Chpt 5 part 2

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  • Image sources: Brand X Pictures (Image Ch05_01SobrietyTest) Royalty-Free/Corbis (Image Ch05_05Injection)
  • Figure 5.4 from text
  • Image source: Royalty-Free/Corbis (Image Ch05_04OralIngestion)
  • Image source: Royalty-Free/Corbis (Image Ch05_05Injection)
  • Image source: McGraw-Hill Companies, Inc./Gary He, photographer (Image Ch05_07AbsorptionCocaine)
  • Chpt 5 part 2

    1. 1. Chapter 5The Actions of Drugs
    2. 2. ADMEDistribution of drugsthrough the body  Absorption  Distribution  Metabolism  Elimination/ExcretionAdditional factors  Cultural issues  Mechanisms of tolerance & withdrawal symptoms
    3. 3. Routes of Administration Oral  Absorption from the gastrointestinal (GI) tract is a complicated process  Drugs must withstand the digestive processes and pass through the cells lining the GI tract into the bloodstream Inhalation  The drug moves from the lungs into the bloodstream through capillary walls  Effects are rapid because blood moves quickly from the lungs to the brain
    4. 4. Routes of Administration: Injection Intravenous (IV) injection involves putting the drug directly into the bloodstream Effects are rapid High concentrations can be delivered Potential damages Subcutaneous injection (under the skin) “Skin popping” Can cause necrosis Intramuscular injection (into a muscle) Greater blood supply in muscles Less chance of irritation
    5. 5. Routes of Administration: Topical Application Absorption through the skin can provide slow, steady drug delivery Depending on the substance, can be a less commonly used route of administration However, a range of topical applications can be used with psychoactive substances Absorption through the mucous membranes occurs more rapidly

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