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Pharmacogenetics

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A new algorithm to predict drugs which may display population differences in response through the interrogation of the human genome and drug response pathways. The robustness of this strategy is evident from the accurate prediction of 10 of 11 drugs which were previously reported to show population differences in response. A high proportion of drugs with pharmacogenetics warning-labels are also predicted to show population differences in response.

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Pharmacogenetics

  1. 1. © Copyright Lean LaunchPad Singapore. All Rights Reserved. 1 Pharma-X Maulana Bachtiar Postdoc Fellow/ Entrepreneur Tony Sugiarta Entrepreneur Siang Yun Ang Postdoc Fellow Theodora Chung Researcher Mentor : Joseph Lee PI : A/Prof Caroline Lee Leaping Forwards, Towards Personalized Medicine
  2. 2. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Drug Response Differences mb Good Response Moderate – Few Side Effects Adverse Drug Reaction (ADR) Images: pixabay.com
  3. 3. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Pharmacogenetics Algorithm Predict drug-response based on ethnicity, aim to reduce risks of adverse drug reactions 1 What Disease? or Drugs? 2 3 PharmacoGenomicsDrugPedia  Similar drugs  Adverse drug reaction  Response Prediction  Genes, Mutations 4 Custom Report mb Pharmacogenetics Algorithm What's your ethnicity? Images: pixabay.com
  4. 4. © Copyright Lean LaunchPad Singapore. All Rights Reserved. 4 Initial Business Model Canvas
  5. 5. © Copyright Lean LaunchPad Singapore. All Rights Reserved. 5 Customer segment Doctors working on mental diseases 0 0 2 Doctor/Nurses/Pharmacists 0 0 3 Pharmaceutical R&D scientists 0 3 1 Drug-related researchers 0 3 4 Institutes of higher learning 0 1 0 Pharmacogenetic scientists 0 3 4 Clinical Research Organizations (CRO) 0 1 2 Health Agencies 0 2 0 Nobody Said It Was Their Must-Have’
  6. 6. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Health Authority Need clinical validation 6 Researchers Will use only if it’s free Clinicians Need actionable components Pharma R&D Need clinical validation Images: pixabay.com Multiple Obstacles in Finding Customers
  7. 7. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Aha - Our ‘Software’ requires a ‘System’! Genetic testing & diagnostic kits providers Interested in our predictive algorithm to help interpret patient data Existing System Cardiovascular diseases Oncology 5 Algorithm
  8. 8. © Copyright Lean LaunchPad Singapore. All Rights Reserved. 8 KEY PARTNERS KEY ACTIVITIES VALUE PROPOSITIONS CHANNELS CUSTOMER SEGMENTS COST REVENUE Genetic Test Kit /Diagnostic Providers Clinicians & Genetic counselors Whole-Genome High Accuracy Updatable Customizable Ethnic-specific Clinical trial info Genetic Test Kit /Diagnostic Providers Oncology Cardio-vascular Universities Licensing Profit-sharing R&D Development R&D Sales Publish/Seminar Marketing & Sales Marketing & Sales IT Companies Talents IT Infrastructure Regular visits New-release demo CUSTOMER RELATIONSHIPS KEY RESOURCES New Model Proposes Value for Genetic Testing Kit Providers Images: pixabay.com
  9. 9. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Future plans Better understand ‘beachhead’ market needs • Genetic testing providers • Oncology/cardiovascular clinicians • Genetic counselors • ++ Interviews Survey competitive landscape • Foundation Medicine, N-of-One Determine MVP features 7 Images: pixabay.com
  10. 10. © Copyright Lean LaunchPad Singapore. All Rights Reserved. 10 Pharma-X Maulana Bachtiar Postdoc Fellow/ Entrepreneur Tony Sugiarta Entrepreneur Siang Yun Ang Postdoc Fellow Theodora Chung Researcher Mentor : Joseph Lee PI : A/Prof Caroline Lee Leaping Forwards, Towards Personalized Medicine
  11. 11. © Copyright Lean LaunchPad Singapore. All Rights Reserved. DRUG Appendix - CONFIDENTIAL Drug/Drug Class Ethnicity Side Effects ADRIndication >400 classes, >10k compounds, >1,500 FDA-approved drugs All major world ethnicities Chinese Japanese Chinese Indian Caucasian Japanese INPUT OUTPUTGenes SNPs >12k population-differentiated genes >3.3m population-differentiated SNPs Genes Alternative Drugs Chinese Japanese SNPs >12k population-differentiated genes >3.3m population-differentiated SNPs Disease Up to 3,000 disease conditions Population Difference Prediction Existing Pgx Label

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