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Experimenting on Experiments
Bringing Lean to Scientific Research

Brian M. Frezza
Emerald Therapeutics
Lean Startup 2013
...
Learn, Build, Measure in Life Science
Hypotheses
Ideas

ANALYSIS
LEARN

DESIGN
BUILD

LAB WORK
Data

Experiment
LAB WORKPr...
Moore’s Law

Intel and Dataquest reports (2002) Gordon E. Moore, “Our Revolution”

Eroom’s Law

Nature Rev. Drug Discovery...
Cost of Innovation
Startup Financing

Mean R&D Expenditures per Employee by Industry Sector
Costs of Instrumentation per L...
Modern Laboratory Research
Scientific Research “Product” Cycle
Design Experiment

Conduct Experiment

Analyze Data

Troubleshooting Time
Most Time Co...
Imagining Lean Research
• Lower Barriers to Entry
– Amortize the fixed costs
– Democratize access

• Faster Iteration
– Mi...
Traditional Laboratory Research
Symbolic Laboratory Research
frezza@emeraldtherapeutics.com
Founding Start-ups
• Tech Founders:
– Outsiders
– Aggressive visionaries
– Singular dedication

• Biotech Founders:
– Insi...
Supplier Ecosystems
• Tech World:
– Startup driven
– Open access
– Interconnecting

• Biotech World:
– Legacy corporations...
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Experimenting on Experiments--Bringing Lean Startup to Scientific Research by Brian Frezza

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Experimenting on Experiments--Bringing Lean Startup to Scientific Research by Brian Frezza

The Lean Startup Conference 2013
http://leanstartup.co/

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Experimenting on Experiments--Bringing Lean Startup to Scientific Research by Brian Frezza

  1. 1. Experimenting on Experiments Bringing Lean to Scientific Research Brian M. Frezza Emerald Therapeutics Lean Startup 2013 v0.92 (16:9)
  2. 2. Learn, Build, Measure in Life Science Hypotheses Ideas ANALYSIS LEARN DESIGN BUILD LAB WORK Data Experiment LAB WORKProduct LAB WORK LAB WORK MEASURE
  3. 3. Moore’s Law Intel and Dataquest reports (2002) Gordon E. Moore, “Our Revolution” Eroom’s Law Nature Rev. Drug Discovery (2012) 11, 191-200.
  4. 4. Cost of Innovation Startup Financing Mean R&D Expenditures per Employee by Industry Sector Costs of Instrumentation per Lab Single Purpose Minimal Complete $500k-$1M $1-3M >$10M $ (USD) Employee-1 Year-1 Dow Jones VentureSource, PWH Coopers / National Venture Capital Association, Thomson Reuters Self report survey, n=130 Scientists (2013) “The Impact of Innovation and the Role of Intellectual Property Rights on U.S. Productivity, Competitiveness, Jobs, Wages, and Exports” N.D. Pham, (2010) NDP Consulting, Washington DC
  5. 5. Modern Laboratory Research
  6. 6. Scientific Research “Product” Cycle Design Experiment Conduct Experiment Analyze Data Troubleshooting Time Most Time Consuming Activity: Conducting Experiments Equipment Access Problems Average Experiment Onboarding Time Acquire Equipment Onboard Experiment Gahh! No Yes Most popular workaround: Troubleshoot Experiment Personal Favor (73%) Self report survey, n=130 Scientists (2013)
  7. 7. Imagining Lean Research • Lower Barriers to Entry – Amortize the fixed costs – Democratize access • Faster Iteration – Minimize experiment onboarding times – Mitigate troubleshooting SNAFUs INNOVATE ON THE PROCESS OR DIE RETIRE
  8. 8. Traditional Laboratory Research
  9. 9. Symbolic Laboratory Research
  10. 10. frezza@emeraldtherapeutics.com
  11. 11. Founding Start-ups • Tech Founders: – Outsiders – Aggressive visionaries – Singular dedication • Biotech Founders: – Insiders – Legendary wisdom – Hedged approach
  12. 12. Supplier Ecosystems • Tech World: – Startup driven – Open access – Interconnecting • Biotech World: – Legacy corporations – Handshake business – Siloed technology stacks

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