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It is vital to add NoFollow tag to affiliate link in all your web pages where affiliate links are presented in order to prevent de-indexing from Google.
If you have affiliate links in your web pages, best is to add NoFollow tag to affiliate link so that this page would not be de-value or de-index by Google. If Google discover that you do not add NoFollow tag to affiliate link in your page, you page would likely be down graded, worst is de-indexed. Your web page would unfortunately not able to rank in all the searches.