Get a life - a presentation about the exposome at Occupational Hygiene

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Describes work in the HEALS project (www.HEALS-eu.eu). This project has received funding from the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement No 603946.

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Get a life - a presentation about the exposome at Occupational Hygiene

  1. 1. INSTITUTE OF OCCUPATIONAL MEDICINE . Edinburgh . UK www.iom-world.org Get a life?! John W Cherrie1,2 Andrew Apsley1 and Sean Semple1,2 1. Centre for Human Exposure Science, Institute of Occupational Medicine 2. Scottish Centre for Indoor Air, University of Aberdeen
  2. 2. Summary •  The exposome, from conception to death •  We’re in the 21st century •  The internet of things •  The quantified self •  Citizen science •  Sensors and the cloud •  Low-cost sensors and what they can do •  HEALS, the biggest environment and health project in Europe •  The implications of all this for occupational hygiene
  3. 3. Two-thirds of the deaths in the world are caused by noncommunicable diseases, especially cancer and cardiovascular disease Only about 10% of this mortality attributed to genetic variation
  4. 4. The exposome is composed of every exposure to which an individual is subjected from conception to death. Chris Wild
  5. 5. The Exposome… The exposome is composed of every exposure to which an individual is subjected from conception to death. It comprises: •  processes internal to the body such as metabolism, gut microflora, inflammation… •  external exposures including infectious agents, chemical contaminants, diet… •  social, economic and psychological influences. Wild, C. P. (2012). The exposome: from concept to utility. International Journal of Epidemiology, 41(1), 24–32.
  6. 6. Critical life stages Wild, C. P. (2012).
  7. 7. Agnostic investigations… •  Steve Rappaport recommends searching for potential causes without any prior hypothesis •  Approach lends itself to “omics” technologies •  Although other measurements can also contribute to this approach •  Follow-up with more focused epidemiological and mechanistic studies
  8. 8. Measuring the exposome… •  “Omics” biomarkers, particularly metabolomics and proteomics, from biobank samples •  Small-low cost sensors, linked to smart phones or the Internet (of Things) •  Integrated environmental sensors and sensor arrays •  Collecting data using tablet computers etc – “citizen science” initiatives •  Accessing “big data” stored others, e.g. electricity consumption, shopping habits
  9. 9. http://googleblog.blogspot.co.uk/2014/01/introducing-our-smart-contact-lens.html
  10. 10. Internet of things...
  11. 11. The tile… http://www.thetileapp.com/
  12. 12. Quantified self… http://www.moves-app.com https://www.fitbit.com
  13. 13. Citizen science… •  Dylos DC 1700 •  Laser-based particle counter •  1 min data logging capability more than 6 days •  Quiet •  Mains operated with battery for 6 hours •  Low cost - £265 Semple S, Apsley A, MacCalman L. An inexpensive particle monitor for smoker behaviour modification in homes. Tob Control. 2013 Sep;22(5):295-8. http://www.refreshproject.org.uk/
  14. 14. Calibration dataset (n=25,301) r2 =0.86 Sidepak PM2.5 = 0.65 + 4.16 x 10-5[Dylos particles] + 1.57x10-11[Dylos particles]2
  15. 15. Dylos and occupational exposure…
  16. 16. Intragastric temperature…
  17. 17. Sensor packages… €155
  18. 18. Smart sensor packages… •  NetAtmo •  Measures temperature, humidity, noise and CO2 •  Cloud enabled, syncs with phone, tablet and computer •  Cost €176 http://www.netatmo.com
  19. 19. HEALS… •  Health and Environment-wide Associations based on Large population Surveys Isabella Annesi-Maesano, www.heals-eu.eu Prof. Dimosthenis Sarigiannis,
  20. 20. Important parameters… •  Location •  Mobile phone technology •  Activity (movement, orientation) •  Walking, running, transport •  Standing, sitting, lying •  Temperature and humidity •  Indoor / outdoor •  Light / dark (maybe UV) •  Indoor / outdoor pollutants •  Sound level •  Diet http://mimobaby.com
  21. 21. Confidentiality? •  Exposome projects will collect sensitive personal data •  However, we mostly share personal data already •  And sharing data will become commonplace •  Researchers will need to act under normal rules of medical ethics •  Practitioners may need to develop clear guidelines
  22. 22. Implications for occ. hygiene •  We need to become aware of the possibilities •  Omics offers new ways to investigate work exposures •  Accuracy and precision is not everything, but tools need calibration •  Tracking location and behaviour provides new data •  There are confidentiality issues to be resolved •  Citizen science revolution is coming
  23. 23. http://www.niehs.nih.gov/research/supported/dert/programs/peph/podcasts/exposome/
  24. 24. Acknowledgement… The HEALS project has received funding from the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement No 603946.

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