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microbiologie

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microbiologie

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microbiologie

  1. 1. BACTERIOLOGIE GENERALA $I SPECIALA RAMONA MIIfAELA STOICISCU
  2. 2. CUPRINS Cllibld 1......,...............-................ IihdDc4 ir Mimbiolo3ie Dd. ntrie. crpiblul tr ..............,. .......... ..... .. .. Miorlorgdisq clrsifi@ ri ,macl.tui Molrolo3i. hafuixl.. shcnn elulDi tdai@ Clpibhl m......,............................... c4iblul N..............,..,,..,................ . ..........................,.....21 Iirologi. b'dieL cr.gt u g ntitia 5eilrI CoDdiliitc fzie n@ craraii Capiblul v........ .. .. ,....................... __ __ __.._.._... ...,....._..27 Mdrbolituul 6ddim, C&1. bio.himi€ rL rrDdu6ii d. *rsio &pitolul 4 .......... ...,--.'- ...''- .,...... ..................... 3l C.pibld,II ..... .......................... PeloBi., inf€.ri! b!d6mi. Fl@ s'pofi6 i Dht t€.efia R.r4i. djft Di@,aoim. $ eazdr Pibgmid. b€Gimr vinnq! (oroize, nultipliE ri invzivie, dc i adoroxine) crpiro1 vm.,..................-............., Mrosele d. qare dbrfdid.t. Srrei. lrffi,m. n6!art5e (bqift 0rme, ccld.le fumk 1' plGd dr &smM, M@is.l. de 3pift 306fie di, mj de bu 6upE iDuii4ii. D.6niFe + clsit@ i
  3. 3. .I 13 t3l B$terlologie gener.li C.pitolul I. Iltroduer. in mi.tobtologie D e btoric. M'mh,ologa 6k o Mrr ! 'trnkld brot%,e ,i r o ur6 a !tudrd, .iowemi$dn rje ff dll16iu Mr ob hm,r. d. vn,b, rbr a ocburu mu(dsdrmd. o dimdiui tuhsole, de o i'ul sjtuitq lo.ii nbm.$loi ll}). TonHrlpsme d'u lmba gEcr DlcB.n,c.btd -rup MT'!j"!"q" - mr, tu $udi'n mo.rotop.,. lMuii. m.hbohsutui. criail nJtipricinr smihil'.irii m'lruraeimetor h a.nllE ag6bto, 6.cr, ch.mo si bi.roEro, iddtififfi mr@gmhdd r Etstr td 0 ,edut. h sps d o orlhmut do. Sopd 6ml 6t Exibilida d. a infludla i onlroli icliuea nicmrymisdtr ,d4se ti ner0to36e NpB mului. ._. Yi:qd!s" @ alcriilihr. pr.clicl in nm@ dmenii, dlr ti in vials didiui. 6i'd urild nu nllmi p@alului nediel !j fortl.@nq ci btesn popni4ii. ImB vie de 6Dpus! dii 3 Esnui: . R*nul Potitu i@ orprind.: rlSe, furSi, proroe, haddii). &ali infdioei iDDlicli ln parolosia ma,i sur in moE mjorihc poride dr er4in d ESndui eiorl oclni ii / vimir. Rmuile ni@bioloeiri sur: . Mioloeia @ dudizi nDgii, . ,@irolos3 ff * 6 uTa de prdo@te si hernDqr mplirti ,n p,btogi mri.. BlGoloEa @ sod'd brh . vinelogia ce se mpa o shrtiut vi'leild D. e shdifl Mqobiologir . saiiDtn tu dodralt . MiEobiolocie rylicd!: - Asntultut. dkhre riimN:. cimtu nuhmF.or.erhk mmddo, . Al.hdrderms6e. rlmde lmobr.i d,iq atmmbr, - Enssie / M.diu (tiMDbutibili) Biol.hnologi€, 6r. o d. a +iinlei @ iptid Co.ti@ hddjun D@lebiologic pat! ob$n@ prodrlo untie in lmpii n diclln. MimrrDimel. au u bl 6ali,1 t tchnologja AIrN isnhiMd { a inSinm.i smtuc.. Bi*hnotq,0 ur izril_i { milloie cetut.t. mmb6. Eqele mimbide r' .'l]frete mmbr6c. tu rcr r pDduqia ElrrrlmDcn - Boli (dirElosticul bolitor, bltmratul / viqlera dc exoplu mtibiorie g pEvmiElm boli infeqi@e prin obgnda de v@inui) Nubele UM boli, de *dplu: onsdul, ! fql propB de Bft Hilo@tq ins: tudinl +iintific ,1 o,6tiolosi.i s{ {tftld Doi t ziu. L otichillte. arrcorgenrek ,pe dd dnr qgucr alati in dgqnplffi odm ,*io ciol&tu FllBh (r6.ens) (14?3t553) njt idM cn bolilel. infetio& u' hJMu. prin pmnne mfl. @ pd 6 tum* dud u $dird El tu;@ nmd. d. qifi lh. inE-u poftr e?ic. Sphh a t c m$B got ltil _ i,n t t!!, tn m Dp Mr,srow, tnuul@ lemsnJ d.r.lc.ln t.b3,nedtuti6trm r?l:€sR.dtt02? the7, &ce pr,mii Drti in Espin8@ ra.iel g@l,ci spobe.
  4. 4. M'(rmrcMimele au fod &s..p6ib .rmsm - I590 ri ,q. vd t,e*aho.lr , 1630). Irorr d. A. Lfl&iml Ge. X!T). o ddi o dfldh Fmctn mcGo,D< (2. Prir.le dcsdi al. rld' mjMp,e :u for 1 ntany vn kw nhkk lr 612-1 n!) Igw s.'mJwtu. obqocid isu r ctm,e Alts- oB XJatohu, d,i ,ru, a tuda do'oss ti prfil4 B EIF puryrsie A ftar LEaE diDft irrda tm.ito ., Ehl@ n @cp&6 l. n+ft 3 b.dntor ir , {ndor or ts -.n,ont ff m@ dr El qize{2i r hpnl.i tmele @ nftur msl.tera u riccruh mtr tu. de eL. !i m(ft dei.et. ltr n,sr@ o medcii. (tue,rne dts.ari despR ..pdc e !dsni*' bur@ dio d' et. d. &bps. de cim maron. + ,6ErJlMk; noJ.fllo s fldhdlo,. p€nrut. tums d. rs pGdu moni su b.hsq k hdk 5hrroE. D fful na$mr- Poh ,trelgrlE l):tlm hr rfar .i. .t ,a nlsu & rpite a mtuilor @ bldrm. d. "Jc- + sa@ nfuokto rarsu d. dtiqpnel Mordib,s jd. &matrc pr b& c. ;stm rur *lips't igen, r.Mi'mr Lte id ignm. rdnhul itu bn, tuicpcr. rrrmo, de corc.did ti fo&r sa e oue in Uns&ir. smn tv.is d, inrigar de indihl. rfB,ojlrilo di. frdjctua si 16r sis ob3bomld d. mMr d, tlJl@ d.nuhdL, e ,. rninrli ,E!.nsbrti. rE.u I'ul dr holi lln{)e hdc f,or dr s.Dtme ? sApl.,nar @ $r.u. posb. dopi ce ftlK b.tu d. srd'fl pdi€,u smfia! d @ ,ix€phb h !61,a dupa DM6 h i. ;nd t urpdtu,d.putEr,trsSmmdorhiosphet:el@!nI pd'.iilui sffdncis r* ordhr p6m'et. pro..dstq on6ore t us Pdtu ( r322.'3c.r dm";b^ ;p6,,-bl r smr -s*-r.in bot on,n bdrdoE! rr po, fi dml pn- fiabae. .tu mp! d..n nu 6c airr mnufrn o,6n(sinap Dcrcor8mtsmclo r Fr Phdr,lrfct pmut r.d,u d. onM& bdonul b!fuioui.. folonr r 4dz. rEodue rim rtud, d. ske pdn cl]drj hEodc Mus d. a.Dne lnr.laer E Mod, de lfuputm , otdetor, fara r te o@in. @ ?6rd dmBft,z. .r fe"motrls 6c prodl5t d. tedl. drr d,ojd,r de b.r., d.cr d. m@8mis. ot,be prinr.le vlmiri ,mpoEw ah.i. tuutuj. hdffi prto d. glin, sBFne r.s'ure {mlnin' .rtMnid$ !. , psimqr.to. ptr b@t. 'mhlosi.i. ddoEtud d nimsulmtq in r&ri d. tlptul c€ p^dK tr.qr,, ddmin u dsp1bs inu Dmt @ pd.jui msujsmul
  5. 5. Rohql Kct 03a3-rol0) intodE notill 6lm! o netodi d. dmi@ l, niftrop, idldue pr,ml nediu d. c rurt eld. pah .lndwa ba.ldiil6- Drl.rza bmld lMului. vihndJ holdic F bdlul bb{u16 9i li.,brleslr su/,lrl,b inh GE b6Mr n botrl. E Erve lllE'rl. hdm tobqql@ b 1q05. o6Fn. prmd r,loh€l .I6.Dh Uslq', u ctnurg dSlt, a fdt ,rimul @ a sllidr Dmipiil. de ,!€psie ale lui ?altqn shili@ iNtuokulu !i a pdledt lo, ulili@ &idrlui fenic e dir.pric, ndod. de s.psie id pb1€1i. drilq, impoti!. cdtadn rii ni@6i@ Dis Mcinilov (1345-1915) deopqt pmdul de faS@irdz! d llml irndn tor, aoelode & apie mriniftbiui. Prinq&Fanill Nob.l patuM.dioin!, id 1903 kdisl4 Dansh tI).t,E) (187111939) de6rqr. mrisEul $ oti6ipii li 1399, I390. Edion (135+l cl5) Eope Drinul modol d @!.i Ddgd !tt@rP. ?a!l Erli.h .inldi@d Solvein, pl'm Pat in cldniordpi., deie artoijMftna fltutu od.b,ka")- A fost lolml r! pdinui Nob.l, it 1903, i6pmn o nir AleMdd Fdirs (1331-195s) d6.oDdl Daicilim FodNi in culhdle de nu@8,i, i" 1940, nditr& doi bio.hini$i dSlai, E BI Bori! Hanlcy, ?, u mdic au&lm Hosdd s rE fld.y. iu Dld + ric VmbiFio ri Rob6 Gollo desc.p.r6 viNl 'Bu,rd.6.i6{ei
  6. 6. cotrtibqil rohin$d b dooitua ,r.oblolosi.i vid6 Bab6 {1354 1926) 6t fdd.hl rolii mr'.gti d. ni@biologie A l'e o P,(d I' Peis ri a publid, inpitud d vi@ c.njl, prind mu'r de mimbiotosi. in 1335, lu@a inpftun! @ Robd rs.6, ie, l' 1337, d*ire pnmul p'Dfar de mromi. psbloglci ti bo.t6iolos. di' Bu.urtfti. Mll@ giinli6d a lui Blh€r cupind. Dde lo0o d. publiotji Ddopaa mi mitugei q inclsiv o noui .las5 nmii{ ,cr"sia 11900)i @Dusculj, tudici BiSer-lndl incluiil. nlie ti @lul.lc iflo& ofPa'llii Blb€r N.d; iNdlaz-r noi rr@E d iNtim6tr pi.pad va@n'll etirabic ri sdd miidin c. E.r. ftn&ml Iistiohiui dc Pablosie vidtr tubB, din YidN Bob?.t 1135+1926 Ion cebruino (1363193,1) 6rdi.ra h Pdi. $, ln lg0l, dhnc plofs d. n.drrd Rpei[mEli. h kd l@ d. V.dicin Bu.e$i Mtra @hbJri luj Im cmcuno a br d.tul@ n.&cin. FNan. rn RonM.' l_ lrb.l:tml s pr.!m v@intil. dtiofilmic, mriholdi.j aritfio - 6liporati6c. htodu in R@mia reci'ul BCG. &r. fon&lool Institublui d. Mi@bioL'€rq Pr4ziblosr. ri lpidmioloaie din Buurcfd (ocM tnsiiotul de etui !i vmiMi ,Dr. ion cokujm"). und. e o61,n saui ri vuioui { e lc divielel u,v6ibrn. Ion Conb.uitu { I A6a- I 93 4)
  7. 7. C.onolul ll: Ml.roots.rhme, clrrllicore ti roDer'hturn Morfoloqi. boct.rirrd sructura cldei b"rcnetr' rr, bol'lo' 'n eq,B. muc * iM&@' in : !,'pr de ol8elm' hMi' m'sr bo D@'n lNbbmr hclmin{i) prim' --i;;'l.; : .+a,,r,' p",*ol,. rp-rq..ro*,' nis' j pFraek *^ -uaosi,qo@,*n t-',b Lrm." r 'n'*d: rrglulffsl - i..p*r,. iim oe-'.ac 'mmlM. dr pud dr vedm n'd'el alNi6@ Nmdolstq Ido i6@ a!d. hrecd@, * dsfii in mcrurssom' !' orEe'$e n,msop'r n''-i.--r-i" * a*** .b a.lul d. %b'rrbb il qhrul i "*;;;i:.;';'*'-. -'erureq e'ur. d. trp pomol ru -eajd -ii"*. oi--"^t. i- *, a. *uul m'.lmlo'. d' obid 0'<_r m'mD i#,,''a,"-.i* ,-"* @ miffisdis' 1ore'un' eruk de up *-iL -.*i 'w."o.^ld Erul<lq p'Nrd i Dimsrerd E,d' ripdmd v."L"ii " -.,i -. ,o*t. inralo@ I'Nk dc rdahoLm propiu Mr "jii.* ,i ,iJi:; "'''",i-' v*r. onnn AoN er atu{ 6rd obr's'@nu ;*i.a"* e,,r.. *' tu t,-u drk uu ri wiu.
  8. 8. viMiL & h S.&rl dibdiui c,4riM ln!! 20300 i@dii, iE Drimn b ju d.5 M.ti. rtroEi d r@Lie itf.qi@ S. Yizliu nlmi limimoFl O'A.d.D.L Da$dDbc 5, P@itii rrn@rXi & bdrz&q da@ic !i lEttri4i $ vi@i MIb4 ln 6tr1i. & $-i., dc h.3!n turiMi h DdL l5 E ti. Difiar.te bri. ehrot 6rioL !i Dedioiq - In6m4ir codinon b ADN - Acd-li Miw {te sinkl ! pr*iidd - ll€li studd { nnqic r Mbt&i.iiodaunE - S|doir nEF d.radae Nm.rdF d.lrdqM h{r.aIror unilda rqmid nDih.rdrlr d. rD.d!, sr* . @ o l,ld din.rblr4ir wi !t E ! @@Gdo6 ad. XrSuih LrMi€ n4aim eaului ut nlmt,o.it .l.htr NdEEI Bt &idl.*. bi@iulr.,{od", d Ddm lnn .4ibl( m.l &,r!-i." o'dDd qr,er.&Iq' (tdon!fi !,,.16") ,aI,Ji,rnt-w@ w@, ".Hc) SDod, Tr.tonepahn@ 6
  9. 9. M8I. *cn br.ldim ou fsr suBiviaE F bu stuii dilai@ ln ..r.dpu! pr bu c€d6rc'lo bltue 'n bldlpu( F bu qsibhdti, iirie h rLoth[n. Ad {Hieam e uptud dhid 9r ep'ddioloaid. Tdptr. t€eisl * r.rrdn de h,eii di, '&otr 3pai., imlata inb_u dbitmonat ditrt-u ,lmil pdu prblogie colo r. tut ,.pl?6l'L & 6aeil .1. aEl@ti sr@n, * ru @r I' e.lad le, p. o plu @ r.diu slid d. dlMl dirts-u lMI' f@de tda d. b!oL'ij, nmie @d! fo rM d? 6lm, cEU (olo.y fomins uiE). clo e o mull!. d. b!!ti' ff ! puld dr di$zilm ma rtrur elul. s!l.m& clltlt.E Ednminult sieisn d. claif@ brar. p.: . ci*rerr. d. dlcioi.trhh: c.ld4. cM lmp6i. h'diiL ln betqii Glm mgitiv. (tulo@ otie) + bl* G@ pdftiYe (cdo@ $old). colmtia zi.hl Nels cl4i6d boitriil. in rid dmlo si$6L ti ffii3ld Fmi dio@iuH (d. ddinul nidmedd), di,Dozilio (atm) teiiltr poi fi *iddti& @ ojdEd Diderdui @.ic e Mr tundmmEle . roonr rluBin & bsndit: beili, (uii $h 6m. d. vnrlji: vib'imi) . f(m, spir.li6 Anii {+iDcnd., ItpiorpiE) . rome in6.dim mt.ili d,*ffim N{orlotod. b@drl kr m;dali 66iu d. du'6@ 0 b,@iils, dr a6c loe wi! tr M+' d. mdiriil. d. u,r, s vrlsl culEii o.ror* .-i.o*oo 4ei .lr@ ctud bM'le M @lde din p'!dE Fbloglo l@iide i"inlc de hddd oltbidic, dtttda hrcldidi I d le p' D'dii
  10. 10. pmp,e d. de-^ottu, h rdpsduri, pH !i DidibE opiiD4 a0ac in pftood! de o€irdc l, .ferlcr: mi: ll),m p.ar fi Dster siadd, * Jr,zrlom, oreidata a c.pcr. $ofi., *. step@uil prem,rq foma de ;nichi (..bo,b. tu afeJ,) .x !.r.-crmm'nsar !igonM i Au d.meht a.,nDr,tury0e.,u r. DivMcm b&r rld pr hr m s pM6ul plblost r.relci prn..d.n1t.!o de sm nh. d.;s dp€rdtTofttoe, * d,udi F.ntu, PhNrudr d. dltrhr. n dup, d,%m., dq. de, fin.totrc. vr.nd.9.n,lo t. srfel q h n'm*oo. E ho'.ut . otud. pum lbsm a bs. r6i ,;b,e s- in pdEhi, diplo d..xml|! fncm(rmri eu r.isdile (rriin aliDih {iDi cdr. doi) - rehde, dnp6 diviziua a doun ptaui p.rp€rliolft . luM.d.qn-n! drpr ptmu por:l.te. d. amptu fr.ptu.. (iornir.dnr 66 dJpi plmM no.aLtrk. d.nmdu qaitMJ, ,. Fornl d. bdo..|: b!.ili . dtmtur flstudnrl,.ne m'nr h& mf ,d. ,ptuMsuv Gto mr d r cd - s oFE dRpk (bao tN 4zliz, tr) su mbrk .B,c'lidrp.'{uu.or jn.ubsh.tuma3M.vd..,,4,,okE,,ltrsurbd.I
  11. 11. s.6i. $6 fmi d. r4!l[)r in lmui ( frettobacili), - $b lims lndlor ctin€t+, icotTsld.lim), nt q.!ho.t!hrn) - aB d.ff 'helJ,uorDsilitomeLre l,r.xe,x. ,pr (. ,,ffi i/ t y, I,,, l'I -* Dsporla r sp6nn blcililor din I -.0..C-1sq f, 3. Bredll. N lorin lpn'l.d t s0nl! idsdlr (s,rfilr,oP.d. nPdl . ."'.*t ",r" """".-*;.,.upfldefl$'b'' r m"bre'' @d'e dmpd l! i--"i -_o.a i.i,**r *"--,a ''e m6l'M rod' md! o b.ciilo_ r-r.." r,,-.."r,//'?,. r.,d-P.l ., "&,P .**$
  12. 12. 4. Ceob.dn: 'u fomll i6.diri1,1ntu @i i 6aili,, d. Eo.d.t tL. Bmlh 3- A.d.oBhd: d btuii 6 r@ad filmar.lmsi, g& s asEni'E o 6. MloDlan L: u.tu 'sdlfu B ! elodalt beii, d.t Du.! Dd.L ..Llr; ad llm qplid fipd d Mytopl.ml. ,ot eiB $b f@ vai.bil. (mdar.,rraM,@r) ii p€inir o be nisilit& ,. Ioml L, ur fdnc nodifieL .L b0oi6ijltr, e o o)]ginp a wdiiiiltr trflvoftbil. dc sElh ti r !re.i{.i difdiLld irb.lr'l. dir trEdiq qE a4idui sr4i pqdlui eld6, h riDpul su tupn dri@r ,leia. sur hrfui sfsiE a pad. inmpla iorD.L "L" sr fm. ddiwL din .€lde hei* (@i, h.cili) ti $ fmar-I sb a4illu mmid rtibioU@ (Daisiltu) &pE ps&lui elule bacisid.
  13. 13. CrPiiolut IIL Sttu(hm celul€i btctcri'n' Fd de c.ld.,e More. d rip o. oIse,E rpod dm prtr de v'd* lEusnl . **-.L*,'. "- " .'*.* qmriuili @ sdPk r, sr elure & ti, pllxJid PMint doui dPU de tomlrui lEudMr' t otlebdl (!.tEn.!r., orrdie) . otd.lo roik AErk nd6im - ""ddri r eh,v'lai nudd) . E.nb rdtoDhtudd ' p.reE eluLr (; .icanlLe. ,uE pl6ru F fornd' L' dr.' trmbllS.lod) . apudoet sui. tDeii batui@ SEucluiile obllg.to'n !l. "hLl Dtcl'ri'ne I PrnkL eld!' dr liffi *rdu a rl'le boMioq M mp63 Dmb ' -,#,...'ii,;:"ii; i;;'tu -*.4 p'i*p"r 6c o p,md mri trdir d oditu.*"*i#i."r'-u ." - t*porims o:acmrqra Gtor'q ostol di"r-h o)':)DlMr di.nL + uul FptdL.*'"' i'?5t"j"lr rp,ir;-a'd, Bk "*biu dr ohe rnre p*ar'r'' rn @ llEtrdl N{..rvl.Bl@z,lm3 @ Eid'll N_tcd}l m@c' '-' ;-;;ffi;i;" ,.r*@ d' urtrri rdpetdrq 5sk d"od,, D,^c' * - n "i-i. r* a. ai.a rrrBd o stu'n'i bidBtumdl li hdal Glm ::#,l; #;",..!,''"ff;d,,htu Edn@$trdd' r' bdaii ctu p'ziri*)' *" i,.*i. .1* r. ^*',r. cru F*rn d mirffi. d pori mci' m o *,,,'jil*ii.fi ""i. i,i-;;.', ai*r- -'p'-' rior rro murE rdn --aN a. D"!aaogU".,l al}ao'a) f coDlotrdn tuom
  14. 14. . pEt ln. asirb !€dolui 6lde pde,n A, ors u hs0l! (ump[g frdo,) ta sbphlroM aM, v.nin Nt, li &E b.@ D{sa6 (sr nj ldeim. k $btur, e'!ieti. d. fusirui) . l, ml. b,tur Cftr pobv. tdr dad! ut@ba.t?l&. tud4 paa.t? mFft o dhk rmFn$ri d. ttert !.u er.n. b Jkl. rd. fr.ptlry, rad.te ontift mulc Bluide P.ftl...loh r, brertit Cru me.dr. * or tr6lr tl-B m,, de * mli lmllo db pu( d. vd* *Eral. CflFn. nu,, dtu putin p€pddoSti F N ortlI. rri r.i@ici Erst! eDair de o srr&nr5 cdpl*i nmjra ed,.!m cn mt Mdb,;r a6a Hb dciM$ din lipoprorein. ii Uporolizatddq ar$!E d. D€Dridodiq. "-eel. @1u!@ to bacm ! anah paln-. na Fcfdld..l,llJll ilr_ :;j+nr 7i!*;:,,;n:{a;}'j, :r.r i l ehnt ad bd.wiilc Gtd negdir. nnA lrra Iw!,I. Ddelui elulc . cofrl fdni 5sd6iit8, dlbir! riqidiltii 3.L . B0id! mdin (6i3rrt Dddij mdi.i) . Polsli. impobw oC6iun 6zic a chjnie . P€irA d.rrei p.nd keriofigi (vi@i sle ba.taijtc) !i be0ricift . kaidri dis@ & rupiqi (nuotie anisaici) . Pali.ipi h p,!el. dc crel@ i divizim etn{ri . Mmbrtu qld.i a h.fuiilf Ge egrnv. 6rirc diFul . R.rreiD{ {nia de & i . S.diul sinceld dc tulorr p6r! suhdheL Ntritir do*t* *@n .*rcto.lo (fm. + drprDsul L diferiL odod€ d. 'El-ai nn nrnmnn n nn n nen nnra r"r"5,,[- -llluullJllllluauuuuluuuuu l@ @itu 9i mtibidi€ (E h.rmjElc Paisnino, nff 80fi00s
  15. 15. color.li p.ntn p.dl. ..ruhr f,c olor.l. uzudi in t@iolosi. Darorit tutuii dirdie 3 p€reklui elulE, a{. I;sptrul dil.mfid h olmlo Cns patu b'c16il. G@ p.zirive !i el. Gffi Bdm'|.lff porut.,ptr ormE r virld bdmrle crm o.gati!..in m.u. Utll2,E. pEcdct r .olorll.l cEm: t oitu hMor Gdibilibt difdiln I3 bdaiotie) 2, Coloqn zcblNcl*. A.tdor.d .trt b'd.rilhr urcle tda G@ pozitve (ntroDd.r.nq xdrdr) @n1in i' 6nponnl. F{dr mdk Lpid.. au sB, t .tM,r0!odu s(@ Pd.'ut A.* l. @nf.r, si s4'b'l'dedtuii l, uribiorie. aolmn! Znhl.N..Ld D.rm,te djftrariaB at:er btuii dura ropricrda ld de rrrci@le€indt Beeiil. eid}@iddc rine. ol(fu in squ €1. &ido_ Eisie & dolo€7-t, .poi s. rdlcd-t 1n olbab. sub DIHF dd subscnF rllzam. mbbloba p.pridod'6u'lde fi dciomr. - be'ma -qpbd{r" dr du pr*idiio{mtre ndqr '{r0 M, ln med'n ehiLbrd @ric, por fr ot4nui. r{me pdicde: . Pr.bDldl - Ep€i n o sll]fun sf ici, br.lnaL lip6ne de ,6do ddd El 6G ohtird din 5afrii Gr r sl|m.lrol . .htu; 6h, {u ltrlulari, psrlsl hp$$ de F* c€lul&. E9r' o br;. L _, hF-lA dc p.Dr'dog,'@ a ln@nruru de mdhlm dhi $ mmbBm . s{i-+ * uczint - *t.r 'n p.DLdosll shl rmr. rorm L rdGopsit l Bdtutul Lisi.) ue r pd tm, qb rn@F mbb'deld bdltue chr irdrbiG fti dc ve,4i (fut6 ti siddre Ii b€ld'tuhc Pot 6 smibil' $u II. M.mbdb. dropb![iLl se 3ioe,i inft ;lopbsi ti DBd.,e eua ti &. o tuiJti tildidi, ftdol,ud,c{ s'lui o r uidldE 'mblm eluls. sr ordsr r de u tutui 6n$;d. ,oaa. 0-id", fiind fmruti din doui rintu d. holol. ,orfo' ddle' &?r 6 tuiil9h ntuofobt faF in fiti; id@ .1. s Fs* mlonc pmt ie s]oh'ne d' difdiE l(oziol 6E o tui dinmic4 nuidl, hpor&i ti d6ib a ?oi.ir'le tur a!!rc d. mmpuno(h hpldE. rin in,@qtru pd@ + hldbfob. er re psntr ml,@ k rrn6 ndbmd s. Mddriaza h niw@io .ltui.i Roluil. mnbrrei M nuUple fu4idrir'{t @: r. P.'m*rllt k '.ldht rtunbin d. molirl.lnft el'lls bddian!-r m!di4 pi1 a' hu. eu{ (cl, s hsDd dr Gl@d.. ,l.lmEin. s'u. poraru I lndeph',' mr de b&.d lmohc! (tm4hlhM do, p6h 'pi {i mlml. prorie mo i' 2 slrebrl & tuFt d. .konl i u.ri. hotrg;.r uE nlul niioenilnils din el'l]ele @d'. lr ad vel { Fau, ll s nrhe@ oersr e.luld, e,b fomi d. A'I?) M btui..{dei 6n!inc: ll
  16. 16. - @iGlleDert limluiEsli tr (cib@Di {re amptu cito.moridlz) - ire inpli@ in 3ir@ forfolipidrrd ti r F.dutild atulnld - dift imllao& nr r.pli@ ADN-ului t0 qel ditiziun cchlE { P.dldpa r. dvtd@ elllt{ l! IooG sannui dc r.p.re tuft end.le 6i€. M@dr uI iF{ai Ii @ploi. ,1. 'lmblfui {rioDlMdie id cir.plaml E .ps I' liolEiiL G@ ruiiw $ I' u.l. 6rd-ii Gah E3divq M@n Ddicipi h ftu Erdui d. diviziu., Mo6t|u ciroplMicr sb ffi ldl po,E! d.d,&tur! (dd.r8ali) ti mtliori€ (FliDnin. ri oliBicirc). Ix. ctioDrM d. u 3irra 6loid.l, dcrbil din 30e/o lIa ti Dolelne ni.i: dddd. dgai* Mdor. di! hd,bolimul b'cio dcluiui. 'm anorgoa. ffi. ARN m6e6, AnN & tmsporr, @i@izi, aucl@idul, plamld.. Ea. n@pdihar.ld $ lipw orgmil.l. elul& (m F&d! didl odoplMrriq Djh.odrii. 3pd col8i). cnopl&m, 6re 6r gMJrs ri pueoic b@flI, ddqiu @ntinudui Gs, itr .lbozorl (20.000 pa cddl) !i ^RN. sd !1fui mDlq., al.atriE din mi nulb mlEul. de ArN ti Foroj'. u, ribom.n dcltoit di, &{a subuillti: d ei ]r@ e mncie'1 dc !.dilMr@ 50 uillti svqlbse; i ur mj mjci' d @fidd d. 30 billli sv.d6ag- Pito@ii Ml @rrul 3itrl*i p.or.i6. Sint@I. po&i& d codit@ro d. elE A.DN-ul bidaie, ie infomrli! Br. elirll pc ARN{n D6laF, id, iltroilAl@lio, ARN d. tii6pon .dE h nivd nbmn minMizii cnt ptl zhi s@atei cod,rq Axx-ul iibdmd FniciDt !r 6inb molold D.skic ahdud. u frslidrl. rt. oduLi. . alt tutui dbDl.lfudo: h.ro,fl a tuid & wd p6fu nd.boli$ul elul4 de ddplu: indun d polifciti (dpu ii D€r.@oldoi B.b.r-Erd, lmullii d. hlutin!) Ia b&ild dinaic si iftndi o dimF I' o16ob0cr6ji Incluii oitopLE iiEME Nu por.di nobrat NcLrr, 6ind ftdodit h oiioDlasnl clmmul uic bfrid, e c.dind io6mrli! gmcid, En Msiituir din ADN bi(fu cidnr. ADN 610 Edilr b
  17. 17. -lXX i gnrsine. !i.lm bucli eb qoizonffii lv (k _D6lnd d@ la [u4n] dinj€i ldivi6ea @lulo .ffqati@ clulei, r.P,il]3ru Pr.9nc .b) bipGpidna. sub &nu@ ADN_srMi ti badqii). P. ADN s@t nnt imc & sinrzi (l'1x6ele d. siniza, cr.lba, nut,plir.a, cMomul se replici ln @lDla in d.l@. Fo Drcsrrim divinuii c€llle.' 1. .,-1"*, ..lul.i b,G6. m F e'$ molmre r'.' d. ADN *..-;r. q,--u' a" t--rd.. op,b,[ d. "!.d *,-" dd*'mr,.rb; lkk@l;'e nelul'r' 6'4' d! - ", -rJ. *.*,,r. ,^a*i'a-d dc s mmoanru' rrb' re!Lu'i, inr o bdme f.r -u,i-, **ar o * ., ..lnDle sle r.i u@tr. pl'f,idt Ur.'. ph'md. por F flsEld.l. odi6ci i0 So.'at ffic de patosdidc Tip[i de plMidcl . Plsmi&le R ur plMid. € 6nlin go. d. s ml.i la mbbio@. . radoni cot onlin S6. e codificr p,olueg d€ toxin. alretulN Orldcinc @ltcine) in sF€ial Ia bddii C,m mg'tiv. inbtinde, roxinc @ ir'niba ale b&d6'i ,re ud speii difab eu chitr are eleiEi sp{,t . Fdml r (de ftdilibt ) e s iNai p. clmoznur bd'ie i rrvdzEz' ndhh l],6oli a ]Mb,'tuild (sinlmDililo F). Plmd,' ubl,-e @ "do.i in insindia smdici {!@ e .odi6d mmi' poie1re -k M! abere de DlMide bddin. d DnJripli@ mpidi, 6d.l lnqi explei! lor 6ie . rn relmlosii dc ADNjffbinmr . sinlea d. *obxile, ! Ent - prodnH* mrmtoxi,.i . Ery ptudllEs hdolirmi stuctuil. fe'nbriv. (emq iMnrdh) .lc b.cr.niior s*' t*n*i "p-'a,o'r *.'n"r p6'flo. o ml b prcpul@ 'elule toeoe r l{smohe, sE slN d. htui (Lh6oEis) s-i r",i.u,* r"n* *.'u"r mbtl. u. d. rsur. 'ptu ', bsli {J bnou' rld o lusme nd re deir oD baddim. m--..r- --* - mmm li@' d. Dd()@or. lr bd6'' do'lc F6nd...l'm 'll,!.i.r'e' .ir s13 e rdrsn H fl'selu'' 6nd dplbile 'i ,krff ,id.a de u[@' srto in ts.iie dendn fli snib !i dc qez@ reiD s d.snu Di hulLripun: . .trLhq Iiti cili (badaii ibobile) . mnoti.ha.u cjl uic.la uul dine Doli . Iofod.b.,cilimDltipli(minmcni),ltuddinft poli . .rnti.h.. cudemcil loobiiPoli . erirrl.he.!udl,nuliolr n rmlel'na 6dsihe hq.J, -,,r**ir, a,i "ub-x' nm'G n,sdnc . sd p6 flmo nm'ble' Por 6 *idatali pnn ni.l1epia.l6tui.n:
  18. 18. e--/.t,,-. B C./--r1"-- D FLsd iorgie bim&opie dtui.r Sdr tu m npte &@ d$rq ttMrlq ne . (N ru rct t lomlj.,, Dor dis & la k{r Do6ila cil F l{ et imb .). Evi{rd{ic plt c mc!$opr eltucI Rg"_.r hg" 1. eegdb., Nr"d 6sr Fccr DrrEr. o iD4i. disai.a {.bili@ de , iDde tu ib diqr, rFc-,. Apf ei rlB htt iajiLordnesrriw (Ei*n,&.dM, deot€.tqi). Di! p.lrd d. !rd-. 6rqio.l, M dc doul rire. r Prx @.1 ('lfuio) . 6! mr c.di6c.E Mj.t qi & ol l! dac h llllJfuiL elulE F.e Au digi6 fi, Dohut cdDhr F s arind ti, EEel. c.htn.
  19. 19. Pilji s! nrtljile rEIlaU.Uld..oIiugm).d@d6@ljd.plM,d.-s,fulinb i-'li'J,i,i-i.--,i;I,i..,a", i"R ;ffi' d' *r'r" d""* n "-*bd' p"" Elfrdul de 6iw. -" 1-.. -'*J L'r,r- * -:,ss a edd {iotr@'' * n.*i o 5r Ein ff -,-,i.:i";;. ;',. ''*,*' *iur; l.*red' d ssdd "'pa'r p opn@ no 11 r-Ii::"5#,';;;;;';.,i-,*''"**p-,,*' t* -*"u l. C.Dtox R6'd6mrd4Ln dhtl ffbffiL i-ilH*i"., ilii-i.* "*,; ' "sMIj 'r medLr Mrursr d' EP sr bsdmiror (d. .xdplu, in @rsdsm) 6;-iniE! medraf dc Pili
  20. 20. . Cqsl! ida'M (!* 02rb), vizihila l' @o!d oplio . M6ocs.ul., d.l.oi,l h oia..c.oul cl*6; ! C.rqL nq{rbnr (di!r., Eli6€lix), o i{6 L* & fbE poliz.hiidio., c din@d id idiL rtu e ai&ai.zl Dj@.c(Dic Adgrd 6d@ bionh.r6 b.@iaq r.lrhf,h ir.ei d. 6luL t cdim ln3lo6d. tdtu Eci@ d. lolinai & digi* b..Lri61 @ Foi. 0d6 h Dpiftl. ir.rt (adplu L .d.r., aioddor c&dii., adolrorE , md. d. imbc. .io) s l6$ri vn. S.aidati.,hmiMp( otricFftdnl6ldonhfiud.ndilaoGd, E E tdq @lo!l h jrul 6loki. s. lor ldlia ol6$i rp@i.1. parru aiddE@ 6 (d tor & cti!, s Fnr leE & @ne r c4.uLi @ rjded &d6pi6 !d< (o6.46ur{i} Er. E'alr h: pndJ.[leci (Sr!p@ ,@ntn ), Ea.-ophrlls, xL6ti.llr. ikis ena wnnginni', cbfiann p.,JnnsN _ . hDl.did d6i6a b6eiq . B.icl & pm..biliirGpatu rubrt rF tord.. (dibidd.g i@i Dot tid) . B.ica ',or.6e fiF d. firiai u6A64o'i @@Id6l fuEiL) . n!o$r otflre.ihr . dEe L 'lo.piorii tu nljld$d . i.tiu divi.ra b!.idioidl r ddaulni @plaMt d !.Ib 6dd Eici . Eprai.rl brrEi.l d.Edrt cdulr . .d.en8.oid(@dgouli,cS. r) R.r@idi fqD. & erddd ! heiik n m.tiln]. Dhwrb . dn E dio, o dd! ddrd. heiilor, h @ d s riftdz.d FoLiD. R.rcdon o !.$,tial. d. rtai. n e dilt l! itdi6@ b!.ldiild. c! ljuhl dc!.cqdui .Lit dic s pod. d@i. lllll.d @d.d . r...n ., t @ dr.ml dema pita.@ b sritua ti Ir Dotim ddlnffii h qd$j Efrrmb q 6m. Esdivr. teid nEh f6m & ebiaE (4.r) prnr DtEul & |,o l-e 4m&{.d Ed. &.L4d n' +.cii d. 6oF MiriE s m&E c6rq.bil. .L n dDlu 6rd. Sbrlrt .Fr.cr.zl {dud. 3672 @) Srdiul I . s f{Ml filmabl rirl, @pE dio ADN.
  21. 21. sbd'tn tr - divi2@ sibeid t citElm.i p'lnt-u &p! fom@ pBPorulul lm MMe s filmmr d. AI,N. Mobmr cibpl,sdd lnsloba, prBr'ruI' s;ul ID . lDooblE @ld{ ! pdDonnu. d er. lmd d. ) Bdhe sodiul Iv - fo]rr)!e corhulot d. Fptrdoslr.r lnft el. 2 ndb6c stdiile v-vl - r@sg tukn ;m&t . b eiq i DslUIn@ srmlui unorj $ iomer uo int.lE qh tuDl'mmE. .r6portu. sudrul U - srul mtu d. el'bd. id ".j,.r'I]Mt'. deftga 4 I'ropd.ddlo .Ponnd: ! coniNi s.nnl &.Pd libai . cdrinnr De (Drn! h 109, in dip,@li'd d€ c.lou . Raind la h@tui $ pH *tnq d6i.n , ,!dia!r, rgali chiD'ci ri 6zici i' *ditii fo;hih, tDann s@i"dr, domtildt_s folm v.seL!!d (fda ie@nli 6r. ,@r epcbild s! se dultiplie Si s! pr.dDci 6oila). I ,-.-:l-@ w 3l 'm&--r_6 cr ddDle & bdfl !@l,k .- mpotup r pdolog' m'drdl' goul aaalla o olt.re! s t?%) $ FiaJ.to:ham'. - bar c bo t't'C' P?ftirywl - --iJ J-*."i."*it.. G,e mii nm d..d dmemn o*!@ 'r dds Ldi6 ftr'ri elulei ve 6 rddinola q vedr.l. de: . rleE 6in0l, rrlmr dc bdr d. uJlnta t t lotud ua t.m; . rr.@ $bhi.a]l (fomd iL ncnar rr.i,a eza
  22. 22. C Beii.h.gin adeiFdtud M.bdcl. d. Giti^ F! d & porihl@ pranld nnpmitd +ool&. lm Frlru,ce, de inHotd d. r!rp, .& fl Dwld bp6tu1i s- rd.p&; E m@dr d. mtda @iriz&ii e l@ o tutpli !{.dtftdr Buiia' nMp tl8
  23. 23. C.pitolul lV. flzioloCe b.ct tl.!t. Cretl.E. !t nuHd. b.ct ri. . CondlSI. Iid.e ..e3r. .ettcdt b.ctslo. I.Crtt E. brbrlEt (6r@ bMi.na d. o 6!th.. Mrrdu de bdsii. nu o cEnm d lLn6,s, a elul.i bd6m. Divin6@ c€lului mep. c.itrd s.i@ lfutuoCd elulN 'tjn!. o n0sn citid. Ba.iaiil. E divid Dm ezipuie, 6i. o divi,ue 3iipl6 Rolic,E laDM.rird i o1rmdulo d. Eddr & fmlg <porlu {t' dtdim ;i d. w elul.lo 6s ldw, dc su mr rult dr%m c{,r@w, TGDd ,@ rntu o d,n! "i s divida. dei dlbl.B populaliei mi@himq * ndd.'nMI DE GENEMTIE l, bdm . o divi.be pdr (min@). brul & saf,ti. d. d' r0 Ime ' t baciil. tu d'Me la$ urU r,)robd.Mr. tupd d. S@pe * & 20 Tidpul d. S@Fc d.Diid. llet d. srci., d! F d. dtibta d. $6 n10 nut iE, 6Esn[r Ph. .lu fi.ei & nodir' Cend b!.m o.diu licbid e iDltDinldr oM ba6' A populEia bdmer 6r nu&da la ilidttrL & ri4, s o6tE clrn dfin s c..@ii b0daid. Sul4 le ne ciclului d. d.d* bacimin irvih: r. I..a d. t'rdtt 0.Il EpMin[ o pqioidi ln linpd c.lrcio etuLL bldaim htrde iot-E @u Drdiu e 0daprazl mdc @diFl d. D.diu. Brddin N * imul6.,;dnd 16 iirift @el!.r s poai. chis &'d' in nod Acaslr paio.dl frra diviziN cclulel pod dn d. h o or{ Pd ld "ldr zila . -. i. *;I r"i"dA efiJcle !u o iDrd. iclivi@ narboli'd i' e€id l{i Sm rDFurl ftza. wl. elul. isr w dubla s bpl' rcl@ul. pEdri'dlN patu drvirb;. E k Lz d. 6.rdr c.lulrr ,6h c'rtr* ? mulbpli@' Dul! llei f;-wtszi in ftn4. & cddilii $ de Dtuina inodJului b'tuie
  24. 24. 2, Fu d. cr.lk .rp.Mlrr los.d.Dtd 0oel r ce Etut.h e dud h rhdol i! lrurrd @6 lo8rib! rd. o Ehp. tn,rr tnE tosmb,rt nun&utui d. Cd'nd. in i@er. frzl sur rift, e io!i. csd.d. ]utoto*i6. biehini€ sj di3ai@reei6€idro.n mjbiL h r$iu6.gq4itd fizici ri uriDimbiai. C!,@risdd !l*i f@ ri 6i. cr.llfu ufilljj {r. NtN, i nuntntui d. dbomi A@l! frza d!-zi pe.i cind w $D mi ndb $hsr!4. .rfitiw d onsnaL, 6.,anI s'md*!pr.dw tudboli*e liDit .d 6er&abicraimi. Pah hdciilc a@bq el bri tEve.t f0dord linitui d. s.idm ffird r. ru @lDa rr.fomd Dlpl c&m m, irG o scidm i dErkii bdqioc p€na clnd rD&!l d. Enrl. F@ .pe di, {E $-laEii .oen6ti.i ongmd,i, Eodindii DH-uhi, @u]Irii de ndbolili ioici. ljb diviziune fi{.pc g r6d{ id nmlnrj d. beii dl s divid & .grl o el d b€daiiltr m m. adivide dim'dd a @loldd @i.luitod. .J. idinirr h ssr sudi!. { rvr d. d.drr (mrL 6lotn, Elte f@ t * nmml brctriito * b* d& o.i DE d.cit '16to @ se divid. in @lll fu4 ndirul d. 6hrc bictaitu Br r€dB pr,n Iza * dituqie cdulrtr sub@bl. laiuk dr m.dr 4 .puir.rr El!r( €d. pH-ut ri cffiahps G. o Un trmrr Die & t6e por rup'lviquj ln suDaBi. p6ru o paiodi fo,n. l6e! d. tinD, l6i su chi6 mi C.lul.L slT-vi.fliioc * htu* fl .uni..li clibarli prn t; M.d{L d. c rrd eln n.dii difr.isl. s l6inci.L. cet di tsan dilizr. Ddii Dolru cultiv@ bdsiile mt..L di6cirlo. a@ ru o llre dnd.bro ti & por cJs6o h nbcf. d. Eulr. ciih,, d. daplu. h tucri. d. tu & ,gE3f. mdtr hchidq lostide $h& tD n!.{j. de uiuz&: Dldii uzud., b.dii aeiaL, oig Mofi!.E. ..hr.lor i. fs dpd.n{rn & s.tt F Mali@ u.i p.Duldii 5ict6i@ tn ftdiu tishid tn fu erpoaliali c%) d. .ir9r4. ,orb n '.6fNti b rinp mlisilri pri, .prDvizii]@ o subsi6l. ftitiE, &nr mrEptbrllre. onti'1m pH-llu fl inldh@ htutohFln uK Act dltui ohlitruL l" ip4b r!4i.1. nmib cttubl. & ,me ltui mriru Badhil. sd Eo!I& In hz d. tog fl m b im in f,z sutmd, sqrmi cr.|l.ro b&r.dbr L liE Cn{l@ ba6ur h Eput l)]]u dtd d. 6 dr medirt. & culnra djticide, de ll}odq ID gaEd. d d. -qre r, qD *@{i mi dr'd.r Fo{rci tr infld,@I q.S.ra t€&iui r, rrD: -dDp Dodiu & Eaa+n sl b!.tdiittr - 56tu1 nutiidd .l p!.imhllni - Mrqi! i6 6 d. tidns@ 6lr) - tnlaF Ed.lolor {*drlu: .nciui ,6) - aDIllH Elshrn (siraul diono{dor.lirl - rirptDrd imE Me.l (ioEdslu6di'.L) - @in. .L g.rci (!roh.z., hirllmid@) (:
  25. 25. ll. Nlrtlf. br.sil Urel. spen badaioo lut epabiL si 6. d*olr. in ondiFi divm.! L'i altel€, io s)rl o.le p'luk, & IMer-i! $itu Pah qqh ! UEle pr diz M. $bdblele Dffi p6Dd de b dddidc rl. mr laple. r AIeL nffiin rued{. orsmi€ E!6 th!.tiatc eu El nut l. tot obI,'. pin d.gEd@ .ldic! r lM mlddo mplae (rroi.iro, @i 'ucl.ici) $u pd 6 pr.lur. di' bediu Dn pd d. irdft sninic, b&16i1. sr fomrr. din: - mDuti d.Seioi @ sEtu bol€ul6! ,nE: prDtin , aizi .ul.ici. polizrh&id., lildo eb fom&ld oDoxidiv 3090 di, 8Blb udr a bd@ci - otupqi o4eici a s@rc ml4ul0rn Dicn: ffiie - @rpu9' ,trsmc' ry, { srm mhsal. Pmh r qDnvi.ru d o * mduphs. b€eiil. .u DNie de. - ]bsdlc n66E pah 3irla d. (mplr'Hrt 31iu6&le !i pah nebolisul elul& slEle m6si.i b6cld@ ut Grnablo, EP,nlrr !i fobinra. F..tdr rorxpt i !.g.tl utnFd ucrrtcD. c.le mai inpodol. eldmre m1ei6 ,r@ b&tdilE d: hidioSod, qi8aul, cr.tdul t ir.lul. Hidog4l t origm d obli.uL din spn, ry' fiLd @!dlt paitu @qrde Irincip.ls ulr de mr Mt tltriL {te ',nmiq Dr.lut din r.diu $u ob!'ur. prin ki"ro uGminesizi Eulbd din tia @r.iFld. rbom. NrdSDrL L bd. lsshbilep.b@odounqidii: h lu!.d. & .uDr d. *rd. pui.o clBi66 t6<tnilo id: lobltL ti chffif. Bd;ik forobfe folos; l@im q sftn d. @sc s. na ,Ds d bod'n nsiMi@ (@utiliazr degi. &kn). Pdb boddile ctdtufq 6.rg'' e 6mial{ prin o.lii d. ondoredw ! al]sildd8mici s mrsDci. ln fu.!. de 3Er d. .rbon, badsiile pot 6 daind. h: . tdotror. ("slf fEdffi) - @ folosc cq BdaiiL auroroi. & ddoll! r. n dii ddDi& du ditr fltsldle mrgDie !i lnt.8u] daiil ddu dre si dial po;ind.lfui & l0 COr. A .dolc,. e D.i nme lituf' . h@tuhof. ' tr Mir.i sub6h . dsdie dtcpt surst & c&bon. H*r.nDftL @ nli nm* r {)lFmhf.. rtn mbi;fl c€lo, d.I! m6r llH d. o@e n sm d' srton itnild paN
  26. 26. Berdilo 0uohf. smr ttuii tib.rq n.paEie. Btuin htut mt, i. gm6rl, badcii psuc. s. ctAifi.j h tucli. dc slle dc mleul. ds&ie in: s.lrfilq @ tdie in nr6ii olgmid dt.lI in des@ ei pezil?,m$ i n66&ui d. $he.F neniw & la o EEria vie. vodi D0j6it D . tlfui tr +j roti hbg'i, poMmle g oinat.le sur Bd*iiir pdogo. s *pbfir. o,niljoo& plbg6e poru m chmoldmhfc Ada sul p&u:G + rd!@r .dp uj um. Ii h.li'n d. ,i"1i ,"r'aad.l d. dseituln @ d. s{!* -r"6"1. '6ndd., dieditilq D6r'rnd nmic sI utiliu 'l@itu pr.Drii & bi6inrd. Adfd- brtuii t;ou piddlt m@imle biBi cli* r.* petrd o viqi tib.rl r.r&&i@i P.ieip.l0 Id 8u.t d. *6on sd qrbolrntatii (& obi€i ai@it.), @ d degaddc fi. !trin oxidaq 6. Drin f.mablio iadici &rI oriSa) a61e FB. nbiz..d aEgjr. $6 fomn d. AT? (.d.ndin rifosf,r), @ 6r? m)pusul mivmol do sl@ r Ale .ldd. n.@ psttru tbcliiL c.lubE st rcFrzde d. f6fo, sdf, poi'riu 6lcit! -"s"du, fi6 (oft.ioii didici, tuldr & .ltui). ume dc oupn! obili. mogm, zinc d ]rEdm a 3trbjriahi ai llu dira r.ctod ollrnld tr.can Ntlnd b.d.rtd. sur gmputi oigoici 64lrt e .u pot fi sint iia! do mjdihra bociaiitor, fiiod relii splinabq qoaa4 d6i nmri in @riuti nj.i. r 1. Ani'l@iri Mr obt'rnuti d€ bdnii dh p@n l. F @ ro s6* in n.diu, l. pl iru t Ie {to8Drle.z! tuituri. pirl Ir Mhoeizi, rE vq 6 l|litiz4i itr sinM probi!.lor br416im r 2. Pdnd. { piriDidin t. mi p'EllMi d 4inlf D@Lici Fi @im.lo. Pmd. $ pilmdmt. mr lM6ik D ruLtdde iia c d. r 6 ff.,potr In . 3. vihnie M@ djdit{o patu fo-@ .mineld Tr.upotuI rnbr|ntsr,r rtrldv. a b6@riil0 on por mt M Yilff ll@ L Un l. stdhF '@ b.eiilor ut nololu nici, @ dinezi 2. Ucl. d,nu.!, imFriE uui grdiar d. M6t tiq d aiubiul lm fus,od, oM aa8.do 3. Alb subshF Mt tulEine @i, @ difirad td Euimd. tr &.ilira?_I re.g bllMmbnn&n 0 add motellc nei M . Con$ibrilc (pode mnso . lndu.iibile (,l.dlle,lmi t D,kts $t6!!i!tui) m. Fr.rorfl nd.r e bnMtsrt .r.tba b..t ri.nt 30e?6 di. elul. baeiut Bi. a9tr uDjdide m.diuhi & i.dnpoltbin oqidii bdaid. ti poai. fi u hd- d. limie 0 nusrrulDi d. hi.i6ij dinb-d d6it b.diu (& d.@lur nm b0dcitrr.i ! r.gmmtului), rliin o mibilior. difEin ' i miqldgditueld h dBjce, dc dmrlu: x,i,3.rd tw. ft?poum Nltr*D tut dp.d d'diE d.lips rF. 'r sqlr,.ro Sponi h.eiai @idi tue binc h tip& rp.i (ur fom. d. Mitui4, de
  27. 27. *mplur srdii d. ,err8 ,r,ia.n spl3vi+i6c !d. tO d. di. MimrsMituL neaord're pot tupEvi4i d€i.{iii prtb o FioEr,l de c&va &i, dlcn dd@ ft lE rpid d ompld, prcf@bil in t'mpd insh.l&ii !i halnuti ln vj4 lrk{ told rnchi,r. prdrir I! rdlaliw c6cE la ln6Eic. ale.tt. b@ Ijofilidni C,Iiaz-dtlus), p]e foldir I0 @d'e ontuih bddi6. in lib@re. 2. cotrMnlg! lodllor d. h,droa.q pE-d pn-ul s 6f.r5 h @dibra su dcdinibb aci $luii. Msionds bdaiild ce iftn z.nr fuul4 eFrsn ie 65 ri ?,5. pl]-!l .fliD patu b!6ii 6E 7.2-7,4, Gb fii.d l.sd de tulu!. ln ,so.i@ o ! C!k sp*n pot d@ pH-ul h @ alclli4 ,r6,b cr,leru, e@mpEopdr r!. r (d. 9r), ?6h int@ ,i idari6c@ lui & dilizaz-a u iediu & lnbosdtiE .l.slin (p6 Fpbrr.{). . zdE eidi lr.robr.irtu (rm vuin li) @ prfcr! pE-ul dd (!H de 2). Nes'rul de uiga nddlr diford la h'c16i cainl.h f4i d. oxi8o u o ibpedt s.dici d@.biti ptu imb&a onBpuEitu . culidilu di, plodr pdolog)e d. Ia !€.tmli. i! sDul 6.qhii in nrn ti. dG nederl d. oriF, teiile pot n d8i6* itr 5 @eqii: . Bst rI .tdd.aob. - $ ddofti nmi L Eedii o onsE, nsnn o4od r ae.Pbr Ptu tidrDsa. Exmple sur bd;il. din B6rle Mtflbd{i4 Dacil6 . ar.brn rdd uftb. ' Go @i iB at€€4! oxi3@ului; folo*c Do@I. fasdtiv. F)tu c,ibe@ aasiei Nu & flim de desDdffi r li:q (d.lazt, pdxidu), & i.@ onsdd d. hic (in D,!al. e s-a lodDe H:q, d .f61 ioxjc). Ei.npl. Mr bdaii din gsrlc Cr,r,iA'o, Boct@ida, Febdsi@, Peptostup@, Y.ill ?1h. ldoltldv r.mb.. @ potdaoltiid rtidit ocetui. bsur nE6eA d. obtinub pin ernmuti. {u G',me pramta s 66at oxisFuluj dh Dediq sht rPtId.E d. . Btcl?rll udob. - ere.oLrrt. oblin 66Fr Fn tonnLlo, dir onSeul l' d. dic. S. por d.aolt d in s.dii o oxism (S,El@ DUrd _ di! non da!d0 0 plului ginsilal, inplioi ln pdoaa% di.i dtu). Tdr. eim@imel. E!d@ .up@xid (cr. sup@xidn de bnc p.nh.dul.: "6ln' .lcful. $ps.:idn tdui. ncutralial o, + q'+ ,}l r H,or + o: Pdndd d. hidFgo 6i. do ,sa]mi bxic p.nh clinc $ @buic 'ouhlid BdaiiL sid,n ...,b. nu @edr: suDdid disubzt ( soD ) i erdazl e dtuln in p@iF ua diii! nici & c(l' (5 20pl, ddpL tu. BtuL1la s$, Neis.na 'w- mtr bm ln peanF origaului. dd s
  28. 28. ffiHHH,t DLddqr d. qrn@ CO, To.i. helaii| d mi. iL bili .. i6li d. c(l' pdru . c.tG d, & o5iei, & dirpoibil 6DEdu&odhdim. Moei8 is.L o dt*6 mi lafl s el. pcr@lj@ di, Ad & wdd nuaidY e @i. d. cq (rcrp, Tapdu re.ldtr 6 fr.rd 6&E iqtu d. r.di! oE iliuat.za $lridic@tleiilq. s. hpar h fti 3ru0. F t62 i.kv€Iului Pllfell & t6Dr{.nrt B.@iil. Fik flc (Eiofito) u o iapa$rl oliio! & lub 2(rC, du @ & por dlzrch. ri b OoC tmpmd lI c@l oliE@ld @e I! *J. . B..raiiL Mfre 25-40.C, E.jqid- b.ei e ibrlidc nr pdolo3ir uEi aln oeofl. P.du izl@ ln Et nsdi dd3m ei taDdei de 37eC r B..Liiih hofla 5t8cfc, dr dirri d b.d.rii @ s dadrl L r(XrC (iab@), i4oriol d. tulet n qzul b!.lriild di. 4d. hn d ! sluik qFs l. lmina d €*hia sl,i 6 PrsllE ob.d.t or.ld ra 6r.6.dismrl d. d@r!i. {Mild dir D.diul & .kroltu. Mr.jc !r.. bldEiild Mr tuoiolEut , e darotd ei birc L o d6fulic Exc.Ctii:ud.beii@edadddibi@hFlditi&o'@Lribt .@rl' m d dr@n {ndo6l.), Dalru. ce izdlc & lIiliz*I D.diul ch.Iln.o 6 AbEF heilii 6r. B L.ior frvlabil datttii diqwlnis.lc. Cnir hmi@ difrd dr zi roi{zl rup6vi+iE ba.iaiild. prrdl. dbiola. s o&d bldcioid,
  29. 29. Crpitolul V, M.t bol.Drl br.t .l.r. Cn c blo.bir e rtc prcdu.s[ dc emrgi. Folosin hmd d. m.uSolim ptu r n. rfdi l. brdiuk E4jilor chinic Alr vibra m.hbohlr Er tmpd4iri u I dM it @4 c:)mF dbbol.m (@+, & desrdmr, e ctibaw! mds,e. r anabot,m r e{i d. !incz6,. e dtr,d oogj. h c€l'i' vi.! €qiile cbiBie ii @ e onhii! subsrrrt simple L Doldl. mpla. poirn rlml. d. drbolis. Este 3dd urFislul pod oElrda o.Jul.ra. A6t sqii .lit€raz-I apa ii d6ir! @iq R@Eil. chhrr Fn e ompu' oiEm,ci otrpt.q' ilr @h,tj s mpli rpqind @bohsul l, @ Ed' 6r f.t6iE rs @ o d6fG .qidie ti 6c .libdra aEgs chinid s@tt ln nolot.te olseie. cnplda lwtiilor ce !.ciu tusi. $ s elo, @ clib€lwr F! ATr (ad6oreif6f'0. ATP ialgEiraz, maxtu podu!5 din ri4iit. allboli€ ,i de .libdr, @j rrrzju h uqine Dlborj@ o molEulr de AI? 6G fdr.dn diriH bold,r d. adcnir4 o od@li de nbozl $ lt i gtupfi fosfsr. c6nd gnpul hiIst losfat p de dEfi.ar din ATp. * fmazt AIrP !i s.lib@r mqieu,libd tn e.liile an b.lic. ATPTADP+P+dasie Enaaa E dE din @iiiL dsbotie 6ic folditl pah cebin@ ADp o u sDp rsfd petrh a 6id.tia ATP-ul. ADP+P+@.4i.+AT" Acd aN4r de Ec!' opr& 6k ,@ hD.nm poh d mteutr d. ATp t6e, E l,ire m'bolie !i @bohe aror o pde din masia .liba.li ta eeholio 6te dispojbili pah 6nsliile Eldm, o prd. din 66sie de pie'dD& ln mdiu sb fomn de c{dlrt Est df.l nsoi. drinu! de loi slm d. tusi. ardr p6rru duu c.iil"f, BTocEIMIcE ALE PRoDUcaIEI DE ENERGIE O'sm,scle pr.dr $ shi@i magi. di, nolcul. ssuie prinb o strj. dt e4ii dtulda Patu 0 *t6se emryie din mpuli orguci {i Ftrh a o nM in €lulej (ltuis.l. tuftrn oltul de ld u onpN ls sltul prink{ saie de m4ii d. onde g RBtx). d. ordcr.dueE OxiLre EplEiltl hldlrm d. eltui di.r.{ motdlf, i, nut. e4ii d. onda. eluhr, Mr iininel dmulh 2 eleni i 2 jmi de l dr.Ca; Mr. ehivd@n o ind.E&e ' 2 d@i dc hidoeo. D.oile mjdrara sqi d biolosie de oxide iDpli.a pi.d@ rbito d. biLo8qt, 'l:td Mt n@i. sq,i d. d.nidregffi. D. ddglq cili eidul l.ctic dD ondrr pmrru a fomr eid piflvio, eidul toctic Chd u Mpus pni! .l.cEoni s rhi d. nidDsd a6l Fcd s ,Mer. Edll@. Adfd, !ne$l d. r.dum 6E m qnis d! eldroi fi 6te opusd oxir,&ii. Aoidul pi ic chtiBi 2 rrmi d. hdo8a (r.d@) ri Hdii eidDl ladio. fidaa ti rcdu@ Mr FG. @ple, de fiffi dld cald o $b€d{d Btc onda!6, o !I! s6s4n 6E simultar redrri CuplE s.dc @qii fomdzn uidc
  30. 30. Clnd o suhtuF e uidda, ihii & iidtq@ .lib@li nu t&$, Iibai rn eluL, ci Mt tmf.!! indi.l d. cEta .@in ci@u nr gnpu. sutdq.le eE pot c+. viG4 @silor olini€, fiir . fi dbe, w nme crbliahi !.zin.l. tu qbliddi sp..i6ci, 6@ wiDn vi af.cb ]jlei sbtuh]l rpcinc $bstuile sd tuldrl. c a.tio@, hi!{ lMii n 4i. chihid. acd& sketui drhini qEincic tuii.ld. Urol. dim sbt ijrn& t lnhBihe di! pdim. Mdto @ioo ,!n fl!l1@ din 2 corpolorq o n!4iu. Dstdcl nmili 4oa2iq ri m ..rrDdar r.pollic, nmir 6fetu. AFaziD, s n@!@azl duld lnd?pin.g ofidddui. C.fi.iorul pooL f u im m.&lis sD o ml@ln oau,cd @pld4 ,miit .ffii@ ceEim.l. ljuta aiDr -c-Ird rlmii hknrqi & D. slhd s donind rr@i e srn.cei tubtulli. MuiE ordine d€ivl din vit nirc. Dou! dift MirEIc cal. tui iEporrr o Ir EcLbolimul elDLr Mt NAIF i.j@1imid idai. dinucldid) !i NADP+ (ndi.mid d6in diN.lotid forir} ADtii .@ru{l @nlir dqimt ai v,Ldei B dd nididq (niaiE) !i mbd. nbclim@l s @itr wid. in hd.p&i'e iorilfi d. hidsBa ri r dtuna heroDn fona, tui d. nidosa din srbtui i k n@stil b 6qii ul6i@ rlft mtdule. lnzih.l. ffi ind.pa,.e!z! olomji d. bftogo dbtu mlmL s. m ddldrDsec !i llllrcul e nmet ddideEre C@in l. flivinie, q lr,flr (lhvi, lm.ldid) !i FAD (lavirodai.ditul6iftl) dli, ddiiili ai vnbi@i B ftofiivir! !i Mr ihDotu nr lw{n foiodnrdi€. Ac.d. @ine 6dclinszi i t @qjn. & befei d. hi{Lasa inpEDr 0 ddi&og.@la c]E-im A (@A) mlir. ddiv4i d. Eid p€tuhic, e 6& o .tU vihi B. Ac@ra @iDi juc! m sl iDpo'imt tn sinrat ii debEq srisirnd i htr. si. d. oqii d. di,!r. 'ruin siclul Kr.hs coA * udlidr i' E qiil. dec.,t.d& NAD| ti NADP+ Mr doIt @iDe aadn uiUzr. d. dtuL pah r!'srornn Cid NAD 6E i.du li NADH Mr crgiloti 2 imi dc hi&og6 qi 2 .1tui. rnv6, cind NADH Bio oxi&t I. NAD, e Diad 2 imi d. hidora !i 2 .leroi D. rqidi d6F. sqiib d. ond}'Edw 6i. d ondla d d. oti€i o rotie Cddelc !!rio $btul.l. aftili*, md. sird o rw d. aEsG, !i le dcg tdi din 6pui tulr Fduti o Duti tui d. bidn!.{, tn .qutrli b ond4i (o ouu, !|oni d. sism u l€Itui ouliiph), D. q.rplq .lnd o .€lull qid.r, o ml€uli dc glud-i C.Hlp6 ln Cq !i &O, sreia din nold,r de sluwi 6to lndrpttuit lr.16 9i, in ff.,I, prdu$ do A1?; ATr-ul qto o sNi & adBie Dah Bqiik e Eiri aari. (@oria .tibdat! tn ffid E4iilor & diLE d p'Elurd b irlEidul elulei Fin SrDlE do ATP), Cmpqn lrtu ilu@r, ce e ultiahi &tnhog6,d..quiitn lri.duli, o! !d Dri Dull! a.ai. eohldi delt Mpurii orjd4i. Artftl. il@ 6t o e@ nuldtivl val@rlDah (I@ieq CATABoIISMUL CARIoEIDR]{TII'R Ptu mjdii!@ ni.tueojtuld, s ui M Ddt a GBj.i eue do oblinuf prn ondle 6nohdr.tild. C.! tui uriliz{ sn dr dnohid4i dt .!h eld. 6L gllea dr biordruisd. po! & a6ka 66olizr pDi.in. !i liDnL. Pah
  31. 31. p'.du.dg mdsiei din 3l@zr, niME im.l. 6l@ doDi pm€e Gpir4i' ti lb'ndr4ia. 1n dbele p,r)@, .l@nj p'otu+ p'i ond'B slu6z.i ! pEluli d. kimul stldiu al 6p,E1iei i al fman+i.i Bb rtpltat dc oxid@ sl@i I' &id pituvic A6h Bie p:1x€d d. sliot t .. CU$Uzr dq dsbi€i, pisul sudiu td obholimd @rn lidr1ild, fiind 'runn,i cdo Blnbdd-Mrlqn f. Prin sliolizl d@a 16 lMi d€ cd.n) de ddfioE in z!b@i fl 3 riomi d. rto ii pce .liba6rdu{. o6!r. A6h zhffii Mt .roi oxidd. ii @joi. poh r flmr 2 nol*ul. d. eid piNic. Dr!sd6i, h tinpul 3li@liz.i NAD| e EdB h NADII i s pDdu 2 ftoldn. dc AT? lin f6fdil'g tubstltului. Gliolia N tresitl oila, p.d. apde L @.ditii mb. ri Mb. A@$ col. hdlbolica ffil. id{ se,u. dr z@ E!+i ctimc. fiffi .or.lial! de o cr,mi drfain. b. $mtul p.nrM rar.{ror Mulr. bsctai !u o csl. altuivl rdilionau glioli,a !.nbx oxidm slmlr.i Acl@ & oreqb crl* pabrc fGfrrilor su tutul h*oa Famf.sfrlrld ri fu4ione,zs Fmiaza hijlde pab dcffipu@ polozelor (zalmi 5 rhmi i,. 6rnon) st s sl@zci Din ondda ud nd@lo d. Bluozi Edl.l o holelh & ATP A 12 Bafriil. @ utilizezn c.le paM fosfslrlo suni: Arc,rlB r!6114 toli Imwbc ws.nt id*, st p@famtis. c crLt tuh.FDddorolf Ed. dl! ..1. t6h oxidm slDozi lt &id pi vic. Di!h4 mlali d. d@zn sr p,ute 2 ru16n. de NADPH $ o Mleull d. AT? Badsi . @t pos.d! in pah ..@in colo poi Dett liz tu sli6[, eu cdq p.nba fGf.lil[ A@r, sl. pd. fi lrrilnir! Ir sdn Pr€d,m6 d, h gosd, nu onni la beiil. Cm pdiiivc DDpn d€onpu@ Slte.i l, cid ,i vio, lch pd. Iu clla femablei $u Gpin$.r. Resrn4ia d. u pl@ etu d. ATP, in @ mrugii.hinici I oxid.! !i ae.piofll nnn de elelroni 6b lroop. tddd6lD o bolmld @auic.l .el ei tcvmt q. Acidul ptuvi. prcde prin gli@liz[ d. diviat $ 6 6!eMr d. ltt r d. o @iml nmir, @j6i A (@A): @mbiiali' s nll@b a.etil@-d Ael oA itri rIoi It ciclul Krtbs, Epr€ad d. o si. de reli t, @ sur .lib@! eltuni 9i prtuj. Eleironji .lihasli io ml eli@lizi dibui. la rdtrlE dioA @ in ciou r@bs mr tali mleulcld NAII| s FAD. Aljda podi! d@tuii.a&e lutul d.lr@l de.ltuni, und.6t folmr AI". Unele bafrii pol deSEdr oriB mldll dedicd h inryul Bpinlrei. Moldlcle ()@ie ur ondd. mpld i' Cq a hids36, 6ti10@ d. A1? p. ndoll6rc null mj DE in pn.dl d. ,!3pioli. da in c€l d. fmdrqi. in pMd d. Bpiolic, in smad, &!.ptml 6od d. tidbgo d. ongBul mldnn. Ad iip & Bpir4ie e .mefr. Gpinli. i.idr[ Utr l. bdaii p.s.dn o res,iBlie llrifuta ln 6c accsphl fin l d. ii&osm (de d.e'o!i) * o nolould @srni.n, de qdllu tjh! sulfrr, c{t id n6prE!. ambd @ln in: IrlFn de tuBpd. & dtul
  32. 32. ctdrr xnb3 m ddul eizilotr iricatnilid . FFEad d. o Gi. d€ aqii tio.lisie id @ o cd'@ tle d. aasi. lora|i.ll ei. sio66 b ,ibrn4. ilfu.die d{ivrr. din &id piiwio, a.r3i..litard p.l o pB Irtsl .L rrup.n d. d..fod .d. ftirb, did{ ld.4 d. @Lon 6ia .qibiL do onde ti Ed|@. P. nirri o d.cn6ii k* Ddn l&t &.lihsE",r sgi. .e d. folBir.t to catu AT?. l, Gei.fr t66r elahd fii.l de GlodEi d lelului 6r. o:iraIl. ln r&ir*n '@bl .o.trord frn & ddfui d.6 idryit uqr'icl .lt! &o& oxir.dr. Or LG 6rdl d. iffiibill in uh.l. bFr iLEFrF. h €lul.L @ioia lofll d. borldt & dtui * slinu & n@tru nbi Eft@dilu. k oddd. prEflior. & g&.{. tu ndbre pldici- Sd 3 clB d. dolaL uiEl ! Flr@&in. (nivi!@uolotiiL FMN . ubhrinfu (@iro) b d@ul r.pi!4i.i er6. dintu *le ni do Slu@r! & FldE 33 d. mlanL d. n .DlElt .Di.li ^@are!l ful d. detmi .d. o ot hF dorEbid Jb d..& odsad, & d@lu: d6! rit4 Ei@n Dtar € dtM e d.*rd b Did pidvic! lGL po.i. lu ela Epinlfi u . dibml d&. dr: ,t@i, -rqi-, eiz @id, rim ! pidmidi* (doldul d. dtui, 6iDd ebiol.lo c8rne) t a lmitl dto, cidu Krdr su l&t&tmet & ddMi . Iol6.i.s@dE,,ie6!.c4enuld..lecrtoi . prodr c.rtuli mid & aT?, 'll@i @ u 2 tuldr. ldu 6* mleula d. mt6i.l idurl, dffi 6 @i @ prio dh 6{rio rtah. id l€irEn! cbiBi6 d. plld[liha 6nni o: .ddd ltdio s otelul
  33. 33. CrylloluM. G3rerio ba.rqiul G.tr.do de iiinl. @ $dida d.djhh4 tusilora rcldiv .ebiu 3 ploDricl4ild 6ddi.d6. tnt{ sll6is. de gEdlii. 6ndio abni'r tuil.e infms!.i smdi@ li v6i4ia ad.i!. Tork idrulirile mofrmib smt 6dt6de i ADN Gddo b.derlrl shrdid sadicii bloifridc r $t Io b@ sludiului !@dic n sodl d.@ od'n 6 c*d.inllrcvi.. rdul d $n bi6i @ M m tuD d. Fmoe de )0 minu. Lde ermplu E or,, o;N slrdi'l] ru nm$t mm de !o.ftt',ln riEp fMn *s TN.@dedal. r'ffi@melo'er' moQmE. oceb trlJd. . I@i r .sl;eisticile 3tuL (mrrolosB) . Rastiile biocbini@ (dbolimd) . c!p&iet!. d. s idanctioo @ aI. dicneleisc c;ohsricile Mr busis su@t ro Fn sa., m mi uii4i al. mddirlului Cr ace*ia vi]l&ild A!.N, r..lo niM€nisd. .n infdn.lia sfldicl iMi'l Beiilc d don rildi d. ADN, e oDlin s#le le ADN momi't $ adclmomiol (ddmide). FQ lE nd de o mlella iL ADN Nlr, drblu h.hcoddl. Mokia de aDN e u djjsnm popnr c'Fi c'sui in dmpr ocldu eluh rbnD&c.H rdubrlg, !i lEsi.H utomaEei & p. ADN pr AIrN' 'roul l* . -*.1*u *p6i do uinli rFtriv. .@r' tru'Lorrd' Fie ruldlid .si. nc..si di;b4 tzl aahta, e 8rup fothl $i u z'h! Bele Fr 6 DEid@ s! tiritidini€: . ?uiri@: ,c, G (adoir4 stui) . Pinnidilie C, T (oiftin4 timind)
  34. 34. ADNd o.lul& blcrai& disri srb flm, ! 2 letui & ,u.tdid€ d&ito hiprad (DaEdi & be) r.lN ! firm u dblu h.tir. Fi6e Lnl e o Lgdui hlE u zlba dediv i @ snp ft6f, (3.tda z!r, Ai6@ ana 6i. .rqr dr o hua letol,. C.t. 2 ldFli M d{sl. Fi. I.!in!i d. hidDt6 hb c.lc doul toE ee Corylmr.dta. ta.ror. Brzr. & lnlpslolwa !!oi6c: . Additriut loido@ @ Tujra A1 . Cibziu inrork EecMh4CC D.idjd {nrara-hiti$i h,z,t6, &.! & oerf. $dr Euj l6t, * po.r. rti stu.n@ Ioplui oo@laMb - €Ldoui altr ilcmlcd.i d.ADNdqpld6i& - Lsituil.&hidro€o e. €d$ld f,eln d 6e o dD.nd ridila Deli dis6 e6 l@ 3|.bili@, eL ? l,oili do ADN s. !d *16 $6 itrIul! leadie"d.d6f!4@'. srDtur Lntuild p@ii. o c.L 2 latei .€pte ii. ADN sl wer dl't rips pdtriu EDlicec o @itii r iLua Eolerl. & aDN fiie. leiri d. tuldid. d &np[rtd. (6idne J' cr6 ],] 5' 5' 3', a 1'
  35. 35. codulF..ridodot ia,r i-." *. -n*' L *'drs bddo pmtue !' p,-id oie c' romer hl deaDN ( odol sb.d. d. 'epraur d. o slll€m. d' c'dJri - i-,;- *;*.. r"--; u codoo (i odd 6E 'ep.*'rrd' s hprd d' Glohd.r $ n..& ..do codifilr' P..lio @dmid rn 'htu gro ' *,, -" ti'-r "d".* codoul $p' erel 'cteob i,,a. a. r".'au -a. a"* Codmii codificn Pah C.dJ 36ctc 6e u @d dc 3 rimoid) qr ul*Nd (in ror. Smta oddilor ce mndi uu mimlcid @ific Erini 20 de mimci' i-.. ri*. a"e-*ri' (*i -.lt d" u .rdon p6tu nffie .Ddifica mimacizii ud p,otine 6mdz! o sda -6d uid , de NaLe &!a lme, ! abile ' @. 'rI1]M._ d.odifior'ara Pd 'loJ'r1fufrf,{, rDNinu: i*. xi*;"* q*n .*g" Ax" . nRNA: odon (gmplmad odnui ddu,l ADN) - llNA: sri..don (mrl ab c.doulu) - &*.ii Jr"j *J a"o .'bil ,6h c. por s! ap'rd nodinei in 3*61' dc .Erdide ij€ @ d.hind sDai! #;;;i ;; ;s*- * "" . ,.'omri' e cod"r"r hr ffi{'ere 3'r' r4aD$ pnpnddih poradal._. rJ"p. * " , '" pr"p"*til.csqmG. q!'n* ffhlholebdm'lo rr r --]"lc-a nor-,'rai, e"".tipd 6b o 6l@1ie d' sm' (idftsul ADN)' i{ fmnpnr il'i-.l'r" ",-*.t r *,r- t"'r.s c-m.,r .{. ,e*dr de rr* 'rul gmdic n -i',, l6ani*. r, ,pa tr , dr pos.nr a mirr*e de p..hi de bu' tr I A'r,.l,J-.,ai.". ,oto*- * ,* de.n dn".u@ er L Mffiim'' d' A^D- rlxmd,mxnsh! l0% din loldul eluld - *'i.li".i* nor.-", o,*, obFd@ dnu{ rru'i d' AD p,-@r' 6 obrinaq ' *";;;; *" *p,* rn ele d'ua tmM de ADN dutl! heli'd&le rur -r---". - t.r**p."iE m,hlr pdn padu@ 6r al' ldl "*-ril..[ ^oi',r", i*p-. d6ia; i "ad,- cct- eJ' ukm de aDN ldd i.pL@ ADN ap@ la niv.lul toEullt'i d' Ep['rE'
  36. 36. N_(ld&h lib* plar. D oroplrmt { d @bim o hzct. apu d. p€ clh aDN p.m6t( Dr.. p. tsnrtr msu0l 5. riD hinr rtuci D. mut hl ;6 id6;,,p. r&Fr @&d s@@ F luFi m cib4 , -. .Dupd ,liriE Mtdjddr h dod @rpttub. AD !.tt!.'u & at{rd d. , C.h dou @e d. ADN-uto p.Er, ,e td dBfE ,n .fule p6h , Fucd$, d. mi N.tdid.. apo qhr p4*dr rmsnallr, nN dai ,iddidr r:6id) tkoee 6@ mur mteJr d. ADN dubtu d Mrix o dar 6!inrt, s m m forun plIE, Ephc&I' * nmq( r.DtroF ,.d.M;.dyr. - ' . vdeJr & AD pebl.,lchill dj. doua @ onrl@. d{ 'mhrd & ffi d rclr. d. -i4@ (di! 'd d. !!d@ J qiqrtu ;rtr o, . Piee f6fd Ir sn ut atr. fo.6r a, A-DN-da & d.{d d. @6oul ,, d lru& p c.pdnd I d z.trllni urrbr Bu s4rd E 't !a?,r d. d. c&6mul ct,. D!.r tu rodn ab{ * d6frdrr d. !4jllH ej @ tu ADNi' e o mtaunnEa m g.& t twl E ffn. b Evdut rbqutui cr ,l z.h&ulrj . c.parrl @ ft r sn9 fod{ aqd d. q,bout c5.il abBtu. * ome& . Crrilul ce N u snp hnnDnt dll d. cr,t nul C3, rl anautui e ruer.
  37. 37. Dibnn .dbirdrii ccl6 doui l8'fIi d. ADN, u lml d diaEa 5 calrt 1', dl.d.dioLi3 ctuE5'. C.l. doui 6!60 ul ldDn.bra 3 3 3', f 5 5 r) 5&68 mtpd'l.lMJEtdl E!hu@. aDN din@ po* '1,p, m, Mle& riairli dou ldausrndu.le c.pftfti 3 . D. '.@ lmFn .:!s& nlfui in djEqio 5 drt..ADNe@&prcdlc ml b dlred. s' .tft 3'. Ctud netlil. d. ilpli(m & nitcn dla lunsd moleulei de ADN p{6nd, c.L iiou.r hi tuu foieL Gc ln modui difdir.. ! Cdoi Dearda onmt.l! 3' ..ft 5 E nd.i. oLm p*tpdr GrdI4 it. rd) ircp€i !natit poEuo.olntuttinidial!@nrinuuiddileli05 cIhr' . Clh D!d.l[ dialli, 5' cnft 3' e nmere .6r dd..a Cl4dna rtud"), i{ nou! @l6i w n sidaida dls6tinu din n!€Mr. ce t*ui. ri & u6!ci Frh ! fo@ u lml mri u b nivd fmlikl de Edi4 ele doun oia. prmbl. e d6f!. sub rcliu@ . P@h siDra dari fiiE @trplm @ dtui p@irl. Drincipal. ("lerdin8 stad') ituine ADN p.UD.'E * d{.z!ruI@ii& 'ditioo.lc l0 apitJ 3' . P6!tr si a Br*i fi€ mpldoh da.i seun&E (,Jarging stud') i.ldim o trirna nmi$ A.RN potrrM L AnN polid@ ho.?. 3inra 6e*!l nlgnEnt de ADN I ldldui l€udt 'jeul md.l6 ARN ('rilEi Ar.)O Meiihlilr din trulotidc AIN 2. aDN polii@ dfir& Fmdi ARN, 0roi disd Dinqii ARN $i ii lilmie& @ ADN 3. ADN lis6 idchidc n4ffi&1. oru*i {mil. 6aeBmb & AD}.[) R.plkn{ ADNd.l 6b ntl.Mn.dv.' .d. dour ..r.N P EDrrl lt E @rRI irnd.ln..L dooa ml.dl. d. ADN lxc.. cd. doul Do&.Dr. rdl lddile Ltg.L !i ld..d6.r p.mhrl
  38. 38. . Blo.lrb p.o.d!.lor E+ p:@ul Dnn @ hfo@tt di' ADN et. l]mf(]du in pbid& ffildi divie €lulaa sirr@prd.in ldrE liazilddoua a.F l. Ttureda / TMipFi infroliei Sadi@ dtu aDN id{ mldu do aix_46.3d ). Tm'!6 r'Edlllrg ) . sdlcl tufma ufmlF.i mFnd. in ssF d. ARN h6!3- b ;6p & lJlllm.i, fdnald o tdan - la dddblvmih_ Il.1. Tnd.n.B / tu*riDf. . Infmrio rdid din ADN d. copidl s teqisa idi s6E ii. 6e mDl6 E. a ARN aitul! folo'.lt infwqr codifqrr i0 A.RN megd pah a edM @bM l'.d6cl F! pl*d d. lffibe.. U.lo! n aDN dui 6c urilid o t'rpa poh r sinuiI, u la4 mplmotr & Edrd!dpun&AnN: . AltN d*sE' cod 6d Fh p'Drde dlin. I b@ rodm) . A!l{ nbozaorl : fmaz! p.n. i,r.stu6 din nbo@i, nrtidi! celdod a sinbi Nrae dtin. nhdmul 70 s . AR d. M"F imph{r in suM psrildc t] far millMa'cih nhomi @h sin@ lDlsnelor; d!rc e!..n n : scrali & 3 he gmDlmd/l,{ ddduhi &p.bxxA) Dtftdt.Lbt ^DN y' AnNl - ARNei.-'fuM - ARN zihsn e riboa - mFlaeile bd.lo 6r. a u (addinll@n tn le d. tisind) Pre$l d.llnlMiplio: Utr lul dt ARN m.esE e sinldi2{ fol$i'd o porliw d. ADN cd'nd (o lau 3F.ind) dnDl tip6. Irf@Fd gocdcn li@$ in :s.nts dc b@ !zod. a aDN cai. ffiir str l lr.& '...qi tuf6q,. 4oE ln wvaF d. te 0 AXN: . G' ADN dr.tBz! c-aRNm . C- A.DN djski G-Al.}{n . T- ADN didazt A-AltNm . A.ADNdda.U.ARND ?l1Ial dc @iplie E lkrcic & o diDd ,miil axx polimrua F o mda Nlmi u ldt & ADN sd.tt dtDt tipd pah sinM A!Nm, @t dmindw lel @ ld C"@ ,tmd'),lannn ,nim (etsaF tud ) fiind Mpl@ad ld$rlu R.dua Ede AxN Dolio@ $ la3, idirl & ADN so nD.& lrn proeror (r,mG 3ird ), ll sd Dir.l ln.Drld a prxarn d. lM,pia TMip{' e lisrd.i rt o Do(iw ! wi cdo. AD @ oprinde infdrulir p.ndorrlld'LcstiaD -d, ARN-d 6& sinuid ln diiEli0 5' de 3 . Portiua d. aDN @ @diaz! Dudr & i@in@ ("ad poiri) p@h tasdiD!. .d. sihl h @ AxN poliDdu i loiri noladffi no foro.L de Axx Apoi h.nn & aDN d$lu erqE & ftfae. h curud.,l"lofu.f. ledd D-h tinta prct lr.lor.ta.ta b ADN ah ltmDlra AxN Edrd n dnd turnf.I
  39. 39. En plrcul pon lm ssaF t€rlor dt din ARNb didezi !..uF d. ..difid in ARNn. P. 6@ mlq I d. ARNI .xisri o pdli@ 3Dd.lt fmltd s de 3 Mlod& ,mit! Ilkodoq ffi e .mpla*b cu odsul FtD hjtir. cr!€fuI 5' al molaLi & AftNa * asiri o 6 tibm (s€nid link.i &lommn Mdn 6 ARN 3Dei.l nmn aRNr { prfinnc FiEe ;tm 6G forn.t din 2 eubui&li. b ireDuhn tuhi.i c.L 2 s!5Bit{i dui r u* o AXNm, i! cnoplNan ur 20 mirci, difaiti e pot p!:tiop' lrDqts inMk o ,Dlnl)a.a pohMF c q ua$i p6N ' fom o pnrani fl .riv.lr pin 'hteg d. Axx tufa (ARNo. Po@ fi..e np de mi@id eftl! A.drlo rrlro dlo.: ei]r@idul rpcific r ib9@ do ARNI asi6c Fr. iDsotiii & o uisl d,vrloe . min@inh $ 6qgie din A I?. Fic@ 5., :, Etoride r alNb lnMir odo.) sDo,6cd m sireu bimsid. aRxi'dt.lL" h dbfld tul,lid, Mcod.oul us mddd. d. ARNI Ir dc F ARNd. clpl3E.odm€dqid t a. lMd D{! e enhu ARrr q rlrrmeidul eau * 0rr!,zl dr ARrln & ..ddul sd. s Di$i dd lusd hnnu, d. ArNo d ! {tou ml€ult & ARNi s idd sIu s EUE in p.zitii lab rl doiL. 6do. c.i doi ui'ein sa lffi 6i!f{ log!turl plDridic! ri Diituur AXXi e ddr*zr & rXrh Moldla d.trr.li d. A!.Nl ,o!& !E$d dr diMil ,peifi.! 6ffi d. aflJlr p.6r. 6 tolorir, d. @i Dulr. fi. u, codd oeiil, .odo.l .top dir axxa nmir nm lae c.dm (N speiid nici - ai'fuit) s.]mlEzi tmiua lqdIi poliporidic ii 'Bb eL .Iibar d. & Ribdmd r rra,$ lD cel. dru hitlF al. sd.. hrid. q dbomd c r d'cl d. ! lmsul ARNd M,d.@d bashlr mi eo., -.h ibohn, apo, olhl, e lor rb$ !i inc{. tuliti @luitli ARNI Altfd n@ -ldia d. ARND po€1e 6 tuhbli sihultu td Doi nult @leuL pobie. cmbi!4ji blui ARNm o m m'nF nbozlm potd 0Mal. & pollrlho,,Dr in 6nclu.. @ prcEndd 06La o uJomali gdid dn ADN si 6e mi -I llmf.rali AIND prit-u FG nmii t!Ncip1i.. Um{i predll d. tula!.ln & ARNo m'dw l, astlae dinwinld hi!-u poliperid. AItNm $ 'rqs.zt & u ribom 9i Alxr lilrwi din@iai ARNI orfom ...@lm6l6ri!r p*cnild d. b@ tlc codoilo i uric.ddild- Ami,)Mizii $ tM, sur 64 d. coddi pdibili (ln fD+. d. gvaF d. be ln Axxn), de nE@ 20 -i@izi Ad lm lrstul. o @joile mileirld mt smnni4i d. mi F f ..do.i dta rivi Sitstir r..ri! nlml. de d.saffiala . ..dului 36dic Dn ei 64 dc .oddl, 6l sl codoo s sq codifi.t Mimeizi. I Mr odor fi'r B(m :d) si.i !tuli2.rd smr'fln]l lini*i ioldl.iproLie C.d@ii mngs Mr UAA, UA6, UcA. Ei sqw o sn L h di]]@ sin@i
  40. 40. coddul rh de auc. i.ilrsd sil]b Dst ir.lu, Bb d. lsddj c.dolul pdh n risi'i. MdidiD iniliil! d. d. obiei lIl[Mt uhaid, tdtol h.ni N pr.t i..l. sl in r4a omodm,n& r. coddd.nn de brdd (auc) 2. n$Moll d. doqE & d.9L}2i dd lurEd AXNI 3. T.rub.ru D@rhl: oddrl 'rd,p / p.nD.pdd.r. db.* d fomd d. roa . ;lRx. -. rb" $d cm roe.,t ritr@if 7()3 l.rd .P.E .h@ . lni( rdrfrl.'lro..t l dft nbmrl Pdtn tbta: pbtir.lor v.rr.ll. g@d.r n brd.dr M@im.le m de I' vdaii go.lie &81: . r!rub!. - po.L fi 3ponhl eu irtuli (d.66i 6tici s drmici) . Ttuftnil & lfui.l ea.lic i'hrin&, d rali@ E.i Mur&i 3o.li@ . Mmixl. laeind nod'6crn d Mtr b6ald ir ADN (,1lrG c[md I Mffile M v6i0re h @ w u Dli DdE bE. tL ADN ed 3tliot{c Modidct€*lr.uD nMnbrd,rtErlhli D.ft.tuj Sr*ic po& dtuin.: l|.@pllBdui&t leiplie , !Iq@ sMFi & mi'Mizi a E ipr&in,G.n p'dul w, e@ Mdliil.por6&3tiDr: l. slbrdtutL d. bE o usui t€za . iblmin d b. Ikmini substtqn lNi @imEid id Dtteir! sinr.6atl. ,{. Tmdn : h css Drr@zldi.rl@ pdnci / piriDidinid GC & tohi0b! ln AT a.Tusdt : eial!6Duiricn/PiriDidinide ilhll s; 6E d d odd idade (dop) id nijl@il lellui de ArNb. a?rinl sinld! de potaE nrsFon L (s rirl.liazi doa u Elg'mt d. pdcioi). 3, Munfb ..dtrld ri..rrlrr 3 D.rir.: Disd@ @i be o i mi mult b@ 38. bEr& ! wi 6e di$dn Mrqin por63FnE $ ind!&d. u mull3E Mr.gdii pol 6 onidici 6 fizici (ndialii ultEviol.r., ndiqii XI rlltuF 6.nud Ro nu$a BE plDbtbilida @ o gEr d suftE o mub4. l! orsJ diviluii Mur.4il. spdr$ o tqEF r.d$i ur dui,s6 po.b e.$. nE @ts E@qiild & Ic
  41. 41. & Tru,|rur s.&dc lt brbril s. rcferr ra shinbDr de sm rnft doul moreurc de A.DN pah a fomr a noun obicli. de .m. idu mmoam. & $ mblid, ltrtitu g.ddicl fivorirua apaitia diGiratii, ffi 6t sus Tmf@ e plotue tuci .8nd lirsD6r. d. ADN bddjm qos6 sur -ubi. int{ eui E arom, 6 hmlhl de ADN *osm pde n mmzonial sN plGmidic. Tmsf(r:rlt-E 6r. -rtt pin nodifi@ dd @tu alc baei.i Erp6. Fl@dF das6m&ilo' conjDsm dre ,rrffiisd el Dai inporhr prir tr bdmtlq tn s?..isl -.6daine, acniziidad troi Ba.. ADN 'rl plsmidic de tulat de la o eluli rh h o el'ni E€pbr p,T inhcdiul uui pil sual Fffi pilului sul de dss d. sm pleidid tu Co.jug@ e cfds, rh i'h.di!l plehid.ld -otc Ac6@ tumit i, 9o6.l cil!ful & MiMta flli d. D Mhit dp d. iiic (r/6,ids,t) slD ''l:tmir u r'di 'Jc *t {pti,lpl1 ldet.4 Doun &hh bdtritr: w r+ (,,14,4 n rrb F (,.?rirra) E apirDc r prin 'ul p' rlor s. ral,za, onh dinm c€le doq{ s. ccui u oml Ein re & w tusfEa linir o cfui plmidic! adf.l lncil, l, Db.le c€lule w 6 F+ (/,7rcr./ e pokL Eepbn ,q6ci pmh .i Ap& a@i c3nd 6'.Cndt l. d. ADN momid ur tuslftre mei .lE ii prir i metid uDr bdriofa& Dfu! ,ur ellEu 31. b8@iilsetur alcrtuii drelt . c.p: f@ai din &id nwleic ADN dubh (Md, ADN monoer@ rcidul N.leic et fn@imr de u inwlir Droteic nM epsidl . coad!: de b n$ epl I'mjur dc o r6ci (inwli!) Mlrd,li . Iludebrr: ominco i-i e DrcdM lia D6.dui bddia eluld . Pe ple d. b."-i s. 6xe?-r te fibrc ale ori d tse c-irlrs€ @ 6xs2n 6sul pe Elrrdii sreifici iG p€ $pEi. titui.i Erisll rpclficlbre bft brdrt tl brctoriof.s bdsiofu fixedD s nu'i p. t lii e 6x€i F h..tn. N plae dc bui, liz€, p.dele tockim, mrgia eii @ii { ridul nELic 6te injdr itrd. ArP trl r'sir dffi,n 6nM+a
  42. 42. in qlinle pd qje dou.i cictui: Acidut ,uct.r nln 0tu@ tn ohplto0 $ dnr6a tdhs m.uh.trmJl cdutErplf,rura Ddcirjulu b@of!g,c, Itr 6tr 1 c w N;nbr' b&6ofig' @ tnF; 3ye iTi,r aq',, -, r a,r*r pm tl,r erurq bdn* pr! e v;p* L*;;M odu br. prio iividle alb eiule b,l6.D Acidul kta. fig]c * ubg@ ,n AON.ul b6Eir..e r. *tu *r.ii r,s, *-fr ffi;;";ffi :,tsH..,ffi [oropr64 d. h in t0 u octu trhc _ Ttudlcd. dk o rom. d. tura @ e lm Fn i r@i@pan;@d$smurtiDr';;;;' -''* F- drmdtt,J bdaolasl't -,. ln tu pur Epric_rri bsito h baeie iaetuk dD AD.d Mi,j qpft@c d b.tuiei pd. 6 a6dodt D.tE tn ^Dil-ut r,o. c. q'r., tia- baea !j et,b@ hs,to, c_td ,atu ufdazi ,& bae,,med@r & {DN,s5Er h 6 uuoa* O *-r,o -,,,i*,r u u*, s,aiu Br..tv q ddint pltqjdrr, ei.i. co.t. Ddue h Flenai]] r.adiv e por - -.- Ertuplu Cm6ia f,gid I tutwjtd d? Cotyn?tu 1?tih dtpttaup,r br4re cd E odt6.r p,.a* .^i.a ainoi_ !o". r rurt_"a ;.r.mdu uu rr @F& 4 " ."s-.r . e*d -fu; s*;j,- ;;;# ,,,-"t'HJffi "fjil rffi ,-;ffi'ffi ' #ffi ,""#m . hdph. prldum do bdt tuM I S&!rdr@Dr*id,. "_tur;",r pr"nid,. hh,r,,r];;"i"#;#ffi.;TH^if;+l* , , rrupMd tu esDoE D.i d. ADN m s Dd hrrd! u Du6;h &r+rd @ ho DtMidi lr llb sud. ho ptami,, L u tu;oM e dD
  43. 43. CrpiroM. Prt'ologlo, hfell. b8t .lui. Flori trpsliti tl blul b.n.flc, R.Ld. dlrtrc ml.@rg.oi.ne tl guda. P.iog.trit rc brd.rbrl. VirutdF (olotrihre, nuftipli..re d bvulvlt tq .tG tl .ndotoine) Pdoloai' de stodiul $dinti6c al b.lii (p.dG iiffid .uf6nt4 lq@ - tlii'fl) r qu su diolo8).6.i boti . pibgodj, nodut in m & davou o b.dl . *niDt&il. .f!tu ic d ru4lon l. pr.dDs d. hati i .f6ble sde awc Tmii d. iDfcti. $u d. boil! pd ava mi6c.lii difsi&. Infaia Bb r'Iudir dr inv&ii orEoimului d. mjd@I8ois. Boda opm ahuci csnd o infedie E d@ D.difrci'i .le sdrii d. l.naror. Oinf*licpo.cdirbln.bm10uabolid.te.bbile.DesmplqilfEria viruul AIv h d.6ut nu pdin$ sm sou si-pho Nu loole o4E ioel. rur pdsoe. UneL adE lm.6cii sddq lm, & .@, L,i. de a dish rhn ni.'D.r3Dituid tu prdu..M bolilft, vom *!fl6 r.l4i! dj'ft la! nlrlmli !i ugdimut lfu Mimemimlo lno.p sI mlmta. md de la ndlr*. PiiDul Mlaoi o i(iwSelmo .l nN .nlsdui de El o ltubeilii di! vagird t t m $ w d*ai iowrr',imel. F*hiMk dwd inclpsa GprElrei i httufii, Dupi .Ne aoli a.lrc boobii din iis6r. vtr @lmiz in6iod 3@ Mioerarnsel. u rrn&E in E loelizti p€ h poqsd viqii, jd nMin lorpolte si cEi.i N d $.da ln tu oli. adifrcnq ddiiiilod.m.diu,En rd mtibDi la id$olnivie MrlE d.goim. srpotu s tuhils !i i' rtc ldliz&i .L h ,i.sii Nmhn bddi d ce 6lonia, ddisul ;airul cdd.lm e alrItuB ol@mul. lrlo'' rrd A rrlo". Mr@ra0llJlmle cm mloniE2r supEfq! n ovidple Mhnde rl. dgdis'llr, ie Oon nrmfirt lfi. mrbrro. Aerdr ror! elmdzi mblDist ibli d.0@ Ep{Eattnd u mijl* de .pire a o,leimdDi conpali! dinE bda . E si DrbFe de o mDd!. latu sp4i $hft Dutirir ti pdrtu e.pbii in mmic aiii..rii nm 3@nln Fde DrdE lobolidviri (di, a6t notiv se rpron.l.o(ndoDr p.bs.trl): tin prbrldd ti evi&li u licbid. l@d ftil. (l,n8.,lichjd #n_'fria'n Im, Fd?-hilit .@t&tqej!.u Ff,ini beii c ,]dtoie dorr dibidiesprin.Lm@.i. t.trdlort e !od.6 pratt pdh.3ld. zile, i $l6i F (m @b disnq. Erira b!.erfl D.bFtr. @ plod@ Llotdom hbol'ivio (44u6lrerm , Ein4 nih. D!tu cdf.m4,.i @lmi€ de ldd d. {i ! ,rranid.h & P.lslsi rele popul.r. o brcldii 3apofib aisf m. il. @rpdui lll@ nonn l rE !@eb ds 6gD.L inh., 0nicul,+i s!.ge, taR, lichid Fibeal, plelnl, lo6ua.l. I]Imri 6laiL &n@liD n D.Filc d.hlcii. Fhd @mftt e l@.lirr! sp.oic ln mmi. F$6i.
  44. 44. . sbebtoM eeidhidi' . sr.pl@i vi'idm . Neisii spo6r . Co4E 6.dqii . Hmphiha kttuftu . snad@pMi,. . Ptbgd: stul@ p}'ae."t, y.snid l,4heindB .- ., r l.d :.ncbGdnd efuul 6. o [o,. siDhn ; q a rmns.,lui sh,.dr@ tumt!) d. r6t .tdoflt p]ldui ,.id s polE o.tim b(en rio @GE 6 , Dsdaut.Jquut. oul $,.nd uo 0m Edulrdr iddrifrt gm mFmo Adh.lq,bt qtu d. bo8llt dabli pllali mat, ,j sb,6l.lr D6riv. Beh .L TEg, Mpidn hfaid sp.drl I. liv.lul 'i@firiqdui 6t @jdd rbif.. dr c.t s46n sk @told r |' qq6F buel. s'lh mtik !@Miv tor hldhi i,6irut sm Mr Ep.adi. d.: hporiv! pirudrii ricro@rim;l6 . T.alNbl n o h bmian6 @da[ diDd h h gDJ.l. *[@ !' i. jEut lq !|dmn bdo,L !ll!db: . Bd61 b6b. Eunids, a,inobe,n4 I Bobnc,ui@.@ . 36, *8, EalL Lratuba.ta_ oaobod?r. pn@. xt . . .M!6ijhL.d.@nlr mdmr @d.bahtuEDrtulrp6nrhotu 3:lh:trTjy'I1u] { f4"l d. d. lpuld 106 pa se ,j ,r,!€pe !M eE.t.,D.d,ur i,,"@h ir 6r*."*;|,fur d.;*i;i.";;;ff ., Thl{l 3.dr.I lM inf6@r ! mbdtr d. * otonud d. nmlhdtddr 4 obduru d. t,pl,r@ .pnzdidB, w;btut_ , proi vdvc. pdin.l o osi ,"*r"*i* - . -gi*i p*._t. , *,t 1_':"'.,:. I thl lq04 !U 's* n.d,er Fax-e E oDr.: s,opbr@?trd.qda s'.lt.rE@i_ EtuL.stup,<,.@ h_;I_ " -"-- '*"'* *-,.:l.T-:Y'lifl -'l ,Ydc' si d' in0u6Ftr d. dud homo.n i plEac d,iric aen d. b.fur 8tr6. d 0,66. i, F;od! d. 6uhk k; "1-d p '.1l1yF r*"or, og. * -.ari ii _e,"4 ao.e *-qa .g^ g.l"r. +'hlid. .t. b,.le v!siu,. 6qiad damrbE E ffi E{;iFffi ,H:,l,ffi lfll-glil.r,x":*E"ffi E.mrrEr'ilrt e6i.6didi . col ui.rin h m;!.d {dMt) p,en6 o flGr .s6fi&! ntri dh .^. d. ruzjFc ,p,. eder. o* ; "a* **Gir i"i:J_Iffnu(!'r@io.l.e q{n. ,uhabnlc @Eoh4: t'ztr. t@falA o nt &
  45. 45. u! ievot pr@b b zD.le ued.: m dil0r{ zm inoin l[ PrimipaLle bdsii d. F &gu6t mi Epl*@ d.: I PtoPionibdeno m6 r cci es.5i . stapvtds .pid.nni r CoryEb.{tdii M,i putin ftcvmi !d n idahn. , . StoplElo@all4 Co u.Ll ..ddv eE 6c o pr.lu.Birc 0 teerablui, ie sp€iil. € pot oloiz edn Esu. Mr '€DM.IM dc Stu?ht:t@ ."idnnnb, cortn{sdil. uffii m6d @r. dden @bicldii R.t tr dhE fl ! rcIDlt i 3r,n. u@l Flm :spoiri id!€ ba.6oii sud.i llllme Fin !8ds ot$sji iomrEEim.ls p.bgsq Ac6l prlE e 'M.th rbsorhD Dlcmtlii. D*hilibrut fl@i slroir. !.& du.l' ipaln 6ofii D. qd q nonbaeisl n3rn U m61ie h pH eid. intitand dFtag Lruilt. Clilila ./ri.aE pd. *i$ Eli in n6n Dic h ld dvel. D..r p6pul4ia 6ad6imi & dihln prini ,iibiolicq rdad inhEgiidr *6irr, p'odee de igiai i dontu nepolnv q pH-d wsin l ikri* @ li Ca,nid, abiM & Dd. imulli d*dind nidmlgDisul ddilmr r@8tt rib.lie due Id o fmr d. v4inis (infelie v!rii.!i), R.l.lir dift flm 'ymrE i 3'zd! @od s m6e rldlrhri. a h Elrli! siDbidi.a Dmir! @.dlra mul dinb. dgditu ba.frciun p. wo eluilalt, dd €l dir lm; d. ,feln MulE din@ nicMlgmim.le fi@i nm.l. rut .6aral.. D. ddplu, Dleb0otGiilc dc l. niv.in e.,hnui 4ditjv ilu d!ua?-I, nu aduc ba.6cn). b. mto.nrD el. o foiDi de sintio"n in lm baoncio2t mbcle dsdme De asnplD: inrerilul g o$d.baeii , @r,@ sirleii4d}viMj,!(!ilele vih,'e B. ach ,itarirc sur ib$r6ib h s6nEp $ disribuii. labu !2ut c.td.ld bfri4 hldtinul 3a frnie! stdht le Nr ive pqnru suDiviquiE c A1r tip d. sim6iozn el. rcFuand d. rl$ia nuii pi.ddu! t @ D dgdi toeffcirzl ir d.f8v@ eluiLlt. Trluj. s, dim c4 h mmir. odjtii. rhriile sirhioric s. pd schinb! De daDlu: itr Mire udifii u mi@B&jm a toli po& d.,mi D!!oB6. ,.er, nu Fod@ inia.lii aar tiDp .ri rh&o h irnBtidul goi d& dd rjus. in oll. lwj m & 6: vaid uin&l pliDttri, lziEi DaL prutM inf..tii Ei'rE, eut&@ &u !b* O altr @Bsie Bh Epealrt! d. nideshim.l. oDo.ru&.. A.di6 nu Illdu inf.qii id t'hihn lu rcm.l m.i pfte sr,irre. D. @plu et diul SIDA.t ideqiei I v d nEv6r {lmpmilt d. infclli oDdtoni+ s: pnem@it w PiMcy,i' trnnt ldr infdi. ffidri d@l{ndu* din cM srr$lui imD sizur. CLnn..E bol[.r lnt .drr. b .*.t -t*pr.r po h armc tucF fl s@i al. trsEioulu, F e po, r llrpbD @b ni.rt &9..i. rubidiv. p. @ le Bitu pEiatul {dffi, s@6) b. !.m. @ si aep@ obidiv.l. p. * scdicd L pGr o5ff $ bisw (DIdiro fdtri. i.dultic)
  46. 46. c. !r.di u Srup d. .if,plm A 5m spdfie *6pDi'-i o Dmid bonr AEt podl ,rd. d. .lrdrE &lll.l .dtEFt6: , ffii"-.i',i;;5|r,: .. --r'rb[. rr.tra Moid tutdll]ozr v{ieli bsp6. dEtt-oball) s ili. --r,rtu -o *og'* * tru * lffii & rr o s''' L rlE Adr infdii d Eodr d.: * I.-lJ-ii" **tr -iae rddos@, 'l' rE{isuu 3'2i' ;i;; ;:;s* * p'"d; inr.q. c&d d' inEdc Ftu{ ra@ {d' .;-^b l.6td wi boh bEnioe: . B.di.or.dld, ad @d.l i r'&t otudr h Puopa Us'al . e.a"ia, uat .i*, p'*" o popul4i' (m'ld! ln ^trs tb{broI) . iuaJJ. - "-r, -,i. a. p.-o!; mb'rd@ r"E pqio'dr Mr d' mt tdc d@du gip.) . PId6&a o bodr @ddica fl dlp&dF dobdl MdLD d. oio@lt & i. Dlss4rttrld ;E;ffifi-ffi-d* rr .,rd;i'* *"j "s'r '64* ! 'P"i*'l -d.r h to;. ih *Idd oin &rlui dnh stzdl d @o!o4pi@ Uffir p@ n ;-d r{",,i d. b*h inf4od (p'6'n -f"l'*)- iilBlr hLdd 6r. 6dFml d'' I Mi;.t & !tam.l. orgdi$ului lru ri r"*t ao D@"i,u t a. "u.r4l rl' mEmo4@sdd "'.Lii'i-i'li.:i, ,*,i-rr & E ebd d' +ei' 'r +'a',Y? F,- ;G'-lpell-lmt; ai " a*- * p'*o inrot* to o g"ar mm Io *- *i,.1- ii ua,Ji".a"r a" ,.*d@ i @i lrrpi. b'tui* 'n cted @ sDen v",,r-r"-*"aG - " " *ilov-.j pobsp"r' h Did 'qfllda {!b vin!tu' 'D'lt virulob !d. ddani r.dc ). f.6rii & olodire 3, c$.,i{a d.. Glthdi torie l. F..torlt d. olol,.E gd rqt@nd &: . d. dldd & D..l.rlt d. L Ddrt & inf.F '. r*-vi* "ii'*;* -u di@goim d' r $rehdi in oE3ltrnur - -ai. r " U*i * - r * & in@' ti * buhiplicr d@ It pod & iih -.*i,:t-lr": an-tj ,u" u*I d.prt* buia ? di'L E h e@"1 limfrric !i h l,I!a ductut l. s!pri6i. hl.d&brr.6bE 6rd6.: . ---i t'...r.,1 * elinb@ bGGi n & csh sui(He dr lstui lr * ;-'lir a. Na-r"ii"e 'WLt i eluleki bd6tu fl d' Fa.lr @ ;ffi;; ad."i'd. -' @;d@d' p'*ie d' d,ie @dr6* ffi,;,.r ;"i;dt. * ,,"!'drs iotur@e d tr tubird kert'I rpeiEe o ditoii n!dm. adand! rt ltprEa@ de' Dih (tfu rr 6E b@i 0 !,io€Inul lr tli.tlld). a
  47. 47. ! pe.t L elul- rl u0 ba4i6ii Min sb@ts chihie e o6l'uie h,irurar' lstulL-la. sc.pbM ptasaa otirc Drdeim M e ndjaz5.l!!!8 b3eiild d€ c.lul.L ?ir.lial. .L Brr€i ri imri.dictud fucillu . oprdt * o tu; frculdiv{ E d6r. ui3hts tr@id, lmpi.dicrnd flS@iM i, plvol. etorprls ut.qsuld pe $pnfoP clp6ulo blclaio., * prd@ dktuem p'in f'3@ie-L Exdple d. bfrii inc.Fulab: StupbM pMai , Eamphilll i,t1hMe, Docilla otuhrucb, r%hi" . hvd. @hll . dlr.dt speiil. d. slton h inwd.r2! l*uhiil. pii, id.tiuile elDleld aitli.lt 3. C.pxlr.6 d. . dlbon rotln. Tqircgoa. 6!..peiLl6 niomssis.ld d. a pmdDE bxine. T.]Mul dc bdi. s. i.6!r5 l. sinpl@.le pt dr d. bxinele .libqlt in 3toge ToriD.l. bd6@ rM de 2 bpu .$brln. n ddd n.. E&tod!.L mi p'odNe i i diml lm berdii ln clsul @i6ii ti o.raboliodui Ir !i ur .libd. in sintiul ln6luni6. sBr cfuaidi€ hddiilor clm pornve (ro pd 6 pbd* d d. wto blddii Glm ..sdiw, d. *mplu Eaobxin l. au rh.nmpeici ri mr hohnih. Sut dituzibil. p. cd. ssuinl, mdi 'k@!r, ,odu.3od .ferD Ia distqn d. leul Au o rclile sFifi.I dddiii I.EIrii spaifiE emiln e.prdi de n 6ma. Boul. p'trdus de b&16i @ pr.de d@ih psnnn llmiturr'i eut d. bin ti tru Exdoxin L pr.du sme ii snnDtu sp66e. Or8ai$ur prcd@ mri.,!r nuiti uriroxitu, 6 6mia"l inbil0ic lnPotiva crd .xobxin le u! iuctiv& lrin cildur4 fonMldcnid4 .u D., pmduc bodr, d,' sr Bp'hile d dinula. rodl)..6 d. Mri.oai mriioi.I (l9i piad pdogaitta dd iti E$bxincl. Do. fi t@fmot ln ,,!1orim (wdnui € mi podl ddmiM d. Eii.* fi Ciu9. do 'don'.:. cibtoxinc dirirw etul.le srzdi s n$lia ld . nooiorin l,npidid tumni! Ilmn r inpuhului ne6 . ohioxim ix 'fdsz-r eluLle tului g.@id6tiral Exmpte d.6atuii m pdu dri*: Axddiun botonn@ Cto'tidiD ktui, Coryebdc@in dbhtuiu, tufrl.Jed ei!. Erd6!b.h lErEi i gmpdqt snucnr.l. ,1. nmbmei dtu a pd.hi elulo bidciq n t&iilo g@ tu8&rc !i mt clibqlic nMai dupi D()l@ (lr.) e6roE ?dtillE lipidid s lilrylizloiddtr, Dmiulipidul A d. mdobxins. Endobxin le Mr hdbbilc nu pot 6 tull]lDr€ h mrbxitu (bxoid). T@ addriEl. p,utrc @16?, :€rtr i siDptue (nu Mt tpcifE boi boli): Lrrr, hiptuiun , p.tdi@s.ptic, deicire saadi, ndd.gi. viMd{ EnderiEle nu d.lmi.! frD,B llM Dribxitu (dtiorpi) ofi.i@b. ErdpL d. b0.t6ii @ olihffiz! mddoxitu: laltun.ra rrqp, (G6'i tifoidi), xsi$sa ,gfi ,iiir'tu (nft isrti ElSms"inalr @iddnl.O. viiulol. llM blclgii * hv0iaL d. Dsduw d. ditu dbelln@
  48. 48. ,r,ffirti"6.** & d.6r-*i' s.ped lot disug. norDfl.r. .*"-lffiflfl* * *-' lor 6 ,.dr d' dnr@. st ,.@i. ffiffiffiffim*"TTrmm,* Hffi*?u,ffiffiL*ffiffi,:ffi,ffif,l.Ib@ldE, EtrdE! d. tul]E poliahEd. din tarr, .6rlee dnol* ciiluJ hi.tumq u bp d. Acdi d. cl$rtih d6!$ dMd a ftdd63@ ti ts utui. ftwiztod q.irds6 9mi CoLg.@ ,Ddut! d. c&dr ts+1ul d{eiv din Du!._hi si rlr ii
  49. 49. Crpltohl VIII. Ms.ni.D.le d€ rPtr.r. trtll,f€4ioltt ,1. grzd.i. Mslrllrmc nBpectfle (blliere o@!i.c celol€L ftg@it.re li Prccs de f.go.ltozr) M.Nirtul..L .plr.r. lPcme: nonud d. b.rr rupn i[uiltlit D.llllfte'l hferia s @r. flrdue: . cu b..td,i e dcnuie non nomali, pdn flpa6 ehilibnnui dintc lrd[ t, MstrLDd. d. .prm J! 3rz&l radon' l@i de 4ir@ sazda rJ rrprmb dc stod lNo.€nmit. d' add. mlouFrre esim.r{n'. s rd 'nfd@ rso I Sl,g de nftine malnDtibs Diobc6, vttuinici prdispEe Ia bfdili 2 vesb no-naeurji, h seid pMatuii ds d peimlii in !18l! mr p'Edipuri li l. snxulr lnEri mpotu! o@2io.,1leln d. rieul poli.idol '1. P@: lt]ffii psr.6 6 rstu, d. .xoiplu: tra nagd @ pdnpEi l. obdcdoz! da&ro@ioi 5. O.{Detia: Do0io ]:ditoi u h.1d d. ns, de amplur mtdul l0 mrchni$i rcmDl. de rDi,u cmorm'; d*r,r,4uel. araliui r dsb.t . 'ulinmta h.!!ric{ msr4 Gszda pEzinr! 2 hpfi d? fr@,me & ap&G: lrtEais. ndpei6e d I. M;slmle d. 'pidft n6peme (@ pEtjaz, nnrodiva mi.mrsum.lor s. et dNne D I DGi c!&Nni. s B;d.,e 6ne Ee,?ohk de EgMa,.re t bu@h .nh. b. ?st in. de ripul mplddblui, lizonmdui. inrsfdnului c Colnl.le fagoci@. Ep€mbc dc nob6le, rmro3p !i c.lulcl. NK (Nihl lI. MEt lstul. d. aPIr.E rPcme sd n.@is.le n diarc d. mlicdpi (si3hl iDu uoEI) ti liDrocire T (siddul M.6d.tu1. d. rplrrE nopetlt . . T.:rtu.ltl d Drcdkk . l@oord bbd r$r@nb prm lrn. d. apes inpoh, mllb -im*.. lwmnl *t o bMm mffici .e pH ul !!t,ul inm L) !' ^- J*.."ao, a. ru'aa. cb,F,l. plel''. e mqbt mr bd-ui ti . Mrcour trdJ uplEror cu epibliul ciliot a s6ela ntr,' H' dlen&.,, me@c 'spmrid. n bdnrle. Mr-; . lfr"* ,r. ",,1- Mdu mururl ln5r r"iEro n,ua$ ti oviura buai. d. und. bda,l. Dd fr dmur Apsntul ml@ re nlmr !i . h nul oli!" porE F Edaid. ,l@l frm d. ii!r., afuui l. Ftd's,u saud, l, srE!' bdmae'
  50. 50. .]ed 6pitu rf.ns * @jdar ,l6t.,. dr et sl?6io * @tolur tn 9€r h odd ,l@Erid8.rtri r sdtir buEt. s.rih moc ap,Dtm&r t03 bsfulpaDl,ht! . sto|i*,l@.? Lnndh . Sbp,ulwM . sElplo@i vmd@ . NeiMii *prfiro . cdy'.ba6ii . Emphttq klt@ . snzfl@prMt'z I PMbd: SbPbM Ooscry *eno wdryin&, -- .I"." 3'tupgd'l brssur eo 0orr,iDrur d s ! fsins.nr sMl_ur iM {marr d. r6it d,rdil pfi-uhx aid u M 6tu b'Mi rido-EMrc ett liahekt D|M. . DrDdoul,Jq@ul.,lmutlDFic u o &rr 'ldtref dr ddind !o otrFx o Ilero@d dh de bo8nl deiu Fal.i u]:kh lj sbtuFtq 06!r B;brb dia . Btui .{@otE: Bd.nids, E$AobL@r@ r,so6och.6. @j Dd{6i. Ba.cii @bc E@ti, Erbbhdt, Atuboc@, ptuN, r*h.i.lla, sk ptu@ ktutit, .tc. _ MiGiil. fed.6Dnr@ nm,r@d.bdd trrlt4?I p6n liol,medr ryY: if1 fy'i,"r t !*r & & l"Druft! ron F gM ei ae|r+. sara M M4 rddd oErrr tn ord * molNr d. bdcine @b. ; dtizd,i . , - ITy {"p, *:T Ir-J* r @bds qc * mroiai & f,ft !@Dni{ u@@i6xormiAd&J@p,rrtN@.pideild, 6t1*M_ .. rh dv6a pEilra o oort aktnrbm , cBju, FEerle cffirv + ap, ..r" r. lto'r t.3iM. o iBi@ frerrd pme. &mph. s,./,/erM;.?Mbtt_ @ynrn a6iL E coti, $n@ fo5otb_ . .. "- *+rl q - ,r-ed d d. i,[uaFi, d. tutusd bomoDj d de ::_I:3,,py. pd.'.. d9- ochllui D6,n r^ 'i drp, mloplur rn wsin turpEaE 4r6k 'par d. hGij &!b. $ @bc ti !qo.& d. edvie tu;ddi T--a :D ,t,Tb iollMitd dro8dj. s modi6c. nd wdi.tr d.rozir.te & sl@go dn etut.t. .pirdj,l. .1. @i wsbde f,wi?E, &zstbE Sdutu@/r4. tbbcti ptu uritie giq-,t. poa,. *a t*". O* _ pA -,ogra Ed. .HJr.n lirv.Dbir d."vol4,n ac ,p*, r,r.i* r-*t. p., "f,.".1i i. ,, Cot,r a*- io * *lmr r.I6D p.Efri o 6ca i6.rrloe 0@i !rsDrt., dm @.@ b@rti.. qE adlDt. [o.r s EdE Duac. rr niEtut w ufu dii, 9ule .1",r e *!E *btuF eriD@bia.. baja t@rcr4 Dt d. bci6r tot!.bs pdsDdqii bElcldif,dq I T.aorEht h o lod be,,u admd_ diD,u L tot dtl']@m !€ m,h sM.l. r.blE 'i h jE tc plrd.dd ba.rn . dumh.. Miclws,trjs.t. 6ifm I I ,i I I i I II
  51. 51. AlL neim pDffift de apednui 6piE or sur rrEa@ {te omfi!.lc slvdl@ liuiDul din ml$ ($ g&.* ti itr ltEirr. p<ii rrari, fttlaul de he (@ pEvio.asrilEgidp6rrn. . Me!rk4r. ndDer6e d. r. .lv.lul h6r'd 'xsrdv ,notud di,hde sni@ pH-ul ei4 d. ld DiElul i(rmoilui, @iD.l. d.8Er,&iv. F ''eorre.le, d. L niwld irtdrirului $btiE . Mroo. vqbdr d. Dejdr d. m pH &id p'.du dc lebEili c f@ ptrE din . Acl'e. d..DilE r rrr ..prfulu rMb hDUl mictimi . R.lld.: rdn , ru., wrnl dLE: elinir@ lM dtilAi rui de . Ilon -pddra d. h niv.lul losmotului, Mfeins.tui, nsinului, old ui, inpi.dic! d.zmll,6 { pl lifo@ boddiitd pnbg@ la &€& niv.rd, pdn qnDditia Dah d.rbni .Adei. @!dil,. patu substuI nDriliv { ,ri! p'!dl@ dc subsh!. ddlaeitr OdFieitu) IDDodlrF llmi $poftc & ot6.rw$ iD dlpia mtibiori.a cad se $p.inln ol& mio!trsuin. b.'.t@! !.Dili.d @i b.eii closniaiu dqlciL s, Dbdxr incFj do riDd 6liri p6eDdm6b@@ sN cannidei albieB d prcd{i iofE$i vrsi.d. b. Suh.h! .o r.r rdDrq.bt ! dln rlrr. i sandr Ltzodoul e g&.i. in leini. sdivq s@!i ni"n Nu s pnqlc jn Iichdul c.f:loohidio IrR, turDmli. gi Eina. AE or sliboeim pIjn hidmlia pgELrui bdaid liun nMFpddd. kop.rdhr s !is.ll. in ptmd a4ioda, &suF? brddjild ctu tr sriE si ,crivaz-d ompldad in ih36l. mpl*dd i]M. (@la olldna d. adivm ' B!11116. 6r. h ei'reid prldu do ltonbeiL itr pr6ul @gul&ii. pirde lz 6leiilor cm-pond!. Ldlirh. 6r. o Eliopeinr h div4 isini, sEtii ozlq s6, Smulalit. lelleiEld- rsai icrul , int i in cmpdiF. boddiit. pah ,t:s Alr -@ih dc .qib. + @l pri! @ ratufaie e I.!si de B.flsj, dc F suFrfrF ehJeld bxtdidc Gc la$ d. lipopolizlhEidol. p{.l.hi 6dEi4 ,f.crlrxt pm..bitihe maDbmlr6 rj PEidr diYid. briviDli d otinluica T.ora.dn. e stu.lt i' s t, la ,ivdul D@&lq, lasl nad ri inri ir 6mpdili. o bd.riil. pah &d" q { l0ctofaid Ilbro..l,!. gli..pmcinn din plam( e d in oFoie, tn hcnctilm dinh eldc RaqioM, o cdDlffibl. bt rlse{ M gliolr.tim nmjli ti cibritu, Mr por.irc prldus i dibdb de liDlmib a drprb! h prtdE prbsoilE viNui, heii, pEili d nmdi. DabiH DiDytu & h cqodLla dc r "iefeE" r!,li.@ viil! ln Eld. szd.i. Idaf@dii 3u ti .lE 6bctii: divEd Gtul.l. n iurit sisE. N( (,.onEt *illd), mdGselq dw c{reillb elll.ltr minf@ldo vihl .! Mid. inf61i.i (i.duird nr c.luLle iiGcbb vi'xl podl)@ & Ddd* unyirn.). Ce& prsiDrl limplqrc rl. .fddui inkfmnuluir midgn, f.bn cdplrErd (,ldiu): fiaili. d. rmrirc s,ndizL t fio! sptint, 'n'mfue. se Adr@6pla6n Dirpmepdle D€ doua di: . p. cd. claicr: pr; l]mplq. dig6dri6qi
  52. 52. o. ctl. slt ni. @ffi Pnn rul'nn' ;i"'"^ir brdsia., Druj!, lM mnw: polzlhm& ropedim i*J-f'*ffi*'ii dul pzn pbd,*pdila rilp@urui *-"H!P-*, "--"' * * ffpr* d' ld' ld're n d'n d' s &rmiu t iNsiE (6ib) M'6@ n-n -i l!fub! la led ,nrElo a unnA'lrmlr s6m' iia'-l J*J. i-p.*tn -*-ll I IUid' Mo do *'Y"Sit l":mr*:L**s,*li"*'*-** ,. H*,:i"mlff#ffioiud€06'ic3bE $Dr'rrP rinciosLle dD. u'r #5H',J#*ffiJ'SIffiL -"."-'- dtrc, '@@tmtucrddDq lex*ei6' :.*"-lz,E loJ@'do, d Ptri"dd Prlsns( Celd.l. f.ritr * orl@ ,olindfoMl4 n.@ X.lllff#,**""-**ci*@r'iporpraohi'dvi'.r'r.s@iuri'd' *I"lIH**"m:*x i#,s*:;;ffii ffi;r"ffi lffi ffi l: - ,*Itr;H#itrffiL',1 so"*. p-* ,n d bdtrik {' i4rob6r ffi #'Hffi;'Hff#:ffiffi ,"r*.sffffi Y; ::'rffi ffi{{#,k :'H:rtff rffit fllJl##IJ I';*;.a.i,-a,Hfi5f,*,1'**,1 .** *,,"- *"'i$r";'.. *^, ,' ,.o," vsoro opil@ sDE leur inf&-li'i' 'm i li di4edd4 *Y'fri*.*lji*,*. " d'bror 'rso.:,re,or. tu@kre a,''nd @pM ffitrl! e n.d[z! plcul ' itr ri6dr ' &r'de @ii Psdopdc D Jor r]zl)@n dr-6h6L ldFo @ine tidobte fl drc a-.d - Ginondz.i flmtud 6 hrplt@E:-- i i- rir,-*- L-.t.t rr: in frsoli'e "tu @i@ie l. GddrDlk d'bq..z6 @i['l' insjoM' . s@de liean l. rui' EPrtus r)7! hdd'ltr ! fm6, d rrA@d' sb3hleb;d6 &,mss'3DE @lin mi.lop@nd.'i IbnD
  53. 53. - s ule limrr. mici. Ep@idn 35%, epr.2o1iL d. lefainq p'Dlgz, @l6a !i 2. tuEad.i i d. hipocldir, @ rur ei mi peici 's61i b0ci6,oir. Mrmr.s.r.: ir{ prin acclEi ,,l!c, migm, idgdiq ditusd, o Dioi difaal.: & M!@6s.le ru pG.dI niclopcoridrzl t, ,u pd p.du id hiDocld( illr podw &O) t. Amit niooorgNim o r,4@6d?fl0 .tb.tdlatit, Be o, IMpl!1rtu, Mt i46e, do rrri, iilil. 9i s n riplic! rn €r. &lu!.. cleloM.l. f(fu tn @ut a..@ inf.q,i 6ntin nult Mfur (ddplu smdoud. bb.rcul@) LiE ald. Ml rq.!. Nx (N.tui xfls) Au ml b @MbH @tu rf M tiDfmk Mi o gtuul.b. Ditus eIrn.l. i ee viDI ti o.ld.l. nodde rdn sEqir d. cir&ie. Nu 0u rrei6ci@ Dah u ,rDit yiru, aqil@ lor ru B|e irrluqtFta dc o *plllr* tuioor' n. MlolrD.L & .PInr. Dct Ic Sur doui ne5ism d€ apare speifid: I Rilplrul inb moEl 2. Rlspurul imh..luld sirann iDu etc ldD.1 dir: . or!@ iDW: ot8m linfoid. pii]lE (rrdM mG! !i riouul) !i rasdE &6slimi lirfdici, glin& r|tl{tui ltmfoi& 'ei& fr.tului disdiv tj &aioior incld Wddqa. plrci P.ya) r C.hle imre: Imfcir. B !i liof@ito T L RnPud hq lur.r 3M inplrc.dc lia6cieL B div&, E & terfornu l, pla']Mie !i .lit lwi eii.ori (d!p{br inm Fim). adiafDii s imurotlobulbcL Mt prd.iE F m divihL spcitcr. sur 5 de de Adicupii e tunqio de cpil@ . frDcti.&rihelsio{.lrpia*4..o@ldabnui . n &diz.ldbrin b!.idi6. . f!bi2.!d fu@iioa pri! o?6otze bleiilo O Dln din lhfeiEL B lcivd. e vtr rdfomi tn liDf@i. B d! Mi. b o pibDd@ ulldiorl . @l!i$i disa t' orloio, rliplmul imu E a insLl. m.i reid t, n 6 mi i'ns{r&pwinh.dde s ',rrll11Bio).1 RLpud lbu ..hLr En itnp.rlat ln inftqiil. pr.dEe iL EioMAmim. € D6idn s k -utiipticn itulda (biordjil. e Drdtlc njbdErla bruc.r@ viffii). ljDfo.iLlo T smi o D@dr$. d.liEfeit ,!epos!b c & nlpus inm elutd. san il. Di rulto dpui: linfe . T h.lF, T cftorqio., T eLq,B@. . Mva, lihf(iiol. B in plslEiE e..m r pld@ uiidri . sddDlazd sliim IDfoci|ld T cibnE . Stimd@6 elitl@ linfociidd T &4rae . Sur eI|dcii r&Durului & I'iFmibilie h&zisrI Lin6cir.L T.irobnE diirus elul.lc inGd.r. id !i rlos.fd. Lirnfdir.L T suFEle: ! idlihrpmduq de !',ii.orDi.limfoc$.|. B
  54. 54. . et!r. r sup'E:@ 3 iDui4ii c€ld$ D.tulF rI clrdfiCm r v.dhrdlor Inui@ otiirf.qiols! Dooc fi : . IdElur. Mdldd octiv4 Fn rsa pf,! bdl[ r In8l6r. mhr,li pBivi, lr@isn tmphme, pdn uridpi mtai. tr @igurl pnrdi. ipr.xiDrriv 6 lui dup6 .ah . rtnuillro ditcidn dfi, p'in v@il@ ! Ildu,tu difici'li pasirr. pin dninistu d. otiorpj peftDnoli (wi hipainme rN immoelobuliHpBfi e) V@irul *r. u ,r.p3Ei @ 6nl,'. netui mtis e din sbtu mui uui $or inl.qi6, frind splbil si bducn u rnspu iau prlfu inpoti!. GDdnlui Obi-iiv.L iDui?-irii dive (wEin&ir: - p,ldlllro lmi rih adsat d. di6lp, p.rEloi $ oblin@ l*j p.Ddalii de c€lule o - iDuib dE silr- Dq.i$6F inuii4ii i'dM o p6iod! cii mi lung (ei, bit.r via!.) L rhnnL.E. ..tYI Tlp{d d. n.dirn: r, vGirrn yn ndnrb cu ii.Mr3rlrl.e r,r (rrnrud no b.cbni), cm pdn d[,ci d. dmue $-ru piqnut h 6 nii mm FrG pln.€ prbsm4 de $- pttur .4@ih6 iDuog6ri a6@ s. Duliidicn h o$pisd @ Dimiln ilfedir nrtudi. En IE&t anninisllle wi ri$@ d@. sinrtudoloaii cti.id bln, d, 6d. r.du.a. IrDuillre obti4$ de dubili. sur 6Dtnindi6G h gBvid. (.fd hor@) d imuo&pntuF. stip.timieliic o'al SrUq MMR (a iojotic, stiobaliq briuliM), vEinul rr,vtielG, rainul dimml (uti-fc56 srlb6I) 2. v.olnurl b..dv.L (b.rl.), c! dcrmrgrnD omrtb, liFiE obpla d. p{rw prb8Ei.i. A..fu nu s rultjp$cn h o'zmism lll4 6iDd trEcta.nhinitu r 3 doa (2 doa l. inl!flrl de 46 srdtnani, plDs u nFl h 6l6i). Pd 6 adminkr.ic I. sdvid. ti huod.pnmx!. Luso br mulk tpu d. dfel de la.{[i . radlrn ..D!hb ro .orpur l.rq oE .on{r bd.n. ru vtntur h Eranple v@inul dtipatusis, v@inul mtiholoo, lelind mtil.proslituc, v@iNl mri-t !€rit A, vMinul i@iv0t iDjelrbil drjpoli@ieliic salt b. vrchun oE cMtl! rnstubt. urkde r.u rb rltlf bdri.m N Ilnl. p:otin ,loliz.bojd. MjuE& opotnE, obfnftpnn puinffi ExdDL: lolizlhrid.: v.@nul ulipreul]Giq winul otinhirC@icr vMnd Ddl.aophilu (Xib) .. uebori oblh . Drb rcoEbLE sd.dd Exmptu: v!.ofl di'lEpinlnB. 3.a. o!l!. (roror,0 V@iNi enci6r. i' 6oli in @ bxin. epsind Fi'.,Dfi] frdd prq@, d. Ardoxir.le e ontiI din derind. bictdi@, F! htu q 6m.ld.hid4 I. ald. Ac61a lt, pi6l plfu bncl dst nd!-!i pln@ di36ici. Exatrplu: veirul Di-T. (din@&bnic, nrFbiva dinaiei ri lfuo$lu,) II. Imdzlo prdd Mliz.rzn oUi.m rei imujztri npi&, in dd dupr inj6bE, &r re dwrz, pulin ($pLnani. lmi).
  55. 55. . a*idilr diQaicl, erihir tuict' ditoxiEbotllrid . iruslobdliE diEltic., eri v&ialla-bG (li D&iaf inu'.a.trio4i) lo nDqi. d. dilihr- 16 b pl!.6{ imuidiii, vuiuil. !'tzdt mi s pot n L veioui ,rdispolrbil., & r.sut obltrdii i, tuididh Fr c Bcc, Di-l+Pd, rrripoli@i.lfti. od F ilj.rtbil, di-n?did B ti di-tujolic Rc6! mi @Ndan. tudisra3abiL v@itul rti-t p.iiil Adli-db6lic, sriw,c.U. 2. vqtuEi notdi*, '@ lM 8 4. d. v&!u qE6c (opii, blfiJ) $u o ris i'Lqnx *inul dt i!61, v@irnrl i.nipr.rEo..qq i!q'd Dri'roarqprlB, Yuitr 3. v@iMi 6l6iLo@i@.l,h flg! eliddi€ iLlide: dilMi4@iq dritifoidic 4. v@iMi d. iniqB E8rout (boli toDi€L): dimil, d. 5. v@i.ui Datup@@q ispof6ion l (M): afi{rdlD1dliftbn Q
  56. 56. I Crpit lul IX, Antibtotl@ Antibiotiele i c[inohpiele r u EDl) dc ftdimoE Epabil. si distusi su r. ilih. nurdprire mitubiui. Au 3.t D. (rdvi t. srd'6d h d.r rsaFhf ee Dr t-M etJet Anbbioticcle d sbsbte btibl@ia. n.tuarc. . Pmcilinel. { ..rrr6!.rinel. smr qte din ta$i din saul P.,,ciriuD (!, aue Penicilinclc au fod oblinure di! P'",.rIr, ,oraM. C.frlospo.inele au fod obtnie din Pe,iilhnffi @halawM. c.',]ita de Pail kur eptotosporun . uimslmrd.l., n3mlid.t.i rch!c1clin.l., clomfaiolul, lincmicina $nr ertu. din a.n'm-riei4 ln srsirl 6rg, din ENt sh.pbdtr6: . polnninele i beituim sr prcdE de baclaii din gaul ,cc,llr. Chiniordri@lc Mr $bsble diSatuim obt Nte prin sint?a chifricn. ln pl.h! o d.linie s6icn ift eL dNn mbgtri, nD sl' jBnfidn dore N fon pode nude oribidie de smi{inreE $ de a.€.,i disln t dinl& o ro!& sbshl.l. oridmbim. s! fic drel@ mtibioticq ia lol6iH ld in dmmhl sriinfeFs sn fie .Bfta uribiolmpi..
  57. 57. Fiem ml'Dk r u domir omu! lfulbondr {D C.r , I diknre dmhn 6mire, in fr4clr. de 6n, pl.dd(e d. medr@hre bdsiNt i! m ba.ldioid) . c,L do 0dhinisr@ sdr / plmien]I / roDicn . Paehh'lie D mdrk F3lfu i.rdptu dffi r, beid hmrh.mefstre Deeo!.iirl in ta2c d. Sir alssnd. DenDe_ m . obtdd iDtubru, cEflmr mtulFnl d. su6r{M r o d@ rdi (jlJ|rltlllld pai;rtrr^ cu!&.lrddh rdlrot rtd rur: . spch d.aqiu. Guut l&e) . Mod&iiuqbeciddsruhd6id ic . Asidi 1]@o&r.: bdEicid d Sdaicid a efd Sn ltebn4t nnnns .. str Plmitrg a qp.nlrr€M sr r doted .{ o espener icutrr}J dr punthd,at b'IM bd4ologic.E oDm6h d. 0 rnibi cr.ltm uJDhto de s,p^r/m ctu& L o drulr. de 30oX. El r Mr sttuF. ldjotrA dq nu ! |,fu e o klae - In I s0. Prd ft@ !j HoBsrd pron, & d*old o mod,lik de , rhta pojotM { 4 bicr{ potr! hljMn iif€.lrkr bdntr t al []a d2bo mddst. Nour E.dicer i ind in u tD la40 , Lu m E@ mrl supr. san ltii N6h6.
  58. 58. E^tctst ti Ho*otd Ftte, Pah ,Ate d6opsm, flming, c.hainli Floreyau prinit pldill Nobcl in 1945 Descopsirea lor a soluliomr nedicim ndni ti ! d6.his d@ul &^.llnni lmr r Dhtidie "E.' P.bt tb.r in rimp @ Sir FhinE .retu sndii @plx paicilinei, cerhard Domgl, u nedic a@, & mular d6..pdie uei molmle sr6e pmpierili eribatuifr.. a nmi onpu$l Pl! ci1 i i devmit lnmul dift{ lEgi si. de bb'oto.. si dic cthtdDomak ?6nrosil a los idodus itr hpi. in ii 1930 !i a ftut tulsi! la tal'e inf€liild a@, 3 pll.moniilor ri a .ior infelii. Deri $lf idele nu sd h f.l & eicikte e dribidiele nrorrlc. sut rolosite a6,v b rahmhn ruld infeni. calBrd Domst a p,uit prdiul Nob.l ln I q39. Dattu dsp6i@ Poni8,hnu,. In 1946, paiciliM . drdl djspoibnl p€ pioli Deru hhohrt itrfdliitoi bderi#. in 3,ei.l @le @ulc d. scfl@i ti sftpr{ini E$e iDportd de subliniar 6ptul ci u p'Mr ibpondt dc inleqii sur p'dNe de ele doni loui hdaim. (d8im srEpr@icI, pnMoni., slatr4 ,nf.gi, teguae, lzimi sup':inf.dde, ctc). fdi.ilim ava o qprollre inodibili & a mof 6afriile, Ir'{ . iva efate roxie k .n(lfil 6ile lc4o + itr.€puhn il- 1950, au fei inlodB. noi mlibiorie: @lbnjod chll)lmDhdol. '.kL I'nq 'nepird ft dribiolmFfl
  59. 59. . Anrib:diere d'u .fioft hFfiq @ she tr4, d. batu,. cm.po/ ,h rr ctu{ g8ri., ,eiF h@lule !r b4,tul tobdulq Au fGi ihhdl{i rtmtii dimisobiai sidajci ritlbaol@q &j(ht pn-uincs.licilis (?AS) ri ircni@i{t clnln..H D.dronrrhr rrdEt bht ,!: (sdfomidO qi dosuit (trrH). robrta b.tDLl rdb.'dc. l. Pr.filui.: Pr36iH wi inf.qii par! u D&i6r 4 ri$ (tniida wi I T.rDie Fdr4 bed p. clrhve€ plduuld psrotoEic Iri d.ibiosBrI lmdod. d'tuzo K'roy Bru6, IID Apt. spednt .btr6tsobr.! Sp€bn ,fuisoblu oprnd. bbrMa b,@iitor ,s@ c&M mbrdod *div. Esk tr66x" M sp*hnui mh'@ie itribrt fl modfi.rril. Ltrm@., a&'a prin oqmu ffi hJ@ @tur. Spdd uribaldid iniin 6b sllbiln lad 6@ dibioric h Drd., prG rel,rj F tjlpj.i ba6ide d. 6l.qi., fiitrd pejab dFi e d. beii Hibit.. i am.djr .dih .{sid6r.inoodrlMthuribioncul6pdiv. rn nEqi. d. ad! aatimisobim jriiil, ftt,oticet. ru fd dei6{b in: uthlode E rp..fu hsu( y' rnH.dc. ft rpeh tr4 I Atrbtr@ccl.6 lpdu Eg6 0u fod rlpituc Ir ddut ro h dout gn4u dupi et'lM. in mod pdld. arps bdmrlr C,m pozjbt. fl C,m rs!b!; . dnnide N sptcn dt @ paf,rid. !F citib.tq mbmhd tilxlnn@). d!.p( oci a b€ali eh-pmbu t F @ ij,[.DoE iq . sribidie q tprtu th tip trepbnn.i,nc: miDo3li6.d.: nE?loJcir D@'cin4 Fhin@ l.!l)moM - polipgiid., olinicira loliini. diE p. b*ili ri tr c,m-i@bM, qi otu.@invi .2. Adb'di*t. q 9m IeB 'a. rtuclide. ct@fmiotu, sr dir pr @ tr baoh Cm-D.ges a C@-po.br. ulrolEm. t.pr6pir. ncL@ii. cht;bldn ij d rtu mibilir4i, nqriii dilqn sisrn tubdi (vidi stu&bEnA;.- SDctu de tjD sMdicins Srafu lq d. tiptuicli.4 dMfd@l TiDui iL s?ab eft€eie'clcic. - -Au tud tu d6ep6k m @bdie o !pe@ lars I ,nmt,!& met. dD(.k htu rorosit. @ ur,biorie d. @ tD i.reE ffi tu unpu @sl* isrbspami. mononlfui. efrlospo.rn. d. sffilrt. I l-r, a +!, , t-4 *).
  60. 60. . .ferbd6icid,,Jicndrdishqft ebd*i,tor . .f.db,rnchric.d.hhibms murdDtrlDbadoor -obdlEa du en bdn. .d s, bridotuc d.pde d. n, mdt, dn -Lr.dribru.rtD' !, mtus,t r, & aq,-. I " ;i;.;. ;:;;;i; ,* ,, "l- M.smTri-r D ondtuj m h.c,. jn ,.mp * u atrbrm 'E nici.d.ri u efd h66dd -rLahi,.Ms Jr ub ^rinrsjtrlu s tG j orliciJu hrcmrsbrmsqdi ud. hbb $u de m,J.ip.d..,lme t. spon/ sd'oneh bdaicide rmr n@. ii . 1!f1f!...*"* erg smearizarc Omnr,oprEmoii, moing c peitonn , . n -Dfc!']e ba@m. tr lm,c, & r!..ton.6,e . inldr blfua..n f{u.cm d,it,ab,te ,mdo*il,r. GMtrt'k. Mbon.bir,tub6cutu) R.aoti d. !@is. . rdbtodetor . Andio.ic.te b,Goa. .u s seu . u ete be rnios6,f . ci rEiode ntu"mcd.r-kdr dba de 1tup.u o paic,h, N m hnoglEnd, "-,**;.."0,,. "..","_*,".
  61. 61. I M.ol.m d. *lun. rl. .lrbtod..tor . hhibiga sinla.i Fa.tui ehle . Alrffi sbenrii ']rbm.i ..lut.i b&loidc . ,.,tjbiii 6inki pd.i.tq . I0n$lnril:@i$u.fD4j.iDilzitodrJeici . Idlihiti. o.Lt limtuitGeim L llttud. p.Ehrur..lnl[ , P .qy:. *L-*4r pQtdosn6nruj din shtu pd.ruj eturr rr lntun Jaifu !u bd6.i Bdniit. cnr-pozuv. Mr m l@bit. de& el.(fuieedik Anribidj€te din at:.d @s@. nu sr hE pah Elul.t. lM(€1l6G, hDrfi. r'r ffi c.lul,r! sur Md6dr. Erdlpra . Afri&orie btul'ddie p.nic,l&iq elJ{meL ! C[cop.Dr&: vllllmicq EicopbniDr, . Polinixilq poliDirinr B, @limici4 ba.ituio tr.L Ultr rboz.t Dbrh.lor . hb atrte,r subuirh los a nbomilor biGiaj r minosl@d.k r+.9tm@ km.in. sEhicm lwq ndjln(rr,tuoM) e etk bldqicidi b. tuididi. iDnibl tuhlja I Prn oe'e h Dbuiha ras M,@lid.: dir@jciq clsibiojnr uituidD ?' ?" /'/V. u,,
  62. 62. lll. tudbtor*. e rlt r.!,4 .h.nln Ddnrud ..ldn A1l@.rotuiiD b6ei c€lulE b.ci6im.de de c5t! ottiori€ polip.Dridie: . p.tnnim: poliDixi B, @liricina &liu. beicidi t &nFsoe Bfordici@ B.ni rin Irdu ;od'ficer d. ptub,hrFl bmb,toi ..lulG FD l.8iE de fodolii{te fl llm nd.bolj! iDq&ili di! Elln! W. Arribbdc .s bnibt tbt?. tr furcd. ..idror nud.r.l . ft'mtme i fl@;dxmlm: .od n lrdrt. ci@flol3a oorflot6r lsond@n tuvanorL rihibi r.pli@ ANDului bicloa prin innibils wi o-Dc, ADN Si@ d. d. & 164 Ef.c1 bsdasid. m,n;. -".*i*',t. I[ inhib,Dr onctbla ! @ cubsEts d.rq,d.r" -!t" *p;lit" *aot p-.-i***'c oaBAr Pffi ir cndulu i.mhidnrotc ' irru -" * -w- *r,al! mld b ,trE b4l6 dr aDN. Ax^ s e@ili -iMi;. c.l"t.L mu. .! lli ;i"didr Drcp.i TIHA (fl ptucdi sub fdDr d' aid rt ai',ai*),t *-i"F, nu "ta rfd.E d. dudido @tlMh6z elaTrlFd s fd;ld.le Mi droe stuu.li 'i P r,l' @ * utili2.1 e piinr 6zjrl id h ,r@1. $lrmid.i - lag! d. dinalboli( Thmr,pritul i.hi5i hntlm@ &iddui 6li. ln dnotd (Ddd & @Ftu toeicjd). rumdbd( trim @ q lqea L bod l]mol 'le PABA r^lGnd s F.dE lMv D.rb.lr rmod d. a4ib' eid folinic. rFIl@ dan n drdb L .ldhlodc. ir-a.i n-1"" , "!fur a ob5H bribdcdo n .16 r de l' l!6dt Efuti Bdail. ; eDlmra de , dis ls E!@ Poolnn tlb p'6nJM ;h;"d. *.'&6 bd;' tuiro,q ffi 6 pda pbd@ trftcii d. bp Pn.mdii a**' **"i * a.p,,"a.t.l@dp;dtinutoM pu@ fi crl!4" r1E Cuvid.L hi nmins s dor€dir ! n d*b r'.obr.D rdrr.4.t h ddDbne Itaitutr I. roiciliE a f@r iddin.dn h l9'lo. p. oJ. ,i;.u,t to -trioi* so daolol m'i Epid d@r sitr@ un mi a.{,n dM rl inL6lc u usA dc d. 4{ onim. d. dold p. e Inili0l, diME h mb@e t fd ;odhrr ln 9,olc mr ald ln saFil' d' b@t rFaG flsd R.Ir. i lrmim v.[ Dublid u tediu ln lM.] or l[' Aodi@ M'did ^-J** reii.e" :os2oor r,' .; etu,*, m nhn d. Ia 00o d. dse in t sA- Fr infelii d tolDini naicilinc.@ffi d. sb6l@ Miu (MRSA)'
  63. 63. rr hft ehiDele de dror tj cliEjdii @ p,tgir , o &!, d cr.rrEa EjtuFi Ia uhbime * ,ubth.r,r Et,n dq.5 de h A'Eaouat.inblE embided ar6E L ubbMie.. Mod'6cht. l0 fotociM rmbl@6tn m63 in psnl.t tu Eodj6cnnk id Paomp' o [feql hhlDMt'c.qii pMrd pFblb,Lbra D! lM d 6 .rcitr dibidie, d.dr ,..j6p &n roNb!, marla Selinebidnl,ii.lo@m.il@dn0Mishi.iu!i@oajl@Brid. mbr@e &e tr qt@ posb,tir&r o|m/lIii . Nu dyr rsbrbrJ cj u mblec ta lm bdhrte. in clMt. pdi{re, nu . CDlli! F@ d. elbiolie Mr p,ode..rhiniE iI m.diu . qcl30 dhoe d. krlosm. d. eibios r t2jmhsd. tlnls]rr@ ctuluEe Etiti. irD6 $ in@jvr de @tul..Dh dou! sm mult $eii. h @ Dodtficlnte sde d.9eii ddmu$ d6 godie d. elorlrir '!eiIDob -n.eht notn- pDblm. Fsojului ,a.Suci rosii ,. R.gm Roqr. a lu 1fltu .mrr Ebd! s ,ldF d,n e ,n emi Ep.d. dor pdu r E6 rhAne tnr-d Is. A.iloge modiul E lcnimhd pem,Mr a popul4jit. 8 6u.. *fuk9,fu|u@,pah,@t..lljmfu R.llb!. t .idbtode R€ituF St tdiite h niibidi€ po0ic fi nrrml! tu dob6n&r{_ ^ R.*etrlr uhdr d. e al.fu d. epe. tr d. bbji fr,Dd EaHc dtub qab!]L ttatob.tud tob?m/4n * Eitu 'r par ff, bd;rre s( dEnh.tur Mtu. h mim!li@id.. . . R.ribts doMrdu $ d!l@?l rpetio + ktdin, l@ m@e @d6r. !rohruta@irl /ro) m aoaMd rtc14pM plamd. ti .1]mtplc;u& @juEh b.q6idr) d. h o b!da. €jf,dr to w Mibird MadGL r,t6tt iE rr. r.dtutd ,ur i.Irl!l:l@ dbdicului . ei moi 6Evmi m.hiq .Asiuofln d_'ltmvd FU plldll@ d. min. ll@vlM do crh bd6"adDiu d'tus@ d. dF h<nLc]@ r DclDtu hd,l,fu Bpmh,t Fhjeud6 db.rqim! ! pdflt'Ft0 fl c.eh6poi,.r4 uanotu:4 erJo.porir:, - , sotdsB Fnahrt6i br.rqi.i pm mtuio. ,rm. u p,"r.prat, ll!Iopl''!l. nodi6@ p'Dbdq ai. -ou,m *t nr, a"rra ma mu,o<il. ,i, "iuDor iM h cdub bd6bf E'ro b-@is t-var.t eitupi tn d;bidi' n tuen tu$ etuciwa. 3. Modintu bcului & r4e a uribjoiiorui, ln e tuira s sulm;tut d .e . smr folsire 'pqidr iv de t0 dj mi hhB@ai!tr (L.ry 1997. erid eirslo dd la lrmhj). mult mb,die'D @cultu;. de.3l Dah e & idosc d. ]Oa Dd n'llr ehl';e L lr @oruti., ft.rnd m'log. fl a i I I I
  64. 64. ion inh4iMr &lin. @ind &u + e!€hi ,n nfqiol@ ndnd itr D@atF i (Gr'b@ tn *6 su modi6@ nincrd ce Ep@inti !,n! & rqiw ! 11116lr dob&dfl looto fi ibl! & E linsu uiibjodc (MordrbF) u poib Ed & mdbi@ele wudrE. p.ft fr o '?6hts l,cn lt.d. @i6F h u n: @f.r, @,red fEr d. m Jr bubd. d. ob,q q tu inrdn . rldpt!: Ei!i* raortuicliai Mr €in ItdtuF dr.Ltl 0D@ 0Mci .ni uicl. Ir E odbi@ tu de 4@fqida tats la dtidiE imdi., do mDlu: @isbts ls Fr@icinanu & itrbtdam' d iDpli.i intnqli. chiruEidr D€tu drb@ ,miului alrtui d. rE ria Prlrdru. tnDLl. rtlrl@b,... . ,4 ibiotdapi!*rdrninl.ta,l,]lmiin@it.doohonbdeiDftlti.b'tui!.n . Anntioboul ale tobui. sI fe di p€ dpiu bergirnA (ihlrG !i iddi66n), . a ibi&icul 116 hbuio sl dituuc bine ri s' ulirc 0 @b.ti. divr in 6.elr itr ce e localnri infetio . dieibuF. ddbidiolu u rrLhd,i c.trlo,!6iiM LCR D Eors'kt. bd6m. h hJ*tiil. pDu&. d. trp rbc* ,bdm,n lc mribidjEl. or por p{hrdc i . . s! nu aie mhindic4ii '1. p&iartrbi li substut! ns!6lid (ddsi., minl ,mn idF Mrll, b@did, *.) . Cde dr .dninitu (orna pdaElo ,5 qspun be,iz&ii irtqi.ji doei ge m@z! er & a&dnitu $ Es61.i obtiMi ei Mhtii rdiw. ln i,f€tiile wft (&plrmii, Dditrisir) rlblMnn & adninis@_r lllmi . Doa d.iuh 3:6isw o mcahl,c 66Dunzlle li 1&rJ i.Gqi.i h jrsunciala rnDli d.a€le de edtnoric dinir& p. eI. mfi 6ui. ljubL tn @J mimelj@zit lon ljBGri 6iG F tu mtibio@ bd.ltuiq ir el. o &ire h.polid (dilrmicio) N fttui. !jui.1o, . Exeqn: in inGq,ih uiie des@ mtbiori& @ * ae.r! Drin uiir tn m@r+ie D@. D. *odu: nitufmbin'n { eitul r.lidinc N rri'g 'dodsie utilq dr tu .lirinok .xcluiv p. cdc E dt . Torcie: d.J uttdel. h u sur t6@. m pm6p pq ps@ Ecir rdry. d. dmplu olonFa in rlD , ounkld d8eisutu ir Rrt rdDmid*n d. nfmDlsl Tot,ci@ lei se po* m@fatb In 2 t.tEi: 1 bncie dierl: oioioxiduh Ia mircdiozid., .rleie b.dutrd FrdBi d. 6. hiF!6i6ilidq d. MDlu: h !6jc nn . urili@ .mbiD4jjld d..Dtibidie: U]mi nffi tui cad distl inleqii nnb, h 3ibrtj! tn @ nu di.r! b singur dlbioric @ sa !.o!a. sBalji Eu.li, dr *anplu in paibib ptldlsi d. d*obi . PrcroiE ad8q.i Eisroloi bcdim i, tu6qcul@1 prh fot@i@ mbimliild dt tulidie . Oblirc uui dd sinalic: & qnbimlii b€eicid + tdaicid. asfll@ po.rc fi sinqBici b, baordioid + brciaidiq aqiua poir fi ebsmisln c. blorsiBl]nid b'eillMiq a4illHNte 6 didvl
  65. 65. r- bhrud. rhrat FEl.ror ..r!Lr A1. lrdbtoth. h.rt .a.Die Fmih. &uriiiotie @uin slru.rmchinicr idut b6.lDt nic , M@i$ul. l- d...qihe * inhbli. 3ilrla p.pridost,mutu. h o,t d. pdm64 paD l.lE d. Etusp.rrdet. & p. pdlEtc & t.ss , pajotrrci pBp o . ffiH,*" (f@qind pajcitia bazdin poicli,l, r@djn pc, r PaiciliE lt2]lld t! paicilirlzt (M 4 @cilid, r AminoFGlm t@qlhf bmjli r . Pacili* a lpeto les - lornoDaiclitre o mnibM & bdd*',". ed ch,ridn mpicJintrrdbld@ @tuc lni +&id d,vutmic - Candipaioilim: crdoioilnl - UEidoraicilim: DiDaritina hdeitie - crbqadi (liMici.n si jbjl@) . L P. drh.h.rhnl.. pnn t. d6.or.ir. !i dldE ir rrei.. u m, o !etu'. t? p&rs, d dizi .trdaE 6pell lor & a4iuo {.('!ar: . @i Gq,pozinai {*cDt@i, pir@j. a!@j) . @i Cr4{ESxiyi (r6inS@d !6@.i). beili Gri!,orid{ r@rrr,.bldtu. LBtu mnotoE u), qituhdt {EA,n L.p6iru. ttt@tu, . mjdid@ bad.rinc m6€ . ftddl[ c Erdrnd, ,lfu dc u pdFl.il (dq@ e trEdifq$ d. sErl 8e.r@ FDbrput paicilirEte dEal.. Se !rrq& eb l@r d. w & $diu o d.poutu e drb'orc d. d.qj. poh rc.tiit. o *calmt ba-htuhri. & gBp A - ur.!r rulpiri daF.lMi, .l'!Dl@i vjrid&4 d.ft@i .Ih q, dij ,66fui & - @i Gla-loririri D.c!6i - n.ien (@j cm{@tivi) *Yft o d/.-oH I a a

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