1.
1
TM

2.
2
PROJECT
EsoGlove
JUMPstart-ECD Program
Stage1 Presentation (73 interviews in LLP, Total 110+ interviews)
• A collaborative NUS/NTU Joint University Medtech Commercialization Program
PI: Dr Raye Yeow, NUS, Biomedical Engineering
Team: Jane Wang, Hong Kai Yap, Tiana
Commercial Champion: Vijay Kumar
A soft robotic glove designed to help patients regain lost hand functions

3.
3THE NEED
Regaining Functionality of Impaired Hand
Difficulty of Performing
functional tasks
- Demoralising
At Home
(Courtesy of https://www.youtube.com/watch?v=gP_e6uR9LoY&t=50s
https://www.youtube.com/watch?v=1bRkddWvyUM
Supervision of rehabilitation
with occupational therapists
- Labour Intensive
In Hospital& Clinic
Over 60% of stroke
patients are still
struggling to achieve
full hand recovery

4.
4Every year, 17 million people
worldwide suffer a stroke.

5.
5
THE CHALLENGES
Hospital
Limited manpower & productivity
Existing Solutions
Adopting robotic solutions to
improve productivity
Occupational Therapists
Increasing clinical load
Patients
Cannot perform functional tasks
Not motivated during therapy
Challenges
Group session
Rely on family
members/caretakers
Limitations
• Limited to clinical use only
(Bulky, Size Constraints)
• Intimidating to wear
(Rigid components)
• Long setup time
(>10min, 30% of visit)
• Less Affordable
• Do not support functional
tasks

6.
6
THE APPROACH
A product that is
• Easily Wearable
• Affordable
• Portable (<1kg)
• Translatable from in-clinic use to home
EsoGlove
And Most of all it
• Supports functional tasks in
rehabilitation
• Serves as assistive device

7.
7
EsoGlove
Features
• Soft Actuation Technology
• Wearable & Lightweight
• Portable Control System
• Programmable Actions
Intended Use
Functional tasks during
ADLs and rehabilitation
Continuous passive
hand mobilization
THE APPROACH

8.
8
ADVANTAGES OVER CURRENT SOLUTIONS
Hospital & Occupational Therapists
• Automated solution with higher repetition & intensity
(240-720reps/session) vs OT-assisted therapy (<200reps/session)
• Increased portability
(<1.5kg)
• Lower space constraint
(<1m3)
• Easily wearable, reduces setup time
(<3min)
Patients
• Assist with functional tasks
during therapy session/at home
(grasping bottle, holding pen)
 Increase Patients Motivation
• Allow at-home therapy
(240-720reps/hr)

9.
9
COST – BENEFIT ANALYSIS
Benefits
> 20% improvement in productivity
(treat at least 20% more patients)
>$48,000/yr
Generate revenue through rental
S$900 per patient
Hospitals Patients
>3x improvement in patient
functional outcome with robotic
solution after 6 months
>6x more at home therapy time
(Higher Intensity, Faster
Recovery
Costs
Initial Setup Cost (~$5000/set)
Maintenance Cost (~$500/yr)
Training Cost (~$100/hr)
Component Replacement Cost
(~$100/glove)

10.
10
VALIDATED CLINICAL NEED
We do not have any
equipment that helps
patients exercise their
limbs and then allows at
home usage. I cannot
wait to see this device
available in hospital
My left hand would
benefit from your
device. It helps me with
my grip function. I have
a keen interest to see
this succeed
I have to help my
husband exercising his
hand at home. This
device is extremely
useful to us!
Dr Lim Jeong Hoon,
Neurologist, NUH
Anthony
Quadriplegic
Patient
Mrs Yap
Family member of stroke
survivor
• 100+ Interviews with Clinicians, Occupational Therapists, Caregivers and Patients
• >20 enquiries (purchase interest from hospitals, distributor interest, participate in trial,
online enquiries from patients,)
With the robotic
automation, we see 20%
more improvements in
the upper limb functions
of patients. We can also
serve 20% more patients
Mr Chan
Dpty Director, Rehab Division
St Lukes Hospital

11.
11
COMPETITION
EsoGlove
Hand of Hope
Saebo Glove
Light Weight, Portability, Wearability
Supported Movements,
Functional Tasks
Gloreha
RAPAEL
Unique Soft Robotic Technology
Light Weight (<1kg)
Do not require precise alignment
• Fast setup time (<3min)
Support functional tasks
• Rehabilitation therapy
• Activities of daily living
Mass Producible – Low Cost
800g, 10min 100g, 3min
>5
2
1
0

12.
12
COMPETITION
Lateral Tripod GraspSpherical Grasp Key PinchPower Grip Cylindrical Grip
Critical Movements for Functional Tasks
(Image Courtesy: Rejoyce)

13.
13
THE MARKET
TAM
S$4.5
Billion
SAM
S$450
Million
Target
Market
S$17.5
Million
Target Market – SG and China
S$5,000 x 150 target customers x 10 per customer +
S$100 x 100,000 patients = S$17,500,000
Rehabilitation and Wearable Robots Market:
• US$257.9 million in 2015  US$3.2 billion by 2021
(CAGR: 52.15%)
• Huge opportunity for launching a homecare equipment
• Countries like China with a large number of aging population is
expected to drive the market.
21% of global population will be 65 year old and
above by 2050
~Three-quarters of all strokes occur in people over
the age of 65.

14.
14
Key
Partners
• Manufacturers &
Components
Suppliers
• Health insurance
companies
• Hospitals
• Telemedicine
platform
Key
Activities
• QMS, Regulatory
Approval and
Certification (ISO,
CE, HSA, FDA,
CFDA)
• User Trials
• Technology
development
Value
Propositions
• Assist with functional
tasks during ADLs &
Rehab
• Improved productivity
(treat 20% more patient)
• Product wearability &
portability
(<5min setup time,
<1.5kg)
• Low-cost (~$5K-10K)
Customer
Relationships
• Conferences and
seminars (MFA,ACRM)
• Publications in clinical
journals (APMR,JNER)
• Recommendation from
health professionals;
Customer
Segments
• Hospitals with rehab
department
• Patients undergo
neurological/
orthopaedic rehab
Key
Resources
• Intellectual property
(Technology
Platform)
• Manpower (R&D,
Sales Headcount)
Channels
• Direct sales;
• National and international
distributors;
• Retail stores and
ecommerce platform
Cost Structure
• Certifications and Regulatory Approvals
• Intellectual Property – application, licensing, renewal
• R&D, Clinical Trials
• Recurring Cost (Manpower, Logistics, Sales, Manufacturing)
Revenue Streams
Recurring Revenue
• Maintenance & Services (~$1000/yr)
• Replacement of Parts (~$100/glove)
One-Time Revenue
• Per Unit Sales
(~$5000)

15.
15
DEVELOPMENT STATUS
• Prototype Technology Readiness Level:
6
• Device Manufacturing:
IPTEC
• Intellectual Property:
3 Patent-Pending
• Patient Testing:
7 Patients

16.
16
PATIENT TRIALS
Significant Improvement
in Functional Tasks
Feedback:
Patients like it!

17.
17
REGULATORY PATHWAY
QMS Implementation
CE
HSA
Regulatory
Documentation
FDA CFDA

18.
18
REGULATORY PATHWAY
EsoGlove
Europe: Class IIa, Rule 9
Medical Device Directive 93/42/EEC (MDD), EN-ISO std.
Singapore: Class B, Rule 9 (i)
GN-13-R1.1 Guidance on the Risk Classification of General
Medical Devices

19.
19
REGULATORY PATHWAY
Class II, 890.1375, EMG-triggered powered exercise equipment
(Diagnostic electromyograph), OAL
Class I, 890.5380, Powered Exerciser (Powered Exercise Equipment),
product code BXB
Class I, 890.3475, Support, Arm (Limb Orthosis), product code IOY
Class I, 890.3475, Orthosis Limb Brace (Limb Orthosis), product code
IQI
Class I, 890.5410, Powered finger exerciser
Class I, 890.5380, Powered Exerciser (Powered Exercise Equipment),
product code BXB
Class I, 890.3475, Orthosis Limb Brace (Limb Orthosis), product code
IQI
Predicate: Myomo (FDA Class II)
Predicate: SaeboGlove (FDA Class I)
EsoGlove
US: FDA (PART 890 - PHYSICAL MEDICINE DEVICES)
510k Exempt, Registration & Listing, 21 CFR Part 801 (Labelling) and 820 (QMS)

20.
20
KNOWLEDGE GAPS
QMS Implementation
Regulatory
Documentation
Reimbursement
Strategy
Associated Risks
• Backlog, causing delayed of
successful QMS implementation
• Additional costs incurred in
product design with unclear
design inputs, standards
compliance
• Delayed in regulatory approval
• Delayed in reimbursement
• Commercial Failure

21.
21
TRACTION & MILESTONES
Jan 2016 – EsoGlove was featured in more than 22 local and 25 international media reports
More than 20 enquiries from the public (purchase interest, participate in trial, online enquiries)
Jun 2016 – Pilot Patient Feasibility Trial in NUH
Sep 2016 – Obtained Exclusive License with NUS
Oct 2016 – IPTEC Manufacturing of alpha prototype commenced
Dec 2016 – Patent National Phase Entry
Mar 2017 – Received Alpha Prototype of Control Box

22.
22
HELP & RESOURCES
• Funding: Entrepreneur Project Fund (S$20,000)
 Equipment (3D printer) & consumables for rapid prototyping/refinement of actuators/components (Design for
manufacturing) (S$5,000)
 To engage contract manufacturer for beta prototype manufacturing after refinement (TRL:7) (S$10,000)
 Product demo video for fund raising (S$5,000)
Start EsoGlove Lite Prototype
Design and Manufacturing
' 17 Jan
2017
Feb Mar Apr May Jun Jul ' 17
Glove and control box
prototype – 2 sets
Prototype design
and manufacturing
Discuss Clinical Trial
Partnership
QMS Preparation
EPF: $20,000 funding
Jumpstart
Stage 1
QMI: $20,000
Start Next Clinical Trial
Establish QMS
• Equipment & material –
3D printer - $5,000
• Prototype refinement
(TRL:7) and production -
$10,000
• Product Video - $5,000

23.
23
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