LETTER m R.N.A. PURIFICATIONS PROCES...Current Research in Vaccines ACCEPTATION LETTER m R.N.A. PURIFICATIONS PROCES...
Current Research in Vaccines ACCEPTATION LETTER m R.N.A. PURIFICATIONS PROCES...
 
Graphene Derivates Carbon Products and Separation Properties : the M R.N.A. P...
Graphene Derivates Carbon Products and Separation Properties : the M R.N.A. P...Graphene Derivates Carbon Products and Separation Properties : the M R.N.A. P...
Graphene Derivates Carbon Products and Separation Properties : the M R.N.A. P...
 
m R.N.A. Purifications Process: Affinity Chromato-Graphy, Magnetic Beads and ...
m R.N.A. Purifications Process: Affinity Chromato-Graphy, Magnetic Beads and ...m R.N.A. Purifications Process: Affinity Chromato-Graphy, Magnetic Beads and ...
m R.N.A. Purifications Process: Affinity Chromato-Graphy, Magnetic Beads and ...
 
JOURNAL OF FORENSIC PATHOLOGY ARTICLE IN PRESS LUISETTO ET AL 2022.docx
JOURNAL OF FORENSIC PATHOLOGY ARTICLE IN PRESS LUISETTO ET AL 2022.docxJOURNAL OF FORENSIC PATHOLOGY ARTICLE IN PRESS LUISETTO ET AL 2022.docx
JOURNAL OF FORENSIC PATHOLOGY ARTICLE IN PRESS LUISETTO ET AL 2022.docx
 
Raman (Rs) Spettroscopy for Biopharmaceutical Quality Control and Pat Raw Mat...
Raman (Rs) Spettroscopy for Biopharmaceutical Quality Control and Pat Raw Mat...Raman (Rs) Spettroscopy for Biopharmaceutical Quality Control and Pat Raw Mat...
Raman (Rs) Spettroscopy for Biopharmaceutical Quality Control and Pat Raw Mat...
 
MENTAL ENERGY cover image by ALESSANDRA FALEGGI-Authors luisetto M et al 202...
MENTAL ENERGY cover image by ALESSANDRA FALEGGI-Authors luisetto M et  al 202...MENTAL ENERGY cover image by ALESSANDRA FALEGGI-Authors luisetto M et  al 202...
MENTAL ENERGY cover image by ALESSANDRA FALEGGI-Authors luisetto M et al 202...
 
Sars-cov2 Spike protein and derivates toxicology :fertility and teratogen eva...
Sars-cov2 Spike protein and derivates toxicology :fertility and teratogen eva...Sars-cov2 Spike protein and derivates toxicology :fertility and teratogen eva...
Sars-cov2 Spike protein and derivates toxicology :fertility and teratogen eva...
 
Luisetto M ND agosto 2022 estratto in lingua italiana pubb. 05-08-2022 GRA...
Luisetto M  ND agosto 2022 estratto in lingua italiana pubb. 05-08-2022   GRA...Luisetto M  ND agosto 2022 estratto in lingua italiana pubb. 05-08-2022   GRA...
Luisetto M ND agosto 2022 estratto in lingua italiana pubb. 05-08-2022 GRA...
 
PHYLOSOPHIA ET SCIENTIA.pdf
PHYLOSOPHIA ET SCIENTIA.pdfPHYLOSOPHIA ET SCIENTIA.pdf
PHYLOSOPHIA ET SCIENTIA.pdf
 
Cypress international graduation_programme
Cypress international graduation_programmeCypress international graduation_programme
Cypress international graduation_programme
 
Cbi 7 cypress certificate luisetto m prof.ssorship pharmacology toxicology
Cbi 7 cypress certificate luisetto m prof.ssorship pharmacology   toxicologyCbi 7 cypress certificate luisetto m prof.ssorship pharmacology   toxicology
Cbi 7 cypress certificate luisetto m prof.ssorship pharmacology toxicology
 
Sentenza laureati in farmacia vecchio ordinamento sulmona classi di conco...
Sentenza laureati in farmacia vecchio ordinamento    sulmona  classi di conco...Sentenza laureati in farmacia vecchio ordinamento    sulmona  classi di conco...
Sentenza laureati in farmacia vecchio ordinamento sulmona classi di conco...
 
Officially accepted abstract pdf iran international biotech conf. 2021 lu...
Officially accepted abstract pdf  iran international  biotech  conf.  2021 lu...Officially accepted abstract pdf  iran international  biotech  conf.  2021 lu...
Officially accepted abstract pdf iran international biotech conf. 2021 lu...
 
Mauro luisetto invitation letter for international graduation cypress unive...
Mauro luisetto  invitation letter for international graduation  cypress unive...Mauro luisetto  invitation letter for international graduation  cypress unive...
Mauro luisetto invitation letter for international graduation cypress unive...
 
preprint Pdf book epidemiology and diffusion of some relevant virus latitude...
 preprint Pdf book epidemiology and diffusion of some relevant virus latitude... preprint Pdf book epidemiology and diffusion of some relevant virus latitude...
preprint Pdf book epidemiology and diffusion of some relevant virus latitude...
 
Attestato iscrizione uniparma la certificazione manageriale luisetto m
Attestato iscrizione uniparma la certificazione manageriale luisetto mAttestato iscrizione uniparma la certificazione manageriale luisetto m
Attestato iscrizione uniparma la certificazione manageriale luisetto m
 

Recently uploaded

Study of X - Ray Spectra and its types
Study  of X  - Ray Spectra and its typesStudy  of X  - Ray Spectra and its types
Study of X - Ray Spectra and its typestanishashukla147
 
Hydro-Thermal Liquefaction Of Lignocellulosic biomass to produce Bio-Crude oil
Hydro-Thermal Liquefaction Of Lignocellulosic biomass to produce Bio-Crude oilHydro-Thermal Liquefaction Of Lignocellulosic biomass to produce Bio-Crude oil
Hydro-Thermal Liquefaction Of Lignocellulosic biomass to produce Bio-Crude oilZeeshan Nazir
 
dkNET Webinar: An Encyclopedia of the Adipose Tissue Secretome to Identify Me...
dkNET Webinar: An Encyclopedia of the Adipose Tissue Secretome to Identify Me...dkNET Webinar: An Encyclopedia of the Adipose Tissue Secretome to Identify Me...
dkNET Webinar: An Encyclopedia of the Adipose Tissue Secretome to Identify Me...dkNET
 
Quasar and Microquasar Series - Microquasars in our Galaxy
Quasar and Microquasar Series - Microquasars in our GalaxyQuasar and Microquasar Series - Microquasars in our Galaxy
Quasar and Microquasar Series - Microquasars in our GalaxySérgio Sacani
 
Duchenne Muscular Dystrophy or DMD .pptx
Duchenne Muscular Dystrophy or DMD .pptxDuchenne Muscular Dystrophy or DMD .pptx
Duchenne Muscular Dystrophy or DMD .pptxNavanidhan.M
 
Quality safety and legislations of cosmetics.pptx
Quality safety and legislations of cosmetics.pptxQuality safety and legislations of cosmetics.pptx
Quality safety and legislations of cosmetics.pptxDeviSky1
 
A galactic microquasar mimicking winged radio galaxies
A galactic microquasar mimicking winged radio galaxiesA galactic microquasar mimicking winged radio galaxies
A galactic microquasar mimicking winged radio galaxiesSérgio Sacani
 
REARING EQUIPMENT IN SERICULTURE . pptx
REARING EQUIPMENT IN SERICULTURE . pptxREARING EQUIPMENT IN SERICULTURE . pptx
REARING EQUIPMENT IN SERICULTURE . pptxVISHALI SELVAM
 
An Introduction to Quantum Programming Languages
An Introduction to Quantum Programming LanguagesAn Introduction to Quantum Programming Languages
An Introduction to Quantum Programming LanguagesDavid Yonge-Mallo
 
2024 Insilicogen Company English Brochure
2024 Insilicogen Company English Brochure2024 Insilicogen Company English Brochure
2024 Insilicogen Company English BrochureInsilico Gen
 
Rootstock scion and Interstock Relationship Selection of Elite Mother Plants
Rootstock scion and Interstock Relationship Selection of Elite Mother PlantsRootstock scion and Interstock Relationship Selection of Elite Mother Plants
Rootstock scion and Interstock Relationship Selection of Elite Mother PlantsAmanDohre
 
ROLES OF MICROBES IN BIOCONTROL BY ANKIT CHOUDHARY.ppsx
ROLES OF MICROBES IN BIOCONTROL BY ANKIT CHOUDHARY.ppsxROLES OF MICROBES IN BIOCONTROL BY ANKIT CHOUDHARY.ppsx
ROLES OF MICROBES IN BIOCONTROL BY ANKIT CHOUDHARY.ppsxAnkitChoudhary955647
 
Earth and Planetary Science | Volume 01 | Issue 01 | April 2022
Earth and Planetary Science | Volume 01 | Issue 01 | April 2022Earth and Planetary Science | Volume 01 | Issue 01 | April 2022
Earth and Planetary Science | Volume 01 | Issue 01 | April 2022Nan Yang Academy of Sciences
 
Hypertension in Children and Adolescents
Hypertension in Children and AdolescentsHypertension in Children and Adolescents
Hypertension in Children and AdolescentsTristanBabaylan1
 
Chemistry chapter 1 solutions detailed explanation
Chemistry chapter 1 solutions detailed explanationChemistry chapter 1 solutions detailed explanation
Chemistry chapter 1 solutions detailed explanationayuqroyjohn85
 
Thornyissue testing of slideshow for website
Thornyissue testing of slideshow for websiteThornyissue testing of slideshow for website
Thornyissue testing of slideshow for websitesuelcarter1
 
The ExoGRAVITY project - observations of exoplanets from the ground with opti...
The ExoGRAVITY project - observations of exoplanets from the ground with opti...The ExoGRAVITY project - observations of exoplanets from the ground with opti...
The ExoGRAVITY project - observations of exoplanets from the ground with opti...Advanced-Concepts-Team
 
Construction of Magic Squares by Swapping Rows and Columns.pdf
Construction of Magic Squares by Swapping Rows and Columns.pdfConstruction of Magic Squares by Swapping Rows and Columns.pdf
Construction of Magic Squares by Swapping Rows and Columns.pdfLossian Barbosa Bacelar Miranda
 

Recently uploaded (20)

Study of X - Ray Spectra and its types
Study  of X  - Ray Spectra and its typesStudy  of X  - Ray Spectra and its types
Study of X - Ray Spectra and its types
 
Hydro-Thermal Liquefaction Of Lignocellulosic biomass to produce Bio-Crude oil
Hydro-Thermal Liquefaction Of Lignocellulosic biomass to produce Bio-Crude oilHydro-Thermal Liquefaction Of Lignocellulosic biomass to produce Bio-Crude oil
Hydro-Thermal Liquefaction Of Lignocellulosic biomass to produce Bio-Crude oil
 
dkNET Webinar: An Encyclopedia of the Adipose Tissue Secretome to Identify Me...
dkNET Webinar: An Encyclopedia of the Adipose Tissue Secretome to Identify Me...dkNET Webinar: An Encyclopedia of the Adipose Tissue Secretome to Identify Me...
dkNET Webinar: An Encyclopedia of the Adipose Tissue Secretome to Identify Me...
 
Quasar and Microquasar Series - Microquasars in our Galaxy
Quasar and Microquasar Series - Microquasars in our GalaxyQuasar and Microquasar Series - Microquasars in our Galaxy
Quasar and Microquasar Series - Microquasars in our Galaxy
 
Duchenne Muscular Dystrophy or DMD .pptx
Duchenne Muscular Dystrophy or DMD .pptxDuchenne Muscular Dystrophy or DMD .pptx
Duchenne Muscular Dystrophy or DMD .pptx
 
Quality safety and legislations of cosmetics.pptx
Quality safety and legislations of cosmetics.pptxQuality safety and legislations of cosmetics.pptx
Quality safety and legislations of cosmetics.pptx
 
A galactic microquasar mimicking winged radio galaxies
A galactic microquasar mimicking winged radio galaxiesA galactic microquasar mimicking winged radio galaxies
A galactic microquasar mimicking winged radio galaxies
 
REARING EQUIPMENT IN SERICULTURE . pptx
REARING EQUIPMENT IN SERICULTURE . pptxREARING EQUIPMENT IN SERICULTURE . pptx
REARING EQUIPMENT IN SERICULTURE . pptx
 
INTRODUCTION TO PLANT TAXONOMY WITH DIVERSE TAXONOMIC APPROACHES
INTRODUCTION TO PLANT TAXONOMY WITH DIVERSE TAXONOMIC APPROACHESINTRODUCTION TO PLANT TAXONOMY WITH DIVERSE TAXONOMIC APPROACHES
INTRODUCTION TO PLANT TAXONOMY WITH DIVERSE TAXONOMIC APPROACHES
 
An Introduction to Quantum Programming Languages
An Introduction to Quantum Programming LanguagesAn Introduction to Quantum Programming Languages
An Introduction to Quantum Programming Languages
 
2024 Insilicogen Company English Brochure
2024 Insilicogen Company English Brochure2024 Insilicogen Company English Brochure
2024 Insilicogen Company English Brochure
 
Rootstock scion and Interstock Relationship Selection of Elite Mother Plants
Rootstock scion and Interstock Relationship Selection of Elite Mother PlantsRootstock scion and Interstock Relationship Selection of Elite Mother Plants
Rootstock scion and Interstock Relationship Selection of Elite Mother Plants
 
ROLES OF MICROBES IN BIOCONTROL BY ANKIT CHOUDHARY.ppsx
ROLES OF MICROBES IN BIOCONTROL BY ANKIT CHOUDHARY.ppsxROLES OF MICROBES IN BIOCONTROL BY ANKIT CHOUDHARY.ppsx
ROLES OF MICROBES IN BIOCONTROL BY ANKIT CHOUDHARY.ppsx
 
Earth and Planetary Science | Volume 01 | Issue 01 | April 2022
Earth and Planetary Science | Volume 01 | Issue 01 | April 2022Earth and Planetary Science | Volume 01 | Issue 01 | April 2022
Earth and Planetary Science | Volume 01 | Issue 01 | April 2022
 
Hypertension in Children and Adolescents
Hypertension in Children and AdolescentsHypertension in Children and Adolescents
Hypertension in Children and Adolescents
 
Research methods in ethnobotany- Exploring Traditional Wisdom
Research methods in ethnobotany- Exploring Traditional WisdomResearch methods in ethnobotany- Exploring Traditional Wisdom
Research methods in ethnobotany- Exploring Traditional Wisdom
 
Chemistry chapter 1 solutions detailed explanation
Chemistry chapter 1 solutions detailed explanationChemistry chapter 1 solutions detailed explanation
Chemistry chapter 1 solutions detailed explanation
 
Thornyissue testing of slideshow for website
Thornyissue testing of slideshow for websiteThornyissue testing of slideshow for website
Thornyissue testing of slideshow for website
 
The ExoGRAVITY project - observations of exoplanets from the ground with opti...
The ExoGRAVITY project - observations of exoplanets from the ground with opti...The ExoGRAVITY project - observations of exoplanets from the ground with opti...
The ExoGRAVITY project - observations of exoplanets from the ground with opti...
 
Construction of Magic Squares by Swapping Rows and Columns.pdf
Construction of Magic Squares by Swapping Rows and Columns.pdfConstruction of Magic Squares by Swapping Rows and Columns.pdf
Construction of Magic Squares by Swapping Rows and Columns.pdf
 

EDITORIAL GRAPHENE and DERIVATES CHEMICO-PHYSICAL AND TOXICOLOGICAL PROPERTIES IN m RNA vaccine MANIFACTURING STRATEGY - STATE OF EVIDENCE

  • 1. EDITORIAL GRAPHENEand DERIVATES : PHYSICO- CHEMICAL and TOXICOLOGY properties in the m- Rna VACCINE MANIFACTURING STRATEGY Needed specific proof of absence for the regulatory aspects AUTHORS 1)Luisetto M IMA academy Marijnskaya , professorship toxicology , pharmacology natural science branch italy 2) Tarro G ,President of the T & L de Beaumont Bonelli Foundation for Cancer Research, Naples Italy 3) Edbey K, Professor, Departmentof Chemistry, Libya PhysicalChemistry, University of Benghazi, Libya Keywords : Graphene, covid -19 , m RNA, vaccine, side effects , toxicology,chemistry manifacturing tecnhnology and materials, contaminations, impurity Corresponding author :luisetto M maurolu65@gmail.com +393402479620 italy PC 29121 Abstract Observing thefact that every year various registerd and authorized drugs are recalled by the public regulatory agency ( in example last Ranitidin cases due by the possibility of impurity presence of a cancerogenic sustantia ) it is interesting to observethe innovative production strategy of somem RNA vaccine .
  • 2. Also for the bio- technological drugs product the regulatory agency ask quality stantard for impurity for the obiously safety implications. The biotechnological drugs , as the classic chemical drugs , due by the complex manifacturing process useraw material and industrialprocedurethat require Great quality monitoring according the GMP normativerules. So it is no to strange to discuss of impurities in this new kind of products And also for the covid-19 vaccine. Introduction This work startby recent and really interesting new evicence ( DISINFECTIONad Natura Docet Darkfield microscopeanalysis n 1/ 2022 ) and other research works published also by university professors and other professionals . ( CAMPRA P univerisy of ALMEIRA , YOUNG R O , YOUNG Mi LEE et al , GIOVANNINI F et al) . Before of all it was done a review of interesting article related the chemico- physical and toxicological property of graphene derivates ( also woks published before the Covid-19 Pandemia) as well as distribution profile related the way of subministration. Itwas also analyzed ADR charactheristics that somerecent Covid-19 vaccinehave reported in the pharmacovigilance center ( national and international ) . Great attention was done towards the verify of the manifacturing technology used in field od m RNA vaccine since formthe research in oncology. Fromliterature Grapheneand Grafene Oxide GO and other derivates are subjectof many use in bio- technological research : in diagnostic field but also in production and expecially in last decades. Itis possibleto report Carrier or adiuvant or extractive property ( there are study that show increase in immune responceafter their use) , and objectof research for INTRA NASAL covid-19 vaccine.
  • 3. Properties to improve RNA extraction- purification in manifacturing field. ( absrobtion property, increase RNA stability ) In someliterature are described use of pegylated nanolipids whit graphene oxide In m RNA Vaccineresearch development. ( some producers can providethis raw material and the technical and security sheet are easy available on internet ) . On literature as well as by bio-technological producers there are variuos products made of MAGNETIC MICROBEAS used for extraction of RNA derivates. This are all use Knowed at today and easily verifible in biomedical database since not suspicious times . Interesting also to note as there is also a PREPRINT written by the CEO of a great pharmaceutical industry that produces innovative covid-19 vaccineand other researcher of the same indutry reportamong the reagent for production of a covid- vaccine per non human primates magnetic micro beads . ( see reference on article under publication as reported ). (And on literature are reported article works about grapheneGO - magnetic microbeads.). Materials andmethods With an observationalpoin of view some relevant literature is analyzed in order to producea global conclusion related the topics of this work . Results Fromliterature : Results Are reported reference ( 1-46)
  • 4. Discussion So related to all of this , matching the evidence of sometest on vials of vaccine as well as reseacth on dark filed miscrosocpy and related the fact that the toxicological profile of this particles seem to correlate with the ADRreported ( rare thrombosys , pericarditis and other ). Also the chemico-phyicalproperties of this particles are so peculiar and make possibleto give explanation of somephenomena. According the authors it is clear that it is needed to deeply investigate this evidence verifying the manifacturing technological process in order to clear if are presence or not possible pollutants residues of production even if this are not declared and reported on official techincal sheet and registered by public health authorities. (In the raw materials , reagents of final product). The pharmaceutical producers useoften to buy raw materials form other producers The same author submitto the researcher to analyzea more wider and significative number of vials of the various vaccinefor covid-19 , trought various and certified independet laboratory and using the blind technique. To confirm this proposalthere are the evidence collected in some university as in some research study reported ( TURIN UNIVERSITY- CHEMISTRYfaculty , CAMPRA P. - UNIVERSITYOF ALMERIA professor CHEMICAL SCIENCE). Regarding the contaminants it is of interest to report thay in 26 August2021 BBC news Coronavirus pandemic Japan suspends 1.6 million Moderna doses over contamination fears A staff of Japan"s supermarketgroup Aeon receives a doseof the Moderna vaccine“Japan has suspended the use of about 1.63 million doses of the Moderna vaccine due to contamination. A metallic substantia the react with magnete finded in some lots .
  • 5. Of interest finally to remember two recent italian judgesententia : PISA EFIRENZE 2022 it was recognized in one cause- effect relationship between a covid-19 vaccination and a Thromobocitopenia reaction in an 16 years old ,and in the other case the judge written that this vaccine are experimental , Dna invasive, potentially of irreversibleeffect and not prevedile at today . Even if this drugs areofficially registered by regulatory agency during the last years In example somecountries restricted uses of some covid-19 vaccinein determinate subpopulation even initially not done . The same some technical sheet was recomded to be updated by EMA PRAC introducing some Rare ADR not presentin the first approved VACCINE oneor also changed the name of the vaccinein order To update registrativedocuments reporting new controindications. Conclusion As global concusion it is possibleto ask to the innovative vaccine producers to provideofficial written proof of chemico-analytical absence of graphene and derivates in the final vaccine product.( the same by the international regulatory agency ). The same to providefull clarification of the bio-technological manifacturing process Even if there are patent of industrialsecret
  • 6. REFERENCES 1)Campra, P. (2021, June28). Grapheneoxide detection in aqueous suspension: Observationalstudy in optical and electron microscopy.https://www.docdroid.net/rNgtxyh/microscopia-de-vial-corminaty-dr- campra-firma-e-1-fusionado-pdf 2) Young, R. O. (2021, February 5). Scanning & Transmission Electron Microscopy Reveals GrapheneOxide in CoV-19 Vaccines. Dr. Robert Young. https://www.drrobertyoung.com/post/transmission-electron-microscopy- reveals-graphene-oxide-in-cov-19-vaccines 3) Foreign Materials in Blood Samples of Recipients of COVID19 Vaccines Young Mi Lee MD1, Sunyoung Park MD, PhD, IBCLC2, and Ki-Yeob Jeon MD, PhD, ScD3 1 Hanna GynecologistClinic Doryeong-ro 7, KumgSung Building, 2nd Fl., Jeju, Jejudo, 63098, Republic of Korea (SouthKorea), Tel: +82-64-711-7717, E-mail: youngmil95@gmail.com(ORCID ID: 0000-0002-1210-4726) 4) disinfection 1/ 2022 organo diA.T.T.A. (AssociazioneTossicologie Tecnici Ambientali) Analisi al microsopio in campo scuro sulsanguedi 1006 soggetti sintomatici dopo vaccinazionecon due tipi di vaccino a M rna 5)J. Phys. Mater. 3 (2020) 034009https://doi.org/10.1088/2515-7639/ab9317 Journalof Physics: Materials Graphene, other carbon nano-materials and the immune system: toward nanoimmunity-by-design
  • 7. Arianna Gazzi, Laura Fusco, Marco Orecchioni, Silvia Ferrari5, Giulia Franzoni ,J Stephen Yan, Matthias Rieckher, Guotao Peng, Matteo Andrea Lucherelli, Isabella Anna Vacchi ,Ngoc Do Quyen Chau, Alejandro Criado, Akcan Istif, Donato Mancino, Antonio Dominguez,Hagen Eckert, Ester V´azquez, Tatiana Da Ros, Paola Nicolussi6, Vincenzo Palermo, Björn Schumacher, Gianaurelio Cuniberti, Yiyong Mai, Cecilia Clementi, Matteo Pasquali ,Xinliang Feng, Kostas Kostarelos, Acelya Yilmazer, Davide Bedognetti , Bengt Fadeel ,Maurizio Prato Alberto Bia 6) Nanoscale. 2016 Feb 14;8(6):3785-95. doi: 10.1039/c5nr09208f. Epub 2016 Jan 27. Functionalized grapheneoxide serves as a novelvaccine nano-adjuvantfor robust stimulation of cellular immunity Ligeng Xu , Jian Xiang, Ye Liu, Jun Xu, Yinchan Luo, Liangzhu Feng, Zhuang Liu, Rui Peng DOI: 10.1039/c5nr09208f 7) ChemistryOpen. 2021 Jul;10(7):666-671. doi: 10.1002/open.202000200. Epub 2021 Apr 7. A Novel Graphene Quantum Dot-Based mRNA Delivery Platform Ya Liu , Changhong Zhao , Alan Sabirsh , Lilei Ye , Xiaoqiu Wu , Hongbin Lu , Johan Liu DOI: 10.1002/open.202000200 8) The new era of vaccines: the “nanovaccinology A. FACCIOLÀ, G. VISALLI, P. LAGANÀ, V. LA FAUCI, R. SQUERI, G.F. PELLICANÒ, G. NUNNARI, M. TROVATO, A. DI PIETRO
  • 8. European Review for Medical and PharmacologicalSciences 2019; 23: 7163-7182 9) Journal List FrontMed (Lausanne) v.8; 2021 PMC8211875 FrontMed (Lausanne). 2021; 8: 648005. Large-Sized GrapheneOxide Nanosheets IncreaseDC–T-Cell Synaptic Contact and the Efficacy of DC Vaccines against SARS-CoV-2 Qianqian Zhou,Hongjing Gu,Sujing Sun,Yulong Zhang,Yangyang Hou,Chenyan Li,Yan Zhao,Ping Ma … See all authors Firstpublished: 16 August2021 https://doi.org/10.1002/adma.202102528 10) 2021 Jun 4. doi: 10.3389/fmed.2021.648005 Nanomedicine: A Diagnostic and Therapeutic Approach to COVID-19 Arjun Sharma,KonstantinosKontodimas, and Markus Bosmann 11) Small Methods. 2021 Sep 15; 5(9): 2100402. Published online 2021 Jul28. doi: 10.1002/smtd.202100402 Nano-technology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐ 19 Vaccines Chiara Rinoldi, Seyed Shahrooz Zargarian, PawelNakielski, Xiaoran Li, Anna Liguori, Francesca Petronella, Dario Presutti, Qiusheng Wang, Marco Costantini, Luciano De Sio, Chiara Gualandi, Bin Ding, Filippo Pierini 12) InternationalJournalof Vaccine Theory, Practice, and Research 2(1), May 10, 2021 Page| 38 WorseThan the Disease? Reviewing Some PossibleUnintended Consequences of the mRNA Vaccines AgainstCOVID-19StephanieSeneff1 and Greg Nigh IJVTPR
  • 9. 13) Trends in molecular medicine e, July 2022, Vol. 28, No. 7 https://doi.org/10.1016/j.molmed.2022.04.007 Adverseeffects of COVID-19 mRNA vaccines: the spikehypothesis Ioannis P. Trougakos , Evangelos Terpos, Harry Alexopoulos, Marianna Politou, Dimitrios Paraskevis, Andreas Scorilas, Efstathios Kastritis, Evangelos Andreakos, and Meletios A. Dimopoulos 14) Published: 31 October 2016 Toxicity of graphene-family nano-particles: a general review of the origins and mechanisms Lingling Ou, Bin Song, Huimin Liang, Jia Liu, Xiaoli Feng, Bin Deng, Ting Sun & Longquan Shao Particle and Fibre Toxicology volume13, Article number: 57 (2016) 15) ACS Appl Mater Interfaces. 2011Jul;3(7):2607-15. doi: 10.1021/am200428v. Epub 2011 Jun 30. Cytotoxicity of grapheneoxide and graphenein human erythrocytes and skin fibroblasts Ken-Hsuan Liao 1, Yu-Shen Lin, Christopher W Macosko, Christy L Haynes DOI: 10.1021/am200428v 16) J Appl Toxicol. 2015 Oct;35(10):1211-8. doi: 10.1002/jat.3187. Epub 2015 Jun 23. Accumulation and toxicity of intravenously-injected functionalized grapheneoxide in mice
  • 10. Kai-Ping Wen 1, Ying-Chieh Chen 2, Chia-Hui Chuang 2, Hwan-You Chang 3, Chi- Young Lee 1, Nyan-Hwa Tai DOI: 10.1002/jat.3187 17) ACS Nano. 2011 Jun 28;5(6):4987-96.doi: 10.1021/nn201092p. Epub 2011May 20. Thrombus inducing property of atomically thin graphene oxide sheets Sunil K Singh 1, Manoj K Singh, Manasa K Nayak, Sharda Kumari, Siddhartha Shrivastava, JoséJ A Grácio, Debabrata Dash DOI: 10.1021/nn201092p 18) Nanoscale Exploration of grapheneoxide as an intelligent platform for cancer vaccines† Check for updates Hua Yue, Wei Wei, Zonglin Gu, Dezhi Ni, Nana Luo, Zaixing Yang, Lin Zhao, Jose Antonio Garate, Ruhong Zhou, Zhiguo Su and GuanghuiM 19) Nanoscale Functionalized grapheneoxide serves as a novelvaccine nano-adjuvantfor robust stimulation of cellular immunity† Check for updates Ligeng Xu, Jian Xiang, Ye Liu, Jun Xu, Yinchan Luo, Liangzhu Feng,a Zhuang Liu and Rui Peng 20) Intranasalvaccination with influenza HA/GO-PEI nano-particles provides immune protection against homo- and heterologous strains Chunhong Dong , Ye Wang, Gilbert X. Gonzalez, +5 , Yao Ma, Yufeng Song, Shelly Wang , Sang-Moo Kang, Richard W. Compans, and Bao-Zhong Wang Edited by Peter Palese, Icahn Schoolof Medicine at Mount Sinai, New York
  • 11. May 3, 2021https://doi.org/10.1073/pnas.2024998118 Vol. 118 | No. 19 21) Volume 2021 |ArticleID 5518999 | https://doi.org/10.1155/2021/5518999 Review Article Grapheneas Nanocarrier in Drug Delivery Federica Valentini, Andrea Calcaterra, Vincenzo Ruggiero,Mattia Di Giacobbe, Maurizio Botta and Maurizio Talamo JSM Nano-technology & Nanomedicine 22) J Control Release. 2016 Aug 10;235:222-235. doi: 10.1016/j.jconrel.2016.06.007. Epub 2016 Jun 4. Efficient mRNA delivery with graphene oxide-polyethylenimine for generation of footprint-freehuman induced pluripotent stem cells Hye Yeon Choi , Tae-Jin Lee , Gwang-Mo Yang , Jaesur Oh , Jihye Won , Jihae Han , Gun-Jae Jeong Jongpil Kim , Jin-HoiKim , Byung-Soo Kim , Ssang-Goo Cho DOI: 10.1016/j.jconrel.2016.06.007 23) Adv Drug Deliv Rev. Author manuscript; available in PMC 2017 Oct1. Adv Drug Deliv Rev. 2016 Oct1; 105(PtB): 109–144. Published online 2016 May 3. doi: 10.1016/j.addr.2016.04.028 Toxicology of Graphene-Based Nano-materials Gaurav Lalwani,MichaelD’Agati, Amit Mahmud Khan, and Balaji Sitharaman
  • 12. 24) Front. Med., 04 June 2021 Sec. Infectious Diseases –Surveillance, Prevention and Treatment https://doi.org/10.3389/fmed.2021.648005 This article is part of the Research Topic Coronavirus Disease(COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response, Volume II Nanomedicine: A Diagnostic and Therapeutic Approach to COVID-19 Arjun Sharma, Konstantinos Kontodimas and Markus Bosmann 25) Ahn, M.; Song, J.; Hong, B.H. Facile Synthesis of N-Doped Graphene Quantum Dots as Novel Transfection Agents for mRNA and pDNA. Nano-materials 2021, 11, 2816. https://doi.org/10.3390/nano11112816 26) Review Article Assessmentof the toxic potential of graphenefamily nano-materials☆ Author links open overlay panelXiaoqingGuoNanMei Journalof Food and Drug Analysis Volume 22, Issue1, March 2014, Pages 105-11 27) Nano-materials (Basel). 2017 Mar 8;7(3):59. doi: 10.3390/nano7030059. Chitosan-Functionalized GrapheneOxide as a Potential Immunoadjuvant Ting Yan , Huijie Zhang , Dandi Huang , Shini Feng , Morihisa Fujita , Xiao-Dong Gao DOI: 10.3390/nano7030059
  • 13. 28) ACS Appl Mater Interfaces. 2020Sep 2;12(35):39014-39023. doi: 10.1021/acsami.0c12078. Epub 2020 Aug 24. Lentinan-Functionalized Graphene Oxide Is an Effective Antigen Delivery System That Modulates InnateImmunity and Improves AdaptiveImmunity Zhenguang Liu , Jin He , Tianyu Zhu , Cong Hu , Ruonan Bo , Adelijiang Wusiman Yuanliang Hu , Deyun Wang 29) ACS Nano. doi: 10.1021/acsnano.0c05062. Epub 2020 Sep 15. Efficient Lymph Node-Targeted Delivery of Personalized Cancer Vaccines with Reactive Oxygen Species-Inducing Reduced GrapheneOxide Nanosheets Cheng Xu , Hao Hong , Yonghyun Lee , Kyung Soo Park , Mingjiao Sun , Tianrui Wang , Marisa E Aikins , Yao Xu , James J Moon DOI: 10.1021/acsnano.0c05062 30) Turkey developing intranasalCOVID-19 vaccine. https://www.aa.com.tr/en/economy/turkey-developing-intranasal-covid-19- vaccine/2192492 31) An Update on Self-Amplifying mRNA Vaccine Development by Anna K. Blakney ,Shell Ip 2 andAndrew J. Geall Academic Editor: Norbert Pardi Vaccines 2021, 9(2), 97; https://doi.org/10.3390/vaccines9020097
  • 14. 32) nature reviews drug discovery review articles article Published: 12 January 2018 mRNA vaccines — a new era in vaccinology Norbert Pardi, Michael J. Hogan, Frederick W. Porter & Drew Weissman Nature Reviews Drug Discovery 33) GrapheneOxide Conjugated Magnetic Beads for RNA Extraction Dr. Xuan-Hung Pham,AhruemBaek,TaeHan Kim,Dr. Sang Hun Lee,Dr. Won-Yeop Rho,Prof. Woo-JaeChung,Prof. Dong-Eun Kim,Prof. Bong-Hyun Jun 16 May 2017 https://doi.org/10.1002/asia.201700554 Chemistry an ASIANjournal 34) ACS Appl Mater Interfaces. 2018Sep 12;10(36):30227-30234. doi: 10.1021/acsami.8b12522. Epub 2018 Aug 30. GrapheneOxide as a Bifunctional Material toward Superior RNA Protection and Extraction Yuhui Liao , Xiaoming Zhou , Yu Fu , Da Xing DOI: 10.1021/acsami.8b12522 35) Preprint: A prefusion SARS-CoV-2 spikeRNA vaccine is highly immunogenic and prevents lung infection in non-human primates bioRxiv preprintdoi: https://doi.org/10.1101/2020.09.08.280818 Annette B. Vogel, Isis Kanevsky, YeChe , Kena A. Swanson , Alexander Muik , Mathias Vormehr , Lena M. Kranz , Kerstin C. Walzer , Stephanie Hein , Alptekin Güler , Jakob Loschko , Mohan S. Maddur , Kristin Tompkins , Journey Cole , Bonny G. Lui , Thomas
  • 15. Ziegenhals , Arianne Plaschke, David Eisel , Sarah C. Dany , Stephanie Fesser, Stephanie Erbar , Ferdia Bates , Diana Schneider , Bernadette Jesionek , Bianca Sänger , Ann-Kathrin Wallisch , YvonneFeuchter, Hanna Junginger , Stefanie A. Krumm , André P. Heinen , Petra Adams-Quack , Julia Schlereth , Christoph Kröner , Shannan Hall-Ursone , Kathleen Brasky4 , Matthew C. Griffor, SeungilHan , Joshua A. Lees , Ellene H. Mashalidis , Parag V. Sahasrabudhe, Charles Y. Tan , Danka Pavliakova , Guy Singh , Camila Fontes-Garfias , Michael Pride , Ingrid L. Scully , Tara Ciolino , Jennifer Obregon, Michal Gazi , Ricardo Carrion, Jr. , Kendra J. Alfson , Warren V. Kalina , Deepak Kaushal , Pei-Yong Shi5 , Thorsten Klamp , Corinna Rosenbaum , Andreas N. Kuhn , ÖzlemTüreci, Philip R. Dormitzer , Kathrin U. Jansen , Ugur Sahin Affiliations: BioNTech, An der Goldgrube12, 55131 Mainz, Germany; Pfizer, 401 N. Middletown Rd., Pearl River, NY 10965, United States; Pfizer, 280 ShennecossettRd., Groton, CT 06340, United States; SouthwestNational Primate Research Center, Texas Biomedical Research Institute, 8715 W. Military Dr, San Antonio, TX 78227, United States; University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, United States; Texas Biomedical Research Institute, 8715 W Military Dr, San Antonio, TX 78227, United States;
  • 16. TRON gGmbH – TranslationalOncology at the University Medical Center of the Johannes Gutenberg University, Freiligrathstraße12, 55131 Mainz, Germany; Correspondence: Prof. Dr. Ugur Sahin, BioNTech SE, An der Goldgrube12, 55131 Mainz, Tel: +49 6131 2161 201; Email: Ugur.Sahin@biontech.de 36) Mini-Review 25 October 2006 Magnetic particles for the separation and purification of nucleic acids Sonja Berensmeier Applied Microbiology and Biotechnology volume 73, pages495–504 (2006) 37) Reduced Graphene Oxide-Based Solid-PhaseExtraction for the Enrichment and Detection of microRNA He Yan, Youchun Xu, Ying Lu‡, and Wanli Xing Cite this: Anal. Chem. 2017, 89, 19, 10137–10140 September 21, 2017 https://doi.org/10.1021/acs.analchem.7b03138 38) Advances in carbon nanostructure Magnetic-Graphene-Based Nanocomposites and Respective Applications Oxana Vasilievna Kharissova, Beatriz Ortega García, Boris Ildusovich Kharisovand Ubaldo Ortiz Méndez
  • 17. October 5th, 2016 DOI: 10.5772/64319 39) RSC Advances DNA and RNA extractions from eukaryotic and prokaryotic cells by graphene nanoplatelets Check for updates Ehsan Hashemi, Omid Akhavan, Mehdi Shamsara, Sepideh Valimehra and Reza Rahighib 40) Vaccine. 2021 Apr 15 2021 Mar 24. doi: 10.1016/j.vaccine.2021.03.038 mRNA vaccines manufacturing: Challenges and bottlenecks Sara Sousa Rosa, Duarte M.F. Prazeres, Ana M. Azevedo, and Marco P.C. Marquesb 41) In vitro Transcription on DNA Templates Immobilized to Streptavidin Coated MagneSphereParamagnetic Particles Mingyi Liu, David H Price 1997 JournalPromega Notes 42) Graphene-Coated Iron Nitride Streptavidin Magnetic Beads: Preparation and Application in SARS-CoV-2 Enrichment Jianxing Li , Minglian Wang , Runqing Jia , Zhuang Ma ,Xiaoxu Zhang , Jintao Li ,Xiangqian Xiao , Yunzhi Zhou , and Qun Wang
  • 18. 43) Appl Microbiol Biotechnol. 2006 2006 Oct25. doi: 10.1007/s00253-006-0675-0 Magnetic particles for the separation and purification of nucleic acids Sonja Berensmeier 44)Separation and Purification Technology Volume 267, 15 July 2021, 118616 Separation and Purification Technology RNase-freeRNA removaland DNA purification by functionalized magnetic particles Yunhai Fu Qingmei Chen LiJia 45) ORIGINAL RESEARCH article Front. Bioeng. Biotechnol., 25 May 2020 Sec. Nanobiotechnology https://doi.org/10.3389/fbioe.2020.00421 Biointerfacing 2D Nanomaterials and Engineered Heterostructures GrapheneOxide Nano-Concentrators Selectively Modulate RNA Trapping According to Metal Cations in Solution Valentina Palmieri, Lorena Di Pietro, Giordano Perini, Marta Barba, Ornella Parolini, Marco De Spirito, Wanda Lattanzi and Massimiliano Papi
  • 19. 46) Ouranidis, A.; Vavilis, T.;Mandala, E.; Davidopoulou, C.;Stamoula, E.; Markopoulou, C.K.;Karagianni, A.; Kachrimanis, K. mRNA Therapeutic Modalities Design, Formulation and Manufacturing under Pharma 4.0 Principles. Biomedicines 2022, 10, 50. https://doi.org/10.3390/biomedicines10010050