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De-extinction,
should we?
Undergraduate Seminar
Jay Edneil Olivar
“Gone” by Isabella Kirkland
Passenger Pigeon
STATUS: Extinct
Golden Toad
STATUS: Extinct
Cuban Begonia
STATUS: Extinct
Tree Snail
STATUS: Extinct
Thylacine
Thylacinus cynocephalus
STATUS: Extinct
http://www.naturalworlds.org
/thylacine/history/history.htm
Common thread?
Humans FORCED them
to EXTINCTION
WWF global ESTIMATES that at
LEAST 10,000 species go
EXTINCT every year
Probable Reason for
Extinction
• Paul Martin, an
American
anthropologist, pointed
out that MEGAFAUNAL
EXTINCTIONS were due...
De-extinction
process by which humans
GENETICALLY ENGINEER
embryos of extant species to
hopefully bring back extinct
relat...
Revival Criteria
http://longnow.org/revive/candidates/
De-extinction: History
Karyoplast from
skin biopsy
SB
Revival
Bucardo
Spanish Ibex
De-extinction: Bucardo
First ever revived species by
Folch et al. 2003
SB
Gastric-Brooding Frog
Great Barred Frog
De-extinction: Gastric-brooding Frog
Embryos grown
in medium
Results
Bucardo Gastric-Brooding Frog
Only one female Spanish
Ibex got pregnant
Life span of revived
bucardo was 7 minutes...
MAGE System
Multiplex Automated
Genome Engineering
System
A
B
C
A. Genomes to Cells
Assembly of
the passenger
pigeon
genome
Comparison of the
assembled
genome with the
extant relative’s
...
B. Cells to a Bird
Creation of
passenger pigeon
stem cells
Insertion of germ
cells to rock
pigeon eggs
C. A bird to a flock
Breeding of Chimeras
Where are we now?
• Part A (Genomes to Cell)
Are we playing God?
“Did we play God when we
drove these species to
extinction?”
“It was ENTIRELY human
efforts that made ...
Are we playing God?
“Humans have made a HUGE
hole in nature…We could
consider bringing them back
to a world that MISSES th...
What are we going to do with the
revived species?
Are the revived species really
authentic?
De-extinction,
should we?
http://longnow.org/revive
De extinction
De extinction
De extinction
De extinction
De extinction
De extinction
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De extinction

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Undergraduate Seminar

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De extinction

  1. 1. De-extinction, should we? Undergraduate Seminar Jay Edneil Olivar “Gone” by Isabella Kirkland
  2. 2. Passenger Pigeon STATUS: Extinct
  3. 3. Golden Toad STATUS: Extinct
  4. 4. Cuban Begonia STATUS: Extinct Tree Snail STATUS: Extinct
  5. 5. Thylacine Thylacinus cynocephalus STATUS: Extinct
  6. 6. http://www.naturalworlds.org /thylacine/history/history.htm
  7. 7. Common thread? Humans FORCED them to EXTINCTION WWF global ESTIMATES that at LEAST 10,000 species go EXTINCT every year
  8. 8. Probable Reason for Extinction • Paul Martin, an American anthropologist, pointed out that MEGAFAUNAL EXTINCTIONS were due to the introduction of HUNTING and DOMESTICATION TECHNIQUES by our early ancestors • OVERKILL Hypothesis
  9. 9. De-extinction process by which humans GENETICALLY ENGINEER embryos of extant species to hopefully bring back extinct relatives
  10. 10. Revival Criteria
  11. 11. http://longnow.org/revive/candidates/
  12. 12. De-extinction: History
  13. 13. Karyoplast from skin biopsy SB Revival Bucardo Spanish Ibex De-extinction: Bucardo
  14. 14. First ever revived species by Folch et al. 2003
  15. 15. SB Gastric-Brooding Frog Great Barred Frog De-extinction: Gastric-brooding Frog Embryos grown in medium
  16. 16. Results Bucardo Gastric-Brooding Frog Only one female Spanish Ibex got pregnant Life span of revived bucardo was 7 minutes; Died because of lung defects Embryo’s average life span is 10 days Genetically IDENTICAL to the extinct species
  17. 17. MAGE System Multiplex Automated Genome Engineering System
  18. 18. A B C
  19. 19. A. Genomes to Cells Assembly of the passenger pigeon genome Comparison of the assembled genome with the extant relative’s genome MAGE System
  20. 20. B. Cells to a Bird Creation of passenger pigeon stem cells Insertion of germ cells to rock pigeon eggs
  21. 21. C. A bird to a flock Breeding of Chimeras
  22. 22. Where are we now? • Part A (Genomes to Cell)
  23. 23. Are we playing God? “Did we play God when we drove these species to extinction?” “It was ENTIRELY human efforts that made them extinct.”
  24. 24. Are we playing God? “Humans have made a HUGE hole in nature…We could consider bringing them back to a world that MISSES them.” “What I think is important is that, if it's clear that we exterminated these species, then I think we not only have a MORAL OBLIGATION to see what we can do about it, but I think we've got a MORAL IMPERATIVE to try to do something, if we can.”
  25. 25. What are we going to do with the revived species?
  26. 26. Are the revived species really authentic?
  27. 27. De-extinction, should we?
  28. 28. http://longnow.org/revive

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