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My presentation at NIOSH Asbestos Roadmap meeting


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This is a presentation I made at a meeting to discuss the NIOSH Roadmap for further research into the health hazards associated with asbestos and other elongated mineral particles.

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My presentation at NIOSH Asbestos Roadmap meeting

  1. 1. Comments on the NIOSH Asbestos fibers and other EMPs: State of the Science and Roadmap for Research Overall: The plan is broadly sound and is aimed on important research questions that need to be answered John Cherrie
  2. 2. Epidemiology… <ul><li>Conclusion… “inconclusive as opposed to negative evidence regarding the health hazards associated with exposure to nonasbestoform EMPs” </li></ul><ul><li>Confounding from smoking in the NY talc workers studies </li></ul><ul><ul><li>Axelson – implausible that confounding increase risks by 2-fold </li></ul></ul><ul><ul><li>However, the MMMF studies in Europe found just this </li></ul></ul>
  3. 3. Exposure assessment… <ul><li>I support the plans for research on EMP exposures </li></ul><ul><ul><li>Focus on EM analysis for research </li></ul></ul><ul><ul><li>Consider further developing automated methods for counting and sizing fibres </li></ul></ul><ul><li>Understanding how fibres are released into the air is important, e.g. from soils or non-fibrous matrix </li></ul>
  4. 4. Thresholds… <ul><li>Studies from John Davis and colleagues… </li></ul><ul><ul><li>IP injection studies showed time to first tumour and mean induction period increased with reducing dose </li></ul></ul><ul><ul><li>Inhalation studies with long and short fibre amosite (and chrysotile) </li></ul></ul><ul><ul><ul><li>long fibres produced pulmonary fibrosis and pulmonary tumours </li></ul></ul></ul><ul><ul><ul><li>the short fibre amosite produced neither fibrosis nor tumours </li></ul></ul></ul><ul><ul><ul><li>short fibre chrysotile produced a small amount of fibrosis and some tumours, roughly in proportion to the number of long fibres </li></ul></ul></ul>
  5. 5. Secondary prevention… <ul><li>Very important to identify reliable early detection of mesothelioma (and lung cancer) </li></ul><ul><li>Understanding current and past exposure prevalence and exposures will help target surveillance </li></ul><ul><ul><li>Developments in exposure databases in Europe </li></ul></ul><ul><li>Genetic determinants of risk of mesothelioma (and lung cancer)? </li></ul>
  6. 6. Change in direction? <ul><li>The work should be integrated: </li></ul><ul><ul><li>Toxicology, Epidemiology, Exposure assessment </li></ul></ul><ul><ul><li>Asbestos, other natural EMP, synthetic EMP </li></ul></ul><ul><li>International experience may be relevant for epidemiology </li></ul><ul><ul><li>Consider a wider review/meta analysis of evidence on EMPs </li></ul></ul><ul><li>Focus measurement on EM for research and OM for surveillance </li></ul><ul><ul><li>Increasing sensitivity of OM fibre counting may not be an important priority </li></ul></ul>