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Studie bei Eierstockkrebs
unter der Leitung von
Prof. Dr.
Jacobus Pfisterer
Studie bei Eierstockkrebs unter der Leitung von Prof. Dr.
Jacobus Pfisterer
Studie bei Eierstockkrebs mit zielgerichteter ...
Die Studie AGO-OVAR 17 der AGO Studiengruppe wird in 120 Zentren in Deutschland und
zusätzlich in Frankreich und Skandinav...
Die Webseite von Prof. Dr. Jacobus Pfisterer finden Sie unter
http://www.frauenundkrebs.de
Beschreibung:
Ihr Arzt – Prof. ...
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Studie bei Eierstockkrebs unter der Leitung von Prof. Dr. Jacobus Pfisterer

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Die AGO Studiengruppe hat unter Leitung von Prof. Dr. Jacobus Pfisterer aus Kiel eine Phase III Studie in der Primärtherapie der fortgeschrittenen Eierstockkrebserkrankung gestartet. Die Studie AGO-OVAR 17 der AGO Studiengruppe wird in 120 Zentren in Deutschland und zusätzlich in Frankreich und Skandinavien durchgeführt. Die Beantwortung der Haupt-Fragestellung der Studie, ob eine längere Antikörpertherapie mit einer Effektivitätssteigerung verbunden ist, wird allerdings noch einige Jahre dauern.

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Studie bei Eierstockkrebs unter der Leitung von Prof. Dr. Jacobus Pfisterer

  1. 1. Studie bei Eierstockkrebs unter der Leitung von Prof. Dr. Jacobus Pfisterer
  2. 2. Studie bei Eierstockkrebs unter der Leitung von Prof. Dr. Jacobus Pfisterer Studie bei Eierstockkrebs mit zielgerichteter Behandlungsstrategie rekrutiert deutlich schneller als erwartet Im November 2011 hat die AGO Studiengruppe unter Leitung von Prof. Dr. Jacobus Pfisterer aus Kiel eine Phase III Studie in der Primärtherapie der fortgeschrittenen Eierstockkrebserkrankung gestartet. Nachdem zwei große Phase III Studien, die GOG 218 Studie aus den USA und die AGO-OVAR 11 (ICON7) Studie aus Europa unter federführender Beteiligung der AGO Studiengruppe übereinstimmend gezeigt haben, daß die zusätzliche Gabe des Gefäßneubildungshemmenden Antikörpers Bevacizumab zur Chemotherapie und darüber hinaus gegeben mit einer Verbesserung des progressionsfreien Überlebens einhergeht, wird in dieser Studie (AGO-OVAR 17) die optimale Behandlungsdauer mit dem VEGF-Antikörper Bevacizumab zur Chemotherapie mit Carboplatin und Paclitaxel untersucht. Standardarm in der Studie ist eine Behandlung mit Bevacizumab, die zeitgleich mit der Chemotherapie begonnen wird und nach Abschluss von 6 Zyklen Chemotherapie für insgesamt 15 Monate als Erhaltungstherapie fortgesetzt wird. Hier wird das zugelassene Therapieregime mit Carboplatin AUC 5, Paclitaxel 175 mg/m2 und Bevacizumab 15 mg/kg Körpergewicht alle drei Wochen gegeben, verwendet. Im experimentellen Studienarm wird untersucht, ob eine Verlängerung der Erhaltungstherapie mit Bevacizumab in identischer Dosierung und in identischem Applikationsabstand von drei Wochen, jedoch für maximal 30 Monate gegeben, mit einer Effektivitätssteigerung (Verbesserung des progressionsfreien Überlebens, Verbesserung des Gesamtüberlebens) verbunden ist. Parallel werden die Nebenwirkungsraten und die Lebensqualität der Patientinnen erfasst.
  3. 3. Die Studie AGO-OVAR 17 der AGO Studiengruppe wird in 120 Zentren in Deutschland und zusätzlich in Frankreich und Skandinavien durchgeführt. Hier sind die GINECO (Group d’Investigateurs Nationaux pour l’Etude des Cancers Ovariens) und die NSGO (Nordic Society of Gynaecological Oncology), wie schon häufiger, Partner der AGO Studiengruppe im Netzwerk der ENGOT (European Network of Gynaecological Oncological Trials Group). Wie der Studienleiter, Prof. Dr. Jacobus Pfisterer (Kiel) kürzlich berichtete, war ursprünglich eine Rekrutierungsdauer von 30 Monaten, also bis April 2014 vorgesehen, um die geplanten 900 Patientinnen aufzunehmen. Aufgrund einer extrem schnellen Rekrutierung, die sich in den letzten Monaten nochmals beschleunigt hat, sind bereits 840 Patientinnen aufgenommen worden. Damit wird das Rekrutierungsende bereits für Juli 2013, also 9 Monate früher als kalkuliert, erwartet. Die Patientinnen kommen zum überwiegenden Teil aus Zentren der AGO Studiengruppe, insgesamt mehr als 85%. Dies liegt darin begründet, daß die GINECO und die NSGO zeitgleich auch noch andere Konzepte im Rahmen prospektiv randomisierter Phase III Studien untersuchen und somit nur mit einer kleineren Zentrenzahl an dieser Studie teilnehmen. Der internationale Studienleiter Prof. Dr. Jacobus Pfisterer zeigte sich sehr erfreut über diesen Erfolg: "Wie bereits seit vielen Jahren werden heutzutage nahezu alle großen Therapiestudien bei einer Eierstockkrebserkrankung von international kooperierenden Studiengruppen durchgeführt. Das Design der Studie ist attraktiv, auch für betroffene Patientinnen, da es eine wichtige Fragestellung beantworten werden wird. Insgesamt ist dies ein großer Erfolg und bestätigt wieder einmal den Stellenwert der nationalen und internationalen Vernetzung der AGO Studiengruppe." Die Beantwortung der Haupt-Fragestellung der Studie, ob eine längere Antikörpertherapie mit einer Effektivitätssteigerung verbunden ist, wird allerdings noch einige Jahre dauern. "Zunächst einmal müssen die Patientinnen die Therapie, die im Einzelfall 30 Monate in Anspruch nimmt, ja erst einmal absolvieren", so Pfisterer. Weitere Informationen zur Studie finden sich unter http://www.ago-ovar.de zum Studienleiter Prof. Dr. Jacobus Pfisterer unter http://de.linkedin.com/pub/jacobus-pfisterer/70/824/245 und http://www.about.me/jacobuspfisterer
  4. 4. Die Webseite von Prof. Dr. Jacobus Pfisterer finden Sie unter http://www.frauenundkrebs.de Beschreibung: Ihr Arzt – Prof. Dr. Jacobus Pfisterer Gynäkologische Onkologie Kiel: Im Zentrum für Gynäkologische Onkologie Kiel werden alle frauenspezifischen Krebserkrankungen wie Eierstockkrebs, Brustkrebs, Gebärmutterhalskrebs, Gebärmutterkörperkrebs diagnostiziert und behandelt. Spezialisten aller Fachrichtungen sind eingebunden und beraten gemeinsam jede klinische Situation. So kann in jedem Einzelfall, auch unter Berücksichtigung der Wünsche und Erwartungen der jeweiligen Patientin, die bestmögliche Behandlung empfohlen werden. Operationen werden in enger Kooperation mit spezialisierten Kliniken durchgeführt. Alle medikamentösen Therapieverfahren wie Chemotherapie, Antikörpertherapie, Hormontherapie, die bei diesen Krankheiten zum Einsatz kommen können, werden durchgeführt. Auch neueste und experimentelle Therapieverfahren sind möglich, letztere in der Regel im Rahmen kontrollierter und zertifizierter klinischer Studien. Das Zentrum für Gynäkologische Onkologie ist Mitglied der AGO Studiengruppe. Es beteiligt sich zusätzlich auch an Phase I – III Studien anderer kooperativer Studiengruppen.
  5. 5. Share this: • Twitter • Facebook • LinkedIn • Google +1 • Reddit • Digg • Drucken • E-Mail • Tumblr • StumbleUpon • Schlagworte: AGO Studiengruppe, Behandlung, Brustkrebs, Diagnostik, Dr. Jacobus Pfisterer, Eierstockkrebs, Gebärmutterhalskrebs, Gebärmutterkörperkrebs, Gynäkologische Onkologie Kiel, Jacobus Pfisterer, Phase III Studien, Prof. Dr. Jacobus Pfisterer
  6. 6. Studie bei Eierstockkrebs unter der Leitung von Prof. Dr. Jacobus Pfisterer

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