Propolis – a nature alternative by vaginal disturbances?

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Therapy - Intention to reestablish a physiological situation of the vagina.

How does the optimal therapy look? Reduces the sensible quantity of germs AND represses the subjective disturbances. General antimicrobial (Bacteria, Fungal, Virus). Vaginal equilibrium is established and keep alive itself. Shouldn’t cause Resistance and should be applicable as Prophylaxes.

Antibacterial mechanism of action of Propolis: DNA dependant on RNA Polymerase as follows: Bacteria are spited slowly Penetrability of cell membrane increased as follows: Bacteria get more sensitiv. The Hydroxy-cinnamon-acid inhibits reversible the Motility of Bacteria s follows: slow dissermination

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Propolis – a nature alternative by vaginal disturbances?

  1. 1. Propolis – a nature alternative byvaginal disturbances?Martin Imhof MD, PhDMartin Imhof MD, PhDUniversity Hospital for Gynecology ViennaUniversity Hospital for Gynecology ViennaDep. of Endocrinology and Treatment ofDep. of Endocrinology and Treatment ofFertilityFertility
  2. 2. Vaginal Infektion InzidenceInzidence 70-75% of all women 1 x in live70-75% of all women 1 x in live 40-50% suffer from reoccuring Infection40-50% suffer from reoccuring Infection(=> 4 Infections / year)(=> 4 Infections / year)
  3. 3. Vaginal Complaintsgermgerm = Primary cause for= Primary cause forcomplainscomplainscausecause = Failure of defense system= Failure of defense system
  4. 4. Therapy - Intention…… to reestablish a physiologicalto reestablish a physiologicalsituation of the vaginasituation of the vagina
  5. 5. Problem of AB TherapySelection of a pathological germ-groupSelection of a pathological germ-groupGood casePhysiological equilibriumis reached againWorst caseanother pathogenicgerm renews theInfection => Relapse1-6 weeks after Therapy
  6. 6. Antibiotika und AntimykotikaDisadvantageDisadvantage Adverse effects (for ins.: digestion)Adverse effects (for ins.: digestion) Resistance of treated germsResistance of treated germs barely prophylactic applicable!barely prophylactic applicable!
  7. 7. How does the optimal therapy look?Reduces the sensible quantity of germs ANDReduces the sensible quantity of germs ANDrepresses the subjective disturbancesrepresses the subjective disturbancesGeneral antimicrobial (Bacteria, Fungal, Virus)General antimicrobial (Bacteria, Fungal, Virus)Vaginal equilibrium is established and keepVaginal equilibrium is established and keepalive itselfalive itselfShouldnShouldn’t cause Resistance and should be’t cause Resistance and should beapplicable as Prophylaxesapplicable as Prophylaxes
  8. 8. P R O P O L I S ?P R O P O L I S ?
  9. 9. PropolisMakes the Bee-yard „asepticMakes the Bee-yard „aseptic““““CementCement”” andand ““Carpet of epidemicCarpet of epidemic””
  10. 10. Antibacterial mechanism of actionof Propolis DNA dependant on RNA PolymeraseDNA dependant on RNA Polymeraseas follows: Bacteria are spited slowlyas follows: Bacteria are spited slowly Penetrability of cell membrane increasedPenetrability of cell membrane increasedas follows: Bacteria get more sensitiv.as follows: Bacteria get more sensitiv. The Hydroxy-cinnamon-acid inhibitsThe Hydroxy-cinnamon-acid inhibitsreversible the Motility of Bacteriareversible the Motility of Bacteriaas follows: slow disserminationas follows: slow dissermination
  11. 11. Anti-fungal effect of Propolis Propolis in the Concentration of 0,25% to 2% isPropolis in the Concentration of 0,25% to 2% iseffective against div. Dermal-phyteneffective against div. Dermal-phyten Flavenoide legates Enzymes und Metal-ionsFlavenoide legates Enzymes und Metal-ionswhich is important for the fungal-metabolismwhich is important for the fungal-metabolism
  12. 12. Antiviral Effect of Propolis Is affected by different Virus (Influenza,Is affected by different Virus (Influenza,Herpes, Polio, Hepatitis as well as felinesHerpes, Polio, Hepatitis as well as felinesHIV)HIV) viral DNA Productionviral DNA Production in vitro isin vitro is inhibited toinhibited tofactor 32.factor 32. Inhibits the viral Adsorption at the cellsInhibits the viral Adsorption at the cellssurface areasurface area
  13. 13. Effectively of Propolis againstProtozoa typical Parasite:typical Parasite: Trichomonas vaginalisTrichomonas vaginalis.. Propolis in the Concentration of 150 µg/mlPropolis in the Concentration of 150 µg/mlshows a significant Inhibition ofshows a significant Inhibition oftrichomonal Proliferation.trichomonal Proliferation.
  14. 14. Antibacterial effectively ofPropolis01020304050607080901000 200 400 600 800concentration [µg/ml]colonyformingunit[%ofcontrol]6 h B.s.18 h B.s.18 h E.coliAntibacterial effects of Propolis on colony formation by Bacillus subtilis (Gram +)and Escherichia coli (Gram -) suspensions incubated on agar for 6 and 18 hours
  15. 15. In vitro Survival rate of Trichomonasvaginalis in different Concentration ofPropolis01020304050607080901000 50 100 150 200 250time [h]survivalrate[%]control150 µg/ml50 µg/ml5 µg/ml0.5 µg/ml0.05 µg/ml
  16. 16. The local anesthetic Propolis effect„„ ....... by subcutaneous application, the....... by subcutaneous application, thePinocembrin starts developing and the CaféPinocembrin starts developing and the Caféacid-rest has almost the same anestheticacid-rest has almost the same anestheticeffect than Lidocaineeffect than Lidocaine““Paintz M, Metzner J.Paintz M, Metzner J.Pharmazie 1979 Dec;34(12):839-41Pharmazie 1979 Dec;34(12):839-41
  17. 17. Propolis-therapy Reduction of the total germ-exposureReduction of the total germ-exposure RELATIVE physiologic gap by LactobacillusRELATIVE physiologic gap by Lactobacillusacidophilusacidophilus Reestablishment of physiologic situationReestablishment of physiologic situation
  18. 18. Propolis-therapy Rapid abatement of disorders through local-Rapid abatement of disorders through local-anesthetic effect (reinforcement)anesthetic effect (reinforcement) No resistence due to biologic VariationNo resistence due to biologic Variation Low side effectsLow side effects
  19. 19. Propolis as a Therapy ofvaginal disordersM ImhofM ImhofUniversitätsklinik für FrauenheilkundeUniversitätsklinik für FrauenheilkundeWienWien
  20. 20. melprotect® Propolis (5%) camomile Lime-tree blossom pH 4.5
  21. 21. Study Propolis (melprotect®) -Irrigation 56 symptomatic Patients with reoccuring56 symptomatic Patients with reoccuringVaginal-Infection (>=4/year)Vaginal-Infection (>=4/year) Anonymised questionnaires for EvaluationAnonymised questionnaires for Evaluation2 weeks before and after the closing of2 weeks before and after the closing ofstudies.studies. After 6 months telephonic questionnairesAfter 6 months telephonic questionnaires
  22. 22. Using of MELPROTECT1 x daily 30 ml per Applicator for one week1 x daily 30 ml per Applicator for one weekAfter acute therapy reduce melprotect slowlyAfter acute therapy reduce melprotect slowly(every 2 day, every 3 day etc.)(every 2 day, every 3 day etc.)
  23. 23. Questionnaire 1. How strong have been/are the vaginal pains before/after the1. How strong have been/are the vaginal pains before/after thetherapy?therapy? 2. How strong was/is the itching before/after the therapy?2. How strong was/is the itching before/after the therapy? 3. How strong was the cauterization before/after the therapy?3. How strong was the cauterization before/after the therapy? 4. How strong was/is the vaginal defluxion in the last month/after4. How strong was/is the vaginal defluxion in the last month/afterthe therapy?the therapy? 5. How hindering was/is the Vaginal-Infection before/after the5. How hindering was/is the Vaginal-Infection before/after thetherapy during the sexual intercourse?therapy during the sexual intercourse? 6. How hindering was/is the eventual Vaginal-Infection6. How hindering was/is the eventual Vaginal-Infectionbefore/after the therapy during normal sportive activities?before/after the therapy during normal sportive activities? 7. How hindering was/is the Vaginal-Infection in the last month /7. How hindering was/is the Vaginal-Infection in the last month /after the therapy during the daily life activitiesafter the therapy during the daily life activities(shopping, going out,...) ?(shopping, going out,...) ? 8. How satisfied have you been/are you with the previous/actual8. How satisfied have you been/are you with the previous/actualmedicinal therapy for the Vaginal-Infection?medicinal therapy for the Vaginal-Infection?
  24. 24. Questionnaire - Analyse012345678Vorher 1,54 3,77 2,84 4,88 3,68 1,36 1,25 2,91Nachher 0,13 1,09 0,93 2,09 0,79 0,11 0,38 7,36Frage1 Frage2 Frage3 Frage4 Frage5 Frage6 Frage7 Frage8
  25. 25. Result 49 (87%) of patients described a reduction of disorders49 (87%) of patients described a reduction of disordersafter the using of Propolis (melprotect)after the using of Propolis (melprotect) 7 (13%) of patients couldn7 (13%) of patients couldn’’t notice a change of disorderst notice a change of disordersafter the using of Propolis (melprotect)after the using of Propolis (melprotect)0510152025Abstrichauswertung vor TherapieSoorinfektionE1MischinfektionGardnerellaAbstrich o.B.01020304050Abstrichauswertung nachTherapieSoorinfektionE1MischinfektionGardnerellaAbstrich o.B.
  26. 26. Telephonic Questionnaireafter 6 MonthFollowing Question was asked:Following Question was asked: 1. Did you suffer on a new infection?1. Did you suffer on a new infection? 2. Did you get a therapy for the infected2. Did you get a therapy for the infecteddisorders again?disorders again? 3. How do you judge the therapy-success?3. How do you judge the therapy-success?
  27. 27. Telephonic - QuestionnaireResultsPatient, where an positive result was seen:Patient, where an positive result was seen:31 (63%) of patients report no reinfection31 (63%) of patients report no reinfection16 (33%) of patients report about the recurrence of16 (33%) of patients report about the recurrence ofSymptomsSymptoms2 (4%) there was no questionnaire possible2 (4%) there was no questionnaire possible
  28. 28. * * ** * *Imhof M, Lipovac M, Kurz Ch, Barta J, WiesenthalB, Huber J 5% propolis solution for the treatment ofchronic vaginitisInt J Gynaecol Obstet. 2005 May;89(2):127-32.
  29. 29. Conclusion Antimicrobial effect against common germsAntimicrobial effect against common germs No resistance similar to a Antibiotic therapyNo resistance similar to a Antibiotic therapy Relative support of the physiological Vagina-floraRelative support of the physiological Vagina-flora Local-anaesthetic effectLocal-anaesthetic effect Allergic reaction very seldomAllergic reaction very seldom The use for Gardnarella- und Chlamydien-The use for Gardnarella- und Chlamydien-infection is not assuredinfection is not assured
  30. 30. * * ** * *Thank you very muchThank you very muchfor yourfor yourattentionattention
  31. 31. Epicutaneous Test 30 patients30 patients melprotectmelprotect®®was applied in a test chamberwas applied in a test chamberon the skin for 48hrson the skin for 48hrs evaluation after 42hrs and 78hrsevaluation after 42hrs and 78hrs no allergenicity in any patientno allergenicity in any patient no irritation in any patientno irritation in any patient

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