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In an era of increasing human longevity, it is becoming ever more critical to prioritize no only improved treatment of disease but also approaches for maintaining wellness to preserve the quality of life for aging adults. Spaceflight-induced physiological changes represent deviations from this state of wellness, with some changes serving as accelerated models of Earth-based conditions, including musculoskeletal disease, immune dysfunction, and delayed wound healing. This session will highlight research onboard the ISS National Lab that seeks to exploit these spaceflight-induced physiological effects to improve human health on Earth through studies that advance the prevention, detection, and treatment of disease. In parallel, spaceflight research and development efforts also seek to improve the human condition by employing the space environment to advance diagnostic tools and drug discovery, development and delivery systems.