Mohammad Iqbal Hussain
Department of pharmacy
Jagannath university,Dhaka Bangladesh
Objectives of the study
Objectives of the study
Collect information on taxonomical classification,
vernacular names, botanical description, ayurvedic
application of Abroma augusta.
Collect and deliver valuable information on
pharmacological acitivities and toxicity of Abroma
It is estimated that more than 80,000 of total plant
species have been identified and used as medicinal
plants around the world. Among these plants 600-900
species are considered by various experts to be
medicinal plants in Bangladesh.
Among these Abroma augusta is an important
medicinal plant belonging to the family stercluaceace,
having a lot of pharmacological properties and are
extensively used to treat various health ailments.
Species: Abroma augusta
English Devil’s cotton
Chinese Shuo ma
Malaysia Rami sengat
Thailand Thian dam
French Abrome, abrome royal
Abroma augusta is a
large shrubs and small
Height: 3 to 5 meter
about 10-30 cm.
long and 6-18
5 cm. in
red, or yellow
It is widely distributed (native or cultivated)
throughout the warm area of India such as Uttar
Pradesh, Sikkim, Khasi Hills, Assam and in
Bangladesh throughout the hilly regions of Sylhet.
It is also found in Java, Philippines, China,
Australia and Africa (Uganda, Democratic
Republic of Congo)
Grows in open areas. Requires deep, fertile
alluvial soil, good drainage.
Propagation done from seeds or stem- cutting;
Seeds germination power is poor, fresh seeds
soaked in water for 15 min at 280c.The optimum
temperature for germination is 320c.
Sowings are done before the rainy season. The
field should be ploughed properly alone with farm
manure to a fine tilth.
Abroma augusta Linn. f has a long history of
medicinal use in ayurvedic system.
It is highly possesses in gynecological disorders.
It regulates the menstrual flow and also used as
abortifacient and anti-fertility agent .
Chakma community use seeds for neck pain.
Jhenaigatiupazila in Sherpur district uses root
and bark for the treatment of uterine disorders,
diabetes, rheumatics pains of joints and headache
Pahan tribal healer in Dinajpur district use bark
of root and root to treat diabetes and urinary
In Jamalpur Sadar Upazila it is used to induce
regular menstruation, abscess, sexual disease in
men, low sperm count.
The folk medicinal herbalists of Bhola district
uses bark to treat rise of blood pressure during
Garo tribal healers of Netrakona district use leaf
juice to treat diabetes and root juice for sexual
The Santal tribe in Rajshahi district uses leaf and
root to treat pain.
In India, it is used in dysmenorrhea but in
Indonesia it is used as anti-scabies, anti-
dermatitis, anti-inflammatory and analgesic
Plant parts Chemical constituents
Leaves Taraxerol, lupeol and octacosanol.
Root Abromine,betaine, friedelin ,choline,
β –sitosterol and stigmasterol.
Root bark α –Amyrin, masilinic acid, protocatechuic acid,
vanillic acid, caffeic acid.
Stem bark β -sitosterol and friedelin.
Seed Palmitic acid, linoleic acid and stearic acid.
Heart wood β-sitosterol, glycol and octacosane-1, 28-diol.
Abromine Friedlin Choline
β-sitosterol Stigmasterol Masilinic acid
Protocatechuic acidTaraxerol Lupeol
Methanolic extracts of the leaves Dose of 300 mg/kg
body weight Alloxan (110 mg/kg) induced diabetic rats
Ethanolic extract of the roots Alloxan (100 mg/kg) induced
diabetic rats Exhibit the hypoglycemic effect .
Aqueous extracts of the Abroma augusta Dose of
(100,200 mg/kg respectively) STZ (65 mg/kg) and STZ
nicotinamide (110 mg/kg) induced diabetic rats
Aqueous extract of the leaves Dose of 2ml/kg body
weight twice daily for a period of 21 days Alloxan
(80mg/ml) induced diabetic rabbit Antidiabetic activity.
Methanolic extracts of the leaves of Abroma
augusta has potential antioxidant activity with the
IC50 value of 51.9786mg /ml.
Wound healing activity:
Alcoholic extract of Abroma augusta
Dexamethasone suppressed wound healing in
wistar rats Increase the breaking strength,
dexamethasone suppressed wound healing and
inhibit oxidative damage.
Methanolic root extract Dose of 200 and 400
mg/kg Significantly reduced the carrageenan
induced rat paw edema.
Petroleum extracts of the roots Dose of 200
mg/kg Carrageenan induced rat inflammation
Due to inhibition of COX and LOX enzymes by the
alkaloids and flavonoids present in extracts.
Methanolic extract of leaves Dose of 400 mg/kg
Adult male Wistar albino rats with high cholesterol
diet Reduction in TC, TG and LDL-c levels and
a rise in HDL-c levels.
Antipyretic and analgesic activity:
Methanolic extract of leaves, barks and roots
Rats with pyrexia (pyrexia was induced in rats by
intravenous injection of 15% suspension of
Brewer’s yeast) Antipyretic and analgesic
n-hexane extract of the seeds Tested against
Trichophyton schoenleinii, Pseudallescheria boydii,
Microsporum canis, Trichophyton simii , Candida albicans,
Aspergilus niger , Fusarium solani var. lycopersici,
Macrophomina phaseolina Effective against
Trichophyton schoenleinii and Microsporum canis.
Acetone extracts of leaves Tested on Aspergillus flavus,
Aspergillus niger, Candida albicans, Aspergillus fumigates,
Rizopus oryzae Effictive antifungal activity.
Seed oil of Abroma augusta Tested on Corynebacterium
diphtheria, Escherichia coli, Klebsiella pneumonia, Proteus
morganni, Pseudomonas aeruginosa, Salmonella typhi,
Shigella boydii and Staphylococcus aureus Significant
Acetone extract of leaves Tested against three gram-
positive (Bacillus subtilis, Bacillus megaterium and
Staphylococcus aureus)and four gram-negative (Escherichia
coli, Shigella dysenteriae, Shigella sonnei and Salmonella typhi)
bacteria Significant antibacterial activity.
Methanolic extracts of leaves Treatment of clots
with 100 µl of extracts 50.1% clot lysis.
Chloroform and methanol extracts of the leaves,
root wood, stem bark, stem wood and seeds
Tested against Tribolium castaneum(Red flour
beetle) showed insecticidal activity.
Ethanolic extraction of leaves and stems used in
menstrual disorders, leucorrhoea, dysmenorrhoea,
amenorrhorea and sterility.
Powdered roots act as an abortifacient and anti-
Petroleum-ether extract of the roots, at a dose of
50mg/kg body wt, showed anti-implantation as
well as abortifacient action in mice.
Aqueous extract of the roots showed oxytocic
In cytotoxicity assay with brine shrimp nauplii, the
LC50 value of the acetone extract of leaves of the
plant was 7.06µg/ml.
Ethanolic and petroleum ether extracts of Abroma
augusta show considerable cytotoxic effect with
LC50 value of 380.875 µg/ml and 307.458 µg/ml
Seed oil extracted by the n- hexane from seeds Tested
against the Lemna aequinoctialis Welv. Oil posses
remarkable phytotoxic activity and inhibit the growth of plant
by 82.35% at a concentration of 500 µg/ ml.
Methanolic extracts of Abroma augusta leaves, barks and
roots did not show any sign of toxicity up to 2000 mg/kg body
weight in male or female rats and hence it was considered to
Abroma augusta Linn f. preparation are widely available
in open areas of nature and employed by the practitioners
of natural health for treatment of infection, pain, wound
healing, diabetes, dysmenorrhoea, amenorrhoea, sterility,
gonorrhea, sinusitis and used as a uterine tonic. Though
Abroma augusta has medicinal activity but it is time to
explore its medicinal value at molecular level with the help
of various techniques.
(STZ=Streptozocin ) Betaine is responsible for antihyperglycemic activity. It has been reported that dietary fiber present in aqueous leaf extract of Abroma augusta may be effective in reducing post-prandial glucose absorption from the gastrointestinal tract, which in turn can reduce blood glucose levels.
TC= Total cholesterol TG= Triglycerides Bark has showed the higher effect than leaf and root comparing with the different standard analgesics.
The leaves of Abroma augusta plant contains taraxerol and its acetate, β-sitosterol, lupeol, an aliphatic alcohol (C32H66O), octacosanol, and probably a mixture of long chain fatty acid which are very effective against a fungi.
The leaves of Abroma augusta plant contains taraxerol and its acetate, β-sitosterol, lupeol, an aliphatic alcohol (C32H66O), octacosanol, and probably a mixture of long chain fatty acid which are very effective against a fewbacteria
The potentiality of the chloroform extracts could be arranged in a descending order of seeds> root wood > leaf> stem bark and for the methanol extracts, seed>root wood > stem bark > leaf. Addition of 100-µl Streptokinase, a positive control to the clots along with 90 minutes of incubation at 37°C, showed 86.2% clot lysis. Clots when treated with 100-µl sterile distilled water (negative control) showed only negligible clot lysis (5.2%).