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Breakthrough Water Soluble
Infusion
Dr. Arup Sen | CEO, Infusion Biosciences, Inc.
INFUSION
BIOSCIENCES
| 3
Biotech company focused on discovering and commercializing
lnnovative delivery of cannabis/hemp whole plant benefits
|
Our Scientific Discovery
4
Current Thinking
__________________
 Cannabinoids and terpenes are
insoluble in water but soluble in lipids,
alcohols and other non-polar organic
solvents
 “Truly water-soluble" molecules (like
sugar and salt) homogeneously
incorporate into water as molecules or
ions without any physical manipulation
 Cannabinoids can be formulated to be
water-compatible and appear water-
soluble through the use of well known
technologies used by competitors
Infusion’s Discovery
__________________
 Discovered that the cannabis plant naturally
produces water-soluble forms of
phytochemicals including cannabinoids and
terpenes
 Created patent pending Aqueous
Phytorecovery Process (“APP”) that first
recovers the water-soluble phytochemicals
followed by releasing the “free” oils without
disrupting or “denaturing” the molecules
New Way of Thinking
__________________
 Mother nature enables all natural
molecules, including lipids/oils, to exist in
water solutions so that they can move
around in a living organism and perform
their natural functions
 The naturally water soluble forms determine
the biological “fate/destination/activity” of all
molecules in nature
 Examples of lipid/oil natural molecules that
are naturally water soluble are: Cholesterol
(LDL and HDL); Triglycerides; Fatty acids;
Chlorophyll
APP is a fundamental paradigm shift in the hemp and cannabis industry - supplanting “water
compatibility” with “water solubility” to achieve improved “bioactivity” that is beyond “bioavailability”
5
A New Concept
Safe and Controlled Delivery of Natural Phytochemicals
• Retain native forms of phytochemicals
• Recover “naturally” water soluble forms in water solution
• Elute free lipids in natural carrier oil
Naturally Water Soluble Lipids
Numerous examples in plants and animals
• Multiple natural means
• Distributed differentially through different tissues
• Transport through the organism
• Homing and functionality
6
Naturally Water Soluble Cannabis and Hemp Phytochemicals
A 2-step process separately recovers “water soluble” and “free” lipids
7
Infuz2O - Features
Displays characteristics of the source plants
Rapid onset (<5 min) and offset times (<90 min)
Readily and totally dissolves in water
Contains other water soluble beneficial plant
molecules
Amenable to fractionation
Stable in solution over time, ionic strength, pH,
temperature
Formulated in beverages with other micronutrients
BioNatural Oil - Features
Directly recovered in a natural carrier oil from plant
material
Displays plant characteristics
Contains other beneficial plant oils (that are lost in
traditional extraction)
Ready to consume or use as an ingredient (no
additional processing after recovery)
Amenable to fractionation
|
Infuz20 - A Disruptive Technology
8
Our proprietary APP recovery
technology delivers a truly water-
soluble liquid hemp and cannabis
Session-ability
Less than 5 mins to feel effects and 90 min to wear off making for a session-able experience
Experience
Effects of consumption comparable to smoking and vaping.
Discrete Consumption
Odorless and smokeless consumption experience
Predictable Precise Dosing
Ability to deliver a measurable amount of hemp and cannabis with
predictable onset and offset time
Biopharma Platform
Foundation to isolate and produce pharmaceuticals
Formulation Versatility
Numerous and versatile end-user applications
The Big Opportunity: Addresses the industry’s challenges faced by traditional hemp and cannabis
consumption methods
9
Cognitive Response Profiles
|
Commercial APP Unit
10
First Generation Triple-module Mid-Sized Unit
10kg single variety or 3kg each of 3 different varieties
Second Generation APP Unit
40kg single variety
Infusion APP units are modular and can be configured for ‘craft’ style or large commercial scale runs
|
Hemp and Cannabis Beverage Opportunity
11
Unpredictable and Lengthy Onset
 Unpredictable onset of effects can cause dosage concerns
 Keeps many hemp and cannabis users on the sidelines from edibles
and beverages
Highly Predictable & Rapid Onset
 Less than 5 min onset is similar to alcohol
 Allows users to “self monitor” and control dosage in real-time
Prolonged Offset
 4 – 12 hour offset requires a “Full-day” commitment
 Does not allow for “casual” consumption options
Single Format Dosage
 Limited revenue opportunity due to onset and offset
 Does not allow for a high-volume, low-price consumption model in
one sitting – ie. ‘6-Pack Model’
Rapid Offset
 Offset in 90 min or less does not require “full-day” commitment
 Enables a “casual” or “lunch time” consumption model
Business Model Driven Dosage Model
 Ability to formulate low concentration formulations at lower cost to
drive volume sales – ie. ‘6-Pack’ model
 Ability to formulate high concentration single-shot dosage – ie.
“Sprits” model
CURRENTBEVERAGECHALLENGES
WATER-SOLUBLEBEVERAGESOLUTIONS
Infuz20 solves major hurdles and unlocks massive potential for the Hemp and Cannabis Beverage
Market
|
Infusion Product Samples
12
Beverages Edibles
|
Select Product Formulations
13
Balance FX Relief
Cannabis / Hemp
Water
Topical Cream Edible Oil Capsules
Dosage
60 ml (2 fl. oz.) - 1
serving
60 ml (2 fl. oz.) - 1
serving
60 ml (2 fl. oz.) - 1
serving
60 ml (2 fl. oz.) - 1
serving
Variable 5-50mg per ml 5-15mg per ml
Type
Relaxation
& Sleep
Mood uplifting
& Focused Energy
Stress
Relief
Delivers plant-
specific
benefits/experience
Pain Relief
Multi Multi
Hemp
Ingredient
Hemp & GG#4
Infuz20 Blend
Girl Scout Cookies
& GG#4 Infuz20
Blend
Industrial Hemp
Infuz20
Single Cannabis or
Hemp Infuz20
Hemp or Cannabis
BNO
Hemp or Cannabis
BNO
Hemp or Cannabis
Infuz20
Hemp or Cannabis
BNO
Other
Ingredients
Calcium 50mg
Magnesium 20mg
Zinc 3mg
Potassium 25mg
L-Theanine 50mg
Vitamin B12 3mcg
Vitamin B6 1mg
Natural flavors
Calcium 50mg
Magnesium 20mg
Potassium 25mg
L-Theanine 75mg
Vitamin B12 3mcg
Vitamin B6 1mg
Natural flavors
Magnesium 25mg
Zinc 3mg
Potassium 25mg
L-Theanine 50mg
Melatonin 1.5mg
Natural flavors
Water Selected Essential
Oils
Carrier Oil
Natural Ingredients
Carrier Oil Carrier Oil
Functional Beverages Pure Hemp Topicals CapsulesTinctures
|
 Naturally dissolved in water:
– most efficient means to deliver a bioactive to the human body
– does not need processing by the body to render water soluble and
bioavailable
 Versatility for consumer products (recreational and biopharma):
– Ingested as-is
– Dissolved in water-based beverages products
– Delivered in water-soluble capsules
 Controlled and predictable dosing/effect - similar to alcoholic beverages
 No need for added chemicals or formulation alternatives that are now used to
make cannabinoid oils “stay” in water
Finished Ingredient Overview
14
 Less than 5 mins to feel effects, less than 90 min to wear off,
 Fast onset/offset as expected for ingredients “naturally dissolved” in
water
 Retains strain specific nuances and whole plant experience (similar to wine
varietals)
 Produces true beverage products free of formulation chemicals used to blend
oils in water (emulsions, encapsulation, etc.)
 May be reduced to achieve higher concentration/potency
 Onset as early as 25 minutes, offset of 4+ hours like all other oils
 Retains strain specific nuances and whole plant experience
 Recovered directly in carrier oil and ready for consumption as a hemp or
cannabis oil or processed further
 May be fractionated by routine distillation methods into separate molecular
subpopulations (cannabinoids, terpenes, other oils)
 May be used in all products that are now made using oils produced by older
technologies (such as solvent extractions or supercritical fluid extraction followed
by polishing)
 Homogeneously dissolved in natural oil already in human use (GRAS)
– Customized for desired use by client
– Can be sold as is as hemp or cannabis oil in Canada
– Predictable onset and offset time
 May be formulated into:
– Water-based products using off-the-shelf technology
– Edibles
– Topicals
Characteristics Benefits
Infuz20Bio-NaturalOil
For more information please contact:
Paul Marcelino (COO) – paul@infusionbiosciences.com
www.infusionbiosciences.com
Thank you!
Sponsors
Media Partners

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Breakthrough water soluble infusion

  • 1. Breakthrough Water Soluble Infusion Dr. Arup Sen | CEO, Infusion Biosciences, Inc.
  • 3. | 3 Biotech company focused on discovering and commercializing lnnovative delivery of cannabis/hemp whole plant benefits
  • 4. | Our Scientific Discovery 4 Current Thinking __________________  Cannabinoids and terpenes are insoluble in water but soluble in lipids, alcohols and other non-polar organic solvents  “Truly water-soluble" molecules (like sugar and salt) homogeneously incorporate into water as molecules or ions without any physical manipulation  Cannabinoids can be formulated to be water-compatible and appear water- soluble through the use of well known technologies used by competitors Infusion’s Discovery __________________  Discovered that the cannabis plant naturally produces water-soluble forms of phytochemicals including cannabinoids and terpenes  Created patent pending Aqueous Phytorecovery Process (“APP”) that first recovers the water-soluble phytochemicals followed by releasing the “free” oils without disrupting or “denaturing” the molecules New Way of Thinking __________________  Mother nature enables all natural molecules, including lipids/oils, to exist in water solutions so that they can move around in a living organism and perform their natural functions  The naturally water soluble forms determine the biological “fate/destination/activity” of all molecules in nature  Examples of lipid/oil natural molecules that are naturally water soluble are: Cholesterol (LDL and HDL); Triglycerides; Fatty acids; Chlorophyll APP is a fundamental paradigm shift in the hemp and cannabis industry - supplanting “water compatibility” with “water solubility” to achieve improved “bioactivity” that is beyond “bioavailability”
  • 5. 5 A New Concept Safe and Controlled Delivery of Natural Phytochemicals • Retain native forms of phytochemicals • Recover “naturally” water soluble forms in water solution • Elute free lipids in natural carrier oil Naturally Water Soluble Lipids Numerous examples in plants and animals • Multiple natural means • Distributed differentially through different tissues • Transport through the organism • Homing and functionality
  • 6. 6 Naturally Water Soluble Cannabis and Hemp Phytochemicals A 2-step process separately recovers “water soluble” and “free” lipids
  • 7. 7 Infuz2O - Features Displays characteristics of the source plants Rapid onset (<5 min) and offset times (<90 min) Readily and totally dissolves in water Contains other water soluble beneficial plant molecules Amenable to fractionation Stable in solution over time, ionic strength, pH, temperature Formulated in beverages with other micronutrients BioNatural Oil - Features Directly recovered in a natural carrier oil from plant material Displays plant characteristics Contains other beneficial plant oils (that are lost in traditional extraction) Ready to consume or use as an ingredient (no additional processing after recovery) Amenable to fractionation
  • 8. | Infuz20 - A Disruptive Technology 8 Our proprietary APP recovery technology delivers a truly water- soluble liquid hemp and cannabis Session-ability Less than 5 mins to feel effects and 90 min to wear off making for a session-able experience Experience Effects of consumption comparable to smoking and vaping. Discrete Consumption Odorless and smokeless consumption experience Predictable Precise Dosing Ability to deliver a measurable amount of hemp and cannabis with predictable onset and offset time Biopharma Platform Foundation to isolate and produce pharmaceuticals Formulation Versatility Numerous and versatile end-user applications The Big Opportunity: Addresses the industry’s challenges faced by traditional hemp and cannabis consumption methods
  • 10. | Commercial APP Unit 10 First Generation Triple-module Mid-Sized Unit 10kg single variety or 3kg each of 3 different varieties Second Generation APP Unit 40kg single variety Infusion APP units are modular and can be configured for ‘craft’ style or large commercial scale runs
  • 11. | Hemp and Cannabis Beverage Opportunity 11 Unpredictable and Lengthy Onset  Unpredictable onset of effects can cause dosage concerns  Keeps many hemp and cannabis users on the sidelines from edibles and beverages Highly Predictable & Rapid Onset  Less than 5 min onset is similar to alcohol  Allows users to “self monitor” and control dosage in real-time Prolonged Offset  4 – 12 hour offset requires a “Full-day” commitment  Does not allow for “casual” consumption options Single Format Dosage  Limited revenue opportunity due to onset and offset  Does not allow for a high-volume, low-price consumption model in one sitting – ie. ‘6-Pack Model’ Rapid Offset  Offset in 90 min or less does not require “full-day” commitment  Enables a “casual” or “lunch time” consumption model Business Model Driven Dosage Model  Ability to formulate low concentration formulations at lower cost to drive volume sales – ie. ‘6-Pack’ model  Ability to formulate high concentration single-shot dosage – ie. “Sprits” model CURRENTBEVERAGECHALLENGES WATER-SOLUBLEBEVERAGESOLUTIONS Infuz20 solves major hurdles and unlocks massive potential for the Hemp and Cannabis Beverage Market
  • 13. | Select Product Formulations 13 Balance FX Relief Cannabis / Hemp Water Topical Cream Edible Oil Capsules Dosage 60 ml (2 fl. oz.) - 1 serving 60 ml (2 fl. oz.) - 1 serving 60 ml (2 fl. oz.) - 1 serving 60 ml (2 fl. oz.) - 1 serving Variable 5-50mg per ml 5-15mg per ml Type Relaxation & Sleep Mood uplifting & Focused Energy Stress Relief Delivers plant- specific benefits/experience Pain Relief Multi Multi Hemp Ingredient Hemp & GG#4 Infuz20 Blend Girl Scout Cookies & GG#4 Infuz20 Blend Industrial Hemp Infuz20 Single Cannabis or Hemp Infuz20 Hemp or Cannabis BNO Hemp or Cannabis BNO Hemp or Cannabis Infuz20 Hemp or Cannabis BNO Other Ingredients Calcium 50mg Magnesium 20mg Zinc 3mg Potassium 25mg L-Theanine 50mg Vitamin B12 3mcg Vitamin B6 1mg Natural flavors Calcium 50mg Magnesium 20mg Potassium 25mg L-Theanine 75mg Vitamin B12 3mcg Vitamin B6 1mg Natural flavors Magnesium 25mg Zinc 3mg Potassium 25mg L-Theanine 50mg Melatonin 1.5mg Natural flavors Water Selected Essential Oils Carrier Oil Natural Ingredients Carrier Oil Carrier Oil Functional Beverages Pure Hemp Topicals CapsulesTinctures
  • 14. |  Naturally dissolved in water: – most efficient means to deliver a bioactive to the human body – does not need processing by the body to render water soluble and bioavailable  Versatility for consumer products (recreational and biopharma): – Ingested as-is – Dissolved in water-based beverages products – Delivered in water-soluble capsules  Controlled and predictable dosing/effect - similar to alcoholic beverages  No need for added chemicals or formulation alternatives that are now used to make cannabinoid oils “stay” in water Finished Ingredient Overview 14  Less than 5 mins to feel effects, less than 90 min to wear off,  Fast onset/offset as expected for ingredients “naturally dissolved” in water  Retains strain specific nuances and whole plant experience (similar to wine varietals)  Produces true beverage products free of formulation chemicals used to blend oils in water (emulsions, encapsulation, etc.)  May be reduced to achieve higher concentration/potency  Onset as early as 25 minutes, offset of 4+ hours like all other oils  Retains strain specific nuances and whole plant experience  Recovered directly in carrier oil and ready for consumption as a hemp or cannabis oil or processed further  May be fractionated by routine distillation methods into separate molecular subpopulations (cannabinoids, terpenes, other oils)  May be used in all products that are now made using oils produced by older technologies (such as solvent extractions or supercritical fluid extraction followed by polishing)  Homogeneously dissolved in natural oil already in human use (GRAS) – Customized for desired use by client – Can be sold as is as hemp or cannabis oil in Canada – Predictable onset and offset time  May be formulated into: – Water-based products using off-the-shelf technology – Edibles – Topicals Characteristics Benefits Infuz20Bio-NaturalOil
  • 15. For more information please contact: Paul Marcelino (COO) – paul@infusionbiosciences.com www.infusionbiosciences.com