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Throughout the world, especially in Africa, condom-compatible lubricant is inaccessible for most people who engage in anal intercourse. A number of analyses in various settings indicate the use of oil-based products is the most common form of lubrication – and is known to significantly reduce condom effectiveness. Faced with the lack of condom-compatible lubricants, people often resort to such products as body lotion, soap, cooking oil, spit, pre-cum, antibiotic creams, and even motor oil to provide lubrication during anal intercourse. This lack of appropriate lubricant products for people who practice anal intercourse is unacceptable. International Rectal Microbicide Advocates (IRMA) and Project ARM (Africa for Rectal Microbicides) recently released a report “On the Map: Ensuring Africa’s Place in Rectal Microbicide Research and Advocacy” (see: www.rectalmicrobicides.org/ProjectARMreport2012.pdf). A key recommendation in the report is to make affordable condom-compatible lubricant available to all Africans who engage in anal intercourse, including gay men and other men who have sex with men, transgender individuals, and heterosexual men and women. With this recommendation, IRMA and amfAR, the Foundation for AIDS Research’s MSM Initiative propose to launch the Global Lube Access Mobilisation (GLAM).