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Heart & thyroid DR. SHARDA JAIN DR. JYOTI AGARWAL

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Heart & thyroid DR. SHARDA JAIN DR. JYOTI AGARWAL
RELATIONSHIP that matters Every doctor should know
IN PATIENTS WITH DYSLIPIDEAMIA, HYPOTHYROIDISM IS CAPABLE OF AGGRAVATING PRE- EXISTING LIPID DYSFUNCTION

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Heart & thyroid DR. SHARDA JAIN DR. JYOTI AGARWAL

  1. 1. DR. SHARDA JAIN DR. JYOTI AGARWAL …Caring hearts, healing hands Heart & thyroid
  2. 2. RELATIONSHIP that matters Every doctor should know
  3. 3. IN PATIENTS WITH DYSLIPIDEAMIA, HYPOTHYROIDISM IS CAPABLE OF AGGRAVATING PRE- EXISTING LIPID DYSFUNCTION DECREASED THYROID FUNCTION Increased TC & LDL – C levels
  4. 4. IN HYPOTHYROID PATIENTS Reduced activity of HMG – Coa reductase Decreased LPL activity Decreased activity of LDL- receptors Decreased receptor- Mediated Catabolism of LDL & IDL Reduced cholesterol Biosynthesis Decreased clearance of TG – rich lipoprotein Increase in the serum total cholesterol concentration Elevated TG levels
  5. 5. SCREENING FOR HYPOTHYRODISM IS IMPORTANT IN Dyslipidaemia & in all patients with unexpected alteration of lipid profile INDIAN THYROID GUIDELINES 2011 Recommends all patients with elevated lipid levels should be screened for hypothyroidism
  6. 6. IN PATIENTS WITH HYPOTHYROIDISM CATEGORY START WITH TITRATE CONTINUE TILL Adults 50-100mcg/day By 50 mcg /day at 4-6 weeks interval Attainment of clinical & biochemical euthyroidism Elderly (>50 Y) Not to exceed 50 mcg/ day In patients with Cardiac diseases 25 mcg/ day (or 50 mcg on alternate days) By 25mcg/day (or 50 mcg on alternate days) at 4 weeks intervals
  7. 7. • ELTROXIN has a narrow therapeutic index. During the initial titration period, careful dosage titration & monitoring is necessary to avoid the consequences of under or over – treatment. • Special care is needed in the elderly & in patients with symptoms of myocardial insufficiency or ECG evidence of myocardial infarction or ischaemia & also those with diabetes mellitus or insipidus. • ELTROXIN raises blood suger levels & this may upset the stability of patients receiving References 1. Rizos CV, elisaf MS, liberopoulos EN. Effects of thyroid dysfunction on lipid profile. Open cardiovasc med j 20011;5:76-84. 2. Liberopoulos EN elisaf MS dyslipidemia in patients with thyroid disorde. Hormones (athens) 2002 oct-dec;1(4):218-23 3. Tandon N,et all j assoc physician india jan 20011;59 suppl:21-5 4. Prescribing information of eltroxin version :ELT/PL/IN 2015/01 dated 12 june 2015 Important safety information for eltroxin
  8. 8. ADDRESS 11 Gagan Vihar, Near Karkari Morh Flyover, Delhi - 51 CONTACT US 9650588339 9599044257 011-22414049 WEBSITE : www.lifecareivf.in www.lifecarecentre.in www.lifecareabs.in ISO 14001:2004 (EMS) …..Caring hearts, healing hands ISO 9001:2008 26 Year In your service

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