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In my presentation I describe the foundation frameworks for improving crop production in developing countries firmly based on the successes, failures and issues identified during the Green Revolution. I describe the status of Genetically Modified Biotechnology in developed and developing countries,describe the regulatory activities that examine environmental/biodiversity and food/feed safety, as GM bio-technologies are the only regulated biotechnologies globally with a few exceptions. I describe our experiences and issues related to socioeconomic assessments of potential and actual impacts of GM crops in Uganda, Philippines, Colombia and Honduras. I summarize some lessons and conclusions learned in this process.