1|Page Kopyrrol (Pyrrolidino diamino pyrimidine oxide) An enlivening hair growth active Rejuvenates hair follicle Increases the growth of hair Protects against hair loss Favors a better hair anchoring
2|Page Kumar Organic Products Pvt Ltd At Kumar Organic Products, we are committed to develop and deliver our valued customers who are in pharmaceutical and personal care industries with superior quality products at most competitive prices.Worldwide, 85% of Men (15% women) suffer from hair loss. Day by day, the number of hair losssufferers is increasing in number and is more than doubled between 2008 to 2010. The importanceof hair in our lives cannot be overstated. Whether men or women lose their hair, they lose muchmore than their natural, youthful appearance. People also lose their self-esteem and self-confidence associated with healthy looking hair. The scalp and hair requires an optimal amount ofnutrients that is not always provided by the daily nutritional intake leading to Hair. Hair growthactives have a strong presence in our everyday lives and are integrated to help prevent hair lossand nurture hair regrowth.KOPYRROL recovers weak follicle cells by supplying the nutrition which hair needed for growth andincrease the growth of hair and increases the volume of hair in the growth stage by working on thedeep structure of the roots. Through the bloodstream, KOPYRROL works at the level of the hairroot, which is responsible for a healthy scalp and beautiful hair. KOPYRROL is used in hair cosmeticsto combat hair loss due to premature exhaustion of the hair root.Product Specification Molecular StructureTrade Name KOPYRROLINCI Name Pyrrolidinil diaminopyrimidine oxide OChemical Name 6-pyrrolidino 2,4-diaminopyrimidine 3-oxideMolecular Formula C8H13N5O NH2 H2N NCAS NO 55921-65-8Harmonized Tariff No. 2932.00 NAppearance Pale White crystalline powderAssay by HPLC (on dried basis) NLT 99% NSolubility 2% solution in ethanol/water (70:30) Clear & ColourlessSuggested use level 0.1-5%Storage Preserve in well closed container
3|Page Mechanism of Hair Growth CycleThe scalp has at an average 100,000 hairs. A healthy scalp sheds hair continuously and new hair replaces them.Hair growth follows a series of cycle. Each cycle includes a growth phase (anagen), a transitional phase(catagen), and a resting phase (telogen). Any changes to the normal hair growth cycle would result in hair loss. Itoccurs when the old hairs are shed and no new hair is growing from beneath to replace it. However, when thescalp is not able to produce new hair to replace the shed hair, baldness develops and the condition isscientifically called as alopecia. The most common type of hair loss is androgenetic alopecic (AGA) both in men (Male pattern baldness) and women (Female pattern hair loss) and is caused by heredity hormones and genetics. Normal Hair Growth Cycle Altered Hair Growth Cycle Normal A: T (80:20) Decrease A: T Multiplication of group of Return to Anagen: The cells at the base of the hair follicle re-enters hair. Typically lasts from 2 the growth phase. The to 6 years. older hair is shed, and then replaced by a new one. The growth in the hair The hair rests and no growth • Miniaturization of follicles follicles stops and is experienced which lasts 2 • Gradually Shorter Anagen Phase & degeneration begins. This to 3 months. phase lasts about 2 to 3 longer telogen phase weeks. • Empty follicles- Disruption of hair cycle * Everyday around 100 old hairs are shed before new hair replaces them. Average hair growth rate is upto 1cm per month Mechanism of KOPYRROL on stimulating hair growth
4|Page Hair Growth Activity Efficacy of KOPYRROL
5|Page TOXICOLOGICAL INFORMATIONAcute Toxicity:LD50 Oral rat 820mg/kgLD50 Oral mouse 780mg/kgLD50 Cutaneous Rat >2000mg/kgChronic Exposure:Primary irritation skin rabbit : not irritantPrimary irritation eye rabbit : not irritantPrimary irritation skin Guinea pig : not irritantMutagenicity:Animal cellule ‘in vitro’ negativeCytotoxicity:“Salmonella Typhimurium”Range: 100mcg/dishes – 10000 mcg/dishes negativeECOLOGICAL INFORMATIONNo information is available about the potential of this product to produce adverseenvironmental effects. Local regulations and procedures should be consulted prior toenvironmental release.
6|Page Features & BenefitsFeatures BenefitsPotassium channel opener Transition from telogen to anagen phase of the hair cycle. Maintains the anagen phase for a long period of time.Nourish the hair follicles Dilates blood vessels and increases nutrients and oxygen supply to the hair root.Increases matrix cell proliferation Strengthens hair from root to tip by strong anchoring of the hair root. Works on crown of the scalp in certain, usually younger, men.Known for its efficacy Safe and Effective for Both Men and Women. RECOMMENDED DOSAGE AND APPLICATIONS Recommended dosage: The compound generally used in the proportion of between 0.001 and 10% w/w and preferably in the concentration of 0.1 -5% w/w. Applications: -Hair Tonic -Hair Cream -Scalp Treatment -Hair Gel -Hair Shampoo -Hair ConditionerRegulatory Status*:Not approved by FDAEurope : Allowed for personal care applicationUSA : Allowed for personal care applicationJapan : Allowed in selected product categoryRest of world : Allowed for use in most of the Asian countries*Consult your regulatory authority for use level and restrictions.
7|Page Formulation guidelines: • Charge 5%w/w of KOPYRROL into the vessel and add all other ingredients(50 wt% Propylene Glycol, 15 wt% Ethanol, 15 wt% Benzyl Alcohol, QS to 100 wt% Distilled water, 0.25 wt% Perfume and 0.50 wt% Tween 20) one by one with stirring in the order mentioned. Continue stirring until KOPYRROL dissolves and forms a clear solution. • Typical use level of KOPYRROL: 0.001-1.5 wt% of finished formulation • The finished product should be protected from prolong exposure to heat and light. References: • Won Seok Park et. al. Hair growth activity of cosmetic diaminopyrimidine oxide compound invitro and in murine anagen induction. Amore pacific corporation. • A.G.Messenger and J .Rundegren. Minoxidil: Mechanisms of action on hair growth. British Journal of Dermatology 2004; 150: 186–194. • Davies GC et.al., Novel and established potassium channel openers stimulate hair growth invitro: Implications for their mode of action in hair follicles. J Invest Dermatol 2005. 124: 686-94.Disclaimer:The information given and the recommendations made herein are based on literature search and are believed to be accurate but no guarantee oftheir accuracy is made. Information is supplied upon the condition that the receivers will make their own determination as to its suitability for theirpurposes prior to use. In no event will KUMAR ORGANIC PRODUCTS LTD be responsible for the damage of any nature whatsoever resulting from theuse of or upon reliance of the information