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IMRT_VMAT_Session 5_How to fine-tune the commissioning of a TPS.pptx

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IMRT_VMAT_Session 5_How to fine-tune the commissioning of a TPS.pptx

  1. 1. 5 How to fine-tune the commissioning of a TPS Stephen Gardner Medical Physicist June 18 Henry Ford Health System (Detroit, MI, USA) 1
  2. 2. Outline for today’s session 1. Spot checking your commissioning data 1. Using MPPG 5A report as a reference/outline for photon beam model validation 2. Summary of validation tests 2. Tweaking TPS: DLG and MLC transmission • Create a new “commissioning” machine in your TPS • Compare to measured data and perform iterations of DLG and MLC transmission adjustments 2
  3. 3. Learning Objectives: After this session, you will… o Be able to perform a comprehensive but quick spot-check of commissioning data o Understand the detailed, step-by-step process of how to adjust DLG and MLC transmission in the TPS, referencing their clinic’s data o Be able to execute the logistics and team communications needed to safely fine-tune commissioning (e.g., creating a separate “machine”)
  4. 4. 1. Spot checking your commissioning data 4
  5. 5. ZOOM POLL The dosimetric leaf gap (DLG) represents: A. The difference in the physical leaf end and the dosimetric field edge B. The minimum gap that is possible for an MLC system C. The width of the sweeping gap field used during measurements D. The width of the penumbra of an MLC-defined field 5
  6. 6. ZOOM POLL The dosimetric leaf gap (DLG) represents: A. The difference in the physical leaf end and the dosimetric field edge B. The minimum gap that is possible for an MLC system C. The width of the sweeping gap field used during measurements D. The width of the penumbra of an MLC-defined field 6
  7. 7. References/Guides for Photon Beam Commissioning o MPPG 5A has proven to be an extremely helpful guide for commissioning photon algorithms – published in 2015 • https://doi.org/10.1120/jacmp.v16i5.5768 o The strength of this document is that it covers many aspects of algorithm performance in a comprehensive, clear, and concise way o Scope of the document – gives recommendations for: • Data Acquisition and Processing • Algorithm Validation (Photon and Electron) – Basic model validation – Heterogeneity correction validation (not included in this lecture) – IMRT/VMAT dose validation 7
  8. 8. MPPG 5A Breakdown o Table 3 • Basic validation of beam model – comparison in beam configuration workspace, dose normalization is accurate o Table 4 • More in-depth validation of 3D-CRT delivery – measurements of dose agreement in high-dose region, penumbra, and out-of-field region o Table 5 • Summary of dose agreement tolerances o Table 6 (N/A for this lecture) – heterogeneity correction validation o Table 7 • IMRT/VMAT Validation – including TG-119/Clinical Case validation
  9. 9. Table 3: Basic Model Validation o Use Table 3 from the MPPG document to perform basic validation of the model: • (5.1) Within the physics/beam config module, compare PDD and profile for large field (calculated vs. measured) • (5.2) Within a test plan in the TPS - calculate a plan using absolute dose calibration conditions and ensure that you are calculating 1 cGy/MU at the calibration point (sanity check!) • (5.3) Quick check of PDD and output factor (OF) – within a test plan in the TPS, compare calculated PDD and OF to measured data o Note – these tests don’t require any new measurements! Just some re 9
  10. 10. Table 3: Examples – Test 5.1 o Test 5.1 – Within the physics module (beam configuration workspace), compare the PDD and profile – measured vs. calculated dose 10
  11. 11. Table 3: Examples – Test 5.2 o Test 5.2 – Calculate plan using calibration geometry and ensure dose at calibration depth is 1 cGy/MU. ** For our clinic, the calibration geometry is 10x10 cm2 field size, 100 cm SSD, with calibration depth at dmax. 11
  12. 12. Table 3: Examples – Test 5.3 o Test 5.3 – Calculate a plan in the TPS that simulates scanning data and compare calculated vs. measured • This requires the user to take a line profile at the appropriate depth ** For our clinic, this involved calculating a plan at 100 SSD for the relevant field size
  13. 13. Table 4: Basic Photon Beam Validation Summary o To perform this set of validation tests, measure the absolute dose at several points for each of these fields: • Different depths (slightly beyond dmax, mid-range/10-15 cm depth, and deep/25-30 cm depth) • Different off-axis positions – high dose, penumbra, and low dose 13
  14. 14. Table 4: Examples - Test o Test 5.4 – small MLC-defined field (4x4 cm2 MLC field and 5x5 cm2 jaw) o Test 5.5 – large MLC-defined field with extensive blocking o Test 5.6-5.7 – use same aperture with different SSD ** For each of these, perform measurements at high dose, penumbra, low dose regions at dmax depth, 10 cm depth, and 25 cm depth. Test 5.4 Test 5.5 Tests 5.6-5.7
  15. 15. Table 5: Evaluation Methods and Tolerances o Three different regions are specified: high dose, penumbra, and low dose tail • For high dose and low dose tail regions – tolerance is based on dose difference (Percent) • For penumbra – tolerance is based on distance to agreement (DTA)
  16. 16. Table 7: VMAT/IMRT Summary o The IMRT/VMAT tests are in addition to the tests in Table 3/4 from prior slides o In my opinion - the most important tests from this group are the TG-119 tests (7.3) and Clinical tests (7.4) • These plans will be used to validate and adjust the TPS model as needed to ensure optimal IMRT/VMAT delivery
  17. 17. Summary – Validation Testing (Scanning/Open Field) o Scanning Data – • Verify profiles using flatness and symmetry for small, mid-size, and large field sizes at dmax, 10 cm, and 30 cm depth – For example: 4x4, 10x10, and 30x30 cm2 field sizes (you can verify additional field sizes if warranted) – Typically, we want to see symmetry < 1% and then flatness consistent with past results (within 1% of baseline if available) – Compare measurement to calculation in TPS to verify model behavior • Verify PDD for small, mid-size, and large field sizes by comparing measured and calculated doses – While you are scanning these - include MLC-defined small field PDD to satisfy MPPG 5A test 7.1 (if you have access to a small field detector such as diode) o Output Factors – verify agreement between calculated and measured output factors for a variety of field sizes, ranging from 3x3 to 40x40 cm2 • While you are measuring these - include MLC-defined small field OF to satisfy MPPG 5A test 7.2 (again if you have access to a small field detector such as diode, micro ion chamber, etc.)
  18. 18. TG-119 and Clinical Case PSQA o TG-119 Planning Guide, Reporting Form, and Structure Sets can be found on the AAPM website: https://www.aapm.org/pubs/tg119/default.asp o TG-119 data set includes DICOM CT, RT Structure files as well as planning goals and instruction document: • C-Shape • Mock HN plan • Mock Prostate • Multi-Target o Additional plans for testing – representative plans from previous patients • Replan as needed with new machine/beam model • Should include typical disease sites encountered at your center – HN, Prostate, Lung, Brain, etc.
  19. 19. 2. Tweaking TPS: DLG and MLC transmission 19
  20. 20. Overview for this Section o MLC DLG and Transmission – effect on the dose distribution for various delivery modalities (static fields, IMRT, and VMAT) o Practical Overview/Tips on MLC Parameter Adjustment o Creating a new ‘commissioning’ machine for your testing o How to adjust DLG and MLC Transmission - Detailed, step-by- step process of how to adjust these within the TPS, referencing their clinic’s data o Practical dry-run of adjusting model parameters with realistic clinical data
  21. 21. MLC DLG and Transmission – Effect on the Dose Distribution for Various Delivery Modalities
  22. 22. MLC DLG Effect – Static Fields 0 20 40 60 80 100 0 2 4 6 8 10 12 14 16 Distance Along Profile (cm) DLG =0.100 cm DLG =0.200 cm
  23. 23. MLC Transmission Effect – Static Fields 0 20 40 60 80 100 0 2 4 6 8 10 12 14 16 Distance Along Profile (cm) MLC_trans = 1.6% MLC_trans = 2.5%
  24. 24. MLC DLG Effect – IMRT Delivery 0 20 40 60 80 100 120 0 2 4 6 8 10 12 14 16 18 20 Relative Dose (%) Distance Along Profile (cm) DLG Effect - IMRT Delivery DLG = 0.14 cm DLG = 0.16 cm DLG = 0.115 cm
  25. 25. MLC DLG Effect – IMRT Delivery (cont’d) 0 20 40 60 80 100 120 8 9 10 11 12 13 14 15 16 17 18 Relative Dose (%) Distance Along Profile (cm) DLG Effect - IMRT Delivery DLG = 0.14 cm DLG = 0.16 cm DLG = 0.115 cm Change in penumbra width Change in high dose magnitude
  26. 26. MLC Transmission Effect – IMRT Delivery 20 30 40 50 60 70 80 90 100 110 0 2 4 6 8 10 12 14 16 18 20 Relative Dose (%) Distance Along Profile (cm) MLC Transmission Effect - IMRT Delivery MLC_trans = 1.65% MLC_trans = 1.85%
  27. 27. MLC DLG Effect (TG-119 C-Shape) VMAT Delivery 0 20 40 60 80 100 120 0 2 4 6 8 10 12 14 Relative Dose (%) Distance Along Profile (cm) DLG Effect - VMAT Delivery DLG = 0.14 cm DLG = 0.16 cm DLG = 0.115 cm
  28. 28. MLC DLG Effect (TG-119 C-Shape) VMAT Delivery 90 92 94 96 98 100 102 104 0 2 4 6 8 10 12 14 Relative Dose (%) Distance Along Profile (cm) DLG Effect - VMAT Delivery DLG = 0.14 cm DLG = 0.16 cm DLG = 0.115 cm Smaller Change in penumbra width compared to IMRT Smaller change in high dose compared to IMRT
  29. 29. MLC Transmission Effect – VMAT Delivery 10 20 30 40 50 60 70 80 90 100 110 0 2 4 6 8 10 12 Relative Dose (%) Distance Along Profile (cm) MLC Transmission Effect - VMAT Delivery MLC_trans = 1.65% MLC_trans = 1.85%
  30. 30. How to – create a new ‘commissioning’ machine in your TPS and adjust DLG/MLC Transmission o General idea is to… • Create a copy of the machine • Create a copy of the beam model • Adjust DLG/MLC Transmission to improve agreement
  31. 31. Creating a ‘Commissioning’ Machine o For ARIA Users, the process is: • RT Admin Workspace – Step 1: Select machine to copy -> Insert -> Export Machine… – Step 2: Re-import the machine you just exported and name it appropriately – Step 3: Rename imported machine something like ‘Test_Physics’ – Step 4: Ensure MLC add-on information matches the real machine and enter starting DLG/MLC transmission values Step 1: Export Step 2: Re-import Step 4: MLC Add-on Material and DLG/MLC trans Step 3: Update Machine Name
  32. 32. Creating a copy of the beam model for testing o For ARIA Users, the process is: • Beam Config Workspace – Step 1: select the machine (Test_Physics) / energy (6x) / algorithm (AAA_11030) and right-click -> New Beam Data… – Step 2: setup copy of beam model ▪ Enter appropriate therapy unit name ▪ Select ‘Copy existing data to the calculation model’ • DO NOT select ‘assign’ • Ensure that you have selected the correct beam model to copy and click OK – Step 3: Match and Assign Add-Ons – select ‘In Use’ for open field and EDW and select Automatic Match for All. – Step 4: Spot check values for Gamma Error Histogram and Output Factors to verify consistency against clinical machine and approve test model (right-click on the model -> Approve) Step 3: Match and assign Add-ons Step 2: Setup copy of beam model Step 1: select model Step 4: Approve Model
  33. 33. Practical Overview/Tips on MLC Parameter Adjustment
  34. 34. How do I adjust the DLG/MLC Transmission Values? o For ARIA v13 and later: • RT Admin Workspace – – **Note – this will define these values for all beam models for this machine** – Go to ‘Radiation and Imaging Devices’ – Select the test physics machine and go to ‘MLC’ tab – Enter values for MLC Transmission factor and DLG within the ‘Dosimetric Properties’ section o For ARIA v11 and earlier: • Beam Configuration Workspace – – Select the test physics beam model – Go to Beam Data -> Dosimetric Data and enter MLC Transmission factor and DLG o For other TPS vendors – consult with the manual for instructions on this process
  35. 35. Initial Overview – Iterative Tweaking Process • Resource for TPS beam model validation – Medical Physics Practice Guideline 5.A • MLC Parameter/Beam Model Optimization (like any optimization process) is iterative • The overall process goes something like: 1. Acquire initial measurements for MLC parameters -> input to TPS 2. Calculate Beam Model 3. Generate/calculate IMRT/VMAT plans for verification • For conventional planning – use TG-119 dataset and some previous clinical plans if available • For SRS/SBRT planning – critical to use representative stereotactic plans to validate the beam model!!! • These treatment plans should meet the relevant clinical goals/constraints to best simulate a typical IMRT/VMAT delivery 4. Acquire point dose measurements for verification IMRT/VMAT plans • Proper detector selection is critical – ideal chamber is a small volume ion chamber such as CC01 or PinPoint chamber • High dose readings to simulate the target volume! • Low dose readings to simulate critical organs at risk! • The point dose measurements will the primary means for MLC parameter selection 5. Acquire planar dose measurements using Gafchromic film or array device • Compare results once MLC parameters are finalized from point dose measurements
  36. 36. MLC Parameter Testing – Practical Key Points • Key Points for Emphasis • Use real IMRT/VMAT plans to validate the beam model/MLC parameter values • TG-119 data sets • Previous clinical cases • Make sure the intended use of the linac is included in the test cases! • Measurements should include both point and planar dose analysis • My clinic preference – use point dose measurements for initial tweaking of MLC parameters • When is the model good enough? • TG-119 utilized confidence limits for QA results • High Dose Point Measurement → CL = ±4.5% • Low Dose Point Measurement → CL = ±4.7% • Planar Dose Measurement → Gamma(3%,3mm) > 87.6% • TG-218 proposed tolerance limits and action limits for pre-treatment QA: • Tolerance Limit: • Ion Chamber Measurement <2% • Gamma(3%,2mm) > 95% • Action Limit: • Ion Chamber Measurement <2% • Gamma(3%,2mm) > 95% • Investigate outliers for additional measurements • Aim to get average percent difference close to 0% (Mean Perc. Diff.) • Minimize spread in QA results (Standard Deviation Of Perc. Diff.) • Compare to other institutions/literature with similar linac and TPS • If possible – obtain independent audit of IMRT/VMAT delivery from another physicist/institution • How much can you tweak the TPS values? • My preference – tweak as little as possible to get agreement that fulfills clinical goals of the machine
  37. 37. MLC Parameters – Interpreting Results • Which way do I need to tweak the value? • Increasing DLG value → Increase in calculated dose • Increasing MLC Transmission value → Increase in calculated dose • Example: • If plan dose is higher than measured dose → the next step is to increase DLG and/or MLC Transmission and re- calculate Example: Plan dose is higher than film dose → consider decreasing DLG and/or MLC Transmission
  38. 38. DLG Adjust Details – Test Plan Process 1. Treatment Planning – Develop a good quality plan using the test plan structure set. Have primary treatment planning staff generate the plan if possible! 2. QA Plan – Map the plan from step 1 onto the appropriate phantom • Need to perform both chamber measurement and a planar dose/fluence measurement • Planar dose measurement can be using film, detector array, or even the EPID • Phantom choices include: • Solid Water slab phantom with place for chamber/film • Acrylic phantom with place for chamber/film • Detector array (MapCheck, ArcCheck, Delta4, Matrixx, etc.) • EPID measurement (Portal Dosimetry) 3. Measure QA plan and compare to predicted dose from TPS calculation 4. Compile all test plan results (IMRT and VMAT) before making any adjustments • Note – IMRT and VMAT trends can differ!!
  39. 39. Practical dry-run of adjusting model parameters with realistic clinical data o The background information for this example: • TG-119 plans and Clinical Cases (IMRT and VMAT) for 10x energy modewere measured with ion chamber in high dose and lose dose region • Starting point was the initial measured DLG value of 0.115 cm and MLC Transmission = 1.65% • Total Case Breakdown – TG-119: 3 IMRT and 3 VMAT – Clinical Cases: 2 IMRT and 2 VMAT
  40. 40. MLC Parameter Selection Summary Points – 10 MV beam modeling process • Decision on MLC parameters such as DLG and Leaf Transmission depend on: • The clinical goals for the beam model: • Which disease sites will be treated routinely? • Which modality will be used more often – IMRT or VMAT? • The trend in the data: • Which parameter values will minimize the percent difference between planned and measured doses? • Which parameter values will minimize the spread in the results comparing planned and measured doses? • Which parameter values will minimize outliers in the data?
  41. 41. Plan Type Measured Point Dose (cGy) Calculated Dose (DLG = 0.115 cm) [MLC_trans = 0.0185] Perc. Diff. C Shape 2.154 2.052 4.73% H&N 2.100 2.095 0.24% H&NSIB 2.176 2.135 1.86% Prostate 1.988 1.957 1.54% Prostate LN 1.968 1.946 1.11% C Shape 2.481 2.470 0.45% H&N 2.195 2.191 0.19% H&NSIB 2.122 2.127 -0.22% Prostate 1.997 1.977 1.02% Prostate LN 1.893 1.937 -2.32% VMAT Average 1.90% VMAT St. Dev. 1.70% IMRT Average -0.18% IMRT St. Dev. 1.28% Overall Average 0.86% Overall St. Dev. 1.79% Plan Type Measured Point Dose (cGy) Calculated Dose (DLG = 0.115 cm) [MLC_trans = 0.0185] Perc. Diff. C Shape 0.320 0.344 -7.51% H&N 1.314 1.297 1.28% H&NSIB 1.124 1.126 -0.18% Prostate 1.322 1.279 3.22% Prostate LN 0.890 0.874 1.80% C Shape 0.489 0.520 -6.41% H&N 1.316 1.331 -1.16% H&NSIB 1.201 1.236 -2.94% Prostate 1.650 1.630 1.18% Prostate LN 1.136 1.163 -2.35% VMAT Average -0.28% VMAT St. Dev. 4.22% IMRT Average -2.33% IMRT St. Dev. 2.77% Overall Average -1.31% Overall St. Dev. 3.54% IMRT Results (TG-119 Table VII)- High Dose VMAT IMRT Results (TG-119 and Clinical Cases)- Low Dose VMAT Iteration 1 – DLG = 0.115 cm / MLC_Trans = 1.65% -4.0% -3.0% -2.0% -1.0% 0.0% 1.0% 2.0% 3.0% 4.0% 5.0% 6.0% 0 1 2 3 4 5 6 Percent Difference Iteration # VMAT - High Dose IMRT - High Dose VMAT - Low Dose IMRT - Low Dose
  42. 42. Iteration 2 – DLG = 0.140 cm / MLC_Trans = 1.65% Plan Type Measured Point Dose (cGy) Calculated Dose (DLG = 0.140 cm) [MLC_trans = 0.0165] Perc. Diff. C Shape 2.154 2.048 4.91% H&N 2.100 2.087 0.62% H&NSIB 2.176 2.128 2.19% Prostate 1.988 1.954 1.69% Prostate LN 1.968 1.942 1.31% C Shape 2.481 2.448 1.34% H&N 2.195 2.173 1.01% H&NSIB 2.122 2.113 0.44% Prostate 1.997 1.974 1.17% Prostate LN 1.893 1.921 -1.47% VMAT Average 2.15% VMAT St. Dev. 1.65% IMRT Average 0.49% IMRT St. Dev. 1.15% Overall Average 1.32% Overall St. Dev. 1.60% Plan Type Measured Point Dose (cGy) Calculated Dose (DLG = 0.140 cm) [MLC_trans = 0.0165] Perc. Diff. C Shape 0.320 0.338 -5.64% H&N 1.314 1.287 2.04% H&NSIB 1.124 1.117 0.62% Prostate 1.322 1.275 3.52% Prostate LN 0.890 0.867 2.59% C Shape 0.489 0.496 -1.50% H&N 1.316 1.311 0.36% H&NSIB 1.201 1.220 -1.61% Prostate 1.650 1.626 1.43% Prostate LN 1.136 1.149 -1.11% VMAT Average 0.63% VMAT St. Dev. 3.66% IMRT Average -0.49% IMRT St. Dev. 1.33% Overall Average 0.07% Overall St. Dev. 2.66% IMRT Results (TG-119 Table VII)- High Dose VMAT IMRT Results (TG-119 and Clinical Cases)- Low Dose VMAT -4.0% -3.0% -2.0% -1.0% 0.0% 1.0% 2.0% 3.0% 4.0% 5.0% 6.0% 0 1 2 3 4 5 6 Percent Difference Iteration # VMAT - High Dose IMRT - High Dose VMAT - Low Dose IMRT - Low Dose
  43. 43. Plan Type Measured Point Dose (cGy) Calculated Dose (DLG = 0.115 cm) [MLC_trans = 0.0165] Perc. Diff. C Shape 2.154 2.040 5.29% H&N 2.100 2.074 1.24% H&NSIB 2.176 2.116 2.74% Prostate 1.988 1.945 2.14% Prostate LN 1.968 1.932 1.82% C Shape 2.481 2.385 3.88% H&N 2.195 2.151 2.01% H&NSIB 2.122 2.096 1.24% Prostate 1.997 1.966 1.57% Prostate LN 1.893 1.892 0.06% VMAT Average 2.65% VMAT St. Dev. 1.57% IMRT Average 1.75% IMRT St. Dev. 1.39% Overall Average 2.20% Overall St. Dev. 1.48% Plan Type Measured Point Dose (cGy) Calculated Dose (DLG = 0.115 cm) [MLC_trans = 0.0165] Perc. Diff. C Shape 0.320 0.337 -5.33% H&N 1.314 1.276 2.88% H&NSIB 1.124 1.108 1.42% Prostate 1.322 1.262 4.50% Prostate LN 0.890 0.862 3.15% C Shape 0.489 0.482 1.36% H&N 1.316 1.290 1.96% H&NSIB 1.201 1.203 -0.19% Prostate 1.650 1.615 2.09% Prostate LN 1.136 1.131 0.47% VMAT Average 1.33% VMAT St. Dev. 3.88% IMRT Average 1.14% IMRT St. Dev. 0.98% Overall Average 1.23% Overall St. Dev. 2.67% IMRT VMAT IMRT Results (TG-119 and Clinical Cases)- High Dose Results (TG-119 and Clinical Cases)- Low Dose VMAT Iteration 3 – DLG = 0.140 cm / MLC_Trans = 1.85% -4.0% -3.0% -2.0% -1.0% 0.0% 1.0% 2.0% 3.0% 4.0% 5.0% 6.0% 0 1 2 3 4 5 6 Percent Difference Iteration # VMAT - High Dose IMRT - High Dose VMAT - Low Dose IMRT - Low Dose
  44. 44. Plan Type Measured Point Dose (cGy) Calculated Dose (DLG = 0.16 cm) [MLC_trans = 0.0165] Perc. Diff. C Shape 2.154 2.056 4.54% H&N 2.100 2.097 0.15% H&NSIB 2.176 2.138 1.73% Prostate 1.988 1.960 1.39% Prostate LN 1.968 1.949 0.96% C Shape 2.481 2.498 -0.68% H&N 2.195 2.192 0.14% H&NSIB 2.122 2.127 -0.22% Prostate 1.997 1.981 0.82% Prostate LN 1.893 1.943 -2.64% VMAT Average 1.75% VMAT St. Dev. 1.67% IMRT Average -0.52% IMRT St. Dev. 1.31% Overall Average 0.62% Overall St. Dev. 1.85% Plan Type Measured Point Dose (cGy) Calculated Dose (DLG = 0.16 cm) [MLC_trans = 0.0165] Perc. Diff. C Shape 0.320 0.340 -6.26% H&N 1.314 1.296 1.36% H&NSIB 1.124 1.123 0.09% Prostate 1.322 1.285 2.76% Prostate LN 0.890 0.872 2.03% C Shape 0.489 0.508 -3.96% H&N 1.316 1.328 -0.93% H&NSIB 1.201 1.234 -2.77% Prostate 1.650 1.633 1.00% Prostate LN 1.136 1.155 -1.64% VMAT Average 0.00% VMAT St. Dev. 3.64% IMRT Average -1.66% IMRT St. Dev. 1.88% Overall Average -0.83% Overall St. Dev. 2.86% IMRT Results (TG-119 Table VII)- High Dose VMAT IMRT Results (TG-119 and Clinical Cases)- Low Dose VMAT Iteration 4 – DLG = 0.160 cm / MLC_Trans = 1.65% -4.0% -3.0% -2.0% -1.0% 0.0% 1.0% 2.0% 3.0% 4.0% 5.0% 6.0% 0 1 2 3 4 5 6 Percent Difference Iteration # VMAT - High Dose IMRT - High Dose VMAT - Low Dose IMRT - Low Dose
  45. 45. Plan Type Measured Point Dose (cGy) Calculated Dose (DLG = 0.16 cm) [MLC_trans = 0.0185] Perc. Diff. C Shape 2.154 2.059 4.40% H&N 2.100 2.105 -0.23% H&NSIB 2.176 2.145 1.40% Prostate 1.988 1.963 1.24% Prostate LN 1.968 1.954 0.70% C Shape 2.481 2.520 -1.57% H&N 2.195 2.209 -0.63% H&NSIB 2.122 2.141 -0.88% Prostate 1.997 1.984 0.67% Prostate LN 1.893 1.960 -3.53% VMAT Average 1.50% VMAT St. Dev. 1.74% IMRT Average -1.19% IMRT St. Dev. 1.54% Overall Average 0.16% Overall St. Dev. 2.10% Plan Type Measured Point Dose (cGy) Calculated Dose (DLG = 0.16 cm) [MLC_trans = 0.0185] Perc. Diff. C Shape 0.320 0.345 -7.83% H&N 1.314 1.306 0.60% H&NSIB 1.124 1.132 -0.71% Prostate 1.322 1.289 2.46% Prostate LN 0.890 0.879 1.24% C Shape 0.489 0.531 -8.66% H&N 1.316 1.348 -2.45% H&NSIB 1.201 1.250 -4.11% Prostate 1.650 1.637 0.76% Prostate LN 1.136 1.173 -3.23% VMAT Average -0.85% VMAT St. Dev. 4.07% IMRT Average -3.54% IMRT St. Dev. 3.40% Overall Average -2.19% Overall St. Dev. 3.81% IMRT Results (TG-119 Table VII)- High Dose VMAT IMRT Results (TG-119 and Clinical Cases)- Low Dose VMAT Iteration 5 – DLG = 0.160 cm / MLC_Trans = 1.85% -4.0% -3.0% -2.0% -1.0% 0.0% 1.0% 2.0% 3.0% 4.0% 5.0% 6.0% 0 1 2 3 4 5 6 Percent Difference Iteration # VMAT - High Dose IMRT - High Dose VMAT - Low Dose IMRT - Low Dose
  46. 46. MLC Parameter Iteration Summary – Graphical Analysis -4.0% -3.0% -2.0% -1.0% 0.0% 1.0% 2.0% 3.0% 4.0% 5.0% 6.0% 0 1 2 3 4 5 6 Percent Difference Iteration # VMAT - High Dose IMRT - High Dose VMAT - Low Dose IMRT - Low Dose Final Value Chosen for Planning
  47. 47. Summary – DLG Testing Plan Process 1. Treatment Planning – Develop a good quality plan using the test plan structure set. Have primary treatment planning staff generate the plan if possible! 2. QA Plan – Map the plan from step 1 onto the appropriate phantom • Need to perform both chamber measurement and a planar dose/fluence measurement • Planar dose measurement can be using film, detector array, or even the EPID • Phantom choices include: • Solid Water slab phantom with place for chamber/film • Acrylic phantom with place for chamber/film • Detector array (MapCheck, ArcCheck, Delta4, Matrixx, etc.) • EPID measurement (Portal Dosimetry) 3. Measure QA plan and compare to predicted dose from TPS calculation 4. Compile all test plan results (IMRT and VMAT) before making any adjustments • Note – IMRT and VMAT trends can differ!!
  48. 48. Practical Tips – Adjusting Parameters on Approved Beam Models • If you have a beam model that is already approved and need to make adjustments for IMRT/VMAT commissioning: 1. Use caution! Think about what could go wrong before making any adjustments. Discuss with other physicists to make sure you have thought of everything that could come up. 2. Communicate! Once you have a plan, talk about it with relevant staff 3. Calculate! Plan out a time when you can perform the dose calculations with the preliminary MLC DLG/Transmission values. 1. This may need to be done after-hours or on a weekend. 4. Reset! Depending on the workflow, make sure to reset the MLC parameters back to the clinically approved values. 1. If you have multiple DLG/Transmission values you would like to test (multiple iterations), this is the time to perform all iterations 5. Verify! Once you have reset the MLC parameters back to the original values, re-calculate a set of test plans to verify constancy. 6. Compare! Once you have the calculations done, you can compare to the measured values and determine optimal parameters
  49. 49. SRS/SBRT – You may need a separate algorithm! • My experience – the level of modulation for conventional IMRT/VMAT planning is quite different than for SRS/SBRT planning • Typically, the optimal DLG value for TG-119 planning is different than for representative SRS/SBRT cases • Example at left: 6FFF beam used for SRS/SBRT delivery at one of our • More data for this example shown on next slide
  50. 50. CONCLUSION o A ‘commissioning’ machine can be created to test out the parameters for the TPS model o The TPS model will be adjusted based on comparison of calculated and measured results for IMRT/VMAT plans o A representative process for adjusting MLC parameters has been shared for learning purposes o The next lecture is transitions from commissioning and adjusting the beam model to routine QA of treatment plans. The topic is: “Patient-Specific and High-yield Machine QA for IMRT” 50
  51. 51. REFERENCES o AAPM Task Group 119: https://www.aapm.org/pubs/tg119/default.asp o Medical Physics Practice Guidelines (MPPG) 5A: https://doi.org/10.1120/jacmp.v16i5.5768 51 Thank you for your attention!

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