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NACIONAL UNIVERSITY
  PEDRO RUIZ GALLO
COLLEGE OF HUMAN MEDICINE
Medical English

Dr. Rosa Gonzales

   Calderon Baldera Karen Eliana
   Diaz Mino Marlon Werner
   Fernandez Ferreyra Ana Maria Sofia
   Niño Effio Brenda Stefanny
   Popuche Cabrera Pedro Luis
   Razuri Farro Juan Alessandro
Presents
Hematopoietic Stem Cell
Pediatric Transplatation
      Medical English
Hematopoietic Stem Cell Pediatric Transplatation



                                                           standard procedure

                                                   treatment of hematological diseases
            of
                                                   in solid tumors
 infusion

                 Reconstitution of hematopoiesis



treatment of multiple malignancies in children.
Hematopoietic Stem Cell Pediatric Transplatation


The infusion of hematopoietic progenitors
cells from the patient in cases of
secondary                myelosuppression
administration of high dose chemotherapy




               known as



      AUTOLOGOUS OR
AUTOLOGOUS TRANSPLANTATION
Hematopoietic Stem Cell Pediatric Transplatation

                  This procedure is used for the
                  treatment of some high-risk tumors
                  in childhood:



Neuroblastoma                     Ewing sarcoma

                Medulloblastoma                        Nephroblastoma
Hematopoietic Stem Cell Pediatric Transplatation



 Its use as consolidation treatment
 in acute myeloid leukemia is
 discussed.




                                In the case of lymphoblastic leukemia,
                                their use is more controversial.
Hematopoietic Stem Cell Pediatric Transplatation



 UNRELATED DONORS (UNRELATED)   RESTRICTED USE




 SHOULD BE DISCUSSED ON THE
 BASIS OF INDIVIDUAL CASES
Hematopoietic Stem Cell Pediatric Transplatation



      However…                  IN RECENT YEARS




                    The results obtained with unrelated donor




                         Is approaching those obtained
                         with donor family
Hematopoietic Stem Cell Pediatric Transplatation




So the use of unrelated donors


  is spreading and expanding indications.
Hematopoietic Stem Cell Pediatric Transplatation

       Initially, hematopoietic progenitors were
               obtained from bone marrow



             in a surgical procedure involving the
                  direct puncture of the same
Hematopoietic Stem Cell Pediatric Transplatation
       In the nineties saw the widespread use of
        hematopoietic progenitors derived from
                    peripheral blood

          This     procedure     consisted      in
          administering drugs able to raise the
          number of progenitors in the circulating
          blood, to be removed later by
          leukapheresis.
Hematopoietic Stem Cell Pediatric Transplatation


                                          although with
  Such parents get faster hematopoietic
                                              higher
   recovery than those obtained from
                                           incidence of
              bone marrow
                                          chronic GVHD.
Hematopoietic Stem Cell Pediatric Transplatation


     Finally          in          Pediatrics Units

                  increasing


            Use Progenitors Cells
                           from


             Umbilical Cord Blood
Hematopoietic Stem Cell Pediatric Transplatation

             These progenitors cells
                         have



  A Slower Recovery of          Lower Incidence of
                         but
 Hematopoetic Function              Disease
Hematopoietic Stem Cell Pediatric Transplatation

                                          In the future


              Two important proteins



     Noggin                                      Chordin

        They have a better proliferation function



         Many scientists say talk of a possible cure of pediatric cancer
Thank you so much!

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5 pediatric research

  • 1. NACIONAL UNIVERSITY PEDRO RUIZ GALLO COLLEGE OF HUMAN MEDICINE
  • 2. Medical English Dr. Rosa Gonzales  Calderon Baldera Karen Eliana  Diaz Mino Marlon Werner  Fernandez Ferreyra Ana Maria Sofia  Niño Effio Brenda Stefanny  Popuche Cabrera Pedro Luis  Razuri Farro Juan Alessandro
  • 4. Hematopoietic Stem Cell Pediatric Transplatation Medical English
  • 5. Hematopoietic Stem Cell Pediatric Transplatation standard procedure treatment of hematological diseases of in solid tumors infusion Reconstitution of hematopoiesis treatment of multiple malignancies in children.
  • 6. Hematopoietic Stem Cell Pediatric Transplatation The infusion of hematopoietic progenitors cells from the patient in cases of secondary myelosuppression administration of high dose chemotherapy known as AUTOLOGOUS OR AUTOLOGOUS TRANSPLANTATION
  • 7. Hematopoietic Stem Cell Pediatric Transplatation This procedure is used for the treatment of some high-risk tumors in childhood: Neuroblastoma Ewing sarcoma Medulloblastoma Nephroblastoma
  • 8. Hematopoietic Stem Cell Pediatric Transplatation Its use as consolidation treatment in acute myeloid leukemia is discussed. In the case of lymphoblastic leukemia, their use is more controversial.
  • 9. Hematopoietic Stem Cell Pediatric Transplatation UNRELATED DONORS (UNRELATED) RESTRICTED USE SHOULD BE DISCUSSED ON THE BASIS OF INDIVIDUAL CASES
  • 10. Hematopoietic Stem Cell Pediatric Transplatation However… IN RECENT YEARS The results obtained with unrelated donor Is approaching those obtained with donor family
  • 11. Hematopoietic Stem Cell Pediatric Transplatation So the use of unrelated donors is spreading and expanding indications.
  • 12. Hematopoietic Stem Cell Pediatric Transplatation Initially, hematopoietic progenitors were obtained from bone marrow in a surgical procedure involving the direct puncture of the same
  • 13. Hematopoietic Stem Cell Pediatric Transplatation In the nineties saw the widespread use of hematopoietic progenitors derived from peripheral blood This procedure consisted in administering drugs able to raise the number of progenitors in the circulating blood, to be removed later by leukapheresis.
  • 14. Hematopoietic Stem Cell Pediatric Transplatation although with Such parents get faster hematopoietic higher recovery than those obtained from incidence of bone marrow chronic GVHD.
  • 15. Hematopoietic Stem Cell Pediatric Transplatation Finally in Pediatrics Units increasing Use Progenitors Cells from Umbilical Cord Blood
  • 16. Hematopoietic Stem Cell Pediatric Transplatation These progenitors cells have A Slower Recovery of Lower Incidence of but Hematopoetic Function Disease
  • 17. Hematopoietic Stem Cell Pediatric Transplatation In the future Two important proteins Noggin Chordin They have a better proliferation function Many scientists say talk of a possible cure of pediatric cancer
  • 18. Thank you so much!