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Translating Advanced Science into Personalized             Health and Wellness               Paula J Nenn MD            Se...
Who? What? Why?    • 501c3 Non-profit research foundation    • Formed 2 ½ years ago, San Diego based    • Self-care and pe...
‘New’ science                     preventive / predictive                   conventional diagnostics                    fu...
Tree of Health and Disease                                   PULMONOLOGY     CARDIOLOGY                              ENDOC...
Optimal Health and Prevention Program                                                                               1    C...
Demonstration Project     • 100 subjects chosen from volunteers     • Age, gender, ethnicity matched     • Each acts as th...
Week 1               Registration,                 EHR &              Questionnaires         10                    2     9...
Week 1: Blood and Urine tests               Urine & Blood Tests                        &                 questionnaires   ...
Week 2 - Genetics              1                         SNPs                    (Genomic Saliva         10               ...
Week 3 – Autonomic Nervous System                1          10         2                            24-hr ABPM            ...
Week 4 - sleep                 1          10         2      9                         3                         Sleep Asse...
Week 5 & 6: Caloric Balance, Sleep Actiography                      1             10                   2        9         ...
Week 7: Non-Invasive Physical Tests                            1                 10             2       9                 ...
Week 8: MD and coach                      1                 10            2        9                          3           ...
Week 8: Start Program     • Personalized Interventions       •   Nutritional recommendations       •   Physical activity  ...
Week 26                            1                  10             2   Interim Data                      3     Analysis ...
Week 52: Program Finish                        1         Final Data          2          Analysis     9                    ...
Biomonitoring• Assessment Phase     • 24 hour HRV     • 24 hour AMBP     • 2/52 Body Media – calorie balance, sleep       ...
Questions?     Paula.Nenn@OptimalHealth.org19
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Paula Nenn - Quantified Self San Diego

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Slides which accompany the talk Paula Nenn gave to the Quantified Self San Diego Group

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Paula Nenn - Quantified Self San Diego

  1. 1. Translating Advanced Science into Personalized Health and Wellness Paula J Nenn MD Senior Medical Director
  2. 2. Who? What? Why? • 501c3 Non-profit research foundation • Formed 2 ½ years ago, San Diego based • Self-care and personal health accountability key to US economics • New science – 800 articles per DAY! • Public Interest in all things ‘alternative’ • New science – personalized medicine, genomics, systems biology, early predictive biomarkers • Personal health tracking devices • Bring it all together into one program? Optimal Health2 AND PREVENTION RESEARCH FOUNDATION
  3. 3. ‘New’ science preventive / predictive conventional diagnostics functional assessments EARLIEST SUB-CLINICAL IMBALANCE clinical diagnostic AND RISK FACTOR BIOMARKERS threshold of disease DYNAMIC CONTINUUM optimal sub-optimal pre- chronic EARLY DETECTION health health disease disease CHRONIC DISEASES NEVER JUST HAPPEN TO YOU, THEY ARE THE END RESULT OF A LONG, PROGRESSIVE DECLINE. Hyperinsulinemia Insulin resistance Cardiometabolic American Diet Syndrome Standard Pre-Diabetes Diabetes Diabetes Complications - Leg Amputations - Blindness - Kidney & Heart Disease - Erectile Dysfunction, … Optimal Health3 AND PREVENTION RESEARCH FOUNDATION
  4. 4. Tree of Health and Disease PULMONOLOGY CARDIOLOGY ENDOCRINOLOGY IMMUNOLOGY GASTROENTEROLOGY NEUROLOGY PSYCHIATRY ONCOLOGY PRE-DISEASE Clinical Diagnostics Functional Imbalances Genetic Predispositions Systemic Inflammation ( gate-keepers ) Oxidative Stress Functional Assessment Biomarkers SUB-OPTIMAL HEALTH SPIRITUAL & MACRO & MICRO SOCIAL BALANCE NUTRITION SLEEP, EMOTIONAL & MENTAL CIRCADIAN RHYTHMS BALANCE AND PHYSICAL ACTIVITY & & RESTORATION ‘ENERGY SYSTEM’ STRUCTURAL BALANCE STRESS RESILIENCE BALANCE MICRO ENVIRONMENTAL PROTECTION Optimal Health4 AND PREVENTION RESEARCH FOUNDATION
  5. 5. Optimal Health and Prevention Program 1 Comprehensive Predictive, OHP Preventive Functional Program Biomarker Assessment Optimal Health OHP Dx GPS Translational Algorithm & 2 Artificial Intelligence 1 3Personalized, Integrative Self- care Recommendations 3 OHP Rx Genetic Predispositions 4 Ongoing Educational, ( gate-keepers ) Optimal Health Coaching and Functional Assessment Biomarkers Progress Monitoring Support roots & trunk SPIRITUAL & MACRO & MICRO SOCIAL BALANCE NUTRITION, AIR, WATER SLEEP, CIRCADIAN RHYTHMS PHYSICAL ACTIVITY & EMOTIONAL & MENTAL & RESTORATION STRUCTURAL BALANCE ‘ENERGY SYSTEM’ BALANCE AND MICRO ENVIRONMENTAL BALANCE STRESS RESILIENCE PROTECTION Optimal Health5 AND PREVENTION RESEARCH FOUNDATION
  6. 6. Demonstration Project • 100 subjects chosen from volunteers • Age, gender, ethnicity matched • Each acts as their own control • Start Spring 2011 • In collaboration with Scripps Center for Integrative Medicine • Age ≥ 18 • Exclusion criteria: acute illness, pregnancy • Current chronic illness not an exclusion criterion but must be stable • Consent from primary physician Optimal Health6 AND PREVENTION RESEARCH FOUNDATION
  7. 7. Week 1 Registration, EHR & Questionnaires 10 2 9 3 8 4 7 5 Optimal Health 6 AND PREVENTION RESEARCH FOUNDATION
  8. 8. Week 1: Blood and Urine tests Urine & Blood Tests & questionnaires 10 2 9 3 8 4 7 5 Optimal Health 6 AND PREVENTION RESEARCH FOUNDATION
  9. 9. Week 2 - Genetics 1 SNPs (Genomic Saliva 10 Panel) & questionnaires 9 3 8 4 7 5 6 Optimal Health AND PREVENTION RESEARCH FOUNDATION
  10. 10. Week 3 – Autonomic Nervous System 1 10 2 24-hr ABPM 24-hr Holter 9 Saliva Cortisol + DHEA & questionnaires 8 4 7 5 6 Optimal Health AND PREVENTION RESEARCH FOUNDATION
  11. 11. Week 4 - sleep 1 10 2 9 3 Sleep Assessment 8 EEG + Oximetry & questionnaires 7 5 6 Optimal Health AND PREVENTION RESEARCH FOUNDATION
  12. 12. Week 5 & 6: Caloric Balance, Sleep Actiography 1 10 2 9 3 8 4 Physical Activity 7 Food Diary, FFQ 6 Optimal Health AND PREVENTION RESEARCH FOUNDATION
  13. 13. Week 7: Non-Invasive Physical Tests 1 10 2 9 3 8 4 Physical Tests 5 (Onsite) 6 Optimal Health AND PREVENTION RESEARCH FOUNDATION
  14. 14. Week 8: MD and coach 1 10 2 9 3 START… Integrative 4 MD Consult 7 5 6 Optimal Health AND PREVENTION RESEARCH FOUNDATION
  15. 15. Week 8: Start Program • Personalized Interventions • Nutritional recommendations • Physical activity • Breathing • Sleep • Environmental toxicity • Stress • Energy medicine • Spirituality / connections / gratitude Optimal Health15 AND PREVENTION RESEARCH FOUNDATION
  16. 16. Week 26 1 10 2 Interim Data 3 Analysis Week 12 8 4 7 5 6 Optimal Health AND PREVENTION RESEARCH FOUNDATION
  17. 17. Week 52: Program Finish 1 Final Data 2 Analysis 9 3 8 4 2012 7 5 6 Optimal Health AND PREVENTION RESEARCH FOUNDATION
  18. 18. Biomonitoring• Assessment Phase • 24 hour HRV • 24 hour AMBP • 2/52 Body Media – calorie balance, sleep actiography • 3 day Apnea link sleep apnea screening • Zeo Sleep Monitor 7/7 • Text and IVR food diary• Intervention • Body Media • Zeo • Emotional sampling18 • Biofeedback devices: meditation, HRV etc O p t i m a l Health AND PREVENTION RESEARCH FOUNDATION
  19. 19. Questions? Paula.Nenn@OptimalHealth.org19

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