WORKING FOR A HEALTHY FUTUREA Review of the United KingdomHistorical Hygiene Assessment (HHA)of National Semiconductor UKJ...
Acknowledgements•    Work funded by the Health and Safety Executive     (HSE)•    Part of an updated mortality study and “...
Summary…•    The main stimulus for the study•    Outline of the plant history•    Key processes carried out•    Gender dif...
The stimulus for the study…•    Phase II pressure group•    Results form a previous cohort     study undertaken by HSE    ...
NSUK, Greenock, Scotland                        4547 employed                        before the end of                    ...
Methodology…•    Interviews with long-service employees and former     employees    •   Nominated by company and pressure ...
Plant history…
Possible exposure hazardous agents•    Shift work•    Ionising and non-ionising radiation sources•    Toxic metals•    Tox...
Gender differences…•    Originally all operators were female•    The first male operators began in the mid-     1980s By t...
Shift work…
Ionising radiation•    Variety of sources, including sealed sources, high     voltage x-ray sources and Krypton-85•    In ...
Antimony and arsenic•    Antimony used in diffusion furnace operations     •   Measurements in 1982 showed levels well bel...
Results from the epidemiological study•    SMRs for the three cancers of prior interest for     women reduced in new follo...
Public response
Further information at…•    Leaflet summarising the findings of the follow-up     study•    Main report for the follow-up ...
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The Historical hygiene assessment of National Semiconductor UK

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  • The findings of our study together with the wider epidemiological evidence available to date do not support earlier concerns about a link between working at this semiconductor manufacturing plant and developing cancer
  • The Historical hygiene assessment of National Semiconductor UK

    1. 1. WORKING FOR A HEALTHY FUTUREA Review of the United KingdomHistorical Hygiene Assessment (HHA)of National Semiconductor UKJohn W Cherrie and Karen GaleaINSTITUTE OF OCCUPATIONAL MEDICINE . Edinburgh . UK www.iom-world.org
    2. 2. Acknowledgements• Work funded by the Health and Safety Executive (HSE)• Part of an updated mortality study and “cluster analysis” • Principal Investigator Dr John Osman • Other collaborators: Brian G. Miller, Laura MacCalman, Sam Wilkinson, Andrew J. Darnton, Amy Shafrir, Damien M. McElvenny
    3. 3. Summary…• The main stimulus for the study• Outline of the plant history• Key processes carried out• Gender differences in exposures• Key exposures of interest• The results from the epidemiological investigations
    4. 4. The stimulus for the study…• Phase II pressure group• Results form a previous cohort study undertaken by HSE • 11 female lung cancers 4 expected • 3 female stomach cancers <1 expected • 4 male brain cancers <1 expected • 20 female breast cancers 15 expected
    5. 5. NSUK, Greenock, Scotland 4547 employed before the end of April 1999• Wafer fabrication started in the early 1970s• Many individuals from the local area employed in plant
    6. 6. Methodology…• Interviews with long-service employees and former employees • Nominated by company and pressure group• Scrutiny of records, blueprints etc • Occupational hygiene measurement data • Details of ionising and non-ionising radiation sources • Details of Personal Protective Equipment (PPE) / Respiratory Protective Equipment (RPE) • Smoking / health surveillance policies • Accident / incident reports • Shift pattern records
    7. 7. Plant history…
    8. 8. Possible exposure hazardous agents• Shift work• Ionising and non-ionising radiation sources• Toxic metals• Toxic gases• Sulphuric and other acid mists• Various organic solvents• Asbestos (in buildings) and ceramic fibre
    9. 9. Gender differences…• Originally all operators were female• The first male operators began in the mid- 1980s By the mid-1990s when there was equal numbers of males and females• Supervisory, maintenance, lab technicians and engineering were predominantly male• In the early-1990s in Fab 2, men worked on processes where propylene glycol methyl ether acetate was used
    10. 10. Shift work…
    11. 11. Ionising radiation• Variety of sources, including sealed sources, high voltage x-ray sources and Krypton-85• In 1983 tracer flow/leak test process started• Same year the dose rates from process exceeded legal limits (Kr-85) • Additional shielding • In 1984 process redesigned• 1986 further problems with Kr-85 imregnatingo- ring seals• 1990 process discontinued
    12. 12. Antimony and arsenic• Antimony used in diffusion furnace operations • Measurements in 1982 showed levels well below OEL• Arsenic used in diffusion furnaces, ion implanters (arsine), epitaxial reactors (arsine), vapour deposition reactors • Monitoring during process operations below OEL • Some maintenance tasks resulted in exposures above OEL, but respirators used
    13. 13. Results from the epidemiological study• SMRs for the three cancers of prior interest for women reduced in new follow-up• No further brain cancers in men• Poor response rate from subjects/proxies in cluster analysis• No consistent evidence that cases more likely to be exposed to hazards than controls
    14. 14. Public response
    15. 15. Further information at…• Leaflet summarising the findings of the follow-up study• Main report for the follow-up study• Appendices to the main report• Detailed Historical Hygiene Assessment• www.hse.gov.uk/statistics/publications/nsuk.htm

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