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Ammg las vegas 2012 110312 final dr bill andrews

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Dr. Bill Andrews on telomeres, their biology, and importance.

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Ammg las vegas 2012 110312 final dr bill andrews

  1. 1. Bill Andrews, Ph.D.  Discovered Human Telomerase  2nd Place United States Inventor of the Year  Telomere Biologist for 19 Years  31 Years in Biotech Research  43 U.S. Issued Patents on Telomerase  Founder, President & CEO Sierra Sciences  Popular Science, The Today Show, etc.
  2. 2. Short Telomere Disease
  3. 3. Bad Things Happen When Telomeres Get Short! Telomere
  4. 4. Telomere
  5. 5. Congratulations Elizabeth Blackburn, Carol Greider, and Jack Szostak 2009 Nobel Prize in Medicine!
  6. 6. Some People are Born with Short Telomeres
  7. 7. Progeria Mech Ageing Dev. 2009 Jun;130(6):377-83. Epub 2009 Mar 20. Short Telomere Disease
  8. 8. Progeria Mech Ageing Dev. 2009 Jun;130(6):377-83. Epub 2009 Mar 20. Short Telomere Disease Life Expectancy - 20 Years
  9. 9. Progeria Mech Ageing Dev. 2009 Jun;130(6):377-83. Epub 2009 Mar 20. Short Telomere Disease Life Expectancy - 20 Years Preventing Telomere Shortening Could Cure These Kids!
  10. 10. Bad Things Happen When Telomeres Get Short!
  11. 11. Normal Health & Aging
  12. 12. Short Telomere Diseases • Cardiovascular • Cancer • COPD • Degenerative Disc Disease • Alzheimer’s • Osteoarthritis • Rheumatoid Arthritis • Osteoporosis • General Immunity • Skin Aging • Macular Degeneration • Liver Cirrhosis • Muscular Dystrophy • Cell & Tissue Transplants • AIDS • Progeria • Dyskeratosis Congenita • Idiopathic Pulmonary Fibrosis • Cri du Chat syndrome • Down’s Syndrome • Fanconi’s Anemia • Tuberous Sclerosis • Werner’s Syndrome • And, Aging Itself???????
  13. 13. Bad Things Happen When Telomeres Get Short!
  14. 14. Dr. David Woynarowski
  15. 15. 1971: Nixon declares War on Cancer
  16. 16. War on Short Telomere Disease!
  17. 17. September 2-8 is Telomere Research Week
  18. 18. What Can Be Done About Telomere Shortening?
  19. 19. Managing Telomere Length 1. Know the length of your telomeres
  20. 20. Telomere Testing 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
  21. 21. Telomere Testing 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength Normal Line
  22. 22. A Normal 50 Year Old 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
  23. 23. Telomeric < Chronological 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
  24. 24. Telomeric > Chronological 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
  25. 25. Accelerated Aging 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
  26. 26. Progeria 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
  27. 27. Always Hope to Be 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
  28. 28. Never Want to Be 0 2 4 6 8 10 0 20 40 60 80 100 Age (Years) TelomereLength
  29. 29. Telomere Length Measurement 1. Terminal Restriction Fragment (TRF) 2. Q-PCR 3. Fluorescence In Situ Hybridization (FISH) 4. Flow FISH 5. HT Q-FISH 6. Universal STELA
  30. 30. Telomere Length Measurement 1. Terminal Restriction Fragment (TRF) 2. Q-PCR 3. Fluorescence In Situ Hybridization (FISH) 4. Flow FISH 5. HT Q-FISH 6. Universal STELA Short Telomeres
  31. 31. Telomere Length Measurement 1. Terminal Restriction Fragment (TRF) 2. Q-PCR – Commercially available 3. Fluorescence In Situ Hybridization (FISH) 4. Flow FISH – Commercially available 5. HT Q-FISH – Commercially available 6. Universal STELA
  32. 32. Telomeres Shorten as Cells Divide Hastings, et al. Cell Prolif. 37, 317-324 (2004)
  33. 33. Telomeres Shorten with Age Tsuji, et al., Forensic Sci Int 2002
  34. 34. Okuda, K., et al., Atherosclerosis, 2000 Telomeres Shorten with Age
  35. 35. Weak Correlation?  People born with different telomere lengths  Rates of cell division differ between people  Different environmental factors accelerate telomere shortening  Poor Signal Detectability
  36. 36. Weak Correlation? Good for Population Studies or Looking at Major Differences in Individuals
  37. 37. Abundance of Short Telomeres?
  38. 38. Before Before After After Small Differences Easier to Detect!
  39. 39. Managing Telomere Length 1. Know the length of your telomeres 2. Decrease the rate of telomere shortening
  40. 40. Exercise
  41. 41. German National Track and Field Team Werner, et al., Circulation. 2009 Dec 15;120(24):2438-47 p < 0.001
  42. 42. German National Track and Field Team p < 0.001 Werner, et al., Circulation. 2009 Dec 15;120(24):2438-47
  43. 43. Vigorous Aerobic Exercise LaRocca, et al., Mech Ageing Dev. 2010 Feb;131(2):165-7.
  44. 44. Physical Activity in Leisure Time Cherkas, et al., Arch Intern Med. 2008 Jan 28;168(2):154-8.
  45. 45. Stress
  46. 46. Stress p = 0.05 Damjanovic, et al., J Immunol. 2007 Sep 15;179(6):4249-54
  47. 47. Stress Epel, et al., Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17312-5.
  48. 48. Stress Tyrka, et al., Biol Psychiatry. 2010 Mar 5. [Epub ahead of print]
  49. 49. Depression
  50. 50. Mood Disorders Simon, et al., Biol Psychiatry. 2006 Sep 1;60(5):432-5.
  51. 51. Obesity, Diet, Antioxidants, & Smoking
  52. 52. 2284 women from the Nurses’ Health Study Cassidy, et al., Am J Clin Nutr. 2010 Mar 10. [Epub ahead of print]
  53. 53. Valdes, et al., Lancet. 2005 Aug 20-26;366(9486):662-4. p = 0.031 p = 0.019 p = 0.017 p = 0.045 Obesity Smoking
  54. 54. Smoking p = .001 Morlá, et al., Eur Respir J. 2006 Mar;27(3):525-8.
  55. 55. Omega 3 Fatty Acids
  56. 56. Omega 3 Fatty Acids Farzaneh-Far, et al., JAMA. 2010 Jan 20;303(3):250-7.
  57. 57. Vitamin D
  58. 58. Vitamin D Richards, et al., Am J Clin Nutr. 2007 Nov;86(5):1420-5.
  59. 59. Attitude
  60. 60. The MONICA Northern Sweden Study Self Perceived Aging Nordfjäll et al., Scand J Public Health. 2008 Sep;36(7):744-52
  61. 61. The MONICA Northern Sweden Study Self Perceived Aging Nordfjäll et al., Scand J Public Health. 2008 Sep;36(7):744-52
  62. 62. The MONICA Northern Sweden Study Self Perceived Aging Nordfjäll et al., Scand J Public Health. 2008 Sep;36(7):744-52
  63. 63. Pessimism O’Donovan, et al., Brain Behav Immun. 2009 May;23(4):446-9.
  64. 64. Keeping Telomeres Long  Exercise  Anti-Oxidants  Omega 3’s  Vitamin D3  Don’t Smoke  Don’t be Obese  Reduce Stress  Reduce Depression  Reduce Pessimism  Be Happy!
  65. 65. Managing Telomere Length 1. Know the length of your telomeres 2. Decrease the rate of telomere shortening 3. Increase the length of the telomeres
  66. 66. Telomerase Telomere Telomerase
  67. 67. Sierra Sciences, LLC
  68. 68. ABC News Diane Sawyer
  69. 69. Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, Blasco MA. EMBO Mol Med. 2012 Aug;4(8):691-704. Epub 2012 May 15. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer.
  70. 70. Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, Blasco MA. EMBO Mol Med. 2012 Aug;4(8):691-704. Epub 2012 May 15. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer.
  71. 71. Searching for Telomerase Inducers
  72. 72. Reproductive Cells Produce Telomerase Telomerase GeneRegulatory Element
  73. 73. Telomerase GeneRegulatory Element The Gene is Repressed in All Other Cells
  74. 74. Sierra Sciences, LLC
  75. 75. 39 Families of Chemicals Identified Human Testing within 3 Years
  76. 76. Natural Products Already on the Market!
  77. 77. Clinical Studies
  78. 78. Study #1 Not Published
  79. 79. Study #2
  80. 80. Telomerase Induction In Vitro Chaps 100%Hela 5%Hela MRC5DMSO MRC5Media 0.01uM 0.1uM 1uM 10uM 100uM
  81. 81. Abundance of Short Telomeres Reduced (Harley, Liu, Blasco, Andrews, Briggs and Raffaele, Rejuvenation Research, 2010)
  82. 82. Clinical Study  Telomerase Induction  Short Telomeres Lengthened  CD28- T Cells  Neutrophils  Natural Killer Cells
  83. 83. Study #3 Completed, but Not Published Yet
  84. 84. Clinical Study  Naive T Cells  Blood Pressure  Skin Elasticity  Bone Density  Cholesterol  Homocysteine  Cognitive Function  Glucose Levels
  85. 85. Clinical Studies Underway
  86. 86. Study #4
  87. 87. Clinical Study  Faces, Hands, etc., Photographed  Short telomeres measured  Waist circumference  Body Mass Index (BMI)  Total Body Water (TBW)  Total Body Fat (TBF)  Oxidative Stress Panel  Routine Urinalysis
  88. 88. Clinical Study  CBC w/Diff  Thyroid panel including a Free T3  HSCRP (Highly sensitive C Reactive Protein)  Total and free Testosterone  Total Estrogen  Chem 20 including a lipid profile  IGF-1
  89. 89. Study #5
  90. 90. Clinical Study  Double Blind Placebo Controlled  Short Telomeres Measured
  91. 91. The War has Just Begun!
  92. 92. Recent Publications www.sierrasci.com/RecPubs.html
  93. 93. www.sierrasci.com/RecPubs.html
  94. 94. QuestionsForBill@yahoo.com Thank you!

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