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Cosmetic sodium hyaluronate

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Cosmetic sodium hyaluronate

  1. 1. KUMAR ORGANIC PRODUCTS LIMITED Ingredients for us BIO/002/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  2. 2. SODIUM HYALURONATE (KOPURON) Cosmetic grade BIO/002/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  3. 3. Sodium Hyaluronate - Identification• INCI name: Sodium hyaluronate• CAS No. 9057-32-7• Product name: Poly-(sodium-b-D-glucuronate-[1-3}-β N-acetyl-D-glucosamine-[1-4]•Other names: Hyaluronic acid, Hyaluron, Hyaluronan• EINECS/ELNICS: 232-678-0 BIO/002/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  4. 4. Sodium Hyaluronate - StructureSodium hyaluronate –Is a linear chain muco-polysaccharide composed ofdisaccharide units formed from D-glucuronic acid & N acetylglucosamineheld together by β 1,3 linkages BIO/002/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  5. 5. Source• Fermentation: Streptococcus equi, subsp.•Bacterial strain, non-haemolytic• Non-GMO•No animal products used during the manufacturing process BIO/001/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  6. 6. Process Flow Diagram BIO/001/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  7. 7. Sodium Hyaluronate - specificationS.No. Tests Specification 1. Appearance White powder or granules Transparency of 0.1% aqueous NLT 99.5% 2. solution 3. Loss on drying NMT 20% 4. Residue on Ignition NMT 20% 5. pH (0.1% aqueous solution) 5.0 – 8.0 6. Protein content NMT 0.1% 7. Glucuronic acid 44 – 50 % 8. Sodium Hyaluronate 93 – 103 % 9. Molecular weight 1.0 – 1.6 MDa 10. Total bacterial count NMT 100 cfu/g BIO/001/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  8. 8. Sodium hyaluronate in the body• Hyaluronic acid – significant constituent of human skin,connective tissue, lubricant in joints, vitreous humor of the eye BIO/002/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  9. 9. Sodium Hyaluronate• Skin has 10 to 20 % water• As we age, water is lost & the skin appears dry & wrinkled• Great ability to hold water – 1000 times its weight• Forms a film on the surface of skin to moisturize• Smoothens the skin – anti-wrinkle effects 0.025% Kopuron Max: Skin Moisturizing Effect 25 20 15 10 5 0 % H n o d s e c a y r BIO/002/2012-13 t I i 15 30 60 120 180 Dr. Lakshmi Sridhar 240 300 Time (mins) 360 18th Sep 2012
  10. 10. Sodium Hyaluronate Comparison between Sodium hyaluronate & other moisturizers under identical conditions Kopuron Max Sorbitol GlycerineSodium pyrrolidone cyboxylate 0 5 10 15 20 25 30 35 40 Hydration Increase % BIO/002/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  11. 11. Sodium Hyaluronate• Moisturizing property used in cosmetics for sun care, skin care,repair, lipsticks, pre & after shave, cleansers, hair care, etc. BIO/002/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  12. 12. Sodium hyaluronateTransparency – of 1 % aqueous solution of Sodium hyaluronatewas measured at 660 nm – transparency of 99.99 % was measured– very transparent – ideal for cosmetic applications 100 80 60 40 20 % A n o b e c a s r 0 400 nm 600 nm BIO/002/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  13. 13. Sodium HyaluronateHeat Stability – Aqueous solution of Sodium hyaluronate wasincubated at different temperatures for different times.Corresponding changes in kinematic viscosity were measured.Sodium hyaluronate is stable at temperatures lower than 80 C Kopuron Max: Heat Stability 60 50 40 60 deg C 30 80 deg C 90 deg C 20 10 m K V n o e y s c a t i 0 0 15 30 45 60 75 90 BIO/002/2012-13 Time (mins) Dr. Lakshmi Sridhar 18th Sep 2012
  14. 14. Sodium Hyaluronate• Sodium hyaluronate’s moisturizing property demonstrated inlip sticks using corneum hydration measurements. Hydrationincreases with Kopuron Max BIO/002/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  15. 15. Sodium Hyaluronate• Sodium hyaluronate in lipsticks decreases trans epidermalwater loss (TEWL). Kopuron reduces TEWL. BIO/002/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012
  16. 16. SODIUM HYALURONATE Biodegradable & eco-friendlySodium hyaluronate is completely naturalProduced by bacterial fermentation“Green technology” BIO/002/2012-13 Dr. Lakshmi Sridhar 18th Sep 2012

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