A Uniform Framework for Computer-Aided Biologics Design - Dinner Short Course


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This dinner short course is sponsored by Chemical Computing Group and will be held on
June 19, 2013 at the Revere Hotel in Boston, MA. The course takes place at the conclusion of day one of CHI's 13th Annual Structure-Based Drug Design conference (June 19-21).

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A Uniform Framework for Computer-Aided Biologics Design - Dinner Short Course

  1. 1. A Uniform Framework for Computer-Aided Biologics Design ***** A Dinner Short Course Announcement ***** with Chris Williams, Ph.D., Principal Scientist, Chemical Computing Group June 19, 2013 – The Revere Hotel – Boston, MAProtein engineering plays a pivotal role in modulating the function, activity and physical propertiesof biologics. Representative strategies employed in protein engineering include rationale proteindesign and directed evolution. In general, disparate work has been done in applying computer-aided biologics design (CABD) to protein engineering for the development of novel biologicaltherapeutics. Here, we describe a unified framework of in silico protein engineering tools andinvestigate its applicability to the modulation of protein properties such as affinity and stability.The course will cover current in silico technologies used in protein engineering and biologicsdesign. More specifically, applications for visualizing, and analyzing mutations will bedescribed. Tools for calculating surface properties such as electrostatic hot-spots or patches, aswell as physicochemical properties will be presented. A number of case studies will be used todescribe how residue scanning technology can be used to address challenges in species cross-reactivity, stability, and aggregation.This course will be held from 6:00 pm – 8:00 pm which starts immediately after theconclusion of day one of CHI’s Structure-Based Drug Design conference (June 19-21).WAYS TO REGISTER:Online: https://chidb.com/register/2013/sbd/reg.aspCall: 781-972-5400Email: reg@healthtech.com http://www.healthtech.com/sbd