The Future of the Endotracheal Tube


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The Future of the Endotracheal Tube

  1. 1. The Disappearing Endotracheal Tube Bryan Bledsoe, DO, FACEP Clinical Professor of Emergency Medicine University of Nevada School of Medicine
  3. 3. Introduction When paramedics were introduced in the early 1970s, ETI was a mandatory skill. Prior to that, ETI was solely in the domain of physicians and nurse anesthetists.
  4. 4. Introduction Eventually, paramedics were accepted into the operating room for clinical ETI education.
  5. 5. Introduction Prior to the late 1980s and early 1990s, the vast majority of people who received prehospital ETI were dead or died. Missed ETI was not that closely scrutinized because it often did not contribute to patient’s demise.
  6. 6. Introduction In the 1990s there was a push to intervene earlier in the injury/disease continuum. Trauma patients with GCS  8 should be intubated. Medical patients in respiratory failure should be intubated.
  7. 7. Introductions Paramedics were now intubations patients who had a good chance of survival. This subsequently put the practice in a whole new light.
  8. 8. Introduction Now that it mattered, it was found that paramedic ETI success rates were woefully low.
  9. 9. Introduction Procedures were changed and devices were added to improve the success rate of prehospital ETI.
  10. 10. Introduction Scrutiny has now moved to patient outcomes.
  12. 12. Gold Standard? Is the endotracheal tube still the gold standard for prehospital care? In certain situations, maybe yes; in other situations, maybe no.
  13. 13. Gold Standard? “Endotracheal intubation is the most definitive means to achieve complete control of the airway.”
  14. 14. Gold Standard? “This [ETI] is the preferred technique for managing a patient’s airway in the field setting.”
  15. 15. Gold Standard? “The gold standard of airway care in patients who cannot protect their airway or those needing assistance in breathing is the endotracheal tube.” Ron Stewart, MD
  16. 16. Gold Standard? Many paramedics have graduated with the idea that failure to intubate a patient was substandard care. In reality, failure to ventilate a patient is substandard care—not failure to place an endotracheal tube. The difference, here, is significant.
  18. 18. Are Paramedics Good at ETI? Paramedic education courses have always been rather brief when compared to other allied health professions.
  19. 19. Are Paramedics Good at ETI? 1998 United States DOT Curriculum for Paramedics: 1,000-1,200 total hours 500-600 classroom & practical hours. 200-300 clinical hours. 250-300 field internship hours.
  20. 20. Are Paramedics Good at ETI? Minimum required ETIs: Anesthesiology resident: >400 CRNA student: 200 EM Resident: 35-200 USDOT requires a minimum of 5 intubations prior to paramedic graduation.
  21. 21. Are Paramedics Good at ETI? Research has shown that paramedic students require at least 15-20 intubations to attain basic skills proficiency. Wang HE, Seitz SR, Hostler D, Yealey DM. Defining the learning curve for paramedic student endotracheal intubation. Prehosp Emerg Care. 2005;9:156-62
  22. 22. Are Paramedics Good at ETI? Author(s) No of Intubations (Misplaced/Total) Misplaced Intubations (%) Jenkins et al 2/39 5.1 Bozeman et al 1/100 1 Stewart et al 3/779 0.4 Sayre et al 3/103 2.9 Pointer 5/383 1.3 •Jenkins, WA, Verdile VP, Paris PM. The syringe aspiration technique to verify endotracheal tube position. Am J Emerg Med. 1994;12:413-416 •Bozeman WP, Hexter D, Liang HK, et al. Esophageal detector device versus detection of end-tidal carbon dioxide level in emergency intubation. Ann Emerg Med. 1996;27:595-599. •Stewart RD, Paris PM, Winter PM, et al. Field endotracheal intubation by paramedical personnel. Chest. 1984;85:341- 345. •Sayre MR, Sackles JC, Mistler AF, et al. Field trial of endotracheal intubation by basic EMTs. Ann Emerg Med. 1998;31:228-233. •Pointer JE. Clinical characteristics of paramedics’ performance of endotracheal intubation. J Emerg Med. 1988;6:505- 509.
  23. 23. Are Paramedics Good at ETI? Katz SH, Falk JL. Misplaced endotracheal tubes by paramedics in an urban emergency medical services system. Ann Emerg Med. 2001;37:32-7
  24. 24. Are Paramedics Good at ETI? Maine study: 81% success rate 19% missed rate Jemmett ME, Kendal KM, Fourre MW, Burton JH. Unrecognized misplacement of endotracheal tubes in a mixed urban to rural emergency medical services setting. Acad Emerg Med. 2003;10:961-5
  25. 25. Are Paramedics Good at ETI? 132 patients intubated in prehospital setting: 12 (9%) misplaced 11 esophageal 1 hypopharynx 20 (15%) right main stem bronchus. Wirtz DD, Ortiz C, Newman DH, Zhitomirsky I. Unrecognized misplacement of endotracheal tubes by ground prehospital providers, Prehosp Emerg Care. 2007;11:213-8.
  26. 26. Are Paramedics Good at ETI? 1-year county-wide EMS system study: 592 ETI attempts: 536 (90.5%) successful intubations. No single reason for prehospital ETT failure. Only a small percentage of patients had a “difficult airway.” Wang HE, Sweeney TA, O’Connor RE, Rubinstein H. Failed prehospital intubations: an analysis of emergency department courses and outcomes. Prehosp Emerg Care. 2001;5:134-41
  27. 27. Are Paramedics Good at ETI? Prehospital ETI often requires multiple attempts. 1,941 cases of prehospital ETI: >30% of patients required more than 1 attempt. Cumulative success rate overall per attempt (for first 3 attempts): 69.9%, 84.9%, & 89.9% Cumulative success rate for non-arrest: 57.6%, 69.2% & 72.7% Wang HE, Yealey DM. How many attempts are required to accomplish out-of-hospital endotracheal intubation. Acad Emerg Med, 2006;13:372-7
  28. 28. Are Paramedics Good at ETI? 1989 study of pediatric cardiac arrests: ETI success rate: 64% 63 pediatric patients in Milwaukee County, WI: ETI success rate: 78% Losek JD, Bionadio WA, Walsh-Kelly C, Hennes H, Smith DS, Glaeser PW. Prehospital pediatric endotracheal intubation performance review. Pediatr Emerg Care. 1989;5:1-4. Aijian P, Tsai A, Knopp R, Jailsen GW. Endotracheal intubation of pediatric patients by paramedics, Ann Emerg Med. 1989;18:489-94.
  29. 29. Are Paramedics Good at ETI? Some systems have had good ETI rates: San Diego County: 1 UEI/264 PEDIATRIC intubations (99%) Seattle/King County: 98.4% success Bellingham, WA: 20-year review 95.5% ETI success rate 0.3% UEI Vilke GM, Steen PJ, Smith AM, Chan TC. Out-of-hospital pediatric intubation by paramedics: the San Diego experience. J Emerg Med. 2002;22:71-4 Bulger EM, Copass MK, Maier RV, Larsen J, Knowles J, Jurkovich GJ. An analysis of advanced prehospital airway management. J Emerg Med 2002;23:183-9. Wayne MA, Friedland E. Prehospital use of succinylcholine: a 20- year review. Prehosp Emerg Care 1999;3:107-9.
  31. 31. Outcomes As EMS has evolved, managers and medical directors must ask, “Does this practice, procedure, or drug improve outcomes?” If so, does cost justify benefit?
  32. 32. Outcomes Multi-center study of prehospital ETI: Overall success rate was 86.8% There was no association between prehospital ETI and field or initial ED survival. Wang HE, Kupas DF, Paris PM, Bates RR, Yealey DM. Preliminary experience with a prospective, multi-centered evaluation of out-of-hospital endotracheal intonation. Resuscitation. 2003;58:49-58
  33. 33. Outcomes Prehospital ETI associated with decreased survival in patients with moderate to severe TBI. Davis DP, Peay J, Sise MJ, Vilke GM, Kennedy F, et al. The impact of prehospital endotracheal intubation on outcome in moderate to severe traumatic brain injury. J Trauma. 2005;58:933- 9.
  34. 34. Outcomes New Orleans Study: ETI was associated with similar or greater mortality than B-V-M ventilation alone. Stockinger ZT, McSwain NE Jr. Prehospital endotracheal intubation for trauma does not improve survival over bag-valve- mask ventilation. J Trauma. 2004;56:531-536
  35. 35. Outcomes Pennsylvania Trauma Registry: 4,098 trauma patients 43.9% received prehospital ETI. 56.1% received in- hospital ETI. Adjusted rates of death higher for prehospital ETI (OR=3.99 [95% CI=3.21-4.93]) Chances of poor neurologic outcome were worse for prehospital ETI (OR=1.61 (95% CI=1.15-2.26]). Wang HE, Peitzman AB, Vassidy LD, Adelson PD, Yealey DM. Out-of-hospital endotracheal intubation and outcome after traumatic brain injury. Ann Emerg Med. 2004;44:439-450.
  36. 36. Outcomes Dallas, TX study: Prehospital ETI and positive-pressure ventilation were associated with hypotension and decreased survival. Shafi S, Gentilello L. Pre-hospital endotracheal intubation and positive-pressure ventilation is associated with hypotension and decreased survival in hypovolemic trauma patients: an analysis of the National Trauma Data Bank. J Trauma. 2005;59:1140-7.
  37. 37. Outcomes Oregon study: 8,786 patients 534 (6%)-OOH-ETI 307 (57.5%)-OOH-RSI 227 (42.5%)-OOH Only Cudnick NT, Newgard CD, Wang H, Bangs C, Herrington IV R. Distance Impacts Mortality in Trauma Patients with an Intubation Attempt. Prehosp Emerg Care. 2008;12:459-466
  38. 38. Outcomes Mortality by Distance Category Odds Ratio (95% CI) Nonintubated patient at any distance Reference OOH-ETI with distance < 10 miles 2.70 (1.63-4.46) OOH-ETI with distance 10 miles - <20 miles 1.87 (1.09-3.21) OOH-ETI with distance 20 miles - <30 miles 1.80 (0.92-3.52) OOH-ETI with distance 30 miles - <40 miles 0.90 (0.38-2.16) OOH-ETI with distance 40 miles - <50 miles 0.20 (0.02-1.65) OOH-ETI and  50 miles 1.83 (0.61-5.46) Helicopter 0.36 (0.24-0.56) Propensity 119.61 (65.63-217.99)
  39. 39. Outcomes Australia: “Overall current paramedic airway practice in most states of Australia is not supported by the evidence and is probably associated with worse patient outcomes after severe head injury. For road- based paramedics, rapid transport to hospital without intubation should be regarded as the standard of care.” Bernard SA. Paramedic intubation of patients with severe head injury: a review of current Australian practice and recommendations for change. Emer Med Australas. 2006;18:221-8.
  40. 40. Outcomes United Kingdom: Best-evidence report on prehospital ETI in adult major trauma victims with TBI: “It is concluded that prehospital intubation is associated with increased mortality in these patients.” Sen A, Nichani R. Best evidence topic report. Prehospital endotracheal intubation in adult major trauma patients with head injury. Emerg Med J. 2005;22:887-9.
  41. 41. Outcomes Pediatric ETI: RCT of 830 consecutive children < 12 years of age (or who were estimated to weigh < 40 kg). Randomized to receive: BVM ventilation BVM ventilation followed by prehospital ETI. No significant difference in survival to discharge or neurological status at discharge between groups. Gausche M, Lewis RJ, Stratton SJ, Haynes BE, Gunter CS, et al. Effect of out-of-hospital pediatric endotracheal intubation on survival and neurological outcome: a controlled clinical trial. JAMA. 2000;283:783-790
  42. 42. Outcomes Pediatric patients with severe TBI: No survival advantage or functional advantage for patients receiving prehospital ETI when compared to those who only received BVM ventilation. Cooper A, DiScala C, Foltin G, Tunik M, Markenson D, Welborn C/ Prehospital endotracheal intubation for severe head injury in children: a reappraisal. Semin Pediatr Surg. 2001;10:3-6.
  44. 44. Anesthesia Practice Changes Decreased ETI for general anesthesia due to acceptance of the LMA and similar supraglottic airways.
  45. 45. Anesthesia Practice Changes HIGH • Anesthesiology Residents • CRNA Students HIGH • Critical Care/Emergency Residents • IM/General Surgery Residents MEDIUM • Medical Students • Respiratory Therapy Students LOW • Paramedic Students • EMT-Intermediate Students
  47. 47. Decreased OR Exposure Access to the OR has always been difficult for paramedic programs. EMS education tends to be community based. EMS education is shorter than similar allied health disciplines. EMS providers in many states are not truly licensed. CMS and third-party payers limit access to patients to “licensed providers.”
  48. 48. Decreased OR Exposure University of Pittsburgh study: Anonymous survey of 192 accredited paramedic programs. 161 (85%) responded. 156 (97%) of programs surveyed used OR training, but it was limited to a median of 17-32 hours/student. Half of the programs provided fewer than 16 hours OR training. Students attempted a limited number of ETIs (median, 6-10).
  49. 49. Decreased OR Exposure University of Pittsburgh study: 61% of programs reported competition from other health care educational programs as a reason for decreased OR access. Other reasons: Increased LMA usage Medical/Legal concerns. Of the survey group: 33% reported a recent reduction in OR access. 36% anticipated decreased OR access. Johnston BD, Seitz SR, Wang HE. Limited opportunities for paramedic student endotracheal intubation training in the operating room. Acad Emerg Med. 2006;132:1051-5
  50. 50. Decreased OR Exposure Psychomotor skill development: Imitation Manipulation Precision Articulation Naturalization Students should reach this point prior to graduation
  51. 51. Decreased OR Exposure ETI requires repetition of the skill for mastery. Number of reps varies with student and skill performed. Estimated that 100+ reps are required before cortical ingraining occurs.
  52. 52. Decreased OR Exposure There is a relationship between increased success rate of ETI and accumulated live experience. Wang HE, Seitz SR, Hostler D, Yealey DM. Defining the learning curve for paramedic student endotracheal intubation. Prehosp Emerg Care. 2005;9:156-62
  53. 53. Increased Experience & Survival Evaluation of paramedics in Pennsylvania 2000- 2005: Low (1-10 ETIs) Medium (11-25 ETIs) High (26-50 ETIs) Very High (> 50 ETIs)
  54. 54. Increased Experience & Survival 25,718 ETIs by 5,433 paramedics linked to patient outcomes (77.7% linkage rate): Low: 4,835 (18.8%) Medium: 9,850 (38.3%) High: 8,513 (33.1%) Very High: 2,289 (8.9%) Survival: Cardiac arrest: 17.4% Non-arrest: 68.2% Adjusted survival was higher for cardiac arrest patients intubated by high- and very-high-ETI- experience paramedics.
  55. 55. Increased Experience & Survival Survival odds ratio (compared to low ETI experience) [95% CI]: Medium: 1.04 (0.91- 1.18). High: 1.18 (1.01-1.38). Very High: 1.29 (1.04- 1.61). Survival odds better for non-arrest patients (compared to low ETI experience) [95% CI]: Medium: 1.05 (0.8-1.25). High: 1.31 (1.07-1.38). Very High: 1.59 (1.21- 2.10). Wang HE, Balasubramani KG, Lave JR, Yealey DM, Cook LJ. Paramedic endotracheal intubation experience improves survival. [Abstract] Prehosp Emerg Care. 2009;13:90-91.
  57. 57. Decreased Field Opportunities It has been generally assume that ETI and IV therapy were the most frequently performed paramedic skill.
  58. 58. Decreased Field Opportunities The number of prehospital ETIs per paramedic per year is low. For most systems, the number of intubations per paramedic per year are too low for skills maintenance. Factors: Number of patients who require ETI not as high as thought. Number of providers authorized to perform ETI has increased dramatically.
  59. 59. Decreased Field Opportunities Milwaukee, WI study: Average annual number of paramedics was 177. Each paramedic only performed 3.7  3.3 intubations a year. Cady CE, Pirrallo RG. The effect of Combitube use on paramedic experience in endotracheal intubation. Am J Emerg Med. 2005;23:868-871.
  60. 60. Decreased Field Opportunities Rural state (Maine) study: 957,836 patients encounters during 5- year study period. Average number of EMS providers who could perform ETI. 5,612 total ETI attempts during the 5- year study period. Only a range of 37%- 42% of eligible providers annually performed ETI. A mean of 18 providers attempted more than 5 intubations annually. Only 137 ETIs were pediatric.
  61. 61. Decreased Field Opportunities Rural state (Maine) study: ETI success rate: 84% in providers with < 5 annual intubations 86% in providers with > 5 annual intubations Burton JH, Baumann MR, Maoz T, Bradshaw JR, Lebrun LE. Endotracheal intubation in a rural state: procedure utilization and impact of skills maintenance guidelines. Prehosp Emerg Care. 2003;7:352-6.
  62. 62. Decreased Field Opportunities 1-year study of 11,484 ETIs performed by 5,245 prehospital providers: 67% performed two or fewer ETIs. 39% did not perform any ETIs. Wang HE, Kupas DF, Hostler D, Cooney R, Yealy DM, Lave JR. Procedural experience with out-of-hospital endotracheal intubation. Crit Care Med. 2005;33:1718-21
  63. 63. Decreased Field Opportunities AHA recommends that prehospital ALS providers perform a minimum of 6-12 intubations a year to remain current. The American Heart Association in collaboration with the International Liaison Committee on Resuscitation. Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2000;102(suppl 8):I87.
  64. 64. Decreased Field Opportunities EMS systems with high ETI success rate require a minimum of 15 ETIs per provider per year. All but a few extremely busy EMS systems can ever achieve this level. Bulger EM, Copass MK, Maier RV, Larsen J, Knowles J, Jurkovich GJ. An analysis of advanced prehospital airway management. J Emerg Med 2002;23:183-9
  65. 65. Decreased Field Opportunities High-fidelity human simulation may help the student or paramedic get ETI reps. It will never replace the need for supervised practice on living tissues.
  67. 67. Better Alternative Airways When EMS began, there was really no acceptable alternative to ETI.
  68. 68. Better Alternative Airways First-generation airways: EOA EOA-GT Problems: No more effective than BVM Esophageal rupture Tracheal intubation Bryson TK, Benumof JL, Ward CF. The esophageal obturator airway: a clinical comparison to ventilation with a mask and oropharyngeal airway. Chest. 1978;74:567- Scholl DG, Tsai SH. Esophageal perforation following use of esophageal obturator airway. Radiology. 1977;122:315-6 Yancey W, Wears R, Kamajian G, Derovanesian J. Unrecognized tracheal intubation: a complication of the esophageal obturator airway. Ann Emerg Med. 1980;9:18-20.
  69. 69. Better Alternative Airways Second-generation airways: PtL ETC ETC first alternate airway to receive significant OR usage.
  70. 70. Better Alternative Airways Third-generation airways much better. Primarily supraglottic. LMA Cobra
  71. 71. Better Alternative Airways CobraPLA CobraPlus King LT LMA
  72. 72. Better Alternative Airways After introduction of an ETC airway to an EMS system, the ETI success rate fell from 93.5% to 91.6%. Cady CE, Pirrallo RG. The effect of Combitube use on paramedic experience in endotracheal intubation. Am J Emerg Med. 2005;23:868-871.
  73. 73. Better Alternative Airways RCT of 52 paramedics using mannequins. Time to ventilation (): ET = 46 seconds LMA = 23 seconds Mean number of attempts to achieve ventilation: ET = 1.27 LMA = 1.1 Malpositioning: Esophageal = 9 (17%) Right mainstem = 14 (27%) LMA malposition = 5 (9.5%) Chin L, Hsiao AL. Randomized trial of endotracheal tube versus laryngeal mask airway in simulated pediatric cardiac arrest. Pediatrics. 2008;122:e294-e297.
  74. 74. LITIGATION
  75. 75. Litigation Alleged airway misadventures are still a major cause of malpractice suits. 10-year review by one malpractice carrier: 24 EMS claims 10 (42%) airway- related. Cumulative claims from these 10 cases > 19.6 million dollars.† † - HPSO
  76. 76. SUMMARY
  77. 77. Summary Paramedics see skills as being an important part of their practice. In a survey, they ranked ETI as their most important skill followed by defibrillation and patient assessment.
  78. 78. Summary When paramedics were confronted with the many negative studies on ETI, they became ad hominem and said that the studies were a priori (especially Wang and Davis).
  79. 79. Summary If ETI remains in a system: 1. There must be adequate initial education including OR time. 2. There must be a constant monitoring of skills performance. 3. Paramedics not receiving enough ETIs annually must undergo refresher training. 4. Probably should not intubate pediatrics of moderate to severe TBI patients.
  80. 80. Summary If ETI remains in a system: 5. Waveform capnography should be mandatory. 6. All receiving hospitals should document tube placement. 7. Alternative (rescue) airways must always be available. 8. Failure to intubate is not a deficiency— failure to ventilate is.
  81. 81. Summary The design and efficacy of alternate airways has reached a point where they can be used in EMS in lieu of ETI.
  82. 82. Summary New technologies may improve paramedic ETI performance: AirTraq GlideScope Ranger McGrath Video Laryngoscope Supraglottic Airway Laryngopharyngeal Tube (SALT)
  83. 83. Summary Ironically, it is not the accumulating body of evidence that will be the death knell for prehospital ETI. It will be the lack of opportunity for OR exposure.
  84. 84. Summary We must re-task our paramedics and change the educational approach: 1. It is not the airway, it is ventilation that the patient needs. 2. Airway is a technique or device to used to ventilate a patient. 3. Failure to place an airway is not substandard care. 4. Failure to ventilate a patient is substandard care.