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5. ART example

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The fifth lecture on modelling exposure for a course held in Norway 2011. Note, the input screens in ART refer to an older implementation of the model than is currently available.

Published in: Health & Medicine
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5. ART example

  1. 1. Example calculations using ART Powder exposure in pharmaceutical industry John Cherrie
  2. 2. Data collection – BOHS survey <ul><li>BOHS funded project </li></ul><ul><li>Using BOHS Registered Consultants to collect data and contextual information </li></ul><ul><li>We developed: </li></ul><ul><ul><li>Spreadsheet for collecting contextual information </li></ul></ul><ul><ul><li>Guidelines for data quality </li></ul></ul><ul><li>Data were checked by IOM </li></ul>
  3. 3. Results for BOHS – ART data collection <ul><li>Three consultants contributed data </li></ul><ul><li>18 exposure scenarios </li></ul><ul><ul><li>Pharmaceutical industry (5 scenarios) </li></ul></ul><ul><ul><li>Rubber (4 scenarios) </li></ul></ul><ul><ul><li>Metal industry (3 scenarios) </li></ul></ul><ul><ul><li>Woodworking (1 scenarios) </li></ul></ul><ul><ul><li>Dental laboratory (1 scenario) </li></ul></ul><ul><ul><li>Construction (1 scenario) </li></ul></ul><ul><ul><li>Manufacture of labels (1 scenario) </li></ul></ul><ul><ul><li>Histology laboratory (1 scenario) </li></ul></ul><ul><ul><li>Paint manufacture (1 scenario) </li></ul></ul><ul><li>Total 143 Measurements with contextual data </li></ul>
  4. 4. Case 1: Scenario description … <ul><li>Manufacturing of pharmaceutical products. </li></ul><ul><li>Handling pharmaceutical active ingredients in powder form (discharge of mixer into kegs or IBC, and check-weighing) </li></ul><ul><li>Activities include Mixing, Blending, Filling kegs and IBCs, Tablet compression, and Film coating. Some process steps were automated and carried out inside closed equipment, with others requiring manual intervention. </li></ul><ul><li>LEV and other engineering controls, plus PPE were used depending on the activity </li></ul>
  5. 5. Operator checks powder flow
  6. 6. Filling kegs from blender…
  7. 7. Check weighing…
  8. 8. Application of ART
  9. 9. Scenario overview…
  10. 10. Scenario overview: activities…
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  27. 27. Exposure Data … Data set 1 (only site A) and 2 (Site A and B) Data set 3
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  30. 30. Summary … <ul><li>ART is relatively straightforward to use </li></ul><ul><li>Follows a logical scheme </li></ul><ul><li>Allows for the easy input of data to update the mechanistic model prodictions </li></ul>

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