Regulatory Model of Dramatic Life Span Increase

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This is a simplified model of increased life span through changing regulatory set point between systems.

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Regulatory Model of Dramatic Life Span Increase

  1. 1. Cell  Maintanance     Factors   Repilac1on     Factors   Cell  Mortality     Factors   Interac1ng  vectors  push  body  systems  in  different  direc1ons   forming  a  stable  ballanced  regulatory  plane  of  system   Outside  the  stable  regulatory   plane  body  systems  behave     chao1cally  and  1ssue  can     destablize  (e.g.  illness/death).   80  Yr.     Life  Span   New  Regulatory     Plane  >  Life  Span   >  160  Yr.  ???     Change  in  Regulatory  Vectors   Tissue  Spacific     Life  Span  Regula1on   Stable     Regulatory     Plane   Tissue  Spa.   Stable     Regulatory     Plane   Tissue  Spa.     Stable     Regulatory     Plane   Mul1ple   Body     Systems     Co-­‐regulate   Crea1ng  a   Global   Regulatory   Complex   Defining  a   Plane   of  Life-­‐Span   Regula1on   for  the  Body   as  a  whole.    
  2. 2. Adverse   Childhood   Experiences   (ACEs)   Autonomic     Dysregula1on   Allosta1c     Load   Telomerase   Telemeres   ROS,  CASP9,   CREB,  Bcl2  etc.   Apoptosis   Regulators   Cell  Markers  of     Cell  Health     and  Self   Removal  of     Healthy  Cells   Neuroplas1c     Immunofunc1ons     Neuroplas1c  Changes   Remove  Brake   On  Plas1city   Increase  Rate     of  Brain  Tissue     Change   Glial  Func1oning   •     Glutamate  Reuptake   •     Immune  Barrior   •     Synap1c  Plas1city   •     Apop1c  Signal   Rapid  Tissue     Loss   Cell  Repair  Cycles   •  Neurogenesis     •  LTP   •  Cell  Repair   Lesion     Regrowth   Metabolic   Changes   (e.g.  Sugar/Insulin,     Mitochondria  fxn)   Model  of   Mul1ple   Sclerosis   Balance     Decrease  Cell   Replacement   And  Reduced   Cell  Health   Gene1c   &  Other     Factors  

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