Phthalates•Mainly used as plasticizersadded to plastics.•Human-made chemicalsused in the manufacture ofhousehold and industrialproducts such as childrenstoys, infant-care andpersonal-care products,cosmetics, garden hoses,raincoats, adhesives andlubricants.
Who is at Risk?• Everyone!• Mainly infants andtoddlers due to theirmouthing behavior withproducts containingphthalates
Health Effects: Immediate Health Effects • If SWALLOWED, phthalates is Slightly Toxic • If ABSORBED THROUGH SKIN, phthalates is Moderately Toxic • If INHALED (SNIFFED OR BREATHED IN), phthalates is Slightly Toxic Long-term or Delayed Health Effects • This chemical is likely to cause cancer. • Allergen • Suspected Endocrine Disruptor = May interfere with, mimic or block hormones • Development Toxicant = Can interfere with normal development of a fetus or child • Reproductive Toxicant = Can harm reproductive system
Findings : Phthalates have been shown to be reproductive and developmental toxins and may contribute to what is known as • Testicular dysgenesis syndrome -increasing incidence of birth defects of the male reproductive tract such as undescended testis, and lower sperm count While a lot of attention has been focused on the "demasculation" of boys by phthalates, women are not immune to their effects. Phthalates are implicated in premature puberty in girls. Phthalates are endocrine (hormone) disruptors, meaning they interfere with normal brain function Phthalates send signals in the body that could result in Autism, Breast Cancer, Testicular cancer and reduced sperm counts
•It causes malformation of vital organs andskeletal structure. Rat testis Left = Unexposed Center and right = DEHP exposure during development Rat seminal vesicle Left = Unexposed Right = DEHP exposure during development
FindingsPrenatal exposure to phtlalates can cause brain damage: Attention deficit hyperactivity disorder ( Adhd)- characterized by either significant difficulties of inattention or hyperactivity and impulsiveness or a combination of the two Oppositional Defiant Disorder(ODO)- an ongoing pattern of anger guided disobedience, hostilely defiant behavior toward authority figures which goes beyond the bounds of normal childhood behavior
Exposure Route For Chemicalpoisoning -- Dimethyl Phthalate •Inhalation •eye •skin •ingestionSymptoms of Chemical poisoning –Dimethyl Phthalate•Eye irritation •Coma•Upper respiratory system irritation •Gastrointestinal irritation•Abdominal pain •Nausea•Diarrhea •Vomiting•Oral burns •Paralysis•Coughing •Unconsciousness•CNS depression•Reduced blood pressureTreatment List for Chemicalpoisoning -- DimethylPhthalate•Decontamination, symptomatic and supportivemeasures