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By the end of 2017, NASA plans to purchase both crew and cargo delivery services to the International Space Station from commercial suppliers. Near the planned end-of-life for ISS, NASA intends to transition low Earth orbit (LEO) operations from government-led to commercially-driven as a result of greater involvement from the private sector. CASIS has seen increasing demand for use of the ISS National Lab to support research and development in numerous fields. This session will highlight the R&D opportunities in low Earth orbit ranging from LEO commercialization efforts related to advancing protein crystal growth studies for drug discovery and delivery; stem cell, organs-on-chips, and vascularized tissue research for organ bioengineering; and use of 3D printing capabilities and superior optical fiber manufacturing for on-orbit production.