Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Colon Patch

859 views

Published on

We are developing a biomedical device to be used in colorectal surgery to reduce the risk of leakage from the intestine (anastomotic leakage). Based on our pilot experiments, our proposed solution to this problem is comprised of a novel sealant and propriety delivery device that can be easily adopted into the current surgical workflow. The sealant will be delivered at the site of the anastomosis as a prophylactic to reduce leak rates.

Published in: Health & Medicine
  • Be the first to comment

  • Be the first to like this

Colon Patch

  1. 1. © Copyright Lean LaunchPad Singapore. All Rights Reserved. A Surgical Sealant for Anastomosis LeakageAjith Isaac David Ng Ee Bin Liew Gary Ang Samarth Bhargava Shawn Xiang Gao Ridzuan Farouk* *Principle Investigator
  2. 2. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Value Proposition A fast and effective way to prevent post-op anastomosis leak (AL) 2
  3. 3. © Copyright Lean LaunchPad Singapore. All Rights Reserved. -Reduce risk of anasto motic Leakage -Improve healing rate -Lower Risk of re-surge ry -Ease-of-use, versatile Surgeons Patients Nurses face-to-face meetings academic conference stalls road show demos Publications and conference posters Technical assistance Generating Clinical data -SOPs for synthesis of adhesives and additives (antibiotics, healing factors) -Animal experiments, clinical trials -Regulatory approvals -Clinical adoptability -IP -materials science exp -Bioengineers Universities Hospital Colorectal Department Suture/Staple manufacturers Nurses -Sale of product -technology license and product license -Government subsidy Animal testing and clinical trials Cost for making the delivery medical device Clinican training Chemical Pre-cursors Labor Cost Initial Business Assumptions 3
  4. 4. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Key Interviewees Clinicians • Ridzuan Farouk, Dept. of Colorectal Surgery, NUH • Alfredo Franco, General Surgery, NUH • Clement Chia, General Surgery, KTP Hospital • Wu Qiang, Shenyang Chest Hospital • Dr. Yang, China Medical University Hospital • Lawarence Ho Khek Yu, NUH • Sharon Koh ZL, NUH Scientists • Chooi Kum Fai, Preclinical Research & Drug Dev.,TP • Zhang Pengchi, Biotechnology, TP • Patel Kadamb, Biosensors, TP • TAN ENG LEE, Biomedial Center, SP • Pastorin Giorgia, Dept. of Pharmacy, NUS HCPs • Ma Yuntao XNY Medical, Medical Disposables & equipments • Sales Rep, KXBD, Stapler Manufacturer • Joyce Wang, Alton, Medical Equipments • Jina Ha, BNR Endoscopic Surgical Instruments • Former New Zealand Health Ministry Official • Ding Ding, Changi General Hospital, Nurse 4 Colorectal Cancer Patients 4
  5. 5. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Overview of Interviews Customer segments Very interested Nice to have Not interested Surgeons / Doctors Total=15 5 (Colorectal) 10 (General) - Patients Total=4 - 3 1 HCPs Total=20 2 14 4 NUMBER OF INTERVIEWS: 39 5
  6. 6. © Copyright Lean LaunchPad Singapore. All Rights Reserved. -Reduce risk of anasto motic Leakage -Improve healing rate -Lower Risk of re-surge ry -Ease-of-use, versatile Surgeons Patients Nurses KOL/MSL/Distributors Surgeons Direct Sales Publications and conference posters Technical assistance Generating Clinical data -SOPs for synthesis of adhesives and additives (antibiotics, healing factors) -Animal experiments, clinical trials -Regulatory approvals -Clinical adoptability -IP -materials science exp -Bioengineers Universities/Polytech nics Hospital Colorectal Department Suture/Staple manufacturers Nurses -Sale of product -technology license and product license -Government subsidy Animal testing and clinical trials Cost for making the delivery medical device Clinican training Chemical Pre-cursors Labor Cost After 10 weeks… 6
  7. 7. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Key Learning Points • Surgical adoptability is THE key factor • No MVP for our device, the product has to be effective and safe from the beginning • R&D of Medtech product takes >3 years • We have a well-defined market segment 7
  8. 8. © Copyright Lean LaunchPad Singapore. All Rights Reserved. AHA! Moments • >100 companies manufacture ‘copycat’ medical devices in the surgical stapler sector alone • Globally, 2-3 groups are working on the same problem (AL) • AL is indeed an unmet medical need • Stapler companies are stuck with legacy products = limited innovation 8
  9. 9. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Institutes / Academia • Chemistry Innovation • Research and Development • Provide animal platform for preclinical testing • Train Students and Technicians A safe and effective surgical product Hospital • Full support from Dept. of Colorectal Surgery • Patient samples and grant application support Key Partners Build collaboration framework 9
  10. 10. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Our endpoint users What they said.. Surgeons VP: Effective, Safe, Fast, Adoptable • AL happens erratically and no current solution • Has to be bio-degradable; abscess should no form post-application Patients VP: Effective, reimbursable • Stoma bag interferes with daily life and reduces Quality of Life HCPs VP: Sustainable • Should consider sustainable development (other revenue streams) Customer Segments 10
  11. 11. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Competitor Analysis 11 Speedandeaseofuse Effectiveness * $= cost per unit Circular Staplers All Sutures *Grey out, not available in the market $$$ $
  12. 12. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Competitor Analysis(+Colon Patch) 12 Speedandeaseofuse Effectiveness * $= cost per unit Circular Staplers All Sutures *Grey out, not available in the market $$$ $ + +
  13. 13. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Market Opportunity • Average cost per Colorectal Surgery: US$ 25,000 • Number of Surgeries a year: 1.1 million • Colon Patch is to be used as a prophylactic in every surgery 13
  14. 14. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Next Steps Human Trials (Mar 2020) Regulatory approvals (Nov 2020) Marketing (Dec 2020) Proof of Value Funding: PoV Grant, ONEstart OBR, Tech Incubator Scheme Market Efficacy Pilot Study (Nov 2019) Proof of Concept Funding: Practicum Grant, PoC Grant; SMART Improving Synthesis & Adhesion (Nov 2017) Animal Efficacy Studies (Jul 2018) Delivery system (Nov 2017) Patents (Nov 2018) • Raising SGD 500k to complete the Proof of Concept stage at 30k burn pm 14
  15. 15. © Copyright Lean LaunchPad Singapore. All Rights Reserved. Team Shawn Gao PhD - NUS Medicine Ajith Amrithraj PhD - NUS Medicine Dr Ridzuan Farouk Senior Colorectal Surgeon Ee Bin Liew Industry Mentor • Dr Gary Ang, Epidemologist, NHG • David Ng, Biomed Engineer • Dr John Kuang, Materials Scientist, IMRE, A*Star • Dr Hongye, Materials Scientist, IMRE, A*Star • Andriana Justine, Industrial Design, NUS • Samarth Bhargava, PhD Chemistry, NUS Potential Collaborators: • Dr Giorgia Pastorin, Pharmacy, NUS • Animal Facility, Temasek Polytechnic • Biomedical Research Centre, Singapore Polytechnic 15

×